Sugar acids and derivatives
Medchemexpress LLC Benzamide, N-[[(5-chloro-2-pyridinyl)amino]thioxomethyl]-3-nitro-4-(1-piperidinyl)- | 838810-96-1 | 98.0% | 25 MG
MAC-545496 is a nanomolar inhibitor of glycopeptide-resistance-associated protein R (GraR). It demonstrates strong binding affinity to the full-length GraR protein (Kd ≤ 0.1 nM) and functions as an antivirulence agent, effectively reversing β-lactam resistance in Methicillin-resistant strains (MRSA).
- Potent synergism with cefuroxime
- Reduces β-lactam MIC against S. aureus USA300
- Enhances activity against S. aureus clinical isolates
- Potentiates effects against various circulating MRSA strains
- Synergizes with antimicrobial peptides colistin and polymyxin B
- Inhibits mprF expression
- Inhibits citrate-induced biofilm formation
- Effective as monotherapy for MRSA-infected larvae
- Increases survival in drug-treated larvae
- Correlates with concentration-dependent bacterial killing
![eMolecules cis-Bicyclo[3.1.0]hexan-3-ol | 694-43-9 | MFCD20921684 | 1g](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502193492.JPG-250.jpg)
eMolecules cis-Bicyclo[3.1.0]hexan-3-ol | 694-43-9 | MFCD20921684 | 1g
Combi-Blocks | cis-Bicyclo[3.1.0]hexan-3-ol | 1g | 267210850 | ST-7476 | 97.000 | 694-43-9 | MFCD20921684 | 98.145 | C6H10O
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Sigma Aldrich Fine Chemicals Biosciences 3dGROTM Colon Intestinal O
Patient derived organoids (PDOs) are novel in vitro 3D cell models that preserve original tissue physiology and molecular pathology thus representing a clinically-relevant alternative to traditional 2D cell lines and an effective tool to refine and reduce animal models. PDOs can be derived from adult patient biopsies or resected tissues containing native LGR5 stem cell populations and cultured within an ECM-rich substrate using specialized organoid media such as L-WRN conditioned media. Adult tissue derived organoids are phenotypically and genetically stable in long term culture presenting more mature phenotypes compared to iPSC-derived organoids. Importantly PDOs have shown to be able to predict patient clinical responses to chemotherapeutics.We are now offering a comprehensive biobank of highly characterized tissue-derived human gastrointestinal organoids from normal and diseased patients. The intestinal organoid biobank contains over 50 highly characterized intestinal organoids f
Medchemexpress LLC SN-38 glucuronide (SN-38G) | 121080-63-5 | 99.5% | 568.53 | 10 MG
SN-38 glucuronide is an inactive metabolite of the anticancer active molecule Irinotecan and has toxic effects on the gastrointestinal tract. Irinotecan is a topoisomerase I inhibitor which can be used for researching colon and rectal cancer.
- Inactive metabolite of the anticancer active molecule irinotecan.
- Has toxic effects on the gastrointestinal tract.
- Cells capable of metabolizing SN38 to SN38-G show increased resistance to extracellular SN38.
- Can serve as a substrate for gut microbial β-glucuronidase enzymes, which reactivate SN-38 in the intestine, leading to increased toxic effects on the gut.
Chem-Impex International, Inc. 4-Methylumbelliferyl-b-D-glucuronide hydrate | 6160-80-1 | MFCD09039280 | 5G
4-Methylumbelliferyl-b-D-glucuronide hydrate, 6160-80-1, MFCD09039280, 5G
Medchemexpress LLC Complement factor D-IN-1 | 1386455-76-0 | 98.9% | 483.32 g·mol⁻1 | C21H19BrN6O3 | 10 MG
Complement factor D-IN-1 is a potent, selective, small-molecule reversible inhibitor of complement factor D intended for research into complement system biology and complement-mediated inflammation. It has been characterized in biochemical assays and is supplied as solid or solution for laboratory studies.
- Potent inhibitory activity: IC50 = 0.006 μM (FD thioesterolytic assay) and IC50 = 0.05 μM (MAC deposition assay).
