Sugar acids and derivatives
![Medchemexpress LLC 7-chloro-3-(2,4-dimethoxyphenyl)-5-methyl-thiazolo[4,5-d]pyrimidine-2-thione | 2459916-56-2 | 98.5% | 353.85 g/mol | C14H12ClN3O2S2 | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000286978.png-250.jpg)
Medchemexpress LLC 7-chloro-3-(2,4-dimethoxyphenyl)-5-methyl-thiazolo[4,5-d]pyrimidine-2-thione | 2459916-56-2 | 98.5% | 353.85 g/mol | C14H12ClN3O2S2 | 10 MG
CDK1/Cyc B-IN-1 is a small-molecule inhibitor selective for the CDK1-cyclin B kinase complex. It inhibits CDK1-cyclin B activity (reported IC50 ≈97 nM) and induces G2/M cell-cycle arrest and apoptosis in cancer cell lines. The compound is supplied as a solid with high purity and is used in biochemical and cellular studies of cell-cycle regulation.
- Selective CDK1-cyclin B inhibitor with reported IC50 ≈97 nM.
- Induces G2/M cell-cycle arrest and apoptosis in cell lines.
- Suitable for biochemical kinase assays and cell-based studies.
- High supplied purity for reproducible results.
- Soluble in DMSO at 100 mg/mL; use newly opened DMSO.
- Stable as a powder under recommended cold storage conditions.
Medchemexpress LLC (2R)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)butanamide | 1147883-03-1 | 99.3% | 265.30 g/mol | C14H19NO4 | 25MG
EPI-589 is a redox-active small-molecule neuroprotective compound used in research on oxidative stress and neurodegenerative disorders. Supplied as a light yellow powder, it is formulated for both in vitro and in vivo experimentation and is readily soluble in DMSO with recommended vehicle formulations for animal dosing. The compound is characterized and shelf-stable under appropriate storage conditions.
- High purity: 99.3%.
- Chemical formula: C14H19NO4.
- Molecular weight: 265.30 g/mol.
- Form: solid powder, light yellow to yellow.
- In vitro solubility: DMSO 100 mg/mL.
- Recommended in vivo vehicles and clear solution ≥ 2.5 mg/mL.
- Storage: powder at -20°C (long term) or 4°C (short term).
Medchemexpress LLC Protac α-synuclein degrader 5 | 2781922-42-5 | 100.0% | 767.78 g/mol | C39H41N7O10 | 10 MG
PROTAC α-synuclein degrader 5 is a small-molecule PROTAC designed to selectively target and promote degradation of α-synuclein aggregates in cellular models. Supplied as a high-purity solid for preclinical research, it shows dose-dependent activity in fibril-seeding assays and is formulated for in vitro and in vivo use.
- Selective degradation of α-synuclein aggregates (DC50 ≈ 7.5 μM, Dmax 89%).
- Demonstrated reduction of aggregates within 48 hours in PFF seeding cell models.
- High-purity solid suitable for biochemical and cellular assays.
- High solubility in DMSO for in vitro applications (≥100 mg/mL).
- Compatible with in vivo formulation protocols and frozen storage for stability.
![Apexbio Technology LLC vitamin D binding protein precursor (353-363) [Homo sapiens] 10mg](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000096705.png-250.jpg)
Apexbio Technology LLC vitamin D binding protein precursor (353-363) [Homo sapiens] 10mg
Vitamin D binding protein precursor 353-363 is a serum glycoprotein fragment derived from Homo sapiens It is associated with vitamin D binding protein (DBP) a plasma protein that binds vitamin D metabolites and actin monomers mediating transport in the bloodstream and regulation of extracellular actin levels DBP is present on surfaces of various immune cell types including B and T lymphocytes as well as placental cytotrophoblasts Based on these pharmacological properties vitamin D binding protein precursor 353-363 holds research potential in studies of vitamin D metabolism immune regulation and cytoskeletal interactions
Medchemexpress LLC JBI-589 | 2308504-22-3 | 99.8% | 481.56 g·mol⁻¹ | C29H28FN5O | 10 MG
JBI-589 is a non-covalent, isoform-selective inhibitor of peptidylarginine deiminase 4 (PAD4) with oral bioavailability, developed for preclinical cancer and immunology research. It reduces CXCR2 expression, blocks neutrophil chemotaxis, and has shown activity in reducing primary tumor growth and metastasis in experimental studies.
- Selective PAD4 inhibition with demonstrated activity in cellular assays.
- Orally bioavailable small molecule suitable for in vivo studies.
- High chemical purity for research use.
- Soluble in DMSO at high concentrations (requires sonication).
- Stable when stored under recommended powder and solvent conditions.
Medchemexpress LLC Heparin calcium | 37270-89-6 | MFCD00131296 | ≥98.0% | 3600-5000 | Not specified (heterogeneous polysaccharide; no single chemical formula) | 25 MG
Heparin calcium (MW 3600-5000) is a low-molecular-weight heparin anticoagulant supplied for research use. It binds antithrombin III to inactivate thrombin and other activated clotting factors, preventing fibrin formation. The material is provided as a white to off-white solid with good aqueous solubility and is intended for laboratory assays involving anticoagulation or coagulation pathway studies.
- Intended for research use only.
