Acetylides
Aobchem 3-Butyn-1-ol | ≥95% | CAS 927-74-2 | C4H6O | 25g
3-Butyn-1-ol | ≥95% | CAS 927-74-2 | C4H6O | 25g
Aobchem 1-(4-Methylphenyl)propyne | ≥97% | CAS 2749-93-1 | C10H10 | 5g
1-(4-Methylphenyl)propyne | ≥97% | CAS 2749-93-1 | C10H10 | 5g
Aobchem 4 4 5 5-TETRAMETHYL-2-(4-(PENTYLOXY)PHENYL)-1 3 2-DIOXABOROLANE | ≥95% | CAS 1174548-77-6 | C17H27BO3 | 1g
4 4 5 5-TETRAMETHYL-2-(4-(PENTYLOXY)PHENYL)-1 3 2-DIOXABOROLANE | ≥95% | CAS 1174548-77-6 | C17H27BO3 | 1g
Aobchem 4-Ethynylaniline | ≥97% | CAS 14235-81-5 | C8H7N | 25g
4-Ethynylaniline | ≥97% | CAS 14235-81-5 | C8H7N | 25g
eMolecules 2949-26-0 | NAPHTHYLENE-2-ACETYLENE | AstaTech | MFCD00870424 | 152.196 | C12H8 | 98.000 | C#Cc1ccc2ccccc2c1 | 25g | 331088040
NAPHTHYLENE-2-ACETYLENE | AstaTech | 2949-26-0 | MFCD00870424 | 152.196 | C12H8 | 98.000 | C#Cc1ccc2ccccc2c1 | 25g | 331088040
Medchemexpress LLC N-(Propargyl-PEG4-carbonyl)-N-bis(PEG1-methyl ester) | 2112732-01-9 | 519.58 | 100 MG
N-(Propargyl-PEG4-carbonyl)-N-bis(PEG1-methyl ester) is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, featuring an Alkyne group capable of copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. PROTACs themselves contain two distinct ligands linked together, one targeting an E3 ubiquitin ligase and the other the protein of interest, utilizing the intracellular ubiquitin-proteasome system for selective target protein degradation. This product is for research use only.
- PEG-based PROTAC linker
- Used in PROTAC synthesis
- Click chemistry reagent
- Contains an alkyne group
- Capable of copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Reacts with azide-containing molecules
- Exploits ubiquitin-proteasome system
- Selectively degrades target proteins
Apexbio Technology LLC VX-765 273404-37-8 10mM (in 1mL DMSO)
VX-765 (CAS 273404-37-8) is an orally bioavailable prodrug of VRT-043198 a selective inhibitor targeting caspase-1 (also known as IL-1 converting enzyme ICE) Caspase-1 plays a pivotal role in processing pro-inflammatory cytokines specifically converting inactive precursors of IL-1 and IL-18 into bioactive forms VX-765 downstream metabolite VRT-043198 selectively reduces the secretion of IL-1 and IL-18 in stimulated human peripheral blood mononuclear cells without affecting release of other cytokines such as IL-6 or TNF- Preclinical studies demonstrate VX-765 activity in mouse models of arthritis dermatitis and HIV-associated CD4 T-cell death indicating utility in inflammatory and immunological research
eMolecules 1261791-09-6 | 2-Chloro-6-(trifluoromethoxy)benzyl alcohol | Apollo Scientific | MFCD18393817 | 226.580 | C8H6ClF3O2 | 95.000 | OCc1c(Cl)cccc1OC(F)(F)F | 1g | 562428505
2-Chloro-6-(trifluoromethoxy)benzyl alcohol | Apollo Scientific | 1261791-09-6 | MFCD18393817 | 226.580 | C8H6ClF3O2 | 95.000 | OCc1c(Cl)cccc1OC(F)(F)F | 1g | 562428505
(C)C#C | 25g | 410166967](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000471112.jpg-250.jpg)
eMolecules 1066-54-2 | Ethynyltrimethylsilane | AA Blocks LLC | MFCD00008569 | 98.220 | C5H10Si | 0.000 | C[Si](C)(C)C#C | 25g | 410166967
Ethynyltrimethylsilane | AA Blocks LLC | 1066-54-2 | MFCD00008569 | 98.220 | C5H10Si | 0.000 | C[Si](C)(C)C#C | 25g | 410166967
Medchemexpress LLC 4-Ethynylaniline | 14235-81-5 | 117.15 | 1 ML
4-Ethynylaniline is a biochemical reagent used in life science research. It serves as a click chemistry reagent, specifically containing an Alkyne group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules possessing Azide groups.
- Used as a biochemical reagent
- Utilized in life science research
- Functions as a click chemistry reagent
- Contains an alkyne group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Reacts with azide-containing molecules
eMolecules 177596-38-2 | 3-Fluoro-4-(trifluoromethoxy)phenol | Apollo Scientific | MFCD06660342 | 196.101 | C7H4F4O2 | 95.000 | Oc1ccc(OC(F)(F)F)c(F)c1 | 1g | 562451566
3-Fluoro-4-(trifluoromethoxy)phenol | Apollo Scientific | 177596-38-2 | MFCD06660342 | 196.101 | C7H4F4O2 | 95.000 | Oc1ccc(OC(F)(F)F)c(F)c1 | 1g | 562451566
Medchemexpress LLC Propargyl-PEG8-Boc | 2055014-96-3 | 1 G
Propargyl-PEG8-Boc is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, featuring an Alkyne group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules containing Azide groups. This compound is instrumental in developing PROTACs, which are designed to selectively degrade target proteins by utilizing the intracellular ubiquitin-proteasome system.
- PEG-based PROTAC linker
- Used in PROTAC synthesis
- Click chemistry reagent
- Contains an Alkyne group
- Capable of copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Interacts with Azide groups
- Facilitates selective degradation of target proteins
Aobchem 1-(3 5-Dimethoxyphenyl)-1-pentanone | ≥97% | CAS 5333-29-9 | C13H18O3 | 250mg
1-(3 5-Dimethoxyphenyl)-1-pentanone | ≥97% | CAS 5333-29-9 | C13H18O3 | 250mg
Medchemexpress LLC Propargyl-peg2-beta-d-glucose | 2353409-73-9 | 98.0% | C13H22O8 | 10MG
Propargyl-PEG2-beta-D-glucose is an alkyne-functionalized PEG2 linker designed for PROTAC construction and bioconjugation. It offers a terminal propargyl group for click chemistry and a beta-D-glucose-derived spacer to improve solubility and biological compatibility, enabling efficient conjugation in research-scale synthetic workflows.
- Provides terminal alkyne for copper-catalyzed click reactions.
- Contains a two-unit polyethylene glycol spacer for solubility and flexibility.
- Features a beta-D-glucose-derived moiety for biological compatibility.
- Supplied at high purity suitable for synthetic applications.
- Available in small pack sizes for research-scale synthesis.