- High reported purity (~98.9%); consult lot-specific COA for exact value.
- Supplied as solid or as DMSO solution for flexible experimental workflows.
- Stable storage: powder at -20°C (long term) or 4°C; in solvent, -80°C recommended.
- Molecular weight 483.32 g·mol⁻1 and formula C21H19BrN6O3 for analytical reference.
- For research use only; not for human or clinical applications.
Chem-Impex International, Inc. 4-Methylumbelliferyl-b-D-glucuronide hydrate | 6160-80-1 | MFCD09039280 | 1G
4-Methylumbelliferyl-b-D-glucuronide hydrate, 6160-80-1, MFCD09039280, 1G
Medchemexpress LLC Oxacillin-13C6 sodium | 1173-88-2 | 99.0% | 429.37 g/mol | C1313C6H18N3NaO5S | 10 MG
Oxacillin-13C6 sodium is the 13C6 stable-isotope labeled form of oxacillin sodium supplied as an analytical standard for research and mass spectrometry applications. It provides an isotopically enriched internal standard for accurate quantitation and method validation.
- 13C6-labeled oxacillin sodium for isotope-dilution assays.
- High purity: 99.0%.
- Supplied in small vial sizes suitable for analytical use, including 10 MG.
- Provided with supporting documentation: SDS, COA, and data sheet.
- Intended for research and analytical applications; not for clinical use.
Medchemexpress LLC NH2-C6-ARC186 sodium | 92.5% | 12,881.00 | 10 MG
NH2-C6-ARC186 sodium is an NH2-C6-modified aptamer supplied as the sodium salt that inhibits complement C5 convertase activity. The terminal aminohexyl (NH2-C6) linker enables covalent coupling to other peptides or molecules for conjugation studies. It is provided as a white to off-white solid with defined purity and molecular weight for research applications in small milligram quantities.
- Function: complement C5 convertase inhibitor
- NH2-C6 aminohexyl linker for conjugation
- Purity: 92.5%
- Physical form: white to off-white solid
- Typical sizes: 1 mg, 5 mg, 10 mg, larger sizes by quote
- Storage: in solvent -80°C (6 months) or -20°C (1 month); sealed and dry
- Molecular weight approximately 12,881 Da
Medchemexpress LLC D-Glucuronic acid sodium salt monohydrate | 207300-70-7 | 1 G
D-Glucuronic acid sodium salt monohydrate is a primary constituent of numerous anti-inflammatory proteoglycans, facilitating embryonic development and inhibiting cell aggregation. When metabolized into ethyl glucuronide, it activates Toll-like receptor 4 (TLR4), leading to pain. Both D-Glucuronic acid sodium salt monohydrate and its derivative, glucurono-lactone, can function as liver detoxifiers for human health prevention, and its derivatives also exhibit anti-tumor activity. It is intended for research use only.
- Major component of many anti-inflammatory proteoglycans.
- Can promote embryonic development.
- Inhibits cell aggregation.
- Activates Toll-like receptor 4 (TLR4) after metabolism into ethyl glucuronide, causing pain.
- Serves as a liver detoxifier for human health prevention.
- Derivatives possess anti-tumor activity.
Medchemexpress LLC KVA-D-88 | 2410550-31-9 | 99.81% | 382.19 | 25 MG
KVA-D-88 is a blood-brain barrier-permeable PDE4 inhibitor with IC50 values of 140 nM for PDE4B and 880 nM for PDE4D. It inhibits cocaine-induced hyperlocomotor activity and sensitization by selectively inhibiting PDE4B and reducing cAMP degradation, thereby modulating neuroadaptive responses. This compound can be utilized in the study of cocaine addiction.
- Blood-brain barrier-permeable PDE4 inhibitor
- Selectively inhibits PDE4B and reduces cAMP degradation
- Modulates neuroadaptive responses
- Inhibits cocaine-induced hyperlocomotor activity and sensitization
- Useful in the study of cocaine addiction