Hydrochlorides
Medchemexpress LLC Sb-258585 hydrochloride | 1216468-02-8 | 99.7% | 523.82 g·mol⁻¹ | C18H23ClIN3O3S | 5 MG
SB-258585 hydrochloride is the hydrochloride salt of a selective, high-affinity antagonist for the serotonin 5-HT6 receptor. Supplied as a research-grade powder, it is intended for in vitro receptor binding and pharmacology studies and is characterized by high purity and defined storage conditions.
- Selective 5-HT6 receptor antagonist with high affinity.
- Suitable for in vitro receptor binding and pharmacological assays.
- Provided as a hydrochloride salt in powder form for accurate dosing.
- High purity (>99.7%) for reproducible results.
- Stable when stored under recommended conditions (powder: -20°C).
Medchemexpress LLC Ipn60090 dihydrochloride | 2102101-72-2 | 99.7% | 605.44 g/mol | C24H29Cl2F3N8O3 | 1 ML
IPN60090 dihydrochloride is a potent, selective small-molecule inhibitor of glutaminase 1 (GLS1), provided as a dihydrochloride salt for preclinical research. It is offered as a ready-to-use 10 mM solution in DMSO (1 mL) or as solid samples, with reported high purity and documented in vitro and in vivo activity supporting use in solid tumor studies.
- Highly selective GLS1 inhibitor with reported IC50 = 31 nM.
- Inhibits A549 cell proliferation (IC50 = 26 nM).
- Available as 10 mM solution in DMSO (1 mL) or multiple solid sizes for experimental flexibility.
- High purity suitable for biochemical and cell-based assays.
- Documented pharmacokinetic and efficacy data in preclinical models.
![Medchemexpress LLC 1,1′,1′′,1′′′-[1,4-Piperazinediylbis(2,1-ethanediylnitrilo)]tetrakis[2-dodecanol] | 1265904-26-4 | 98.0% | 909.54 | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000437403-Logo.png-250.jpg){kind=logo}
Medchemexpress LLC 1,1′,1′′,1′′′-[1,4-Piperazinediylbis(2,1-ethanediylnitrilo)]tetrakis[2-dodecanol] | 1265904-26-4 | 98.0% | 909.54 | 50 MG
1,1′,1′′,1′′′-[1,4-Piperazinediylbis(2,1-ethanediylnitrilo)]tetrakis[2-dodecanol] is a lipid/lipidoid chemical compound primarily used in the preparation of lipid-based or lipidoid nanoparticles. This product is for research use only.
- Solid appearance, light yellow to orange in color.
- Suitable for lipid-based or lipidoid nanoparticle preparation.
- High purity of 98.0%.
- Soluble in DMSO.
- Specific storage conditions for powder and solutions to maintain stability.
Medchemexpress LLC RS-127445 hydrochloride | 199864-86-3 | C17H17ClFN3 | 100 MG
RS-127445 hydrochloride is a selective, high-affinity, and orally bioavailable 5-HT2B receptor antagonist. It exhibits 1000-fold selectivity for the 5-HT2B receptor compared to numerous other receptor and ion channel binding sites, making it a valuable tool for research into serotonin receptor activity and related biological pathways.
- Selective and high-affinity 5-HT2B receptor antagonist
- Orally bioavailable
- Exhibits 1000-fold selectivity over many other receptors
- Potently blocks 5-HT evoked increases in intracellular calcium concentrations
- Reduces faecal output in rats dose-dependently
Medchemexpress LLC Biotin-PEG4-picolyl azide | 2222687-71-8 | MFCD29052186 | 98.7% | 622.74 | C27H42N8O7S | 5 MG
Biotin-PEG4-picolyl azide is a biotinylated click-chemistry reagent containing a PEG4 spacer and a picolyl azide moiety. It is designed for copper-catalyzed azide-alkyne cycloaddition (CuAAC) to conjugate biotin to alkyne-containing biomolecules for labeling, enrichment, and detection in chemical biology workflows.
