Hydrochlorides
Medchemexpress LLC Prazosin (hydrochloride) | 19237-84-4 | 1 ML
Prazosin hydrochloride is a well-tolerated, CNS-active α1-adrenergic receptor antagonist used for research of high blood pressure and alcohol use disorders. It potently inhibits Norepinephrine (NE)-stimulated 45Ca efflux with an IC50 of 0.15 nM and inhibits organic cation transporters OCT-1 and OCT-3 with IC50s of 1.8 and 13 μM.
- CNS-active α1-adrenergic receptor antagonist
- Research for high blood pressure and alcohol use disorders
- Potently inhibits norepinephrine (NE)-stimulated 45Ca efflux (IC50 = 0.15 nM)
- Inhibits organic cation transporters OCT-1 and OCT-3 (IC50s = 1.8, 13 μM)
- Effectively inhibits proliferation, migration, and invasion of U251 and U87 cells
- Decreases protein expression of PI3K/AKT/mTOR signaling pathway components
- Suppresses central α1-adrenergic-mediated hyperexcitability and stress-induced anxiety
Medchemexpress LLC SKF-96365 hydrochlor 10mg
SKF-96365 hydrochloride is a potent TRP channel blocker and a store-operated Ca2 entry (SOCE) inhibitor SKF-96365 hydrochloride significantly inhibits hERG hKCNQ1/hKCNE1 hKir2 1 and hKv4 3 current and significantly prolongs the QTc interval in isolated guinea pig hearts SKF-96365 hydrochloride exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal cancer cells1]2]
Medchemexpress LLC Dopamine (hydrochloride) | 62-31-7 | MFCD00012898 | 99.8% | 100 MG
Dopamine hydrochloride is a catecholamine neurotransmitter produced in the brain's substantia nigra, ventral tegmental area, and hypothalamus. It plays important roles in the brain and body. This compound acts through D2 dopamine receptors to induce endocytosis of VEGFR2, which is critical for promoting angiogenesis.
- Catecholamine neurotransmitter
- Produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain
- Plays several important roles in the brain and body
- Acts through D2 dopamine receptors
- Induces endocytosis of VEGFR2
- Critical for promoting angiogenesis
Medchemexpress LLC Amiloride hydrochloride dihydrate | 17440-83-4 | MFCD00211292 | 99.9% | 1 ML
Amiloride hydrochloride dihydrate is an inhibitor of both epithelial sodium channel (ENaC) and urokinase-type plasminogen activator receptor (uTPA). It also acts as a blocker of polycystin-2 (PC2; TRPP2) channel.
- Inhibits epithelial sodium channel (ENaC)
- Inhibits urokinase-type plasminogen activator receptor (uTPA)
- Blocks polycystin-2 (PC2; TRPP2) channel
Medchemexpress LLC Mafenide hydrochloride | 138-37-4 | 99.97% | 100 MG
Mafenide hydrochloride is an effective sulfonamide-type antimicrobial agent used for burn wounds. It exhibits activity against both Gram-positive and Gram-negative organisms, including Pseudomonas aeruginosa, by inhibiting nucleotide synthesis. It is a white to off-white solid with a purity of 99.97% and a molecular weight of 222.69.
- Effective sulfonamide-type antimicrobial agent
- Active against Gram-positive and Gram-negative organisms
- Inhibits nucleotide synthesis
- Purity of 99.97%
- Soluble in DMSO (125 mg/mL)
- Recommended storage at 4°C in sealed container, away from moisture
Medchemexpress LLC PNU-22394 hydrochloride | 15923-42-9 | 98.8% | 236.74 g/mol | C13H17ClN2 | 5 MG
PNU-22394 hydrochloride is a research-grade small-molecule agonist of serotonin (5-HT) receptors, showing selectivity for 5-HT2C and activity at 5-HT2A. Supplied as a hydrochloride salt, it is intended for in vitro pharmacology and receptor signaling studies.
- Selective agonist at 5-HT2C with Ki = 6.1 nM.
- Also active at 5-HT2A (Ki = 10 nM).
- Assay-dependent EC50: 5-HT2C 7.7 nM (Fluo-4/Ca2+) and 0.12 μM (IP-One); 5-HT2A 23 nM (Fluo-4/Ca2+) and 0.21 μM (IP-One).
