Dimethyl Sulfoxide
Apexbio Technology LLC Tie2 kinase inhibitor 948557-43-5 10mM (in 1mL DMSO)
Tie2 kinase inhibitor (CAS 948557-43-5) is a selective and reversible small-molecule inhibitor targeting the Tie2 receptor tyrosine kinase a critical modulator of endothelial cell survival angiogenesis and vascular integrity By inhibiting Tie2 autophosphorylation this compound disrupts subsequent signaling pathways involved in endothelial maturation and tumor-associated angiogenesis In vitro studies demonstrate potent inhibition of Tie2 kinase activity (IC50 0 25 M) with substantial selectivity over other kinases including p38 In vivo treatment reduces angiogenesis and tumor progression in murine xenograft tumor models This inhibitor is thus relevant for research examining angiogenic mechanisms and cancer progression
Apexbio Technology LLC Ulipristal 159811-51-5 10mM (in 1mL DMSO)
Ulipristal is a selective progesterone receptor modulator (SPRM) exhibiting tissue-specific agonist and antagonist activities on progesterone-sensitive targets It functions through competitively binding to the progesterone receptor thereby modulating downstream cellular and physiological responses Ulipristal has been explored in biomedical research primarily for emergency contraception administered within 120 hours following unprotected intercourse Additionally ulipristal demonstrates potential utility in managing benign gynecological disorders such as uterine fibroids (leiomyomas) by mediating apoptosis in myomatous cells and controlling cellular proliferation In vitro studies indicate that ulipristal acetate inhibits progesterone-stimulated acrosome reactions and hyperactivation of human spermatozoa highlighting its potential receptor-mediated modulation of sperm functions
Apexbio Technology LLC BX795 702675-74-9 10mM (in 1mL DMSO)
BX795 (CAS 702675-74-9) is a small-molecule inhibitor targeting 3-phosphoinositide-dependent kinase-1 (PDK1) through ATP-competitive binding inhibiting its enzymatic activity with an IC50 of approximately 11 nM Additionally BX795 selectively inhibits TBK1 and IKK with reported IC50 values of 6 nM and 41 nM respectively In macrophages activated by poly(I C) and LPS BX795 suppresses TBK1/IKK -mediated interferon regulatory factor-3 (IRF3) phosphorylation nuclear translocation transcriptional activity and consequent interferon- production This compound is utilized in biomedical research examining kinase signaling pathways and innate immune responses
Sigma Aldrich Fine Chemicals Biosciences SIGMA ALDRICH FINE CHEMICALS BIOSCIENCES
NC3995859 DIMETHYL SULFOXIDE STERIL-50ML
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide | 67-68-5 | MFCD00002089 | 500 mL
Dimethyl sulfoxide | Purity: ≥99.7% | Mol Wt: 78.13 | 67-68-5 | MFCD00002089 | 500 mL
Apexbio Technology LLC Bilobalide 33570-04-6 10mM (in 1mL DMSO)
Bilobalide (CAS 33570-04-6) is a terpenic trilactone derived from Ginkgo biloba noted for neuroprotective activities It modulates neuronal function partly via interactions with ion channel receptors as evidenced by altered potencies upon receptor-site mutations Bilobalide promotes -secretase-mediated cleavage of amyloid precursor protein (APP) resulting in increased sAPP secretion and reduced amyloid-beta (A ) levels through a PI3K-dependent signaling pathway Animal studies indicate analgesic activity reducing hyperalgesia and inflammation-induced edema comparable to diclofenac Additionally bilobalide improves cognitive performance in animal models associated with enhanced antioxidant markers (SOD/GSH) and reduced oxidative stress (NOS/MDA)
Apexbio Technology LLC Ro 3306 872573-93-8 10mM (in 1mL DMSO)
Ro 3306 (CAS 872573-93-8) is an ATP-competitive inhibitor targeting cyclin-dependent kinase 1 (CDK1) It selectively inhibits CDK1/cyclin B1 and CDK1/cyclin A complexes (Ki values of 35 nM and 110 nM respectively) thereby interfering with mitotic entry In DU145 cells Ro 3306 at 1 M diminishes BRCA1 localization at DNA double-strand breaks and suppresses RAD51 foci formation sensitizing these cells to DNA-damaging agents such as AZ12253801 Hence Ro 3306 is useful in studying cell cycle regulation DNA repair mechanisms and sensitization of cancer cells to targeted therapies
Medchemexpress LLC Terbufoxon sulfoxide | 56165-57-2 | 1 MG
Terbufoxon sulfoxide (Terbufos oxon sulfoxide) is a metabolite of the insecticide Terbufos found in the pepper leaf matrix. This product is intended for research use only.
