Hydrochlorides
Cayman Chemical 1Deoxynojirimycin hydrochlor
An inhibitor of α-glucosidase I and II (IC50s = ~2 µM for both); inhibits virus spread in HIV-infected lymphocyte cultures at 0.4 mM
Medchemexpress LLC RS-127445 hydrochloride | 199864-86-3 | C17H17ClFN3 | 50 MG
RS-127445 hydrochloride is a selective, high-affinity, orally bioavailable 5-HT2B receptor antagonist with a pKi of 9.5. It demonstrates 1000-fold selectivity for this receptor compared to numerous other receptor and ion channel binding sites. It is intended for research use only.
- Selective 5-HT2B receptor antagonist
- High-affinity binding
- Orally bioavailable
- Demonstrates 1000-fold selectivity
- Suitable for research applications
Medchemexpress LLC Acetamide, N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]- | 893990-34-6 | 99.7% | 342.44 | 25 MG
VU 0240551 is a potent and selective neuronal K-Cl cotransporter KCC2 inhibitor with an IC50 of 560 nM, demonstrating selectivity against NKCC1. It also inhibits hERG and L-type Ca2+ channels. VU 0240551 has been shown to attenuate GABA-induced hyperpolarization of P cells, induce a positive shift in the P cell GABA reversal potential, and enhance P cell synaptic transmission.
- In HEK293 cells, VU 0240551 showed an IC50 of 568 nM for antagonist activity at KCC2.
- It exhibited an IC50 > 50 μM for antagonist activity at NKKC1 in human HEK293 cells.
- VU 0240551 reduces the P cell response to GABA in a concentration-dependent manner.
Abcam Serotonin hydrochloride (5-HT/5-Hydro x ytryptamine), 5-HT receptor agonist, 1G
MW 212.67 Da, Purity >99%. Endogenous 5-HT receptor agonist. Neurotransmitter involved in diverse physiological functions such as mood, appetite, sleep, sex and temperature in addition to modulating cardiovascular function and the gastrointestinal system. Also a 5-HT transporter substrate.
The product is subject to the following: Abcam Restricted Use Statement
Medchemexpress LLC Benzamide, N-(aminoiminomethyl)-2-methyl-5-(methylsulfonyl)-4-(1H-pyrrol-1-yl) hydrochloride | 211813-86-4 | MFCD31560490 | 99.5% | 356.83 | C14H17ClN4O3S | 10 MG
Eniporide hydrochloride is a small-molecule Na+/H+ exchanger inhibitor provided as the hydrochloride salt for use in biochemical and pharmacological research. It has been used in preclinical studies of cardiac ischemia/reperfusion and cellular ion regulation. The compound is supplied as a high-purity solid with recommended cold storage to preserve stability.
- Potent Na+/H+ exchanger inhibitor
- Hydrochloride salt form for improved stability
- High purity (99.5%) suitable for research applications
- Solid form, convenient for storage and handling
- Recommended storage: 4°C; in solvent -80°C (6 months) or -20°C (1 month)
- Suitable for studies of ion transport and cardiac models
Medchemexpress LLC Aldoxorubicin hydrochloride | 480998-12-7 | 98.0% | 787.21 g/mol | C37H43ClN4O13 | 5 MG
Aldoxorubicin hydrochloride is an albumin-binding proagent of doxorubicin that functions as a DNA topoisomerase II inhibitor and exhibits acid-sensitive release properties. It is supplied as a high-purity research reagent for preclinical laboratory use.
- Albumin-binding proagent of doxorubicin
- Acid-sensitive release of active doxorubicin
- Acts as a DNA topoisomerase II inhibitor
- Available as small-mass research packs (e.g., 5 mg)
- High reported purity (around 98%)
Medchemexpress LLC Benzenepropanamine, gamma-(2-methoxyphenoxy)-N-methyl-, hydrochloride | 57754-86-6 | 99.9% | 307.82 | C17H22ClNO2 | 10 MG
Nisoxetine hydrochloride is a research-grade small molecule that potently and selectively inhibits the noradrenaline (norepinephrine) transporter (NET) and can block voltage-gated sodium channels. It is supplied as a solid powder for use in transporter pharmacology, neurotransmitter uptake assays, and sodium channel studies.
- Potent, selective noradrenaline transporter (NET) inhibitor (reported Kd ≈ 0.76 nM).
- Acts as an antidepressant-class compound and local anesthetic via sodium channel blockade.
- High purity suitable for biochemical assays and pharmacology studies.
- Available in small-scale powder sizes and DMSO solution formats for ready use.
- Stable when stored under recommended conditions (powder and in solvent).
