Hydrochlorides
Medchemexpress LLC Icotinib (Hydrochloride) | 1204313-51-8 | C22H22ClN3O4 | 100 MG
Icotinib Hydrochloride (BPI-2009) is a potent, CNS-penetrant, and specific EGFR inhibitor with an IC50 of 5 nM. It inhibits mutant EGFRL858R, EGFRL858R/T790M, EGFRT790M, and EGFRL861Q. This compound is a click chemistry reagent containing an Alkyne group, enabling it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Potent, CNS-penetrant, and specific EGFR inhibitor
- Inhibits mutant EGFRL858R, EGFRL858R/T790M, EGFRT790M, and EGFRL861Q
- Click chemistry reagent for copper-catalyzed azide-alkyne cycloaddition
- Exhibits potent dose-dependent antitumor effects in nude mice
- Well tolerated at doses up to 120 mg/kg/day in mice
Medchemexpress LLC VU 0364439 | 1246086-78-1 | C18H13Cl2N3O3S | 1 MG
VU 0364439 is a mGlu4 positive allosteric modulator (PAM) with an EC50 of 19.8 nM. It is for research use only. The compound shows better stability in HLM (63% remaining) than RLM (2% remaining). It is a positive allosteric modulator of human mGlu4 receptor expressed in CHO cells, assessed as potentiation of glutamate-induced calcium mobilization. The appearance is a solid, white to off-white.
- Positive allosteric modulator of human mGlu4 receptor
- EC50 of 19.8 nM
- Better stability in HLM (63% remaining) than RLM (2% remaining)
- Appearance: Solid, white to off-white
- For research use only
Medchemexpress LLC Tirofiban hydrochloride monohydrate | 150915-40-5 | 99.9% | 495.07 | 50 MG
Tirofiban hydrochloride monohydrate is a selective and reversible platelet integrin receptor (Gp IIb/IIIa) antagonist that inhibits fibrinogen binding to this receptor and possesses antithrombotic activity. It induces proliferation and migration of endothelial cells by stimulating VEGF production, and can significantly reduce myocardial no-reflow and ischemia-reperfusion injury.
- Inhibits fibrinogen binding to platelet integrin receptor (Gp IIb/IIIa).
- Possesses antithrombotic activity.
- Induces proliferation and migration of endothelial cells.
- Reduces myocardial no-reflow and ischemia-reperfusion injury.
- Increases contraction force and improves heart function in rats.
- Demonstrates anticoagulant effect after microvascular anastomosis.
Medchemexpress LLC Mln120b dihydrochloride | 1782573-78-7 | C19H17Cl3N4O2 | 50 MG
MLN120B dihydrochloride is a potent, orally active IKKβ inhibitor (IC50 60 nM) that inhibits multiple myeloma cell growth in vitro and in vivo. It is also used for rheumatoid arthritis research. In vitro, it blocks IκB phosphorylation/degradation and TNF-a-induced p65 NF-κB phosphorylation, reducing proliferation in various multiple myeloma cell lines. In vivo, oral administration reduces tumor growth markers and protects against bone and cartilage destruction in rheumatoid arthritis models.
- Potent, ATP competitive, orally active IKKβ inhibitor.
- Inhibits IκB phosphorylation and degradation.
- Blocks TNF-a-induced p65 NF-κB phosphorylation.
- Reduces proliferation of multiple myeloma cells.
- Inhibits IL-6 secretion from BMSCs.
- Protects against bone and cartilage destruction in rheumatoid arthritis models.
- Prolongs survival in treated animals.
![Medchemexpress LLC N-butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, monohydrochloride | 257639-98-8 | 99.8% | 5MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000233838.png-250.jpg)
Medchemexpress LLC N-butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, monohydrochloride | 257639-98-8 | 99.8% | 5MG
N-butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, monohydrochloride | 257639-98-8 | 99.8% | 5MG
Medchemexpress LLC Drp1i27 dihydrochloride | C20H28Cl2N6O | 50 MG
DRP1i27 dihydrochloride is a potent inhibitor of human Drp1 (dynamin-related protein 1). It binds to the GTPase site of Drp1, forming hydrogen bonds with Gln34 and Asp218. This compound targets Drp1-mediated mitochondrial fission in cell line models and offers protection against simulated ischemia-reperfusion injury.
- Directly binds to and inhibits the GTPase activity of human Drp1.
- Increases cellular networks of mitochondria in human and mouse fibroblasts.
- Offers protection against simulated ischemia-reperfusion injury.
- Has a binding affinity of 286 μM in SPR assay and a KD value of 190 μM via MST assay.
- Targets Drp1-mediated mitochondrial fission.
Medchemexpress LLC Tirofiban (hydrochloride monohydrate) | 150915-40-5 | 99.9% | 495.07 | 1 ML
Tirofiban (hydrochloride monohydrate) | 150915-40-5 | 99.9% | 495.07 | 1 ML
Medchemexpress LLC Carteolol hydrochloride | 51781-21-6 | 99.96% | 328.83 | 500 MG
Carteolol hydrochloride (OPC-1085 hydrochloride) is a non-selective beta blocker used to treat glaucoma. It is a beta-adrenergic antagonist used as an anti-arrhythmia, anti-angina, antihypertensive, and antiglaucoma agent. It significantly inhibited H2O2-induced cell damage and was able to scavenge O2, showing protective action against UVB-induced HCEC damage.
- Non-selective beta blocker
- Treats glaucoma
- Anti-arrhythmia agent
- Anti-angina agent
- Antihypertensive agent
- Protective action against UVB-induced HCEC damage in vitro
- Radical scavenging ability (scavenges O2)
- Long-acting alginate formulation is as effective as standard for glaucoma treatment
Medchemexpress LLC Pazopanib hydrochloride | 635702-64-6 | >95.0% | 500MG
Pazopanib hydrochloride | 635702-64-6 | >95.0% | 500MG
Medchemexpress LLC Verubulin hydrochloride | 917369-31-4 | 98.7% | 50 MG
Verubulin hydrochloride is the hydrochloride salt of verubulin (MPC-6827), a quinazoline-derived microtubule polymerization inhibitor with reported antitumor activity. It is supplied as a solid research reagent for preclinical studies investigating microtubule dynamics and anticancer mechanisms.
- Hydrochloride salt suitable for enhanced solubility in polar solvents.
- Potent microtubule polymerization inhibitor used in anticancer research.
- Reported to be brain-penetrant, enabling neurobiology applications.
- High purity typical for analytical and preclinical work (98.7%).
- Stable as a solid at 4°C; follow recommended storage conditions for solutions.
Medchemexpress LLC Erlotinib (hydrochloride) | 183319-69-9 | 99.9% | 50 MG
Erlotinib hydrochloride is a small-molecule epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor supplied as the hydrochloride salt for research use in biochemical and cell-based assays.
- Inhibits EGFR tyrosine kinase with low-nanomolar potency.
- Supplied as a solid hydrochloride salt suitable for analytical and biological studies.
- High purity (99.9% by LCMS) for reliable experimental results.
- Soluble in DMSO for preparation of stock solutions.
- Commonly used in kinase assays and cellular signaling research.
Medchemexpress LLC Azvudine hydrochloride | 1333126-31-0 | 99.2% | 322.68 | 1 ML
Azvudine hydrochloride | 1333126-31-0 | 99.2% | 322.68 | 1 ML