Sugar acids and derivatives
Medchemexpress LLC BET bromodomain inhibitor 1 | 2411226-02-1 | 99.7% | 25 MG
BET bromodomain inhibitor 1 is an orally active and selective inhibitor of bromodomain and extra-terminal (BET) bromodomains. It demonstrates anti-cancer activity by inducing G1-phase cell cycle arrest, inhibiting c-Myc expression, and upregulating p21 levels. Its primary applications involve research into acute myeloid leukemia, acute leukemia, and multiple myeloma.
- Orally active and selective BET bromodomain inhibitor.
- High affinity for BRD4 (IC50: 2.6 nM) and other BET bromodomains.
- Demonstrates anti-cancer activity by inducing G1-phase cell cycle arrest.
- Effective against various cancer cell lines (Kasumi 1, MM1.S, MV4-11, and RS4-11).
- Excellent selectivity for BET bromodomain family over other bromodomains.
- Does not inhibit five cytochrome P450 enzymes.
- Exhibits strong antitumor activities in in-vivo models.
Sigma Aldrich Fine Chemicals Biosciences Alginic acid from brown algae | 9005-32-7 | MFCD00081309 | 100G
Alginic acid from brown algae | 9005-32-7 | MFCD00081309 | 100G
Medchemexpress LLC UDP-glucuronic acid trisodium | 63700-19-6 | 5 MG
UDP-glucuronic acid trisodium (Uridine-5'-diphosphoglucuronic acid trisodium salt) is a critical precursor for essential glycoconjugates across biological kingdoms, including mammalian glycosaminoglycans, plant cell wall polysaccharides, and bacterial capsule glycoglycerolipids. It promotes the migration of liver cancer cells (Huh7, SK-Hep1, and SNU449) through induction of EMT process at concentrations of 0.5-1 mM over 24 hours.
- Critical precursor for essential glycoconjugates
- Promotes migration of liver cancer cells
- Induces EMT process in liver cancer cells
- Decreases E-cadherin and increases vimentin levels in Huh7 and SNU449 cells
eMolecules Ambeed -D-glucuronide-pNP-carbonate 100mg 847281787 A1365593 0 000 894095-98-8 913 842 C45H43N3O18
Ambeed -D-glucuronide-pNP-carbonate 100mg 847281787 A1365593 0 000 894095-98-8 913 842 C45H43N3O18
Sigma Aldrich Fine Chemicals Biosciences 3dGROTM Colon Intestinal O
Patient derived organoids (PDOs) are novel in vitro 3D cell models that preserve original tissue physiology and molecular pathology thus representing a clinically-relevant alternative to traditional 2D cell lines and an effective tool to refine and reduce animal models. PDOs can be derived from adult patient biopsies or resected tissues containing native LGR5 stem cell populations and cultured within an ECM-rich substrate using specialized organoid media such as L-WRN conditioned media. Adult tissue derived organoids are phenotypically and genetically stable in long term culture presenting more mature phenotypes compared to iPSC-derived organoids. Importantly PDOs have shown to be able to predict patient clinical responses to chemotherapeutics.We are now offering a comprehensive biobank of highly characterized tissue-derived human gastrointestinal organoids from normal and diseased patients. The intestinal organoid biobank contains over 50 highly characterized intestinal organoids f
Gold Biotechnology Inc NADH Beta Reduced Sodium Salt
Reduced -nicotinamide adenine dinucleotide (NADH) plays a major role in metabolism as a cofactor in redox reactions and as a mobile electron carrier NADH is a high energy compound that donates electrons to the electron transport chain to provide energy for ATP production by oxidative phosphorylation NADH is a required oxidizing cosubstrate in fermentation which regenerates NADH is fluorescent which provides for a relatively simple way to detect NADH in biological samples NADH is also used in enzyme cycling assays to detect relevant biological molecules in tissues
Gold Biotechnology Inc NADH Beta Reduced Sodium Salt
Reduced -nicotinamide adenine dinucleotide (NADH) plays a major role in metabolism as a cofactor in redox reactions and as a mobile electron carrier NADH is a high energy compound that donates electrons to the electron transport chain to provide energy for ATP production by oxidative phosphorylation NADH is a required oxidizing cosubstrate in fermentation which regenerates NADH is fluorescent which provides for a relatively simple way to detect NADH in biological samples NADH is also used in enzyme cycling assays to detect relevant biological molecules in tissues
Medchemexpress LLC D-praziquanamine ((-)-praziquanamine) | 55375-92-3 | MFCD30491837 | 98.9% | 202.26 g/mol | C12H14N2O | 10 MG
D-Praziquanamine ((-)-praziquanamine) is the stereoisomer of L-praziquanamine, provided as a research reagent for use as an experimental control in biochemical and pharmacological studies.
