Sugar acids and derivatives
Sigma Aldrich Fine Chemicals Biosciences 3dGROTM Colon Intestinal O
Patient derived organoids (PDOs) are novel in vitro 3D cell models that preserve original tissue physiology and molecular pathology thus representing a clinically-relevant alternative to traditional 2D cell lines and an effective tool to refine and reduce animal models. PDOs can be derived from adult patient biopsies or resected tissues containing native LGR5 stem cell populations and cultured within an ECM-rich substrate using specialized organoid media such as L-WRN conditioned media. Adult tissue derived organoids are phenotypically and genetically stable in long term culture presenting more mature phenotypes compared to iPSC-derived organoids. Importantly PDOs have shown to be able to predict patient clinical responses to chemotherapeutics.We are now offering a comprehensive biobank of highly characterized tissue-derived human gastrointestinal organoids from normal and diseased patients. The intestinal organoid biobank contains over 50 highly characterized intestinal organoids f
Medchemexpress LLC Beta-Acetoxyisovalerylshikonin | 69091-17-4 | 25 MG
Beta-Acetoxyisovalerylshikonin is a naphthoquinone derivative isolated from Arnebia euchroma.
- High purity: 99.57%
- Molecular weight: 430.45
- Molecular formula: C23H26O8
- Appearance: Brown to black solid
- Used in simultaneous densitometric determination of related compounds
- Applied in isolation and purification processes using preparative HPLC
Medchemexpress LLC Lafadofensine (D-(-)-Mandelic acid) | 99.9% | C32H32F2N2O6 | 25 MG
Lafadofensine (D-(-)-Mandelic acid) is a monoamines reuptake inhibitor that demonstrates sufficient effects after short-term administration. This product is for research use only.
- Purity of 99.95% (LCMS)
- Molecular weight: 578.60
- Chemical formula: C32H32F2N2O6
- Appearance: White to off-white solid
- Storage (powder): -20°C for 3 years, 4°C for 2 years
- Storage (in solvent): -80°C for 6 months, -20°C for 1 month
Medchemexpress LLC D-Glucuronic acid (standard) | 6556-12-3 | 250 MG
D-Glucuronic acid (Standard) is an analytical standard for research and analytical applications. It is a key component of anti-inflammatory proteoglycans, promoting embryonic development and inhibiting cell aggregation. Metabolized into ethyl glucuronide, it activates Toll-like receptor 4 (TLR4), potentially causing pain. This compound and its derivative glucurono-lactone act as liver detoxifiers, with derivatives also showing anti-tumor activity. It is utilized in qualitative, quantitative, and methodological research, particularly with techniques like HPLC, GC, and MS.
- Purity: 99.93%
- Molecular weight: 194.14
- Chemical formula: C6H10O7
- Appearance: Solid, white to off-white
- Promotes embryonic development
- Liver detoxifier
Medchemexpress LLC D-Glucose, O-α-D-glucopyranosyl-(1→6)-O-α-D-glucopyranosyl-(1→4)- | 33401-87-5 | 99.95% | 504.44 | 25 MG
D-Panose is an oligosaccharide composed of glucose units linked by specific glycosidic bonds. It is a PAN-type oligosaccharide and a food ingredient based on isomaltooligosaccharides (IMOs). It can be detected with high sensitivity in SALDI-MS using magnesium oxide nanoparticles as the matrix.
- Composed of glucose units.
- PAN-type oligosaccharide.
- Food ingredient based on isomaltooligosaccharides (IMOs).
- High sensitivity detection in SALDI-MS.
- For research use only.
Medchemexpress LLC OBI-992 drug-linker | 3039487-10-7 | 96.6% | 2173.46 | 1 MG
OBI-992 drug-linker is a drug-linker conjugate composed of a TOP I inhibitor Exatecan (HY-13631) and a linker. It exhibits antitumor property in mouse models and can be used for the synthesis of ADC OBI-992.
- Composed of a TOP I inhibitor and a linker
- Exhibits antitumor properties in mouse models
- Can be used for the synthesis of ADC OBI-992
Medchemexpress LLC Benzamide, N-[[(5-chloro-2-pyridinyl)amino]thioxomethyl]-3-nitro-4-(1-piperidinyl)- | 838810-96-1 | 98.0% | 25 MG
MAC-545496 is a nanomolar inhibitor of glycopeptide-resistance-associated protein R (GraR). It demonstrates strong binding affinity to the full-length GraR protein (Kd ≤ 0.1 nM) and functions as an antivirulence agent, effectively reversing β-lactam resistance in Methicillin-resistant strains (MRSA).
- Potent synergism with cefuroxime
- Reduces β-lactam MIC against S. aureus USA300
- Enhances activity against S. aureus clinical isolates
- Potentiates effects against various circulating MRSA strains
- Synergizes with antimicrobial peptides colistin and polymyxin B
- Inhibits mprF expression
- Inhibits citrate-induced biofilm formation
- Effective as monotherapy for MRSA-infected larvae
- Increases survival in drug-treated larvae
- Correlates with concentration-dependent bacterial killing
Medchemexpress LLC Bet bromodomain inhibitor | 1505453-59-7 | MFCD28144506 | 99.5% | 445.90 g/mol | C24H20ClN5O2 | 100 MG
BET bromodomain inhibitor is a small-molecule research compound that selectively inhibits BET family bromodomains, including BRD4, with reported biochemical potency (BRD4(1) IC50 = 14 nM). It is supplied as a solid (white to off-white) with high purity for preclinical laboratory use.
- Potent BRD4 inhibitor (IC50 = 14 nM).
- High purity (~99.5%).
- Solid, white to off-white powder.
- Recommended storage: powder -20°C (3 years) or 4°C (2 years).