- Metabolite of the insecticide Terbufos
- For research use only
- Molecular weight: 288.36
- Formula: C9H21O4PS2
- Shipping: Room temperature (continental US)
- Storage: As per Certificate of Analysis
Sigma Aldrich Fine Chemicals Biosciences Methyl phenyl sulfoxide >=97% | 1193-82-4 | MFCD00002088 | 25G
Methyl phenyl sulfoxide >=97% | Purity: >=97% | Mol Wt: 140.2 | 1193-82-4 | MFCD00002088 | 25G
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide 99.5 (GC), plant cell culture tested, 67-68-5, MFCD00002089
Dimethyl sulfoxide 99.5 (GC), plant cell culture tested
Apexbio Technology LLC MRT67307 HCl 2095432-39-4 10mM (in 1mL DMSO)
MRT67307 HCl (CAS 2095432-39-4) is a small-molecule inhibitor targeting several kinases including TBK1 IKK MARK1-4 NUAK1 ULK1/2 and salt-inducible kinases (SIK1-3) It inhibits TBK1 and IKK to block phosphorylation of IRF3 reducing interferon- synthesis without affecting NF- B activation Additionally MRT67307-mediated SIK inhibition promotes regulatory macrophage differentiation leading to elevated anti-inflammatory cytokines (e g IL-10 IL-1ra) and decreased pro-inflammatory cytokines (IL-6 IL-12 TNF) It is utilized to investigate innate immunity macrophage polarization autophagy and inflammation pathways
Apexbio Technology LLC Tigecycline 220620-09-7 10mM (in 1mL DMSO)
Tigecycline is a glycylcycline-class antibiotic developed as a structural derivative of tetracycline antibiotics It exerts antimicrobial activity by reversibly binding to the bacterial 30S ribosomal subunit leading to inhibition of protein synthesis Tigecycline demonstrates bacterial growth inhibition in both Gram-positive and Gram-negative pathogens including multidrug-resistant strains In vitro studies showed minimal inhibitory concentration (MIC90) values ranging between 0 12-0 5 g/ml against vancomycin-sensitive and resistant Enterococcus faecalis and Enterococcus faecium In animal infection models using MRSA strains Tigecycline displays in vivo efficacy with an ED50 approximately 0 72 mg/kg This antibiotic is commonly employed in research studies focusing on resistant bacterial infections such as complicated skin infections and intra-abdominal infections
Apexbio Technology LLC INK 128 (MLN0128) 1224844-38-5 10mM (in 1mL DMSO)
INK 128 (MLN0128 CAS 1224844-38-5) is a selective inhibitor of the mammalian target of rapamycin (mTOR) a conserved serine/threonine kinase integral to the PI3K/AKT/mTOR signaling pathway This compound inhibits both mTOR complexes (mTORC1 and mTORC2) demonstrating an IC50 of approximately 1 nM In preclinical studies utilizing human pancreatic and HER2-positive breast cancer cell lines INK 128 significantly reduced cellular proliferation and viability via concentration- and time-dependent suppression of mTOR activity Moreover it exhibited notable tumor suppression in breast cancer xenograft models enhancing efficacy when combined with agents such as sorafenib sunitinib paclitaxel or lapatinib highlighting its potential value for oncology research and therapeutic development
Apexbio Technology LLC SW033291 459147-39-8 10mM (in 1mL DMSO)
SW033291 (CAS 459147-39-8) is a small molecule inhibitor targeting the prostaglandin-degrading enzyme 15-PGDH It inhibits 15-PGDH activity non-competitively displaying potent inhibition with an IC50 of 1 5 nM and an apparent dissociation constant (Ki app) of approximately 0 1 nM Cellular assays in A549 cells demonstrate that SW033291 elevates prostaglandin E2 (PGE2) levels (EC50 75 nM) In vivo administration of SW033291 in mice significantly elevates tissue PGE2 concentrations stimulates hematopoietic cytokine expression expands hematopoietic stem and progenitor cell populations and promotes neutrophil expansion Thus SW033291 represents a research tool for studying PGE2-related pathways in tissue regeneration and hematopoiesis