Hydrochlorides
Medchemexpress LLC AMG-548 dihydrochloride | 2518299-32-4 | 99.86% | 534.48 | 25 MG
AMG-548 dihydrochloride is an orally active and selective p38α inhibitor, showing slight selectivity over p38β and >1000-fold selectivity against p38γ and p38δ. It is also extremely potent in inhibiting whole blood LPS stimulated TNFα and inhibits Wnt signaling by directly inhibiting Casein kinase 1 isoforms δ and ε.
- Orally active and selective p38α inhibitor.
- Exhibits potent inhibition of whole blood LPS stimulated TNFα (IC50=3 nM).
- Inhibits Wnt signaling by directly inhibiting Casein kinase 1 isoforms δ and ε.
- Modest selectivity against JNK2 (ki=39 nM) and JNK3 (ki=61 nM).
- Rat F of 62% and dog F of 47%.
- t1/2 is 4.6 hours in rats and 7.3 hours in dogs.
Medchemexpress LLC 2-iminothiolane hydrochloride | 4781-83-3 | MFCD00039013 | 99.9% | 137.63 g/mol | C4H8ClNS | 50 MG
2-Iminothiolane hydrochloride is a thiolating reagent that introduces sulfhydryl (-SH) groups into primary amines of proteins, peptides, and oligosaccharides for bioconjugation and cross-linking. Supplied as a white to off-white solid, it is intended for research use and should be stored sealed and away from moisture.
- High purity suitable for biochemical applications
- Efficient thiolation of primary amines under mild conditions
- Useful for protein and peptide modification and cross-linking
- Solid form easy to weigh and dissolve for reactions
- Stable when stored sealed and protected from moisture
Medchemexpress LLC O-Ethylhydroxylamine-d5 hydrochloride | 118087-07-3 | 99.7% | 102.57 | 5 MG
O-Ethylhydroxylamine-d5 (hydrochloride) is a deuterium-labeled form of O-Ethylhydroxylamine hydrochloride. It serves as a valuable tool for research, functioning as a tracer and an internal standard in quantitative analysis methods such as NMR, GC-MS, or LC-MS. The incorporation of stable heavy isotopes, like deuterium, into drug molecules is a growing area of study, primarily utilized for quantitative analysis during the drug development process. Deuteration specifically holds promise for modifying the pharmacokinetic and metabolic profiles of pharmaceutical compounds.
- Used as a tracer for quantitative analysis.
- Functions as an internal standard in analytical techniques.
- Suitable for NMR, GC-MS, and LC-MS applications.
- Contains stable heavy isotopes for research in drug development.
- Potential to affect pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Anabasine ((S)-Anabasine) | 494-52-0 | MFCD00006370 | 99.0% | 100 MG
Anabasine ((S)-Anabasine) is an alkaloid found as a minor component in tobacco. It functions as a botanical pesticide nicotine and acts as a full agonist of nicotinic acetylcholine receptors (nAChRs). It induces depolarization of TE671 cells endogenously expressing human fetal muscle-type nAChRs, with an EC50 of 0.7 μM. Studies show it significantly reverses impairment at 0.2 mg/kg and 2 mg/kg doses.
- Functions as a botanical pesticide nicotine
- Acts as a full agonist of nicotinic acetylcholine receptors (nAChRs)
- Induces depolarization of TE671 cells with an EC50 of 0.7 μM
- Significantly reverses impairment at 0.2 mg/kg and 2 mg/kg doses
- Does not significantly affect response latency when administered alone
- Exacerbates dizocilpine-induced impairment at 0.06 mg/kg dose
- Does not independently affect choice accuracy
Medchemexpress LLC Sb-258585 hydrochloride | 1216468-02-8 | 99.7% | 523.82 g·mol⁻¹ | C18H23ClIN3O3S | 5 MG
SB-258585 hydrochloride is the hydrochloride salt of a selective, high-affinity antagonist for the serotonin 5-HT6 receptor. Supplied as a research-grade powder, it is intended for in vitro receptor binding and pharmacology studies and is characterized by high purity and defined storage conditions.
- Selective 5-HT6 receptor antagonist with high affinity.
- Suitable for in vitro receptor binding and pharmacological assays.
- Provided as a hydrochloride salt in powder form for accurate dosing.
- High purity (>99.7%) for reproducible results.
- Stable when stored under recommended conditions (powder: -20°C).
Medchemexpress LLC LY-272015 hydrochloride | 172895-15-7 | 99.5% | 372.89 | C21H25ClN2O2 | 5 MG
LY-272015 hydrochloride is a research compound used as a selective 5-HT2B (serotonin) receptor antagonist for preclinical pharmacology studies. It is orally active in animal models and has been reported to show antihypertensive effects in DOCA-salt hypertensive rats. The material is supplied as a solid for laboratory use with supporting analytical documentation.
- Selective 5-HT2B receptor antagonist for target-specific studies.
- Orally active in preclinical models, useful for in vivo pharmacology.
