Sugar acids and derivatives
![Medchemexpress LLC Sar-[D-Phe8]-des-Arg9-bradykinin | 126959-88-4 | MFCD05662308 | 100.0% | 975.10 | C47H66N12O11 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000244662.png-250.jpg)
Medchemexpress LLC Sar-[D-Phe8]-des-Arg9-bradykinin | 126959-88-4 | MFCD05662308 | 100.0% | 975.10 | C47H66N12O11 | 25 MG
Sar-[D-Phe8]-des-Arg9-bradykinin is a synthetic peptide agonist of the bradykinin B1 receptor used in pharmacological research to study receptor activation and contractile responses. It is supplied as a white to off-white solid with high purity and a defined amino acid sequence.
- High purity suitable for analytical and biological assays.
- Molecular weight 975.10 and formula C47H66N12O11.
- Sequence: {Sar}-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe.
- Stable as powder when stored sealed at -80°C (2 years) or -20°C (1 year).
- Available in multiple sizes, including 25 MG.
Medchemexpress LLC (D-Trp6)-LHRH free acid | 129418-54-8 | 99.7% | 1312.43 | 10 MG
(D-Trp6)-LHRH free acid is a luteinizing hormone-releasing hormone (LHRH) agonist. In vitro, (D-Trp6)-LHRH free acid (10 μM; 24 h or 6 days) reduces the proliferation of human epithelial ovarian cancer cell lines EFO-21 and EFO-27.
- Acts as a luteinizing hormone-releasing hormone (LHRH) agonist
- Reduces proliferation of human epithelial ovarian cancer cell lines EFO-21 and EFO-27
- High purity of 99.67%
- White to off-white solid appearance
Medchemexpress LLC PROTAC BET Degrader-10 | 1957234-97-7 | 99.4% | 783.29 | 1 ML
PROTAC BET Degrader-10 (dBET37) is a potent BET protein BRD4 degrader, connected by ligands for Cereblon and BRD4, with a DC50 of 49 nM. This compound utilizes PROTAC technology, containing two different ligands connected by a linker; one for an E3 ubiquitin ligase and the other for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Potent BET protein BRD4 degrader
- Connected by ligands for Cereblon and BRD4
- DC50 of 49 nM
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins
- For research use only
- Components include a BRD4(BD1BD2) ligand, a Cereblon ligand, and a linker
- Appearance is a solid
- Color is off-white to light yellow
Medchemexpress LLC 4-Methylumbelliferyl-α-d-mannoside | 28541-83-5 | 99.3% | 338.31 | 5 MG
4-Methylumbelliferyl-α-d-mannoside is a fluorescent substrate for α-D-mannosidase. For research use only.
- Fluorescent substrate for α-D-mannosidase.
- For research use only.
Medchemexpress LLC Integrin alpha X bet 50ug
Integrin -X/ -2 is a receptor for fibrinogen that recognizes GPR sequences It plays a key role in inflammatory responses particularly in monocyte adhesion and chemotaxis Integrin alpha X beta 2 Protein Human (HEK293 Flag His) is a recombinant protein dimer complex containing human-derived Integrin alpha X beta 2 protein expressed by HEK293 with C-His C-Flag labeled tag
Medchemexpress LLC Protac α-synuclein degrader 3 | 2412273-77-7 | ≥98.0% | C51H68N6O11S2 | 10MG
PROTAC α-synuclein degrader 3 is a proteolysis-targeting chimera developed for research applications to induce ubiquitination and proteasomal degradation of α-synuclein, useful in Parkinson's disease model studies. It has documented in vitro and in vivo formulation solubility and recommended storage conditions for stable handling.
- Selective α-synuclein degrader that promotes ubiquitination and proteasomal degradation.
- Demonstrated to reduce α-synuclein levels (≈65% reduction at 1 μM).
- Soluble in DMSO at 100 mg/mL with ultrasonic assistance.
- Formulatable for in vivo dosing in multiple vehicle systems at ≥2.5 mg/mL.
- Stable when stored as powder at 4°C; in solution store at -80°C (6 months) or -20°C (1 month).
- For research use only; not intended for clinical or therapeutic use.
Medchemexpress LLC D-(+)-cellobiose | 528-50-7 | MFCD00136034 | 99.8% | 342.30 | C12H22O11 | 10 MG
D-(+)-Cellobiose (Standard) is a high-purity analytical reference standard of the disaccharide D-(+)-cellobiose intended for research and analytical applications. It is supplied as a small packaged standard suitable for method development, calibration, and metabolite identification.
- High purity (99.84%).
- CAS number 528-50-7.
- Molecular weight 342.30 g/mol.
- White, water-soluble powder suitable for analytical use.
- Intended for method development, calibration, and metabolite identification.
Medchemexpress LLC BET bromodomain inhibitor | 1505453-59-7 | MFCD28144506 | 99.5% | 445.90 | C24H20ClN5O2 | 25 MG
BET bromodomain inhibitor is a research-grade small-molecule inhibitor of BET family bromodomain proteins used in preclinical and in vitro studies to probe transcriptional regulation, cell proliferation, and apoptosis. The compound has molecular formula C24H20ClN5O2 and a molecular weight of 445.90, and is supplied as a high-purity solid for laboratory use.
- Research use only; not for human or clinical use.