Apexbio Technology LLC Dapoxetine HCl 129938-20-1 25mg
Dapoxetine hydrochloride (CAS 129938-20-1) is a short-acting selective serotonin reuptake inhibitor (SSRI) It exerts its pharmacological effect by inhibiting the reuptake of serotonin (5-HT) at the presynaptic membrane thereby increasing serotonin activity in the synaptic cleft This modulation of serotonergic neurotransmission has been shown to delay ejaculation latency making dapoxetine hydrochloride an established model compound for investigating serotonergic regulation of ejaculatory control It is widely used in research on the neurobiology and therapeutic approaches to premature ejaculation and related disorders
Apexbio Technology LLC Tirofiban hydrochloride monohydrate 150915-40-5 10mM (in 1mL DMSO)
Tirofiban hydrochloride monohydrate (CAS 150915-40-5) is a small-molecule inhibitor targeting platelet glycoprotein IIb/IIIa receptors It is designed to reversibly antagonize the binding of fibrinogen to these receptors thereby inhibiting platelet aggregation and thrombus formation Tirofiban hydrochloride monohydrate exerts its biological activity primarily through selective reversible inhibition of glycoprotein IIb/IIIa-mediated platelet aggregation Based on these pharmacological properties tirofiban hydrochloride monohydrate holds research potential in antithrombotic therapy and the investigation of unstable angina and thrombus-associated cardiovascular conditions
Abcam VU 0238429, allosteric M5 modulator, 5MG
MW 351.28 Da, Purity >99%. Selective, positive allosteric M5 modulator (EC50 values are 1.16 and >30 μM at M5 and M1/ M3 receptors, respectively). Shows no activity at M2 and M4 receptors.
The product is subject to the following: Abcam Restricted Use Statement
Medchemexpress LLC Cyclopentanecarboxylic acid, 1-(4-nitrophenyl)-, 2-(diethylamino)ethyl ester, hydrochloride | 98636-73-8 | MFCD00673872 | 99.6% | 370.87 g/mol | C18H27ClN2O4 | 25 MG
Nitrocaramiphen hydrochloride is a selective M1 muscarinic receptor antagonist supplied as the hydrochloride salt for research use. It inhibits muscarine-induced hyperpolarization in muscle fibers and is provided as a white to off-white solid suitable for biochemical and pharmacological studies.
- Selective M1 receptor antagonist (Ki: 5.5 nM).
- High purity: 99.6% (manufacturer COA).
- White to off-white solid, molecular formula C18H27ClN2O4.
- Molecular weight 370.87 g/mol.
- Available in small milligram quantities for research use.
- Store sealed away from moisture; in solvent: -80°C (6 months), -20°C (1 month).
Medchemexpress LLC Anabasine ((S)-Anabasine) | 494-52-0 | MFCD00006370 | 99.0% | 100 MG
Anabasine ((S)-Anabasine) is an alkaloid found as a minor component in tobacco. It functions as a botanical pesticide nicotine and acts as a full agonist of nicotinic acetylcholine receptors (nAChRs). It induces depolarization of TE671 cells endogenously expressing human fetal muscle-type nAChRs, with an EC50 of 0.7 μM. Studies show it significantly reverses impairment at 0.2 mg/kg and 2 mg/kg doses.
- Functions as a botanical pesticide nicotine
- Acts as a full agonist of nicotinic acetylcholine receptors (nAChRs)
- Induces depolarization of TE671 cells with an EC50 of 0.7 μM
- Significantly reverses impairment at 0.2 mg/kg and 2 mg/kg doses
- Does not significantly affect response latency when administered alone
- Exacerbates dizocilpine-induced impairment at 0.06 mg/kg dose
- Does not independently affect choice accuracy
Medchemexpress LLC KB-0742 dihydrochloride | 2416874-75-2 | 98.8% | 360.33 | 10 MG
KB-0742 dihydrochloride is a potent, selective, and orally active CDK9 inhibitor with an IC50 of 6 nM for CDK9/cyclin T1. It exhibits significant selectivity over other CDK kinases and demonstrates potent anti-tumor activity.
- Potent, selective, and orally active CDK9 inhibitor
- Shows over 50-fold selectivity for CDK9/cyclin T1
- Exhibits potent anti-tumor activity
- Significantly reduces downstream phosphorylation of RNA Pol II
- Reduces global androgen receptor protein levels
- Shows cytostatic effects in prostate cancer and leukemia cell lines
- Well tolerated and reduces tumor burden in xenograft models
- Soluble in H2O and DMSO
Medchemexpress LLC Harmalol hydrochloride | 6028-07-5 | 25 MG
Harmalol hydrochloride is a beta carboline alkaloid found in medicinal plants like *Peganum harmala*. It is the main metabolite of Harmaline and significantly inhibits the dioxin-mediated induction of CYP1A1 at both transcriptional and posttranslational levels. This compound also exhibits antioxidant and hydroxyl radical-scavenging properties and is intended for research use only.
- Beta carboline alkaloid
- Found in medicinal plants such as *Peganum harmala*
- Main metabolite of Harmaline
- Inhibits CYP1A1 induction
- Exhibits antioxidant properties
- Possesses hydroxyl radical-scavenging properties
- For research use only