Pyrimidine nucleosides
Medchemexpress LLC 4-thio-2'-deoxyuridine | 5580-20-1 | MFCD00058457 | 99.8% | 244.27 g/mol | C9H12N2O4S | 100 MG
4-Thio-2'-deoxyuridine is a sulfur-substituted deoxyuridine nucleoside analogue used in biochemical and nucleic acid research, including studies of nucleic acid chemistry and incorporation into oligonucleotides. It has molecular formula C9H12N2O4S, molecular weight 244.27 g/mol, and a reported purity of 99.78%.
- Sulfur-substituted deoxyuridine analogue useful for nucleic acid studies.
- High reported purity (99.8%), suitable for analytical and synthetic applications.
- Available in multiple pack sizes for research-scale work.
- Provided with certificate of analysis and safety data sheet for quality and handling.
- Offered in solid form and as 10 mM DMSO solution for convenient use.
Medchemexpress LLC KTX-951 | 2573298-36-7 | 99.6% | 850.95 | 1 MG
KTX-951 is an orally active PROTAC degrader targeting IRAK4 and IMiD (Ikaros/Aiolos) substrates. It exhibits a Kd of 3.5 nM for IRAK4, with DC50 values of 13 nM, 14 nM, and 13 nM for IRAK4, Ikaros, and Aiolos, respectively. This compound also shows an IC50 of 35 nM for OCl-Ly10 CTG and demonstrates antitumor activity.
- Orally active PROTAC degrader
- Targets IRAK4 and IMiD (Ikaros/Aiolos) substrates
- Kd of 3.5 nM for IRAK4
- Molecular weight: 850.95
- Formula: C46H52F2N8O6
- Appearance: Solid, light yellow to yellow
- Purity: 99.60%
- Soluble in DMSO at 50 mg/mL (58.76 mM)
- Oral bioavailability in rats: 22% at 10 mg/kg
- Oral bioavailability in dogs: 57% at 10 mg/kg
Apexbio Technology LLC 5-Ethynyl-2'-deoxyuridine (5-EdU), 1g CAS# 61135-33-9
5-Ethynyl-2'-deoxyuridine (5-EdU) is a thymidine analog that can be incorporated into replicating DNA for detection of cell proliferation. 5-EdU can be used as a replacement for BrdU (5-Bromo-2'-deoxyuridine) to measure de novo DNA synthesis during the S-phase of the cell cycle through click chemistry. Click chemistry is a method of covalently coupling an azide with an alkyne. 5-EdU has an alkyne handle that can be detected using azide-containing fluorescent probes through a highly efficient click chemistry reaction. In contrast to the use of BrdU, the new method does not require sample fixation or DNA denaturation. 5-EdU-labelled cells may be isolated to determine the transcript of cells, from neural cancer or tissues that have undergone division in vitro and in vivo. Other sizes are also available. Please inqury us for quote.
Medchemexpress LLC 2'-Deoxycytidine | 951-77-9 | MFCD00006547 | 99.95% | 25 G
2'-Deoxycytidine is a deoxyribonucleoside that can inhibit the biological effects of Bromodeoxyuridine (Brdu). It is essential for the synthesis of nucleic acids and is utilized in cancer research.
- Inhibits biological effects of Bromodeoxyuridine (Brdu)
- Essential for nucleic acid synthesis
- Utilized in cancer research
- Acts as a human endogenous metabolite
- Functions as a microbial metabolite
- Demonstrated to inhibit tumor growth in vivo
Medchemexpress LLC 2'-Deoxyuridine | 951-78-0 | 99.98% | 1 G
2'-Deoxyuridine is a brain-penetrant pyrimidine nucleotide associated with nervous system diseases. It can increase chromosome breakage and reduce thymidylate synthetase activity. This compound serves as a precursor in the synthesis of Edoxudine and is an analogue of 5-ethynyl-2'-deoxyuridine. It has demonstrated the ability to lessen microglial activation and enhance oxidative stress damage by modulating glycolytic metabolism in brain injury models, indicating its potential for Alzheimer's disease research.
- Brain-penetrant pyrimidine nucleotide.
- Associated with nervous system diseases.
- Can increase chromosome breakage.
- Reduces thymidylate synthetase activity.
- Precursor in synthesis.
- Analogue of other compounds.
- Reduces microglial activation.
- Improves oxidative stress damage.
- Modulates glycolytic metabolism in brain injury.
- Promising for Alzheimer's disease research.
Medchemexpress LLC 2'-Deoxycytidine | 951-77-9 | 100.0% | 5 G
2'-Deoxycytidine, a deoxyribonucleoside, can inhibit the biological effects of Bromodeoxyuridine (Brdu). It is essential for the synthesis of nucleic acids and can be used for cancer research.
