Hydrochlorides
![Medchemexpress LLC Cyclopentanecarboxamide, N-[(1S)-4-[(aminoiminomethyl)amino]-1-[2-(2,3,5,6-tetrafluorophenoxy)acetyl]bu | 2097865-47-7 | 97.2% | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/default.jpg-250.jpg)
Medchemexpress LLC Cyclopentanecarboxamide, N-[(1S)-4-[(aminoiminomethyl)amino]-1-[2-(2,3,5,6-tetrafluorophenoxy)acetyl]bu | 2097865-47-7 | 97.2% | 25 MG
Kgp-IN-1 hydrochloride is an arginine-specific gingipain (Rgp) inhibitor, identified as compound 13-R from patent WO2017201322A1. This product is intended for research use only.
- Arginine-specific gingipain (Rgp) inhibitor
- Targets cathepsin
- Pathway: metabolic enzyme/protease
- White to off-white solid
- Store at 4°C, sealed, away from moisture
Medchemexpress LLC Drp1i27 dihydrochloride | C20H28Cl2N6O | 50 MG
DRP1i27 dihydrochloride is a potent inhibitor of human Drp1 (dynamin-related protein 1). It binds to the GTPase site of Drp1, forming hydrogen bonds with Gln34 and Asp218. This compound targets Drp1-mediated mitochondrial fission in cell line models and offers protection against simulated ischemia-reperfusion injury.
- Directly binds to and inhibits the GTPase activity of human Drp1.
- Increases cellular networks of mitochondria in human and mouse fibroblasts.
- Offers protection against simulated ischemia-reperfusion injury.
- Has a binding affinity of 286 μM in SPR assay and a KD value of 190 μM via MST assay.
- Targets Drp1-mediated mitochondrial fission.
Medchemexpress LLC PNU-22394 hydrochloride | 15923-42-9 | 98.8% | 236.74 | C13H17ClN2 | 10 MG
PNU-22394 hydrochloride is a research-grade small molecule agonist of serotonin (5-HT) receptors, reported as a 5-HT2C agonist and partial 5-HT2A/2B agonist. Supplied as the hydrochloride salt and provided at high purity for pharmacology and receptor biology studies in vitro and in vivo.
- Potent 5-HT2C agonist with reported Ki ≈ 6.1 nM and 5-HT2A activity ≈ 10 nM.
- Hydrochloride salt, suitable for dissolution in common assay solvents.
- Molecular formula C13H17ClN2 and molecular weight 236.74 g/mol.
- High purity (>98.7%), appropriate for research applications.
- Intended for pharmacological research and receptor characterization studies.
![Medchemexpress LLC 1,1′,1′′,1′′′-[1,4-Piperazinediylbis(2,1-ethanediylnitrilo)]tetrakis[2-dodecanol] | 1265904-26-4 | 98.0% | 909.54 | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000437399-Logo.png-250.jpg){kind=logo}
Medchemexpress LLC 1,1′,1′′,1′′′-[1,4-Piperazinediylbis(2,1-ethanediylnitrilo)]tetrakis[2-dodecanol] | 1265904-26-4 | 98.0% | 909.54 | 10 MG
1,1′,1′′,1′′′-[1,4-Piperazinediylbis(2,1-ethanediylnitrilo)]tetrakis[2-dodecanol] is a lipid/lipidoid for the preparation of lipid-based or lipidoid nanoparticles. This product is for research use only and not sold to patients.
- Used in preparation of lipid-based or lipidoid nanoparticles.
- Appearance as a solid, light yellow to orange.
- Recommended storage for powder is -20°C for 3 years, 4°C for 2 years.
- Recommended storage for in solvent is -80°C for 6 months, -20°C for 1 month.
- Soluble in DMSO (25 mg/mL), requiring sonication.
eMolecules 5987-82-6 | Oxybuprocaine hydrochloride | Combi-Blocks | MFCD00012512 | 344.880 | C17H29ClN2O3 | 98.000 | Cl.CCCCOc1cc(ccc1N)C(=O)OCCN(CC)CC | 25g | 537622054
Oxybuprocaine hydrochloride | Combi-Blocks | 5987-82-6 | MFCD00012512 | 344.880 | C17H29ClN2O3 | 98.000 | Cl.CCCCOc1cc(ccc1N)C(=O)OCCN(CC)CC | 25g | 537622054
Medchemexpress LLC PS372424 (hydrochloride) | 1596362-29-6 | ≥98.0% | 625.20 | 25 MG
PS372424 hydrochloride, a three amino-acid fragment of CXCL10, is a specific human CXCR3 agonist with anti-inflammatory activity. It prevents human T-cell migration in a humanized model of arthritic inflammation.
- Specific human CXCR3 agonist with anti-inflammatory activity.
- Prevents human T-cell migration in a humanized model of arthritic inflammation.
