Steroids and derivatives
Medchemexpress LLC Elexacaftor-d3 (VX-445-d3) | 2216712-66-0 | 98.3% | 600.67 | 1 MG
Elexacaftor-d3 (VX-445-d3) is a deuterium labeled compound, serving as a tracer and internal standard for quantitative analysis methods such as NMR, GC-MS, or LC-MS. Deuteration may influence the pharmacokinetic and metabolic profiles of drugs. Its unlabeled counterpart, Elexacaftor (VX-445), acts as a next-generation cystic fibrosis transmembrane conductance regulator (CFTR) corrector, aiming to restore Phe508del CFTR protein function and treat cystic fibrosis.
- Deuterium labeled compound
- Used as a tracer
- Used as an internal standard for quantitative analysis
- Potential to affect pharmacokinetic and metabolic profiles of drugs
- Restores Phe508del CFTR protein function
- Has potential to treat cystic fibrosis
- Improves Phe508del CFTR protein processing, trafficking, and chloride transport
Medchemexpress LLC 5,7,4'-Trihydroxy-8-Methylflavanone | 916917-28-7 | 5 MG
5,7,4'-Trihydroxy-8-Methylflavanone, also known as 8-Methyl-naringenine, is a high-purity flavanone compound (99.94%) primarily isolated from *Qualea grandiflora*. This product is intended strictly for research applications and is not for patient use. It is a solid, white to off-white substance with a molecular weight of 286.28 and a chemical formula of C16H14O5. Classified within flavonoids and flavonones, as well as phenols and polyphenols, it can also be sourced from plants like *Ericaceae* and *Rhododendron dauricum Linn.*.
- High purity compound (99.94%)
- Isolated from natural sources such as *Qualea grandiflora*
- Suitable for various research applications
- Identified as a flavanone, phenol, and polyphenol
- Stable for storage at 4°C in sealed conditions, away from moisture
- Can be stored in solvent at -80°C for 6 months or -20°C for 1 month
Medchemexpress LLC Vitamin D3 (Standard) | 67-97-0 | C27H44O | 50 MG
Vitamin D3 (Cholecalciferol; Colecalciferol) is a naturally occurring form of vitamin D and serves as an analytical standard. This product is intended for research and analytical applications, inducing cell differentiation and preventing the proliferation of cancer cells.
- Analytical standard for Vitamin D3
- Intended for research and analytical applications
- Induces cell differentiation and prevents proliferation of cancer cells
- Commonly used in qualitative, quantitative, and methodological research
- Suitable for HPLC, GC, and MS applications
- Naturally occurring form of vitamin D
TARGETMOL CHEMICALS INC 16alpha-Bromoepiandrosterone
Also available in 5 mg, 10 mg, 25 mg and bulk. Please contact Fisher for quotes. 16alpha-Bromoepiandrosterone (BEA) is a water-soluble synthetic sterol related to DHEA and is used in studies of type II diabetes and non-diabetic tuberculosis infections. Purity 98.99%
Apexbio Technology LLC Estradiol Benzoate 50-50-0 10mM (in 1mL DMSO)
Estradiol benzoate (50-50-0) is a small-molecule agonist targeting estrogen receptors exhibiting high binding affinity for estrogen receptor alpha (ER ) It is designed to activate ER thereby modulating estrogen-mediated signaling pathways and hormonal regulation processes Estradiol benzoate exerts its biological activity primarily through ER agonism In in vitro assays involving human murine and chicken ER proteins estradiol benzoate demonstrates agonistic activity with an IC50 value ranging between 22 28 nM Based on these pharmacological properties estradiol benzoate holds research potential in studies of ER-mediated signaling endocrine-related diseases receptor-ligand binding analyses pharmacological screening and investigations of estrogen-dependent physiological and pathological conditions
Medchemexpress LLC Trans-Doxercalciferol | 74007-20-8 | 98.2% | C28H44O2 | 5 MG
trans-Doxercalciferol is a chemical intended for research use only, suitable for laboratory applications and the manufacture of substances. It is a solid that must be handled by qualified scientists in equipped facilities.
- For research use only
- High purity
- Suitable for laboratory applications
- Can be used in substance manufacturing
- Stable under recommended storage conditions
Medchemexpress LLC Glepaglutide acetate | 99.5% | 4376.06 | 5 MG
Glepaglutide acetate is a long-acting GLP-2 analogue and a potent GLP-2R agonist. It functions by reducing faecal output and increasing intestinal absorption. This compound also helps in alleviating small intestinal inflammation, making it suitable for research applications in inflammatory bowel disease (IBD) and Crohn's disease.
