Hydrochlorides
Medchemexpress LLC Duloxetine metabolite Para-Naphthol Duloxetine | 949095-98-1 | 297.41 | 50 MG
Duloxetine metabolite Para-Naphthol Duloxetine is a metabolite of Duloxetine, a serotonin-norepinephrine reuptake inhibitor (SNRI). This product is intended for research use only and is not sold to patients.
- Metabolite of Duloxetine
- For research use only
- Molecular formula: C18H19NOS
- Appearance: Solid
- Color: White to off-white
- Store powder at -20°C for 3 years
- Store in solvent at -80°C for 6 months, or -20°C for 1 month
Medchemexpress LLC Harmalol hydrochloride | 6028-07-5 | 100 MG
Harmalol hydrochloride is a beta carboline alkaloid primarily found in medicinal plants such as *Peganum harmala*. This compound serves as the main metabolite of Harmaline and has been shown to significantly inhibit the dioxin-mediated induction of CYP1A1 at both transcriptional and posttranslational levels. Furthermore, it exhibits notable antioxidant and hydroxyl radical-scavenging properties, making it of interest for various research applications.
- Main metabolite of Harmaline
- Inhibits dioxin-mediated induction of CYP1A1
- Exhibits antioxidant and hydroxyl radical-scavenging properties
- Suitable for research applications
Apexbio Technology LLC VU 0361737 1161205-04-4 100mg
VU 0361737 (CAS 1161205-04-4) is a selective brain-penetrant positive allosteric modulator of the metabotropic glutamate receptor 4 (mGluR4) It demonstrates high selectivity for mGluR4 over other mGluR subtypes with EC50 values of 240 nM for human and 110 nM for rat mGluR4 and shows minimal to no activity at mGluR1 mGluR2 mGluR3 mGluR6 and mGluR7 while exhibiting weak activity at mGluR5 and mGluR8 VU 0361737 crosses the blood-brain barrier and achieves significant brain exposure (brain plasma ratio of 4 1) with a short half-life (T1/2 20 min) following administration in rats This compound is utilized in studies exploring the modulation of basal ganglia neurotransmission and the pathophysiology of Parkinson s disease
Medchemexpress LLC RS-102221 hydrochloride | 187397-18-8 | 98.0% | 649.08 g/mol | C27H32ClF3N4O7S | 1 ML
RS-102221 hydrochloride is a selective 5-HT2C receptor antagonist supplied as a powder and as a 10 mM solution in DMSO (1 mL). It is intended for research use in pharmacology, receptor-binding assays, and in vitro studies where a selective 5-HT2C antagonist is required.
- Selective 5-HT2C receptor antagonist suitable for pharmacological studies.
- High purity: 98.03% (as reported by manufacturer).
- Available as solid (5 mg-100 mg) and as a 10 mM solution in DMSO (1 mL).
- Molecular weight: 649.08 g/mol; chemical formula: C27H32ClF3N4O7S.
- CAS number: 187397-18-8 for unambiguous identification.
- Recommended storage: powder at -20°C long term; solution frozen for stability.
Medchemexpress LLC CP 93129 dihydrochloride | 879089-64-2 | MFCD16875420 | 99.0% | 288.17 g/mol | C12H15Cl2N3O | 5 MG
CP 93129 dihydrochloride is the dihydrochloride salt of a potent and selective 5-HT1B receptor agonist used as a research reagent in neuroscience, including Parkinson's disease models. Supplied as an off-white to light yellow solid, it is intended for research and analytical applications.
- Potent, selective 5-HT1B receptor agonist for pharmacological studies.
- High purity (≈99.0%) suitable for analytical and in vitro work.
- CAS number 879089-64-2 for unambiguous identification.
- Molecular formula C12H15Cl2N3O; molecular weight ~288.17 g/mol.
- Recommended storage: 4°C; in solvent keep at -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC Nitrocaramiphen (hydrochloride) | 98636-73-8 | MFCD00673872 | 99.6% | 370.87 | C18H27ClN2O4 | 10 MG
Nitrocaramiphen hydrochloride is a selective muscarinic M1 receptor antagonist for research use, commonly applied in pharmacology and neuroscience to probe cholinergic signaling. It blocks muscarine-induced hyperpolarization in muscle fibers and is supplied as a purified solid for in vitro assays.
- Selective muscarinic M1 receptor antagonist (Ki 5.5 nM).
- Inhibits muscarine-induced hyperpolarization in muscle fibers.
- High purity solid suitable for in vitro research (purity 99.6%).
- Compact supply size for small-scale studies (10 mg).
- Stable when stored sealed and protected from moisture.
Medchemexpress LLC (R)-VU 6008667 | 2097818-14-7 | 99.8% | 438.85 | C24H17ClF2N2O2 | 1 ML
(R)-VU 6008667 is the (R)-enantiomer of VU 6008667 supplied for research use. It is described as the less active enantiomer and lacks M5 negative allosteric modulator activity (IC50 > 10 μM). Available as a solid or as a 10 mM solution in DMSO, the product includes purity, molecular, and storage information for laboratory applications.