- Molecular formula C13H17ClN2; molecular weight 236.74 g/mol.
- High chemical purity (98.8%).
- Available in small milligram quantities for laboratory research.
eMolecules 21987-29-1 | 4,4-Difluoropiperidine | Apollo Scientific | MFCD03094281 | 121.131 | C5H9F2N | 97.000 | FC1(F)CCNCC1 | 1g | 600856207
4,4-Difluoropiperidine | Apollo Scientific | 21987-29-1 | MFCD03094281 | 121.131 | C5H9F2N | 97.000 | FC1(F)CCNCC1 | 1g | 600856207
eMolecules 18413-14-4 | Ethylhydrazine hydrochloride | MFCD01722460 | 1g
Ambeed | 13-Dimesityl-1H-imidazol-3-ium tetrafluoroborate | 250mg | 627733048 | A539978 | 286014-53-7 | MFCD04971186 | 392.250 | C21H25BF4N2
If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link:
eMolecules Building Block Tool<|a>
TARGETMOL CHEMICALS INC DULOXETINE 50MG
Also available in 5 mg 10 mg 25 mg 100 mg and bulk. Please contact Fisher for quotes. Duloxetine is an inhibitor of serotonin-norepinephrine reuptake(Ki of 4.6 nM)with treatment of major depressive disorder and generalized anxiety disorder. purity: 99%
Medchemexpress LLC PS372424 (hydrochloride) | 1596362-29-6 | ≥98.0% | 625.20 | 25 MG
PS372424 hydrochloride, a three amino-acid fragment of CXCL10, is a specific human CXCR3 agonist with anti-inflammatory activity. It prevents human T-cell migration in a humanized model of arthritic inflammation.
- Specific human CXCR3 agonist with anti-inflammatory activity.
- Prevents human T-cell migration in a humanized model of arthritic inflammation.
Medchemexpress LLC Asciminib hydrochlor 10mM 1mL | 2119669-71-3 | 10MM 1ML
Asciminib (ABL001) hydrochloride is a potent and selective allosteric BCR-ABL1 inhibitor which inhibits Ba/F3 cells grown with an IC50 of 0 25 nM[1
eMolecules 80222-96-4 | 2-Aminopropanamide hydrochloride | MFCD00066144 | 1g
Ambeed | 2-Aminopropanamide hydrochloride | 1g | 588342319 | A291539 | 80222-96-4 | MFCD00066144 | 124.570 | C3H9ClN2O
If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link:
eMolecules Building Block Tool<|a>
Medchemexpress LLC Icotinib (Hydrochloride) | 1204313-51-8 | C22H22ClN3O4 | 100 MG
Icotinib Hydrochloride (BPI-2009) is a potent, CNS-penetrant, and specific EGFR inhibitor with an IC50 of 5 nM. It inhibits mutant EGFRL858R, EGFRL858R/T790M, EGFRT790M, and EGFRL861Q. This compound is a click chemistry reagent containing an Alkyne group, enabling it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Potent, CNS-penetrant, and specific EGFR inhibitor
- Inhibits mutant EGFRL858R, EGFRL858R/T790M, EGFRT790M, and EGFRL861Q
- Click chemistry reagent for copper-catalyzed azide-alkyne cycloaddition
- Exhibits potent dose-dependent antitumor effects in nude mice
- Well tolerated at doses up to 120 mg/kg/day in mice
Medchemexpress LLC MK2-IN-1 (hydrochloride) | 1314118-94-9 | 98.4% | 1 ML
MK2-IN-1 hydrochloride (compound 1) is a potent and selective MAPKAPK2 (MK2) inhibitor with an IC50 of 0.11 μM for MK2 and an EC50 of 0.35 μM for pHSP27. It impairs the phosphorylation level of serine residues in the Tfcp2l1 protein. This product is for research use only and not sold to patients.
- Potent and selective MAPKAPK2 (MK2) inhibitor
- Gradually increases Tfcp2l1 protein level without a change in transcript level within 2 hours
- Induces more alkaline phosphatase (AP)-positive colonies
- Molecular weight of 509.43
- Chemical formula C27H26Cl2N4O2
- Appears as a light yellow to pink solid
- Highly soluble in H2O and DMSO