Sugar acids and derivatives
Medchemexpress LLC 4-Methylumbelliferyl β-D-galactopyranoside | 6160-78-7 | MFCD00036773 | 99.1% | 338.31 | 500 MG
4-Methylumbelliferyl β-D-galactopyranoside is a fluorescent substrate for β-galactosidase. When cleaved, it produces a water-soluble blue fluorescent coumarin fluorophore that can be detected using a fluoroenzymeter or fluorometer.
- Fluorescent substrate for β-galactosidase
- Produces a water-soluble blue fluorescent coumarin fluorophore when cleaved
- Detectable using a fluoroenzymeter or fluorometer
- White to off-white solid
- Molecular weight of 338.31
- Purity of 99.06%
- Excitation at 390 nm
- Emission at 480 nm
Medchemexpress LLC d-KLA Peptide | 286380-05-0 | >99.3% | 1523.99 | 10 MG
d-KLA Peptide is a synthetic pro-apoptotic peptide that specifically targets mitochondria. It induces apoptosis by destroying the mitochondrial membrane and activating associated biochemical pathways, including caspase family proteins and PARP. This peptide can also be utilized to carry and deliver genes or small molecules, enhancing anti-tumor effects.
- Specifically targets mitochondria
- Induces apoptosis by destroying mitochondrial membrane
- Activates caspase family proteins and PARP
- Can deliver genes or small molecules to enhance anti-tumor effects
Medchemexpress LLC Sodium zirconium cyclosilicate | 17141-74-1 | 95.0% | 100 MG
Sodium zirconium cyclosilicate is an inorganic, microporous zirconium silicate compound used as a selective cation-exchange reagent that binds potassium ions for biomedical and kidney disease research.
- Selectively binds potassium ions for removal in vitro or preclinical studies.
- Inorganic, non-absorbed microporous structure suitable for research applications.
- Available in multiple small-scale sizes for laboratory use.
- Supplied as a solid reagent with specified purity for experimental reproducibility.
Medchemexpress LLC BET-IN-14 | 2243669-93-2 | C30H37N7O2 | 25 MG
BET-IN-14 is an orally active pan BET inhibitor with an IC50 of 5.35 nM. It exhibits anti-cancer activity. In vitro studies show that BET-IN-14 (Compound 171) has anti-tumor activity against various cancer cell lines (average IC50: 174.7 nM), particularly in MM.1S, Ty-82, MV-4-11, and KG-1 cells. In vivo, BET-IN-14 (50 and 100 mg/kg, p.o., qd) inhibits tumor growth in MV-4-11 xenograft models by 60.36%.
- Orally active pan BET inhibitor with high potency (IC50 of 5.35 nM)
- Displays anti-tumor activity against various cancer cell lines (average IC50: 174.7 nM)
- Effective in MM.1S, Ty-82, MV-4-11, and KG-1 cells
- Inhibits tumor growth in MV-4-11 xenograft models by over 60% at tested dosages
Medchemexpress LLC D-Glucuronic acid | 99.9% | 240.09 g·mol⁻¹ | 13C6H11NaO8 | 10 MG
13C6-labeled D-glucuronic acid sodium salt monohydrate provided as a stable-isotope internal standard for metabolomics and biochemical research. The material is the sodium salt monohydrate of D-glucuronic acid, isotopically labeled on all six carbons (13C6), and supplied as a high-purity dry solid.
- 13C6 isotopic labeling for tracer and internal standard use.
- High purity (HPLC) - 99.9%.
- Molecular weight 240.09 g·mol⁻¹ and formula 13C6H11NaO8.
- Suitable for LC-MS and metabolomics workflows as a standard or tracer.
- Supplied as a stable dry solid for controlled storage.
Medchemexpress LLC Glucuronic acid sodium | 7182-77-6 | 50 MG
Glucuronic acid sodium is a polysaccharide that shows anti-inflammatory activity, helps heal ulcerative colitis, and improves the intestinal barrier by increasing tight junction proteins like ZO-1 and Occludin. It also modifies gut microbiota by increasing beneficial bacteria and suppressing harmful ones.
- Shows anti-inflammatory activity
- Helps heal ulcerative colitis
- Improves intestinal barrier by increasing tight junction proteins like ZO-1 and Occludin
- Modifies gut microbiota by increasing beneficial bacteria and suppressing harmful ones
Medchemexpress LLC D-Glucuronic acid sodium salt monohydrate | 207300-70-7 | 5 G
D-Glucuronic acid sodium salt monohydrate is a primary constituent of various anti-inflammatory proteoglycans. It has the ability to promote embryonic development and inhibit cell aggregation. Upon metabolization into ethyl glucuronide, it activates Toll-like receptor 4 (TLR4), which can lead to pain. Both D-Glucuronic acid sodium salt monohydrate and its derivative, glucurono-lactone, can serve as liver detoxifiers for human health prevention, and its derivatives also demonstrate anti-tumor activity. The product has a purity of 98.0% and is intended for research use only.
