Sugar acids and derivatives
Medchemexpress LLC SN-38 glucuronide | 121080-63-5 | 99.5% | 568.53 | 10 MM * 1 ML
SN-38 glucuronide is an inactive metabolite of the anticancer active molecule Irinotecan and has toxic effects on the gastrointestinal tract. Irinotecan is a topoisomerase I inhibitor used for researching colon and rectal cancer. SN-38 glucuronide can serve as a substrate for gut microbial β-glucuronidase enzymes, which remove the glucuronic acid moiety to reactivate SN-38, thereby increasing its toxic effects on the gut. SN38-G is the glucuronidated metabolite of SN38, and cells capable of metabolizing SN38 to SN38-G are more resistant to extracellular SN38 than cells lacking this capability.
- Inactive metabolite of Irinotecan
- Used for research on colon and rectal cancer
- Can be reactivated by gut microbial β-glucuronidase enzymes
![eMolecules 383132-63-6 | 6-(Methylsulfonyl)-1h-indole-2-carboxylic acid | Combi-Blocks | MFCD02664464 | 239.250 | C10H9NO4S | 96.000 | CS(=O)(=O)c1ccc2cc([nH]c2c1)C(O)=O | 1g | 401039913](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502184941.JPG-250.jpg)
eMolecules 383132-63-6 | 6-(Methylsulfonyl)-1h-indole-2-carboxylic acid | Combi-Blocks | MFCD02664464 | 239.250 | C10H9NO4S | 96.000 | CS(=O)(=O)c1ccc2cc([nH]c2c1)C(O)=O | 1g | 401039913
6-(Methylsulfonyl)-1h-indole-2-carboxylic acid | Combi-Blocks | 383132-63-6 | MFCD02664464 | 239.250 | C10H9NO4S | 96.000 | CS(=O)(=O)c1ccc2cc([nH]c2c1)C(O)=O | 1g | 401039913
Medchemexpress LLC Tetrahydrouridine | 18771-50-1 | C9H16N2O6 | 25 MG
Tetrahydrouridine (THU) is a potent inhibitor of cytidine deaminase (CDA) that competitively blocks the enzyme's active site. It is intended for research and analytical applications, and can suppress deamination in the catabolism of cytotoxic deoxycytidine analogues.
- Potent inhibitor of cytidine deaminase (CDA)
- Competitively blocks the enzyme's active site
- Can suppress deamination in the catabolism of cytotoxic deoxycytidine analogues
- Improves Gemcitabine sensitivity in certain cell types
- Inhibits S-phase without apoptosis
- For research use only
- Analytical standard
Apexbio Technology LLC HMP Linker 68858-21-9 100g
HMP Linker is an acid-sensitive linker used in solid-phase peptide synthesis (SPPS) It is designed to facilitate the covalent attachment of peptide carboxy-terminal residues to solid-phase resin supports and enables controlled cleavage of synthesized peptides under mildly acidic conditions thereby preserving the structural integrity of sensitive functional groups and peptide termini HMP Linker acts primarily by hydrolyzing upon acid catalysis which allows the intact release of peptides from resin supports Based on these properties HMP Linker holds research potential in peptide therapeutics synthesis and studies requiring mild peptide cleavage conditions
Medchemexpress LLC 2,4-D sodium (Standard) | 2702-72-9 | 97% | 243.02 | 100 MG
2,4-D sodium (Standard) is an analytical standard intended for research and analytical applications. It functions as a selective herbicide, controlling broad-leaved weeds. The compound induces apoptosis and inhibits DNA and protein synthesis, thereby preventing normal plant growth and development. It serves as a reference standard for assay.
- Intended for research and analytical applications.
- Selective herbicide for broad-leaved weeds.
- Induces apoptosis.
- Inhibits DNA and protein synthesis.
- Prevents normal plant growth and development.
- Used in qualitative, quantitative, and methodological research experiments.
- Suitable for HPLC, GC, and MS applications.
Alkali Scientific 4 Methylumbelliferyl α L Arabinopyranoside, 100 Milligrams
Methylumbelliferyl Arabinopyranoside is a high-purity reagent used in biochemical analysis, particularly in testing the activity of enzymes that hydrolyze arabinose-based substrates. This 100mg reagent is commonly employed in assays to study carbohydrate metabolism and glycosylation processes. It is ideal for use in enzyme-linked assays and metabolic studies focused on arabinose or other complex sugars. The high-quality purity of this reagent ensures consistent, reproducible results in laboratory experiments. Methylumbelliferyl Arabinopyranoside is a valuable tool in studying enzymes involved in plant cell wall degradation, microbial digestion, and carbohydrate enzymology.
