Dimethyl Sulfoxide
Cayman Chemical L-MethIonIn SulfoxIde 10g
A sulfoxide-modified methionine; increases weight gain in weanling mice in the diet at 6.3, 12.6, and 18.9 mmol/g; levels are decreased in patients with vitiligo
Sigma Aldrich Fine Chemicals Biosciences DIMETHYL SULFOXIDE 500ML
NC3885792 DIMETHYL SULFOXIDE 500ML
Apexbio Technology LLC (-)-Blebbistatin 856925-71-8 10mM (in 1mL DMSO)
(-)-Blebbistatin is a cell-permeable small molecule inhibitor targeting non-muscle myosin II (NM II) an actin-dependent motor protein involved in cell adhesion migration and differentiation It selectively binds the myosin-ADP-phosphate complex slowing phosphate release and thereby suppressing Mg-ATPase and contractile activities mediated by actomyosin interactions It exhibits inhibitory potency in various model systems (IC50 0 5 5 0 M) with minimal effects on myosin isoforms I V X and reduced activity toward smooth muscle myosin II (IC50 80 M) Its reversible modulation of NM II renders it useful in research on cytoskeletal dynamics cell mechanics and related pathophysiological conditions
Apexbio Technology LLC SB 203580 hydrochloride 869185-85-3 10mM (in 1mL DMSO)
SB 203580 hydrochloride (CAS 869185-85-3) is a selective inhibitor targeting the p38 mitogen-activated protein kinases (MAPKs) specifically isoforms p38-MAPK and p38-MAPK It prevents the downstream phosphorylation and activation of MAP kinase-activated protein kinase 2 (MAPKAPK2) exhibiting an IC50 around 70 nM in neonatal myocytes Additionally SB 203580 hydrochloride inhibits MAPKAPK2 activation and heat shock protein 27 (HSP27) phosphorylation induced by IL-1 osmotic stress or arsenite in KB cells with IC50 values below 1 M It also reduces JNK-mediated activation of c-Jun in neonatal rat cardiac myocytes This compound is widely utilized in research into cellular stress responses inflammation pathways and cardiac signal transduction
Medchemexpress LLC Rsl3 10Mm In 1Ml Dmso Reconsti | HY-100218A-10MM-1ML
Rsl3 10Mm In 1Ml Dmso Reconsti
TARGETMOL CHEMICALS INC TRAMETINIB DMSO SOLVATE 200MG
Also available in 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Trametinib (DMSO solvate) (GSK-1120212 (DMSO solvate)) is a Highly Potent and Selective MEK Inhibitor that specifically inhibits MEK1/2(IC50 2 nM)purity: 99%
Apexbio Technology LLC AZD6244 (Selumetinib) 606143-52-6 10mM (in 1mL DMSO)
AZD6244 (Selumetinib CAS 606143-52-6) is a small-molecule inhibitor selectively targeting MEK1/2 components of the MAP kinase signaling cascade It inhibits MEK1 via a non-ATP-competitive mechanism with an IC50 of 14 1 nM leading to decreased phosphorylation of downstream targets ERK1/2 (IC50 10 3 nM cellular assays) AZD6244 exhibits minimal off-target activity against related kinases including MKK6 EGFR ErbB2 and B-Raf In tumor cell lines harboring activated Ras or B-Raf mutations AZD6244 reduces cell proliferation and inhibits growth in xenograft models Thus AZD6244 is useful for investigating MAP kinase pathway-driven malignancies
Apexbio Technology LLC GDC-0449 (Vismodegib) 879085-55-9 10mM (in 1mL DMSO)
GDC-0449 (Vismodegib CAS 879085-55-9) is a small molecule that selectively inhibits the Hedgehog (Hh) signaling pathway by binding to the Smoothened (SMO) receptor thus preventing downstream activation of Hh target genes implicated in cellular proliferation and differentiation This compound emerged from screening small-molecule libraries followed by medicinal chemistry optimization Preclinical evaluation demonstrated antitumor activity in murine models of medulloblastoma and xenograft models derived from human colon and pancreatic cancers Currently GDC-0449 is under investigation for locally advanced and metastatic solid tumors
Apexbio Technology LLC Foretinib (GSK1363089) 849217-64-7 10mM (in 1mL DMSO)