- Available in small research quantities, including 100 MG packaging.
Medchemexpress LLC IL-18RAP Rhesus Mac 5ug | 5ug
IL-18 is a pleiotropic proinflammatory cytokine that is involved in induction of inflammatory mediators regulation of the cytotoxic activity of NK cells and T cells and differentiation and activation of both Th1 and Th2 cells IL-18 signals through its specific cell surface receptor IL-18R which comprises two subunits IL-18R and IL-18R beta IL-18 forms a signalling complex with the IL-18 receptor (R ) and (R ) chains at the plasma membrane which induces multiple inflammatory cytokines[2] IL-18R complex recruits the IL-1R- activating kinase and TNF- associated factor 6 which phosphorylates nuclear factor k - inducing kinase with subsequent activation of NF- k [3] IL-18R betaknockdown inhibits IL-18 driven tumor cell metastasis in C57/BL6 mice[4] IL-18RAP Protein Rhesus Macaque (HEK293 His) is a recombinant protein with a His label that consists of 357 amino acids (M1-R356) and is produced by HEK293 cells
Medchemexpress LLC D-Glucuronic acid lactone | 32449-92-6 | MFCD00135622 | 98.0% | 176.12 | 5 G
D-Glucuronic acid lactone is an endogenous metabolite and a glucuronic acid derivative. It serves as a starting reagent for the synthesis of 2,3,4-tris (tert-butyldimethylsilyl) glucuronic acid trichloroethyl ester, which is used to prepare 1-O-acyl glucuronic acids, synthesize optically active glucuronic acids, and produce long-chain alkyl glucuronides. It also shows potential for use in studies of reversible cerebral vasoconstriction syndrome (RCVS).
- Endogenous metabolite and glucuronic acid derivative
- Starting reagent for the synthesis of specific glucuronic acid esters
- Prepares 1-O-acyl glucuronic acids
- Synthesizes optically active glucuronic acids
- Produces long-chain alkyl glucuronides
- Potential use in studies of reversible cerebral vasoconstriction syndrome (RCVS)
Medchemexpress LLC D-Glucuronic acid (Standard) | 6556-12-3 | 100 MG
D-Glucuronic acid (Standard) is an analytical standard intended for research and analytical applications. It is a significant component of numerous anti-inflammatory proteoglycans, contributing to embryonic development and inhibiting cell aggregation. When metabolized into ethyl glucuronide, it activates Toll-like receptor 4 (TLR4), which is associated with pain. Furthermore, D-Glucuronic acid and its derivative, glucurono-lactone, are known as liver detoxifiers and its derivatives also exhibit anti-tumor activity.
- Analytical standard for assays
- Intended for research and analytical use
- Utilized in HPLC, GC, and MS research experiments
- Major component of anti-inflammatory proteoglycans
- Promotes embryonic development
- Inhibits cell aggregation
- Acts as a liver detoxifier
- Derivatives possess anti-tumor activity
- Solid, white to off-white appearance
- Purity of 99.93%
Medchemexpress LLC Heparin sodium salt (MW 15kDa) | 9041-08-1 | 15000 (Average) | 5 G
Heparin sodium salt (MW 15kDa) is a polymer of Heparin with a molecular weight of 15kDa. It functions as an anticoagulant by reversibly binding to antithrombin III (ATIII), which significantly increases the rate at which ATIII inactivates coagulation enzymes thrombin factor IIa and factor Xa. This product has shown angiogenic response in late Chorioallantoic Membrane (CAM) assay. It is suitable for laboratory centrifugation and storage.
- Acts as an anticoagulant
- Binds reversibly to antithrombin III (ATIII)
- Accelerates inactivation of coagulation enzymes
- Used in various biological activities targeting thrombin and factor Xa
- Shows angiogenic response in CAM assay
Medchemexpress LLC 2-(4-heptylphenethyl)-6-hydroxybenzoic acid | 1243583-85-8 | MFCD22123243 | 99.6% | 340.46 g/mol | C22H28O3 | 10 MG
MG 149 is a small-molecule inhibitor of Tip60 (histone acetyltransferase) used in preclinical research to probe acetyltransferase activity and related mitochondrial pathways. It shows activity versus MOF/KAT8 and can influence PINK1-dependent mitochondrial clearance; supplied as a white to off-white solid with high analytical purity for laboratory use.
- Tip60 (HAT) inhibitor with reported IC50 ≈ 74 μM for Tip60 and ≈ 47 μM for MOF.
- High purity (HPLC 99.6%).
- Chemical formula C22H28O3; molecular weight 340.46 g/mol.
- White to off-white solid suitable for bench-scale research.
- Storage: powder at -20°C (stable 3 years) or 4°C (stable 2 years); in solvent at -80°C (2 years) or -20°C (1 year).
- Common applications: epigenetics assays, acetyltransferase inhibition studies, and mitochondrial/PINK1 pathway research.
Medchemexpress LLC β-D-glucuronide-pNP-carbonate | 894095-98-8 | MFCD31715405 | 99.6% | 913.83 | C45H43N3O18 | 250 MG
β-D-glucuronide-pNP-carbonate is a cleavable glucuronide-based carbonate linker used as a precursor in antibody-drug conjugate (ADC) synthesis. It features a p-nitrophenyl (pNP) activated carbonate that facilitates conjugation and enzymatic payload release upon glucuronidase cleavage. Supplied as a white to off-white solid with high purity and defined molecular properties, it is intended for research applications.
- Cleavable glucuronide-based ADC linker for payload release
- Activated p-nitrophenyl carbonate handle for efficient conjugation
- High purity (99.6%) suitable for research applications
- Molecular weight 913.83 and formula C45H43N3O18
- Store at -20°C, sealed and protected from moisture