![Alkali Scientific MUP [4 Methylumbelliferyl Phosphate], 1 G](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000661661.jpg-250.jpg)
Alkali Scientific MUP [4 Methylumbelliferyl Phosphate], 1 G
Methylumbelliferyl Phosphate (MUP) 1 g is a high-concentration fluorogenic substrate widely used in enzyme assays to measure enzymatic activity with high sensitivity and precision. This reagent is essential in biochemical assays where the detection of enzymes like alkaline phosphatase is required. MUP, upon enzymatic hydrolysis, releases a fluorescent product that can be quantified using fluorometric analysis. The 1 g formulation is suited for large-scale applications and is commonly used in clinical diagnostics, laboratory research, and environmental testing. This reagent provides a robust method for studying enzyme kinetics and inhibiting activities in various biological systems.
Medchemexpress LLC Guanylyl Cyclase beta 1 Antibody (YA2147) | 50 UL
The Guanylyl Cyclase beta 1 Antibody (YA2147) is a rabbit-derived, non-conjugated IgG monoclonal antibody specifically designed to target Guanylyl Cyclase beta 1. This antibody mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP, making it suitable for various research applications.
- Rabbit-derived recombinant monoclonal antibody
- Non-conjugated IgG isotype
- Targets Guanylyl Cyclase beta 1
- Reacts with human, mouse, and rat species
- Suitable for Western Blot (1:500-1:1000) and Immunohistochemistry-Paraffin (1:50-1:100) applications
- Stored at -20°C for one year
- Avoid repeated freeze/thaw cycles
- Formulated with 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide, and 0.05% BSA
Medchemexpress LLC 2,6-dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide | 1258292-64-6 | 99.8% | 1 ML
GDC-046 (2,6-dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide) is a potent, selective, orally bioavailable TYK2 inhibitor with reported Ki values of 4.8 nM (TYK2), 0.7 nM (JAK1), 0.7 nM (JAK2), and 0.4 nM (JAK3). Supplied for research use, available as a 10 mM solution in DMSO (1 mL) or as solid material.
- Potent, selective TYK2 inhibitor with low-nanomolar activity against JAK family kinases.
- Molecular weight 350.2 g/mol; formula C16H13Cl2N3O2.
- CAS 1258292-64-6; purity 99.8%.
- Physical form solid, off-white to yellow; also supplied as 10 mM solution in DMSO (1 mL).
- Solubility in DMSO 62.5 mg/mL (178.47 mM); ultrasonic assistance recommended.
- Storage: solid at 4 °C; in solvent store at -80 °C (up to 6 months) or -20 °C (up to 1 month); protect from light.
Medchemexpress LLC Sodium zirconium cyclosilicate | 17141-74-1 | 95.0% | 5 MG
Sodium zirconium cyclosilicate is an inorganic, microporous zirconium silicate used as a selective cation exchanger and potassium binder for laboratory research. Supplied as a white to off-white solid in small milligram quantities, it is intended for in vitro ion-exchange and potassium regulation studies.
- White to off-white solid form, insoluble and non-absorbed
- Highly selective potassium binding for ion-exchange research
- Available in small milligram quantities for laboratory use
- Store sealed at 4°C and protect from moisture
- Purity typically around 95.0% for research applications
![Alkali Scientific 4 Methylumbelliferyl 2 acetamido 2 deoxy β D galactopyranoside [4 Methylumbelliferyl N acetyl β D galactosaminide], 25 Mg](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000660548.jpg-250.jpg)
Alkali Scientific 4 Methylumbelliferyl 2 acetamido 2 deoxy β D galactopyranoside [4 Methylumbelliferyl N acetyl β D galactosaminide], 25 Mg
Methylumbelliferyl β-D-Galactosaminide (25mg) is a high-purity biochemical reagent used in assays to analyze enzymatic activity. This compound is commonly employed in research to study enzymes that hydrolyze galactosamine-containing substrates, such as galactosaminidases. Upon enzymatic hydrolysis, the substrate produces a fluorescent product, making it ideal for high-sensitivity detection of enzyme activity. The 25mg product is suitable for laboratory-scale experiments and provides a reliable tool for studying carbohydrate metabolism, enzyme kinetics, and substrate specificity in biochemical and pharmaceutical research.