- Isomer of L-praziquanamine, intended for use as an experimental control.
- CAS number 55375-92-3.
- Molecular formula C12H14N2O, molecular weight 202.26 g/mol.
- Typical purity ~98.9% (batch-specific; see certificate of analysis for details).
- Appearance: solid; also offered as a 10 mM solution in DMSO.
- Available in small sample sizes and milligram-scale quantities (for example, 10 mg).
Medchemexpress LLC Bet-bay 002 | 1588521-78-1 | 99.8% | 403.86 g/mol | C22H18ClN5O | 100MG
BET-BAY 002 is a small-molecule BET bromodomain inhibitor intended for research use. It demonstrates activity in multiple myeloma models and is provided as a high-purity solid for in vitro and preclinical studies. The compound is soluble in DMSO and is offered in multiple pack sizes to support assay development and screening.
- Potent BET bromodomain inhibitor with reported efficacy in multiple myeloma models.
- High purity (99.8%) suitable for biological assays.
- Soluble in DMSO for convenient reconstitution.
- Available in multiple quantities including a 100 mg package.
- Molecular weight 403.86 g/mol and formula C22H18ClN5O.
Medchemexpress LLC UDP-glucuronic acid trisodium | 63700-19-6 | 1 G
UDP-glucuronic acid trisodium (Uridine-5'-diphosphoglucuronic acid trisodium salt) is a crucial precursor for essential glycoconjugates found across various biological kingdoms, including mammalian glycosaminoglycans, plant cell wall polysaccharides, and bacterial capsule glycoglycerolipids. It is intended for research use only.
- Critical precursor for essential glycoconjugates
- Promotes migration of liver cancer cells in vitro
- Decreased E-cadherin and increased vimentin levels in liver cancer cells
- Molecular weight of 646.23
- Purity of 99.87%
- Appears as a white to off-white solid
Medchemexpress LLC Integrin alpha V beta 3 protein, mouse (hFc-tagged) | 20UG
Recombinant heterodimeric integrin alpha V beta 3 protein derived from mouse, produced in HEK293 cells and fused to a C-terminal human Fc (hFc) tag. Supplied as a 20 μg research reagent, it is intended for receptor-ligand interaction studies, cell adhesion assays, and signaling investigations.
- Recombinant heterodimeric integrin alpha V beta 3 derived from mouse
- Expressed in HEK293 cells to support mammalian post-translational modifications
- C-terminal human Fc (hFc) tag for purification and detection
- Suitable for receptor-ligand binding, cell adhesion, and signaling assays
- Molecular weight ranges reported for subunits: 110-135 kDa and 50-60 kDa
- Supplied as a 20 μg unit for laboratory research use
Medchemexpress LLC 4-Methylumbelliferyl β-D-cellobioside | 72626-61-0 | MFCD00063279 | 99.4% | 500.45 | 100 MG
4-Methylumbelliferyl β-D-cellobioside is a substrate for cellulase. It can be hydrolyzed to produce fluorescent 4-methylumbelliferone, which is used to study the kinetics of cellulases.
- Substrate for cellulase
- Produces fluorescent 4-methylumbelliferone
- Used to study the kinetics of cellulases
Medchemexpress LLC Azido-PEG4-beta-D-glucose | 1609083-15-9 | 99.9% | 381.38 | 25 MG
Azido-PEG4-beta-D-glucose is a PEG-based PROTAC linker that facilitates the synthesis of PROTACs. This click chemistry reagent contains an Azide group, allowing it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups.
- PEG-based PROTAC linker
- Utilized in PROTAC synthesis
- Functions as a click chemistry reagent
- Contains an azide functional group
- Participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Enables strain-promoted alkyne-azide cycloaddition (SPAAC)
- Intended for research use only
Medchemexpress LLC D-Glucuronic acid sodium monohydrate-13C6 | 207300-70-7 | 1 MG
D-Glucuronic acid sodium monohydrate-13C6 is a 13C-labeled endogenous metabolite. This compound serves as a tracer and an internal standard for various quantitative analyses.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC D-Dimannuronic acid sodium | 10 MG
D-Dimannuronic acid sodium is an alginate extract derived from brown algae. This compound is primarily used in research to synthesize sulfated polymannuronate (SPMG)-derived oligosaccharides. It is intended for research use only.
- Derived from brown algae
- Used to synthesize sulfated polymannuronate (SPMG)-derived oligosaccharides
- For research use only
- Purity of 99.94%
- Molecular weight of 392.25
- Molecular formula is C12H17NaO13
- Appears as a white to off-white solid
- Soluble in H2O at 125 mg/mL (318.67 mM), requires ultrasonic treatment