Drug Standards
Apexbio Technology LLC Methylprednisolone(Synonyms: Medrol, Depo-Medrol, Solu-Medrol, Advantan, Urbason, Metipred, Medrate, Metilprednisolone), 100mg, CAS: 83-43-2.
Methylprednisolone (CAS 83-43-2) is a synthetic glucocorticoid receptor agonist that exerts anti-inflammatory effects by inhibiting pro-inflammatory cytokines notably TNF- and modulating NF- B signaling pathways In vitro studies demonstrate that methylprednisolone reduces TNF production and enhances IL-10 synthesis in mouse macrophages upon LPS stimulation suppresses chemokine secretion from human peripheral blood mononuclear cells and inhibits acantholysis in skin cultures Animal models indicate that intravenous methylprednisolone administration attenuates inflammation decreases macrophage infiltration and tissue damage post-spinal cord injury Clinically methylprednisolone is investigated for therapeutic use in acute spinal cord injury severe vasculitis and lupus nephritis
Apexbio Technology LLC Moxifloxacin(Synonyms: Avelox, Vigamox, Avalox, Moxeza, Proflox, Octegra, MXF, BAY 12-8039), 200mg, CAS: 151096-09-2.
Moxifloxacin (CAS 151096-09-2) is a fluoroquinolone antibiotic targeting bacterial DNA gyrase an enzyme essential for DNA replication and transcription It demonstrates broad-spectrum antibacterial activity through inhibition of this enzyme Research indicates that Moxifloxacin exerts dose-dependent antiproliferative and cytotoxic effects in mammalian cell models with concentrations between 50 and 1500 g/mL significantly impacting cell viability and inducing morphological damage such as binucleation Animal studies show intravenous administration (100 mg/kg rats) elevates blood glucose and serum adrenaline levels accompanied by enhanced histamine release but no effect was noted at 75 mg/kg Therefore Moxifloxacin is valuable in biomedical studies exploring antibiotic toxicity cellular proliferation and metabolic responses
Medchemexpress LLC Fostamatinib | 901119-35-5 | 99.7% | 200 MG
Fostamatinib (R788) is an oral proagent of the active compound R406. R406 is a competitive Syk/FLT3 inhibitor with a Ki of 30 nM and an IC50 of 41 nM. It also inhibits Lyn (IC50=63 nM) and Lck (IC50=37 nM).
- Oral proagent of the active compound R406
- Competitive Syk/FLT3 inhibitor
- Inhibits Lyn
- Inhibits Lck
Apexbio Technology LLC Nocodazole 31430-18-9 50mg
Nocodazole (CAS 31430-18-9) is an anti-mitotic small molecule commonly utilized in biomedical research as a potent and reversible inhibitor of microtubule polymerization Its mechanism involves direct binding to -tubulin disrupting microtubule assembly and stability It exhibits inhibitory effects on various kinases associated with oncogenesis including Abl c-Kit BRAF and MEK and induces apoptosis in cancer cells In vitro exposure at high concentrations rapidly depolymerizes microtubules while lower concentrations primarily affect their dynamic instability Nocodazole serves as a valuable tool in studies probing microtubule dynamics intracellular trafficking cell cycle regulation and antitumor therapeutic evaluations
Medchemexpress LLC Insulin aspart | 116094-23-6 | ≥95.0% | 10 MG
Insulin aspart (B28Asp) is a fast-acting analog of human insulin. It provides more rapid absorption than regular human insulin after subcutaneous administration. It can be used for researching diabetes.
- Fast-acting analog of human insulin
- Rapid absorption after subcutaneous administration
- Suitable for diabetes research
Selleck Chemical LLC Nitazoxanide 25mg 55981-09-4
Nitazoxanide is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent(IC50 for canine influenza virus ranges from 0.17 to 0.21 ?M). Nitazoxanide modulates autophagy and inhibits mTORC1 signaling. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Apexbio Technology LLC Elacridar(Synonyms: GF120918, GG918, GW0918, GF-120918, GG-918, GW-0918), 50mg, CAS: 143664-11-3.
Elacridar (CAS 143664-11-3) is a potent inhibitor of P-glycoprotein (P-gp) a transmembrane efflux transporter belonging to the MDR/TAP subfamily P-gp actively exports diverse xenobiotics and drugs from cells significantly influencing drug bioavailability and distribution Elacridar inhibits P-gp with an IC50 of approximately 193 nM and markedly reduces transporter activity in P-gp-overexpressing MDCKII cell models at concentrations as low as 1 M In mice elacridar administration (10 mg/kg) enhances brain penetration of P-gp substrates such as sunitinib Thus elacridar is extensively used in biomedical research to study drug transport mechanisms and multidrug resistance
Apexbio Technology LLC Latanoprost 130209-82-4 50mg
Latanoprost (CAS 130209-82-4) is a synthetic analogue of prostaglandin F2 that functions primarily as an agonist at the prostaglandin FP receptor Activation of this receptor enhances aqueous humor drainage through the uveoscleral outflow pathway in ocular tissues resulting in reduced intraocular pressure In research settings latanoprost is employed to study prostaglandin-mediated signaling pathways and serves as a standard reference agent in glaucoma and ocular hypertension models
Sigma Aldrich Fine Chemicals Biosciences Amisulpride British Pharmacopoeia (BP) Reference Standard | 71675-85-9 | MFCD00866691 |
Amisulpride British Pharmacopoeia (BP) Reference Standard | Mol Wt: 369.48 | 71675-85-9 | MFCD00866691 |
U.S. Pharmacopeia Verapamil Related Compound A | 67775-97-7 | 50 mg
Verapamil Related Compound A | Mol Wt: 326.86 | 67775-97-7 | 50 mg
Medchemexpress LLC Edoxaban impurity 63 | 00-00-0 | 513.61 | 50mg
Edoxaban Impurity 63 is an impurity of Edoxaban (HY-10264)