- Potent BET family bromodomain inhibition for mechanistic and cellular assays.
- High purity suitable for analytical and biological studies.
- Available in small solid quantities for laboratory experiments.
Medchemexpress LLC Integrin alpha 6 bet 5ug
Integrin alpha 6 beta 1 Protein Human (HEK293 Flag-His) is the recombinant human-derived Integrin alpha 6 beta 1 protein expressed by HEK293 with C-His C-Flag labeled tag has molecular weight of 110 130 kDa respectively
Medchemexpress LLC Guanylyl Cyclase beta 1 Antibody (YA2147) | 50 UL
The Guanylyl Cyclase beta 1 Antibody (YA2147) is a rabbit-derived, non-conjugated IgG monoclonal antibody specifically designed to target Guanylyl Cyclase beta 1. This antibody mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP, making it suitable for various research applications.
- Rabbit-derived recombinant monoclonal antibody
- Non-conjugated IgG isotype
- Targets Guanylyl Cyclase beta 1
- Reacts with human, mouse, and rat species
- Suitable for Western Blot (1:500-1:1000) and Immunohistochemistry-Paraffin (1:50-1:100) applications
- Stored at -20°C for one year
- Avoid repeated freeze/thaw cycles
- Formulated with 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide, and 0.05% BSA
Medchemexpress LLC KVA-D-88 | 2410550-31-9 | 99.81% | 382.19 | 25 MG
KVA-D-88 is a blood-brain barrier-permeable PDE4 inhibitor with IC50 values of 140 nM for PDE4B and 880 nM for PDE4D. It inhibits cocaine-induced hyperlocomotor activity and sensitization by selectively inhibiting PDE4B and reducing cAMP degradation, thereby modulating neuroadaptive responses. This compound can be utilized in the study of cocaine addiction.
- Blood-brain barrier-permeable PDE4 inhibitor
- Selectively inhibits PDE4B and reduces cAMP degradation
- Modulates neuroadaptive responses
- Inhibits cocaine-induced hyperlocomotor activity and sensitization
- Useful in the study of cocaine addiction
Medchemexpress LLC Ethanone, 1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl | 1839150-56-9 | 98.5% | 471.55 | 25 MG
CHMFL-FLT3-122 is a potent, selective, and orally active FLT3 kinase inhibitor with an IC50 of 40 nM. It demonstrates selectivity for FLT3 over BTK (IC50 of 421 nM) and c-KIT (IC50 of 559 nM) kinases. This compound induces apoptosis by arresting the cell cycle in the G0/G1 phase. It is intended for research use only and is not sold to patients.
- Potent, selective, and orally active FLT3 kinase inhibitor
- Induces apoptosis by arresting the cell cycle into the G0/G1 phase
- Significantly inhibits proliferation of FLT3-ITD positive acute myeloid leukemia (AML) cancer cell lines (MV4-11, MOLM13/14)
- Significantly inhibits FLT3 auto-phosphorylation at Tyr589/591 site
- Inhibits phosphorylation of Stat5 ERK, AKT and expression of cMYC
- Can suppress tumor progression in animal models without significantly affecting body weight
Medchemexpress LLC [D-Trp34]-Neuropeptide Y | 153549-84-9 | 99.7% | 4311.72 | 10 MG
[D-Trp34]-Neuropeptide Y is a potent and selective neuropeptide Y (NPY) Y5 receptor agonist. It is significantly less potent at the NPY Y1, Y2, Y4, and y6 receptors. This product markedly increases food intake in rats.
- Potent and selective neuropeptide Y (NPY) Y5 receptor agonist.
- Markedly increases food intake in rats.
Medchemexpress LLC 4-Methylumbelliferyl-β-D-glucuronide hydrate | 881005-91-0 | 99.9% | 1 ML
4-Methylumbelliferyl-β-D-glucuronide hydrate is a fluorogenic substrate with an excitation wavelength of 362 nm and an emission wavelength of 445 nm. This compound is used in various enzymatic reactions and has applications in detecting β-glucuronidase activity and quantifying *Escherichia coli*.
- Fluorogenic substrate with λex=362 nm and λem=445 nm
- Detects activity of β-glucuronidase
- Quantifies *Escherichia coli*
- Releases 4-methylumbelliferone in enzymatic reactions
- Suitable for kinase assays to measure GLUase activity
Medchemexpress LLC D-Glucuronic acid (Standard) | 6556-12-3 | 100 MG
D-Glucuronic acid (Standard) is an analytical standard intended for research and analytical applications. It is a significant component of numerous anti-inflammatory proteoglycans, contributing to embryonic development and inhibiting cell aggregation. When metabolized into ethyl glucuronide, it activates Toll-like receptor 4 (TLR4), which is associated with pain. Furthermore, D-Glucuronic acid and its derivative, glucurono-lactone, are known as liver detoxifiers and its derivatives also exhibit anti-tumor activity.
- Analytical standard for assays
- Intended for research and analytical use
- Utilized in HPLC, GC, and MS research experiments
- Major component of anti-inflammatory proteoglycans
- Promotes embryonic development
- Inhibits cell aggregation
- Acts as a liver detoxifier
- Derivatives possess anti-tumor activity
- Solid, white to off-white appearance
- Purity of 99.93%