- Picolyl azide enhances copper-catalyzed azide-alkyne cycloaddition kinetics.
- PEG4 spacer improves solubility and provides a flexible linkage.
- Biotin tag enables affinity capture and detection of conjugates.
- High purity suitable for analytical and preparative labeling workflows.
- Small pack size appropriate for milligram-scale reactions.
eMolecules 295327-27-4 | 2-PYRIDINEACETIC ACID, 3-AMINO-, ETHYL ESTER | MFCD11616148 | 0.25g
AstaTech | METHYL 6-N-BOC-AMINO-3-FORMYL-1H-INDOLE-4-CARBOXYLATE | 0.1g | 696739551 | 64055 | 97.000 | 731810-57-4 | MFCD09800496 | 318.329 | C16H18N2O5
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Medchemexpress LLC AMG-548 dihydrochloride | 2518299-32-4 | 99.9% | 534.48 | 10 MG
AMG-548 dihydrochloride is an orally active and selective p38α inhibitor with a Ki of 0.5 nM. It exhibits slight selectivity over p38β (Ki=36 nM) and a greater than 1000-fold selectivity against p38γ and p38δ. This compound is highly potent in inhibiting whole blood LPS-stimulated TNFα (IC50=3 nM) and also inhibits Wnt signaling by directly targeting Casein kinase 1 isoforms δ and ε.
- Selective p38α inhibitor (Ki=0.5 nM).
- Slightly selective over p38β (Ki=36 nM).
- Greater than 1000-fold selective against p38γ and p38δ.
- Potent inhibition of whole blood LPS stimulated TNFα (IC50=3 nM).
- Inhibits Wnt signaling by directly inhibiting Casein kinase 1 isoforms δ and ε.
Medchemexpress LLC SB 206553 hydrochloride | 1197334-04-5 | 99.4% | 328.80 g/mol | C17H17ClN4O | 25 MG
SB 206553 hydrochloride is a research compound that selectively antagonizes 5-HT2B and 5-HT2C serotonin receptors and is used in pharmacology and neuroscience studies to probe serotonergic signaling.
- Selective 5-HT2B/5-HT2C receptor antagonist/inverse agonist
- High purity suitable for research applications
- Solid, light yellow to yellow appearance for easy handling
- Stable when stored sealed and protected from moisture at -20°C
- Available in small milligram quantities for preclinical studies
Medchemexpress LLC XE991 dihydrochloride | 122955-13-9 | 99.6% | 449.37 | 500 UG
XE991 dihydrochloride is a Kv7 (KCNQ) channels blocker that potently inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channel, and M-current with IC50s of 0.75 μM, 0.71 μM, 0.6 μM, and 0.98 μM, respectively. It has an EC50 of 490 nM for enhancement of [3H]ACh release from rat brain slices, and shows good in vivo potency and duration of action.
- Potent Kv7 (KCNQ) channels blocker.
- Inhibits Kv7.1, Kv7.2, Kv7.2 + Kv7.3 channels, and M-current.
- IC50s: 0.75 μM (Kv7.1), 0.71 μM (Kv7.2), 0.6 μM (Kv7.2 + Kv7.3), 0.98 μM (M-current).
- EC50 of 490 nM for enhancing [3H]ACh release from rat brain slices.
- Good in vivo potency and duration of action.
Medchemexpress LLC JMV 2959 hydrochloride | 2448414-54-6 | 545.08 | 10 MG
JMV 2959 hydrochloride is a potent growth hormone secretagogue receptor type 1a (GHS-R1a) antagonist. It demonstrates an IC50 of 32±3 nM in LLC-PK1 cells and a dissociation constant (Kb) of 19±6 nM. This compound does not induce intracellular calcium mobilization on its own.