- Anticoagulant that binds antithrombin III to inhibit coagulation.
- Molecular weight range 3600-5000.
- Supplied as a white to off-white solid.
- Soluble in water (≈200 mg/mL with ultrasonication).
- Store sealed and dry at 4 °C; in solution, store at -20 °C to -80 °C per guidelines.
- Typical purity ≥98% (batch-specific certificate of analysis available).
- Available in small laboratory package sizes (example: 25 mg).
Apexbio Technology LLC HMP Linker 68858-21-9 100g
HMP Linker is an acid-sensitive linker used in solid-phase peptide synthesis (SPPS) It is designed to facilitate the covalent attachment of peptide carboxy-terminal residues to solid-phase resin supports and enables controlled cleavage of synthesized peptides under mildly acidic conditions thereby preserving the structural integrity of sensitive functional groups and peptide termini HMP Linker acts primarily by hydrolyzing upon acid catalysis which allows the intact release of peptides from resin supports Based on these properties HMP Linker holds research potential in peptide therapeutics synthesis and studies requiring mild peptide cleavage conditions
![eMolecules 383132-63-6 | 6-(Methylsulfonyl)-1h-indole-2-carboxylic acid | Combi-Blocks | MFCD02664464 | 239.250 | C10H9NO4S | 96.000 | CS(=O)(=O)c1ccc2cc([nH]c2c1)C(O)=O | 1g | 401039913](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502184941.JPG-250.jpg)
eMolecules 383132-63-6 | 6-(Methylsulfonyl)-1h-indole-2-carboxylic acid | Combi-Blocks | MFCD02664464 | 239.250 | C10H9NO4S | 96.000 | CS(=O)(=O)c1ccc2cc([nH]c2c1)C(O)=O | 1g | 401039913
6-(Methylsulfonyl)-1h-indole-2-carboxylic acid | Combi-Blocks | 383132-63-6 | MFCD02664464 | 239.250 | C10H9NO4S | 96.000 | CS(=O)(=O)c1ccc2cc([nH]c2c1)C(O)=O | 1g | 401039913
Medchemexpress LLC Intestinal Alkaline Phosphatase Antibody (YA1559) | 50 UL
Intestinal Alkaline Phosphatase Antibody (YA1559) is a rabbit-derived, non-conjugated IgG monoclonal antibody that targets Intestinal Alkaline Phosphatase. This enzyme functions as an alkaline phosphatase, hydrolyzing various phosphate compounds. It is a component of the gut mucosal defense system, involved in the detoxification of lipopolysaccharide and the prevention of bacterial translocation in the gut.
- Rabbit-derived, recombinant, monoclonal antibody
- Reacts with human species
- Immunogen is a synthesized peptide derived from human intestinal alkaline phosphatase aa1-55/528
- Subcellular localization: cell membrane, lipid-anchor, GPI-anchor
- Forms a homodimer
- Supplied in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA
- For research use only
Sigma Aldrich Fine Chemicals Biosciences 3dGROTM Colon Intestinal O
Patient derived organoids (PDOs) are novel in vitro 3D cell models that preserve original tissue physiology and molecular pathology thus representing a clinically-relevant alternative to traditional 2D cell lines and an effective tool to refine and reduce animal models. PDOs can be derived from adult patient biopsies or resected tissues containing native LGR5 stem cell populations and cultured within an ECM-rich substrate using specialized organoid media such as L-WRN conditioned media. Adult tissue derived organoids are phenotypically and genetically stable in long term culture presenting more mature phenotypes compared to iPSC-derived organoids. Importantly PDOs have shown to be able to predict patient clinical responses to chemotherapeutics.We are now offering a comprehensive biobank of highly characterized tissue-derived human gastrointestinal organoids from normal and diseased patients. The intestinal organoid biobank contains over 50 highly characterized intestinal organoids f
Medchemexpress LLC MC-GGFG-NH-CH2-O-CH2-(s-cyclopropane)-COOH | 2626930-84-3 | 97.4% | 656.68 g/mol | C31H40N6O10 | 25 MG
MC-GGFG-NH-CH2-O-CH2-(s-cyclopropane)-COOH is an ADC linker compound used for conjugation in antibody-drug conjugate research and bioconjugation workflows. It is supplied as a high-purity small molecule suitable for linker incorporation and payload attachment in ADC development.
- High purity (97.4%).
- Molecular formula C31H40N6O10.
- Molecular weight 656.68 g/mol.
- Supplied in milligram quantities for research use.
- Documentation available: data sheet, certificate of analysis, and safety data sheet.
Medchemexpress LLC 4-Methylumbelliferyl-β-D-glucuronide hydrate | 881005-91-0 | 99.92% | 100 MG
4-Methylumbelliferyl-β-D-glucuronide hydrate is a fluorogenic substrate (λex=362 nm, λem=445 nm). It has potential applications in detecting the activity of β-glucuronidase and the number of Escherichia coli. It is highly soluble in DMSO (150 mg/mL) and moderately soluble in H2O (5.2 mg/mL), requiring sonication for dissolution.
- Fluorogenic substrate with specific excitation and emission wavelengths
- Detects activity of β-glucuronidase
- Used for detecting Escherichia coli
- High solubility in DMSO
- Requires sonication for dissolution in water