Hydrochlorides
Medchemexpress LLC LY-272015 hydrochloride | 172895-15-7 | 99.5% | 372.89 | C21H25ClN2O2 | 5 MG
LY-272015 hydrochloride is a research compound used as a selective 5-HT2B (serotonin) receptor antagonist for preclinical pharmacology studies. It is orally active in animal models and has been reported to show antihypertensive effects in DOCA-salt hypertensive rats. The material is supplied as a solid for laboratory use with supporting analytical documentation.
- Selective 5-HT2B receptor antagonist for target-specific studies.
- Orally active in preclinical models, useful for in vivo pharmacology.
- High purity suitable for research applications.
- Supplied as an off-white to light yellow solid for ease of handling.
- Provided with data sheet, certificate of analysis, and safety data sheet.
eMolecules 211449-19-3 | 4-(TRIFLUOROMETHYL)QUINOLIN-2-AMIN | AstaTech | MFCD11046309 | 212.175 | C10H7F3N2 | 98.000 | Nc1cc(c2ccccc2n1)C(F)(F)F | 1g | 449721176
4-(TRIFLUOROMETHYL)QUINOLIN-2-AMIN | AstaTech | 211449-19-3 | MFCD11046309 | 212.175 | C10H7F3N2 | 98.000 | Nc1cc(c2ccccc2n1)C(F)(F)F | 1g | 449721176
Medchemexpress LLC RS-25344 hydrochloride | 152815-28-6 | 99.9% | 411.80 | 25 MG
RS-25344 hydrochloride is a selective cAMP-phosphodiesterase 4 (PDE 4; PDE IV) inhibitor with an IC50 of 0.28 nM in human lymphocytes. It has only weak inhibitory effects on PDE I, II, and III (IC50 of >100 μM, 160 μM, and 330 μM, respectively). It exhibits anti-inflammatory, memory- and cognition-enhancing, and antineoplastic effects. It is a potent inhibitor of sperm PDE activity, with an effective concentration of 0.3 nM, reaching maximum inhibition in the range of 100 nM. In vivo studies have shown that it can significantly increase stomach weights and gastric retention in mice.
- Selective cAMP-phosphodiesterase 4 (PDE 4; PDE IV) inhibitor.
- Exhibits anti-inflammatory effects.
- Enhances memory and cognition.
- Possesses antineoplastic effects.
- Potent inhibitor of sperm PDE activity.
Medchemexpress LLC Urapidil hydrochloride | 64887-14-5 | 99.86% | 50 MG
Urapidil hydrochloride is an orally active and blood-brain barrier permeable α1-adrenoceptor antagonist and 5-HT1A receptor agonist. It has a pIC50 of 6.13 against α1-adrenoceptor and 4.38 against α2-adrenoceptor. It demonstrates antihypertensive effects.
- Orally active and blood-brain barrier permeable
- Functions as an α1-adrenoceptor antagonist and 5-HT1A receptor agonist
- Demonstrates antihypertensive effects
- Features pIC50 of 6.13 against α1-adrenoceptor
- Features pIC50 of 4.38 against α2-adrenoceptor
Medchemexpress LLC Co 101244 hydrochloride | 193356-17-1 | 99.9% | 377.90 g·mol⁻1 | C21H28ClNO3 | 1 ML
Co 101244 hydrochloride is a research-grade NMDA receptor antagonist selective for NR2B-containing receptor subtypes. It is used as a pharmacological tool in electrophysiology and biochemical studies to probe NMDA receptor function. The compound is available as a solid and as a 10 mM solution in DMSO for experimental use.
- Selective antagonist of NR2B-containing NMDA receptors.
- Provided as 10 mM solution in DMSO (1 mL) for immediate use.
- High reported purity suitable for research applications.
- Light yellow solid form for storage and handling.
- Useful in preclinical electrophysiology and pharmacology studies.