- Antagonist of growth hormone secretagogue receptor type 1a (GHS-R1a)
- IC50 of 32±3 nM in LLC-PK1 cells
- Dissociation constant (Kb) of 19±6 nM
- Does not induce intracellular calcium mobilization
- Attenuates phencyclidine (PCP)-induced deficits in prepulse inhibition in vivo
Medchemexpress LLC Adl-5859 hydrochloride | 850173-95-4 | 99.7% | C24H29ClN2O3 | 10MG
ADL-5859 hydrochloride is the hydrochloride salt of a selective, orally active delta-opioid receptor agonist used as a research tool in pain pharmacology. It is supplied as a white to off-white solid with high purity and characterized potency in binding and functional assays.
- Selective delta (δ) opioid receptor agonist with low-nanomolar affinity.
- High purity (~99.7%) suitable for in vitro and in vivo studies.
- Documented potency: Ki ≈ 0.84 nM, EC50 ≈ 20 nM.
- Known off-target profile: hERG IC50 ≈ 78 μM, CYP2D6 IC50 ≈ 43 μM.
- Supplied in small lot sizes convenient for preclinical research.
Medchemexpress LLC Dazoxiben (hydrochloride) | 74226-22-5 | MFCD00866791 | 99.9% | 268.70 | C12H13ClN2O3 | 10 MM 1 ML
Dazoxiben (hydrochloride) is the hydrochloride salt of dazoxiben, a potent and orally active thromboxane (TX) synthase inhibitor used in research to probe thromboxane-mediated pathways. Supplied as a concentrated solution for laboratory use, it includes accompanying safety and handling documentation.
- Potent thromboxane synthase inhibitor for research applications.
- Provided as a 10 mM solution in DMSO, ready for dilution.
- High purity (99.9%) suitable for biochemical assays.
- Storage guidance for sealed samples: -80°C (6 months) or -20°C (1 month) in solvent.
- SDS and data sheet available for handling and safety information.
Medchemexpress LLC TC-A 2317 (hydrochloride) | 1245907-03-2 | MFCD19690936 | 99.6% | 392.93 | C19H29ClN6O | 5 MG
TC-A 2317 hydrochloride is the hydrochloride salt of TC-A 2317, a potent, orally active Aurora A kinase inhibitor used for research applications. It demonstrates high potency, selectivity, and antiproliferative activity in cancer cell models.
- Potent Aurora A inhibitor with Ki = 1.2 nM
- Selective over Aurora B (Ki = 101 nM)
- Antiproliferative activity in HCT-116 cells (IC50 = 115 nM)
- Hydrochloride salt for improved stability and handling
- High measured purity (~99.6%) suitable for research use
- Available in small-mass packaging for laboratory studies
Apexbio Technology LLC VU 0364439 1246086-78-1 100mg
VU 0364439 (CAS 1246086-78-1) is a positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4) a member of the class C G protein-coupled receptor (GPCR) family involved in regulating glutamatergic neurotransmission In vitro studies have demonstrated that VU 0364439 enhances mGluR4 activity with an EC50 of 19 8 nM exhibiting greater maximal response and potency compared to the partially selective PAM ()-PHCCC Although its pharmacokinetic properties limit in vivo applications VU 0364439 serves as a valuable tool compound for investigating mGluR4 function and modulation in cellular assays
Medchemexpress LLC Naloxone hydrochloride | 357-08-4 | MFCD00069322 | 99.7% | 363.84 g/mol | C19H22ClNO4 | 10 MG
Naloxone hydrochloride is a research-grade reference standard of naloxone, a competitive opioid receptor antagonist used to reverse opioid effects and to support pharmacology and analytical method development. Supplied as a 10 mg reference material with accompanying certificate of analysis and safety data sheet, it is intended for research and analytical applications.
- High purity suitable for analytical and reference applications (99.7%).
- Provided with certificate of analysis and safety data sheet.
- Suitable for opioid receptor pharmacology and receptor-binding studies.
- Molecular weight 363.84 g/mol; formula C19H22ClNO4.
- Packaged as a 10 mg reference standard for method development and validation.