- High purity suitable for research applications.
- Supplied as an off-white to light yellow solid for ease of handling.
- Provided with data sheet, certificate of analysis, and safety data sheet.
Medchemexpress LLC VU-1545 | 890764-63-3 | 99.0% | 402.38 | 50 MG
VU-1545 is a metabotropic glutamate receptor 5 positive allosteric modulator (mGluR5 PAM). It exhibits a Ki of 156 nM and an EC50 of 9.6 nM. This compound promotes AKT activation at concentrations of 0.1 and 1.0 μM and is intended for research use only.
- Functions as a metabotropic glutamate receptor 5 positive allosteric modulator (mGluR5 PAM).
- Demonstrates a Ki of 156 nM and an EC50 of 9.6 nM.
- Promotes AKT activation.
- Promotes Akt phosphorylation in neuronal cells.
- Solid appearance, light yellow to yellow color.
- Powder storage: -20°C for 3 years, 4°C for 2 years.
- In solvent storage: -80°C for 6 months, -20°C for 1 month.
Medchemexpress LLC ZK756326 dihydrochloride | 1780259-94-0 | 99.9% | 429.38 g/mol | C21H30Cl2N2O3 | 100 MG
ZK756326 dihydrochloride is a selective, non-peptide agonist of the CC chemokine receptor CCR8 supplied as the dihydrochloride salt for research use. The compound is provided as a high-purity solid intended for pharmacology and receptor biology studies, including in vitro receptor activation and mechanism-of-action experiments.
- High purity suitable for research assays.
- Selective agonist activity at CCR8 for receptor pharmacology.
- Supplied as a stable dihydrochloride salt for handling and formulation.
- Appropriate for in vitro signaling and binding studies.
- Store sealed and away from moisture to preserve stability.
Medchemexpress LLC Tak-960 dihydrochloride | 2320307-83-1 | C27H36Cl2F3N7O3 | 10 MM 1 ML
TAK-960 dihydrochloride is an orally available, selective inhibitor of polo-like kinase 1 (PLK1) with an IC50 of 0.8 nM. It also shows inhibitory activities against PLK2 and PLK3, with IC50s of 16.9 nM and 50.2 nM, respectively. This compound inhibits the proliferation of multiple cancer cell lines and demonstrates significant efficacy against various tumor xenografts.
- Acts as a selective inhibitor of polo-like kinase 1 (PLK1)
- Shows inhibitory activities against PLK2 and PLK3
- Causes accumulation of G2-M cells
- Leads to aberrant polo mitosis morphology
- Increases phosphorylation of histone H3 (pHH3)
- Induces G2/M cell cycle arrest in HeLa cells without significant cytotoxicity
- Inhibits proliferation of multiple cancer cell lines
- Exhibits significant efficacy against multiple tumor xenografts
Medchemexpress LLC PXS-6302 hydrochloride | 2584947-79-3 | C10H11ClF3NO2S | 1 MG
PXS-6302 hydrochloride is an irreversible lysyl oxidase inhibitor. It demonstrates high permeability across cell monolayers and reduces collagen deposition. This compound has shown significant improvement in scar appearance in porcine models of excisional and burn injury under topical application.
- Irreversible lysyl oxidase inhibitor
- Reduces collagen deposition
- Significantly improves scar appearance
- Readily skin penetrability
Medchemexpress LLC Icotinib hydrochloride | 1204313-51-8 | C22H22ClN3O4 | 25 MG
Icotinib hydrochloride is a potent and specific EGFR inhibitor that is CNS-penetrant. It is effective against wild-type and various mutant EGFR forms, including EGFRL858R, EGFRL858R/T790M, EGFRT790M, and EGFRL861Q. This compound also functions as a click chemistry reagent, featuring an alkyne group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules.
- Potent and specific EGFR inhibitor
- CNS-penetrant
- Inhibits mutant EGFR forms: EGFRL858R, EGFRL858R/T790M, EGFRT790M, and EGFRL861Q
- Click chemistry reagent with an alkyne group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc)
Chem-Impex International, Inc. O-Ethylhydroxylamine hydrochloride | MFCD00012956 | 5G
O-Ethylhydroxylamine hydrochloride, MFCD00012956, 5G
Medchemexpress LLC 2-Iminothiolane hydrochloride | 4781-83-3 | MFCD00039013 | 137.63 | C4H8ClNS | 100 MG
2-Iminothiolane hydrochloride is a thiolating reagent that converts primary amines into free sulfhydryl (-SH) groups for protein, peptide, and oligosaccharide modification. It reacts under mild conditions (pH 7-10) to form an amidine linkage while introducing a reactive thiol, enabling subsequent labeling, crosslinking, or conjugation for research applications.
- Introduces free sulfhydryl groups to primary amines.
- Reacts efficiently at neutral to slightly basic pH (7-10).
- Forms stable amidine linkages upon conjugation.
- Enables protein and peptide labeling and crosslinking.
- Suitable for bioconjugation and assay development.