- Long-acting GLP-2 analogue
- Potent GLP-2R agonist
- Reduces faecal output
- Increases intestinal absorption
- Alleviates small intestinal inflammation
- Suitable for inflammatory bowel disease (IBD) research
- Suitable for Crohn's disease research
Medchemexpress LLC Verapamil-d3 hydrochloride | 2714485-49-9 | 99.57% | C27H36D3ClN2O4 | 1 MG
Verapamil-d3 hydrochloride is the deuterium labeled Verapamil hydrochloride. This compound acts as a calcium channel blocker and a potent, orally active first-generation P-glycoprotein (P-gp) inhibitor. It also inhibits CYP3A4 and has potential for research related to high blood pressure, heart arrhythmias, and angina.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
TARGETMOL CHEMICALS INC Methylprednisolone Aceponate 2
Also available in 1 mL, 5 mg, 10 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Methylprednisolone Aceponate (SH 440), a non-halogenated corticosteroid, is a potent anti-inflammatory agent. Purity 98%
![eMolecules 345909-26-4 | Sodium taurocholate dihydrate | Combi-Blocks | MFCD00150132 | 573.720 | C26H48NNaO9S | 96.000 | O.O.[Na+].C[C@H](CCC(=O)NCCS([O-])(=O)=O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)CC4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C | 1g | 401040224](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502227033.JPG-250.jpg)
eMolecules 345909-26-4 | Sodium taurocholate dihydrate | Combi-Blocks | MFCD00150132 | 573.720 | C26H48NNaO9S | 96.000 | O.O.[Na+].C[C@H](CCC(=O)NCCS([O-])(=O)=O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)CC4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C | 1g | 401040224
Sodium taurocholate dihydrate | Combi-Blocks | 345909-26-4 | MFCD00150132 | 573.720 | C26H48NNaO9S | 96.000 | O.O.[Na+].C[C@H](CCC(=O)NCCS([O-])(=O)=O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)CC4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C | 1g | 401040224
Selleck Chemical LLC Alpha-Estradiol
Alpha-Estradiol ( -Estradiol 17 alpha-Estradiol Alfatradiol Epiestradiol Epiestrol Alora 17 -E2) a natural non-feminizing stereoisomer a hormonally almost inactive isomer of physiological 17 beta-estradiol (17 -E2) is a weak inhibitor of estrogen
Medchemexpress LLC Cinacalcet-d3 hydrochloride | 364782-34-3 | 97.6% | C22H20D3ClF3N | 500 UG
Cinacalcet-d3 (hydrochloride) is the deuterium labeled Cinacalcet (hydrochloride). It is an orally active, allosteric agonist of the Ca receptor (CaR), used for cardiovascular disease treatment. Deuteration has gained attention due to its potential to affect the pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Isotope-labeled compound.
- Endogenous metabolite.
- Inhibitor.
- Targets CaSR and is relevant for cardiovascular disease.
Apexbio Technology LLC Medroxyprogesterone 520-85-4 50mg
Medroxyprogesterone (CAS 520-85-4) is a small-molecule agonist targeting the progesterone receptor It is designed to activate progesterone receptor-mediated intracellular signaling pathways thereby regulating cellular proliferation Medroxyprogesterone exerts its biological activity primarily through agonism of the progesterone receptor modulating pathways such as PI3K/Akt signaling In preclinical mouse models medroxyprogesterone demonstrates inhibitory activity on atherosclerotic lesion formation Based on these pharmacological properties medroxyprogesterone holds research potential in the study of progesterone receptor-mediated biological processes cellular proliferation and vascular pathology
Apexbio Technology LLC Estrone 53-16-7 10mM (in 1mL DMSO)
Estrone (53-16-7) is a naturally occurring estrogen that modulates estrogen receptor-mediated signaling pathways It is primarily synthesized in ovarian and adipose tissues and participates in the regulation of estrogen-dependent cellular and physiological processes Estrone exerts its biological activity primarily through binding and activating estrogen receptors Experimental model activity type and key metric (IC50/EC50) are not specified Based on these pharmacological properties estrone holds research potential in studies of estrogen receptor activation reproductive endocrinology menopausal hormone transitions and estrogen-dependent signaling pathways and diseases