- Deoxyribonucleoside
- Inhibits biological effects of bromodeoxyuridine (Brdu)
- Essential for the synthesis of nucleic acids
- Can be used for cancer research
- Inhibits tumor growth in mice
Medchemexpress LLC 2'-Deoxycytidine | 951-77-9 | 99.95% | 1 G
2'-Deoxycytidine is a deoxyribonucleoside that can inhibit the biological effects of Bromodeoxyuridine (Brdu). It is essential for the synthesis of nucleic acids and can be used for cancer research.
- Inhibits biological effects of Brdu.
- Essential for nucleic acid synthesis.
- Used in cancer research.
- Inhibits tumor growth in vivo.
Medchemexpress LLC 2'-Deoxyuridine-1'-13C | 478510-85-9 | 5 MG
2'-Deoxyuridine-1'-13C is a carbon-13 labeled version of 2'-Deoxyuridine. This compound induces chromosome breakage, thereby reducing the synthesis activity of thymidylate. Additionally, it serves as a precursor in the synthesis of Edoxudine.
- Carbon-13 labeled version of 2'-Deoxyuridine.
- Induces chromosome breakage.
- Reduces synthesis activity of thymidylate.
- Serves as a precursor in the synthesis of Edoxudine.
Medchemexpress LLC 2'-Deoxyuridine-1'-13C | 478510-85-9 | 1MG
2'-Deoxyuridine-1'-13C is a stable isotope-labeled compound with the molecular formula C813CH12N2O5 and a molecular weight of 229.19. It appears as a white to off-white solid with an isotopic enrichment of 99%. This product is intended for research use only and has not been fully validated for medical applications.
- White to off-white solid appearance
- Isotopic enrichment of 99%
- Molecular formula C813CH12N2O5
- Intended for research use only
- Store powder at -20°C for up to 3 years or at 4°C for up to 2 years
- Store in solvent at -80°C for 6 months or at -20°C for 1 month
![Medchemexpress LLC Deoxycytidine triphosphate-15N3 (dilithium) | 2056-98-6 | MFCD00135938 | 99.0% | 482.00 g·mol⁻1 | C9H14[15N]3Li2O13P3 | 1 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000211147.png-250.jpg)
Medchemexpress LLC Deoxycytidine triphosphate-15N3 (dilithium) | 2056-98-6 | MFCD00135938 | 99.0% | 482.00 g·mol⁻1 | C9H14[15N]3Li2O13P3 | 1 MG
Deoxycytidine triphosphate-15N3 (dilithium) is a stable isotope-labeled deoxynucleoside triphosphate provided as a concentrated aqueous solution for molecular biology and analytical applications. The 15N3 label enables sensitive and specific detection in mass spectrometry and tracer experiments, while the dilithium salt formulation offers good aqueous solubility. Typical uses include use as an internal standard, tracer, or reagent in DNA synthesis and sequencing workflows.
- Supplied as a concentrated solution for convenient dilution and use.
- 15N3 isotopic label supports quantitative mass spectrometry and tracer studies.
- High chemical purity for reliable analytical and preparative performance.
- Suitable as an internal standard or tracer in nucleic acid workflows.
- Compatible with PCR, cDNA synthesis, and DNA sequencing applications.
- Dilithium salt form improves solubility in aqueous buffers.
Alkali Scientific 2' Deoxycytidine Hydrochloride, 25 G
2' Deoxycytidine Hydrochloride (25 g) is a high-purity nucleoside, used extensively in molecular biology for research into DNA synthesis, modification, and metabolism. Deoxycytidine is a key building block of DNA, and its hydrochloride form is ideal for biochemical and enzymatic assays, such as PCR and DNA sequencing. This reagent is particularly useful for studies related to nucleotide incorporation, DNA repair processes, and the role of deoxyribonucleosides in cellular functions. Deoxycytidine Hydrochloride is frequently used in molecular and genetic research laboratories to facilitate detailed studies of genetic expression and nucleotide behavior.
Bioworld 2'-Deoxythymidine, 25 g
It is a pyrimidine deoxynucleoside.It is the DNA nucleoside T, which pairs with deoxyadenosine (A) in double-stranded DNA.It can be phosphorylated with one, two or three phosphoric acid groups, creating respectively deoxythymidine mono,di or triphosphate.It is non-toxic and as part of one of the four nucleotides in DNA it is a naturally occurring compound that exists in all living organisms and DNA viruses. Specifications:Ultra Pure GradeEm (267nm, phosphate buffer, pH 7.0): >9,200Appearance: White Crystalline PowderChEBI : Not available.Crystal_Structure : Not available.Density : 1.452 g/cm3InChI : Not available.InChIKey : Not available.IUPAC_Name: 1-[4-Hydroxy-5-(Hydroxymethyl)Oxolan-2-Yl]-5-Methyl-Pyrimidine-2,4-DioneMelting Point: 186-188 °C(lit.)RTECS Number: XP2071000
Crescent Chemical Co Inc BROMO-2 -DEOXYURIDINE
Bromo-2'-deoxyuridine research grade Size - 1G Storage Conditions - +2 °C TO +8 °C Catalog Number - 15240.02 CAS 59-14-3