Medchemexpress LLC FFN 206 dihydrochloride | 1883548-88-6 | 99.5% | 291.17 | 25 MG
FFN 206 dihydrochloride is a fluorescent probe utilized as an excellent Vesicular Monoamine Transporter 2 (VMAT2) substrate with an apparent Km of 1.16 μM. It can detect VMAT2 activity in intact cells using fluorescence microscopy, localizing to VMAT2-expressing acidic compartments without apparent labeling of other organelles. This probe is for research use only and not sold to patients.
- Detects VMAT2 activity in intact cells
- Subcellular localization to VMAT2-expressing acidic compartments
Medchemexpress LLC Urapidil (hydrochloride) | 64887-14-5 | MFCD00078601 | 99.98% | 100 MG
Urapidil hydrochloride (Standard) is an analytical standard intended for research and analytical applications. It is an orally active α1-adrenoceptor antagonist and 5-HT1A receptor agonist, showing an antihypertensive effect.
- Analytical standard grade
- Used in qualitative research experiments
- Used in quantitative research experiments
- Used in methodological research experiments
- Applicable in HPLC
- Applicable in GC
- Applicable in MS
Medchemexpress LLC Azd-7762 hydrochloride | 1246094-78-9 | 99.58% | 398.88 | 25 MG
AZD-7762 hydrochloride is a potent ATP-competitive checkpoint kinase (Chk) inhibitor with an IC50 of 5 nM for Chk1. It inhibits Chk1 and Chk2, abrogates DNA damage-induced S and G2 checkpoints, enhances the efficacy of NSC 613327 and SKF 104864A, and modulates downstream checkpoint pathway proteins. It potentiates antitumor activity and induces lymphoma cell death in combination with CX-5461.
- Potent ATP-competitive checkpoint kinase (Chk) inhibitor.
- IC50 of 5 nM for Chk1.
- Equally potent inhibitor of Chk1 and Chk2 in vitro.
- Abrogates DNA damage-induced S and G2 checkpoints.
- Enhances the efficacy of NSC 613327 and SKF 104864A.
- Modulates downstream checkpoint pathway proteins.
- Binds to the ATP-binding site of Chk1.
- Potentiates antitumor activity in xenograft studies.
- Induces lymphoma cell death in combination with CX-5461.
Medchemexpress LLC Itopride hydrochloride | 122892-31-3 | 99.8% | 5 G
Itopride hydrochloride is a potent dopamine-2 antagonist and an acetylcholine esterase (AChE) inhibitor. It enhances gastric motility through both antidopaminergic and anti-acetylcholinesterasic actions, making it a gastrointestinal prokinetic agent. It can be used for researching gastro-esophageal reflux disease (GERD).
- Potent dopamine-2 antagonist
- Acetylcholine esterase (AChE) inhibitor
- Enhances gastric motility
- Acts as a gastrointestinal prokinetic agent
- Used for researching gastro-esophageal reflux disease (GERD)
- Shows prokinetic effects on ileum and colon by inhibiting AChE and antagonizing dopamine D2 receptor
- Accelerates gastric emptying
Cayman Chemical 1Deoxynojirimycin hydrochlor
An inhibitor of α-glucosidase I and II (IC50s = ~2 µM for both); inhibits virus spread in HIV-infected lymphocyte cultures at 0.4 mM
Medchemexpress LLC KB-0742 dihydrochloride | 2416874-75-2 | 98.8% | 360.33 | 10 MG
KB-0742 dihydrochloride is a potent, selective, and orally active CDK9 inhibitor with an IC50 of 6 nM for CDK9/cyclin T1. It exhibits significant selectivity over other CDK kinases and demonstrates potent anti-tumor activity.
- Potent, selective, and orally active CDK9 inhibitor
- Shows over 50-fold selectivity for CDK9/cyclin T1
- Exhibits potent anti-tumor activity
- Significantly reduces downstream phosphorylation of RNA Pol II
- Reduces global androgen receptor protein levels
- Shows cytostatic effects in prostate cancer and leukemia cell lines
- Well tolerated and reduces tumor burden in xenograft models
- Soluble in H2O and DMSO