Foretinib (GSK1363089 CAS 849217-64-7) is a small molecule inhibitor targeting receptor tyrosine kinases involved in angiogenesis and tumor progression notably receptors for vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) Foretinib inhibits tyrosine kinase activity of Met Ron KDR Flt-1 Flt-4 KIT Flt-3 Tie-2 and PDGFR / exhibiting IC50 values ranging from 0 4 to 9 6 nmol/L In cell-based assays foretinib reduces MET phosphorylation in mouse B16F10 melanoma and human PC-3 prostate cells (IC50 21 23 nmol/L) inhibits HGF-induced cell migration invasion and suppresses proliferation in B16F10 A549 and HT29 tumor cell lines Foretinib is utilized in preclinical cancer research targeting angiogenesis invasion and metastasis pathways
Apexbio Technology LLC Dopamine HCl 62-31-7 10mM (in 1mL DMSO)
Dopamine HCl (CAS 62-31-7) is a catecholamine neurotransmitter that functions as an endogenous agonist at dopamine receptors (subtypes D1 D5) Mechanistically dopamine activates these G protein-coupled receptors modulating neurotransmission and influencing diverse physiological processes such as motor control cognition motivation and neuroendocrine regulation In biomedical research dopamine HCl serves as a standard reagent for investigating dopaminergic signaling pathways receptor pharmacology and the molecular basis of neurological disorders
Apexbio Technology LLC SP 600125 129-56-6 10mM (in 1mL DMSO)
SP 600125 (CAS 129-56-6) is a selective reversible ATP-competitive inhibitor of c-Jun N-terminal kinase (JNK) with reported IC50 values of 40 nM for JNK1 and JNK2 and 90 nM for JNK3 Initially identified via GST-c-Jun substrate and recombinant human JNK2 screening assays SP 600125 demonstrates marked specificity being approximately 300-fold more selective toward JNK isoforms compared to ERK1 and p38-2 kinases In cellular assays SP 600125 effectively suppresses JNK-mediated phosphorylation of c-Jun and attenuates expression of IL-2 IFN- and TNF- It is widely utilized in inflammation and signal transduction research
Apexbio Technology LLC Decernotinib(VX-509) 944842-54-0 10mM (in 1mL DMSO)
Decernotinib (VX-509) is an orally bioavailable inhibitor targeting Janus kinase 3 (JAK3) with additional inhibitory activities toward JAK1 JAK2 and TYK2 (Ki values JAK3 2 nM JAK1 11 nM JAK2 13 nM TYK2 11 nM) Janus kinases are intracellular tyrosine kinases critical for cytokine-mediated signal transmission involved notably in immune cell activation and inflammatory responses By inhibiting JAK-mediated STAT5 phosphorylation VX-509 modulates cytokine-dependent lymphocyte proliferation and activation This compound has been employed in preclinical models exploring therapeutic potential in autoimmune conditions and inflammatory disorders such as rheumatoid arthritis
Apexbio Technology LLC SU11274 658084-23-2 10mM (in 1mL DMSO)
SU11274 (CAS 658084-23-2) is a selective inhibitor targeting Met kinase exhibiting an IC50 of approximately 10 nM The compound specifically suppresses the autophosphorylation of Met at residues Tyr1234/1235 disrupting receptor activity with minimal effects on other receptor tyrosine kinases such as EGFR and PDGFR or serine/threonine kinases including CDK2 In NIH3T3 cells expressing drug-sensitive or resistant MET mutants and in H1993 human lung cancer cells treatment with SU11274 induces a dose-dependent inhibition of Met phosphorylation and impairs receptor ubiquitination leading to receptor accumulation SU11274 serves as a useful tool for investigating Met signaling pathways in oncology research
Apexbio Technology LLC Entecavir Hydrate 209216-23-9 10mM (in 1mL DMSO)
Entecavir hydrate is an antiviral compound that acts as a reverse transcriptase (RT) inhibitor specifically targeting hepatitis B virus (HBV) infection It inhibits HBV DNA replication by interacting with the viral reverse transcriptase enzyme thus preventing the synthesis of complementary DNA from the viral RNA template Entecavir hydrate is frequently employed in antiviral studies and clinical research related to hepatitis B treatment regimens In studies involving chronic HBV-infected patients entecavir hydrate combined with peginterferon alpha-2b therapy has shown significant suppression of viral DNA levels and reduced covalently closed circular DNA (cccDNA) within hepatocytes The reported IC50 value of entecavir hydrate against HBV DNA polymerase activity typically ranges below 10 nM in cellular assay systems enabling its utility in both preclinical and clinical antiviral investigations