- High purity (99.8%).
- Available as solid or 10 mM solution in DMSO.
- White to off-white solid appearance.
- Molecular weight 438.85 and formula C24H17ClF2N2O2.
- Storage: solid at 4°C under nitrogen; in solvent at -80°C (6 months) or -20°C (1 month).
- Intended for research use only; not for human or clinical use.
Medchemexpress LLC VU 0364439 | 1246086-78-1 | C18H13Cl2N3O3S | 50 MG
VU 0364439 is a mGlu4 positive allosteric modulator (PAM), with an EC50 of 19.8 nM. Intended for research use only, this solid compound appears white to off-white. While it demonstrates better stability in Human Liver Microsomes, its less than ideal PK properties prevent its use as an in vivo tool.
- Positive allosteric modulator (PAM) for mGlu4
- EC50 of 19.8 nM
- Purity of 99.42%
- Solid appearance, white to off-white color
- Exhibits better stability in HLM (63% remaining) compared to RLM (2% remaining)
- Target: mGluR
Medchemexpress LLC L-733060 hydrochloride | 148687-76-7 | 99.9% | 439.82 | 1 MG
L-733060 hydrochloride is a selective neurokinin-1 (NK-1) receptor antagonist. It primarily regulates pain transmission and neural plasticity by blocking the binding of Substance P to the NK-1 receptor. It blocks the promoting effect of Substance P on long-term potentiation (LTP) in the hippocampus and reverses orofacial hyperalgesia induced by experimental occlusal interference (EOI) in rats. Additionally, it inhibits neurogenic plasma extravasation and acts as an anti-tumor agent, making it suitable for studying chronic orofacial pain.
- Selective neurokinin-1 (NK-1) receptor antagonist
- Regulates pain transmission and neural plasticity
- Blocks Substance P binding to NK-1 receptor
- Reverses orofacial hyperalgesia
- Inhibits neurogenic plasma extravasation
- Acts as an anti-tumor agent
- Suitable for studying chronic orofacial pain
Apexbio Technology LLC Nitrocaramiphen hydrochloride 98636-73-8 50mg
Nitrocaramiphen hydrochloride (CAS 98636-73-8) is a small molecule that acts as a selective antagonist of muscarinic acetylcholine M1 receptors exhibiting a Ki of 5 5 nM Studies indicate that it effectively inhibits the hyperpolarizing effects induced by muscarinic agonists in muscle fibers Due to its receptor specificity nitrocaramiphen hydrochloride is widely utilized in neurobiological research to investigate cholinergic signaling pathways and the physiological roles of M1 receptor modulation
Selleck Chemical LLC A-438079 HCl 100mg 899431-18-6
A-438079 HCl is a potent, and selective P2X7 receptor antagonist with pIC50 of 6.9. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Medchemexpress LLC Tak-960 dihydrochloride | 2320307-83-1 | C27H36Cl2F3N7O3 | 10 MM 1 ML
TAK-960 dihydrochloride is an orally available, selective inhibitor of polo-like kinase 1 (PLK1) with an IC50 of 0.8 nM. It also shows inhibitory activities against PLK2 and PLK3, with IC50s of 16.9 nM and 50.2 nM, respectively. This compound inhibits the proliferation of multiple cancer cell lines and demonstrates significant efficacy against various tumor xenografts.
- Acts as a selective inhibitor of polo-like kinase 1 (PLK1)
- Shows inhibitory activities against PLK2 and PLK3
- Causes accumulation of G2-M cells
- Leads to aberrant polo mitosis morphology
- Increases phosphorylation of histone H3 (pHH3)
- Induces G2/M cell cycle arrest in HeLa cells without significant cytotoxicity
- Inhibits proliferation of multiple cancer cell lines
- Exhibits significant efficacy against multiple tumor xenografts
![Medchemexpress LLC 4-piperidinamine, N-[(1R,2S)-2-phenylcyclopropyl]-, hydrochloride (1:2), rel- | 2102933-95-7 | 99.5% | 289.24 g/mol | C14H22Cl2N2 | 1 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000212683.png-250.jpg)
Medchemexpress LLC 4-piperidinamine, N-[(1R,2S)-2-phenylcyclopropyl]-, hydrochloride (1:2), rel- | 2102933-95-7 | 99.5% | 289.24 g/mol | C14H22Cl2N2 | 1 MG
GSK-LSD1 dihydrochloride is a potent, selective, and irreversible inhibitor of lysine specific demethylase 1 (LSD1) with an IC50 of 16 nM. It is provided for research use in epigenetics and pharmacology studies. Chemical identifiers include CAS 2102933-95-7, formula C14H22Cl2N2, molecular weight 289.24 g/mol, and reported purity ~99.45%.
- Potent, selective, irreversible LSD1 inhibition with low nanomolar potency.
- High chemical purity suitable for research applications.
- Dihydrochloride salt form for improved handling and solubility.
- Well-characterized with supporting certificate of analysis available.
- Intended for epigenetic and pharmacological research use.