Medchemexpress LLC Icotinib (Hydrochloride) | 1204313-51-8 | C22H22ClN3O4 | 100 MG
Icotinib Hydrochloride (BPI-2009) is a potent, CNS-penetrant, and specific EGFR inhibitor with an IC50 of 5 nM. It inhibits mutant EGFRL858R, EGFRL858R/T790M, EGFRT790M, and EGFRL861Q. This compound is a click chemistry reagent containing an Alkyne group, enabling it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Potent, CNS-penetrant, and specific EGFR inhibitor
- Inhibits mutant EGFRL858R, EGFRL858R/T790M, EGFRT790M, and EGFRL861Q
- Click chemistry reagent for copper-catalyzed azide-alkyne cycloaddition
- Exhibits potent dose-dependent antitumor effects in nude mice
- Well tolerated at doses up to 120 mg/kg/day in mice
Medchemexpress LLC ARC 239 dihydrochloride | 55974-42-0 | 99.2% | 25 MG
ARC 239 dihydrochloride is a selective α2B/2C adrenoceptor antagonist, intended for research use only.
- Selective α2B/2C adrenoceptor antagonist
- Exhibits pKd values of 5.95 at α2A, 7.41 at α2B, and 7.56 at α2C receptors
- Binds to CHO cell membranes expressing human recombinant a2A-, a2B- or a2C-adrenoceptor subtypes
- IC50 & Target includes Alpha-2B adrenergic receptor and 5-HT1A Receptor
Medchemexpress LLC Anabasine (racemic) | 13078-04-1 | MFCD00006370 | 162.24 g/mol | C10H14N2 | 1 ML
(±) Anabasine is the racemic form of anabasine, a nicotinic acetylcholine receptor agonist supplied as a research reagent. The manufacturer provides guidance for preparing DMSO stock solutions at common concentrations and recommended storage conditions for the pure compound and solutions.
- Racemic anabasine for research use
- CAS number: 13078-04-1
- Molecular formula: C10H14N2
- Molecular weight: 162.24 g/mol
- Soluble in DMSO; stock solution preparation guidance provided
- Storage: pure form -20°C (long-term) or 4°C (short-term); in solvent -80°C (long-term)
Medchemexpress LLC T-3775440 hydrochloride | 1422535-52-1 | 99.1% | 346.85 g·mol⁻¹ | C18H23ClN4O | 25 MG
T-3775440 hydrochloride is a potent, irreversible inhibitor of lysine-specific histone demethylase 1 (LSD1) with an IC50 of 2.1 nM. It shows selective inhibition of LSD1 versus MAO enzymes, reduces proliferation in multiple cell lines, and has demonstrated antitumor effects in xenograft models. Supplied as a high-purity research chemical for preclinical biochemical and cellular studies.
- Potent LSD1 inhibition (IC50 2.1 nM).
- Irreversible mechanism of action.
- High purity (~99.1%).
- Suitable for biochemical assays and cell-based studies.
- Available as solid and solution formats for flexible use.
- Stable when stored under recommended conditions.
Chem-Impex International, Inc. 4-Pyridylacetic acid hydrochloride | MFCD00012827 | 5G
4-Pyridylacetic acid hydrochloride, MFCD00012827, 5G
Medchemexpress LLC KHK-IN-1 hydrochloride | 1303470-48-5 | 98.0% | 50 MG
KHK-IN-1 hydrochloride is a selective and cell membrane permeable ketohexokinase (KHK) inhibitor. It effectively inhibits the production of F1P in HepG2 cell lysates, demonstrating an IC50 value of 400 nM. This compound holds potential for research related to diabetes and obesity, offering a valuable tool for scientific investigation.
- Demonstrates selectivity as a ketohexokinase inhibitor.
- Is cell membrane permeable, allowing intracellular action.
- Inhibits F1P production in HepG2 cell lysates.
- Possesses potential for studying diabetes and obesity.
- Stable in human and rat liver microsome preparations.
- Does not significantly inhibit cytochrome P450s.
![Medchemexpress LLC N-[2-[4-(1,3-benzodioxol-5-yl)-2-(1,1-dimethylethyl)phenoxy]ethyl]-N-methylglycine hydrochloride | 1779796-27-8 | ≥98.0% | 421.91 g/mol | C22H28ClNO5 | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000213907.png-250.jpg)
Medchemexpress LLC N-[2-[4-(1,3-benzodioxol-5-yl)-2-(1,1-dimethylethyl)phenoxy]ethyl]-N-methylglycine hydrochloride | 1779796-27-8 | ≥98.0% | 421.91 g/mol | C22H28ClNO5 | 10 MG
LY2365109 hydrochloride is a selective small-molecule inhibitor of the glycine transporter 1 (GlyT1). It blocks glycine uptake in hGlyT1-expressing cells with an IC50 of 15.8 nM and is supplied as the hydrochloride salt for research use in neurochemical and pharmacological studies.
- Selective GlyT1 inhibition (IC50 15.8 nM)
- Hydrochloride salt, solid form
- High purity ≥98% (HPLC)
- Molecular weight 421.91 g/mol
- CAS 1779796-27-8
- Suitable for neurochemical and pharmacological research applications
Medchemexpress LLC Benzamide, 4-butoxy-N-(2,4-difluorophenyl)- | 433967-28-3 | C17H17F2NO2 | 50 MG
VU 0357121 is a positive and highly selective mGlu5R allosteric modulator (PAM) with an EC50 of 33 nM. It is inactive or very weakly antagonizing at other mGlu receptor subtypes.
- Positive and highly selective mGlu5R allosteric modulator
- EC50 of 33 nM for mGlu5R
- Inactive or very weakly antagonizing at other mGlu receptor subtypes
- Appearance: solid, white to off-white
- Solubility in DMSO: ≥ 50 mg/mL (163.76 mM)