- Promotes embryonic development and inhibits cell aggregation
- Activates Toll-like receptor 4 (TLR4)
- Functions as a liver detoxifier
- Demonstrates anti-tumor activity (derivatives)
- Intended for research use only
- High purity
Medchemexpress LLC Integrin alpha V bet 5ug
Integrin V beta 5 proteins specifically the -V (ITGAV) subunit are multifunctional receptors for ligands such as vitronectin and fibronectin and recognize RGD sequences ITGAV ITGB3 binds fractalkine and acts as a coreceptor in CX3CR1-dependent signaling Integrin alpha V beta 8 Protein Human (HEK293 His solution) is a recombinant protein dimer complex containing human-derived Integrin alpha V beta 8 protein expressed by HEK293 with C-His labeled tag Integrin alpha V beta 8 Protein Human (HEK293 His solution) has molecular weight of 187 95 kDa
Medchemexpress LLC Insulin Receptor Beta Antibody (YA341) | Protein A affinity purified | Predicted band size: 156 kDa; Observed band size: 95 kDa | 10 UL
Insulin Receptor Beta Antibody (YA341) is a rabbit-derived, non-conjugated IgG monoclonal antibody that targets Insulin Receptor Beta. This antibody is developed for research use only and mediates the pleiotropic actions of insulin, playing a key role in cell growth, survival, and differentiation.
- Host: rabbit
- Clonality: recombinant, monoclonal
- Species reactivity: human, rat
- Immunogen: synthetic peptide corresponding to human insulin receptor (AA range: 930-970)
- Applications: WB (1:500-1:2000), ICC/IF (1:100-1:500)
- Purity: protein A affinity purified
- Conjugation: non-conjugated
- Formulation: supplied in 1*TBS (pH7.4), 0.05% BSA, 40% glycerol, and 0.05% sodium azide
- Storage: stored at -20°C for 1 year; avoid repeated freeze/thaw cycles
- Shipping: shipped with blue ice
Medchemexpress LLC Acyl coenzyme A synthetase (ACS) | 9013-18-7 | 100 U
Acyl coenzyme A synthetase (ACS) is frequently utilized in biochemical research. It facilitates the activation of fatty acids by coenzyme A through a two-step thioesterification, leading to the production of acyl coenzyme A. This compound then participates in various anabolic and catabolic lipid metabolism pathways, as well as the TCA cycle in aerobic respiration.
- Used in biochemical research.
- Catalyzes the activation of fatty acids by coenzyme A.
- Involved in anabolic and catabolic lipid metabolism pathways.
- Participates in the TCA cycle in aerobic respiration.
- Activity loss of solid powder when stored at 37°C for 7 days is less than 10%.
- Can be dissolved in water at a concentration of 1 mg/mL, or in buffer according to specific experimental references.
Medchemexpress LLC Homo-PROTAC pVHL30 degrader 1 | 2244684-49-7 | 99.4% | 1179.45 | 25 MG
Homo-PROTAC pVHL30 degrader 1 is a potent pVHL30 degrader based on PROTAC, consisting of two ligands of von Hippel-Lindau. It dimerizes von Hippel-Lindau (VHL) with high avidity in vitro and induces potent, rapid, and proteasome-dependent self-degradation of VHL in different cell lines, in a highly isoform-selective fashion and without triggering a hypoxic response. This product is for research use only.
- Dimerizes von Hippel-Lindau (VHL) with high avidity in vitro.
- Induces potent, rapid and proteasome-dependent self-degradation of VHL in different cell lines.
- Acts in a highly isoform-selective fashion.
- Does not trigger a hypoxic response.
Medchemexpress LLC Mac glucuronide linker-1 | 2222981-71-5 | 96.4% | 897.90 g/mol | C42H47N3O17S | 1 G
MAC glucuronide linker-1 is a glycosidase-cleavable antibody-drug conjugate (ADC) linker supplied as a purified small molecule for research use. It incorporates a glucuronide cleavable moiety to enable enzymatic release of attached payloads, and is provided at high purity for synthesis and conjugation workflows.
- Glycosidase-cleavable glucuronide linker enabling enzymatic payload release.
- Molecular weight approximately 897.90 g/mol.
- Molecular formula C42H47N3O17S.
- High purity (96.4%) suitable for research applications.
- Available in multiple sizes including a 1 G package.
- For research use only; not for human therapeutic use.
Medchemexpress LLC Integrin alpha V bet 100ug | 100ug
Integrin alpha V beta 6 Protein Human (HEK293 His) is a recombinant protein dimer complex containing human-derived Integrin alpha V beta 6 protein expressed by HEK293 with C-His labeled tag Integrin alpha V beta 6 Protein Human (HEK293 His) has molecular weight of 130 95 KDa respectively
Medchemexpress LLC 4-Methylumbelliferyl 100mg | 18323-58-5 | 440.61 g·mol^-1 | C28H40O4 | 100 MG
4-Methylumbelliferyl oleate is a fluorogenic substrate for acid and alkaline lipases. Upon enzymatic hydrolysis, it liberates 4-methylumbelliferone (4-MU), enabling sensitive fluorometric detection and kinetic assays (Ex/Em 320/450 nm).
- Provides a fluorogenic readout upon lipase-catalyzed hydrolysis.
- Releases 4-methylumbelliferone with Ex/Em 320/450 nm for sensitive detection.
- High chemical purity suitable for enzymatic assays.
- Stable when stored at -20°C and protected from light; solvent stability guidelines available.
- Available in multiple pack sizes to support assay development and scale-up.
Gold Biotechnology Inc NADH Beta Reduced Sodium Salt
Reduced -nicotinamide adenine dinucleotide (NADH) plays a major role in metabolism as a cofactor in redox reactions and as a mobile electron carrier NADH is a high energy compound that donates electrons to the electron transport chain to provide energy for ATP production by oxidative phosphorylation NADH is a required oxidizing cosubstrate in fermentation which regenerates NADH is fluorescent which provides for a relatively simple way to detect NADH in biological samples NADH is also used in enzyme cycling assays to detect relevant biological molecules in tissues