Sugar acids and derivatives
Medchemexpress LLC Protac α-synuclein degrader 3 | 2412273-77-7 | ≥98.0% | C51H68N6O11S2 | 10MG
PROTAC α-synuclein degrader 3 is a proteolysis-targeting chimera developed for research applications to induce ubiquitination and proteasomal degradation of α-synuclein, useful in Parkinson's disease model studies. It has documented in vitro and in vivo formulation solubility and recommended storage conditions for stable handling.
- Selective α-synuclein degrader that promotes ubiquitination and proteasomal degradation.
- Demonstrated to reduce α-synuclein levels (≈65% reduction at 1 μM).
- Soluble in DMSO at 100 mg/mL with ultrasonic assistance.
- Formulatable for in vivo dosing in multiple vehicle systems at ≥2.5 mg/mL.
- Stable when stored as powder at 4°C; in solution store at -80°C (6 months) or -20°C (1 month).
- For research use only; not intended for clinical or therapeutic use.
Medchemexpress LLC Msx-127 (NSC-23026) | 6616-56-4 | MFCD00087356 | 99.7% | 308.37 g/mol | C16H24N2O4 | 25 MG
MSX-127 is a small-molecule C-X-C chemokine receptor 4 (CXCR4) antagonist supplied for research use. It inhibits CXCR4-mediated signaling and has been used in studies of cancer metastasis. The compound is provided as a high-purity solid with documented storage and solubility properties suitable for in vitro research applications.
- Acts as a CXCR4 antagonist relevant to cancer and immunology research.
- High reported purity (≈99.68%).
- Molecular weight 308.37 g/mol and formula C16H24N2O4.
- White to off-white solid appearance.
- Soluble in DMSO (≈41.67 mg/mL); ultrasonic assistance may be required.
- Storage: powder -20°C (up to 3 years) or 4°C (up to 2 years); in solvent -80°C (up to 6 months).
Medchemexpress LLC D-Glucuronic acid | 6556-12-3 | 1 ML
D-Glucuronic acid is a crucial component of various anti-inflammatory proteoglycans, playing a role in embryonic development and inhibiting cell aggregation. This compound and its derivatives are known for their liver detoxifying properties and have demonstrated anti-tumor activity.
- Promotes early embryonic development
- Inhibits cell aggregation
- Functions as a liver detoxifier
- Derivatives possess anti-tumor activity
- Activates Toll-like receptor 4 (TLR4)
Sigma Aldrich Fine Chemicals Biosciences D Glucuronic acid 98 GC100G
Glucuronic acid is one of the component of xylan backbone a hemicellulose present in plant cell wall.
Sigma Aldrich Fine Chemicals Biosciences Sialic Acid Quantitation K
The Sialic Acid Quantitation Kit provides a rapid and accurate determination of total N-acetylneuraminic acid (NANA sialic acid). NANA is released from glycoconjugates using neuraminidase. The kit uses alpha(2-3 6 8 9) neuraminidase to cleave all NANA linkages including alpha(2-8) and alpha(2-9) linkages as well as branched NANA for the most accurate determination of total sialic acid content.
TARGETMOL CHEMICALS INC BLEOMYCIN SULFATE 10MG
Also available in 1 mg 2 mg 5 mg 25 mg 50 mg 100 mg 200 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Bleomycin Sulfate (Blenoxane) a glycopeptide antibiotic is an anticancer agent for squamous cell carcinomas (SCC). In UT-SCC-19A cells the IC50 of Bleomycin Sulfate is 4 nM. purity: 99%
Sigma Aldrich Fine Chemicals Biosciences 4 Methylumbelliferyl alpha5MG
4 Methylumbelliferyl alpha5MG
Medchemexpress LLC 4-Methylumbelliferyl-β-D-glucuronide hydrate | 881005-91-0 | 99.92% | 100 MG
4-Methylumbelliferyl-β-D-glucuronide hydrate is a fluorogenic substrate (λex=362 nm, λem=445 nm). It has potential applications in detecting the activity of β-glucuronidase and the number of Escherichia coli. It is highly soluble in DMSO (150 mg/mL) and moderately soluble in H2O (5.2 mg/mL), requiring sonication for dissolution.
- Fluorogenic substrate with specific excitation and emission wavelengths
- Detects activity of β-glucuronidase
- Used for detecting Escherichia coli
- High solubility in DMSO
- Requires sonication for dissolution in water
Medchemexpress LLC Aurachin D | 108354-13-8 | 10 MG
Aurachin D is an antibiotic that inhibits Gram-positive bacteria and some fungi. It blocks NADH oxidation in beef heart submitochondrial particles.
- Acts as an antibiotic
- Inhibits Gram-positive bacteria
- Inhibits some fungi
- Blocks NADH oxidation
Medchemexpress LLC UDP-glucuronic acid (trisodium) | 63700-19-6 | 1 ML
UDP-glucuronic acid trisodium (Uridine-5'-diphosphoglucuronic acid trisodium salt) is a critical precursor for essential glycoconjugates found across various biological kingdoms. These glycoconjugates include mammalian glycosaminoglycans, plant cell wall polysaccharides, and bacterial capsule glycoglycerolipids. This product has also been shown to promote the migration of liver cancer cells (Huh7, SK-Hep1, and SNU449) through the induction of the EMT process.
- Critical precursor for essential glycoconjugates
- Supports the formation of mammalian glycosaminoglycans, plant cell wall polysaccharides, and bacterial capsule glycoglycerolipids
- Induces cell migration in liver cancer cell lines
- Decreases E-cadherin levels and increases vimentin levels in liver cancer cells
- Purity of 99.87%
- Appearance as a white to off-white solid
- For research use only
Medchemexpress LLC β-D-glucopyranosiduronic acid derivative (p-nitrophenyl carbonate methyl ester) | 894095-98-8 | MFCD31715405 | 99.2% | 913.83 | C45H43N3O18 | 100 MG
β-D-glucuronide-pNP-carbonate is a cleavable antibody-drug conjugate (ADC) linker used as a building block in the synthesis of ADCs. It features a p-nitrophenyl (pNP) carbonate leaving group attached to a β-D-glucuronide moiety, enabling enzymatic or chemical cleavage to release payloads for targeted delivery. Intended for research use only.
- Cleavable glycosidase-sensitive linker for controlled payload release.
- p-Nitrophenyl carbonate activation enables facile coupling to amines.
- High purity suitable for synthetic and medicinal chemistry workflows.
- Available as a solid reagent in small research quantities for laboratory use.