Dimethyl Sulfoxide
Apexbio Technology LLC TIC10 41276-02-2 10mM (in 1mL DMSO)
TIC10 (TRAIL-inducing compound 10) is a small molecule inhibitor with oral bioavailability capable of penetrating the blood-brain barrier It functions primarily by simultaneously inhibiting Akt and ERK pathways resulting in Foxo3a nuclear translocation and transcriptional activation of TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) TRAIL is involved in apoptosis induction in cancer cells often compromised during tumor progression TIC10 triggers the expression of TRAIL independently of p53 status enabling apoptosis in diverse cancer cell types In preclinical xenograft models and orthotopic glioblastoma studies TIC10 has demonstrated TRAIL-mediated antitumor activity supporting its use in cancer biology research and therapeutic investigations
Apexbio Technology LLC Mupirocin 12650-69-0 10mM (in 1mL DMSO)
Mupirocin is an antibiotic targeting bacterial protein synthesis by inhibition of isoleucyl-tRNA synthetase Structurally analogous to isoleucine it binds the enzyme s active site blocking formation of isoleucyl-tRNA thus arresting bacterial protein production with reported MIC values around 0 05 g/ml for Staphylococcus aureus Primarily active against Gram-positive strains notably methicillin-resistant Staphylococcus aureus (MRSA) it is widely applied in biomedical research focused on antimicrobial resistance soft tissue infections biofilm studies and nasal colonization control strategies
Apexbio Technology LLC EPZ004777 1338466-77-5 10mM (in 1mL DMSO)
EPZ004777 (CAS 1338466-77-5) is a selective small-molecule inhibitor targeting DOT1L a histone H3K79 methyltransferase involved in leukemogenesis It inhibits DOT1L enzymatic activity with an IC50 of approximately 400 pM in radiometric assays EPZ004777 selectively reduces viability in leukemia cell lines harboring MLL rearrangements such as MV4-11 (MLL-AF4) and MOLM13 (MLL-AF9) Additionally treatment with EPZ004777 attenuates Hoxa9 and Meis1 mRNA expression and exhibits inhibitory activity (IC50 range 0 1 1 M) against cells transformed by MLL-AF10 and CALM-AF10 oncogenes Overall EPZ004777 serves as a valuable tool for studying DOT1L-mediated epigenetic regulation and leukemic pathogenesis
Apexbio Technology LLC SB 431542 301836-41-9 10mM (in 1mL DMSO)
SB 431542 (CAS number 301836-41-9) is a selective ATP-competitive inhibitor targeting activin receptor-like kinase 5 (ALK5) a type I receptor within the transforming growth factor- (TGF- ) signaling pathway It inhibits ALK5 activity with an IC50 value of 94 nM thereby preventing phosphorylation of Smad2 proteins and their subsequent nuclear accumulation Additionally SB 431542 inhibits closely related receptors ALK4 and ALK7 while showing minimal or no significant activity against ALK1 ALK2 ALK3 and ALK6 at relevant concentrations Commonly utilized in cellular assays to investigate TGF- signaling this compound is valuable for studying associated cellular processes and diseases
Apexbio Technology LLC MK-5172 1350514-68-9 10mM (in 1mL DMSO)
MK-5172 is a selective inhibitor targeting the hepatitis C virus (HCV) NS3/4A protease an enzyme essential for viral replication The HCV virus genome encodes this protease which cleaves polyprotein precursors enabling functional viral proteins formation during replication MK-5172 inhibits protease activity across multiple HCV genotypes demonstrating IC50 values in enzymatic assays at low nanomolar concentrations In cell-based replicon systems MK-5172 exhibits IC50 values of 2 nM (genotype 1a) 0 5 nM (genotype 1b) 8 nM (genotype 2a) and 13 nM (genotype 3) MK-5172 is utilized in antiviral studies examining various genotype infections viral resistant variants and the dynamics of viral load reductions in experimental chronic infections
Apexbio Technology LLC SGI-1776 free base 1025065-69-3 10mM (in 1mL DMSO)
SGI-1776 free base (CAS 1025065-69-3) is an ATP-competitive inhibitor targeting Pim kinases a serine/threonine protein kinase family implicated in regulating cellular survival pathways It selectively inhibits all three isoforms Pim-1 Pim-2 and Pim-3 leading to decreased phosphorylation of downstream substrates involved in cell cycle regulation and apoptosis such as p21Cip1/WAF1 and Bad Cellular studies indicate that SGI-1776 induces G1 cell cycle arrest promotes apoptosis and overcomes chemoresistance mediated by multidrug resistance protein 1 (MDR1) in taxane-resistant prostate cancer cells
Apexbio Technology LLC GZD824 1421783-64-3 10mM (in 1mL DMSO)
GZD824 (CAS 1421783-64-3) is an orally bioavailable inhibitor of the Bcr-Abl kinase a fusion protein exhibiting tyrosine kinase activity involved in regulating cell cycle progression and genomic stability GZD824 binds competitively to the ATP-binding site of Abl kinase effectively inhibiting the phosphorylation and activation of both wild-type (WT) and resistant mutant forms (e g T315I E255K G250E Q252H H396P M351T and Y253F) GZD824 demonstrates sub-nanomolar IC50 values and substantially reduces proliferation in Bcr-Abl-expressing Ba/F3 cell models Preclinical studies in mouse xenograft leukemia models show GZD824 suppresses tumor growth highlighting its potential applicability in research into resistance mechanisms and targeted leukemia therapies
Apexbio Technology LLC Sirtinol 410536-97-9 10mM (in 1mL DMSO)
Sirtinol (CAS 410536-97-9) is a small-molecule inhibitor targeting class III histone deacetylases (HDAC) specifically the NAD-dependent deacetylases SIRT1 and SIRT2 In MCF-7 human breast cancer cells sirtinol exhibits inhibitory activity against cell proliferation with IC50 values of 48 6 M (24 h) and 43 5 M (48 h) Mechanistically sirtinol reduces SIRT1 expression inducing acetylation of p53 and downregulating cell-cycle proteins such as cyclin B1 cyclin D1 CDK2 and CDK6 leading to G1-phase arrest apoptosis and autophagy This molecule serves as a valuable research tool in epigenetic studies and cancer biology investigations
Apexbio Technology LLC Pyridostatin | 1085412-37-8 | 596.6 g/mol | 10MM IN 1ML DMSO
Pyridostatin | 1085412-37-8 | 596.6 g/mol | 10MM IN 1ML DMSO
Apexbio Technology LLC SBI-0206965 1884220-36-3 10mM (in 1mL DMSO)
SBI-0206965 (CAS 1884220-36-3) is a small-molecule inhibitor targeting ULK1 (UNC-51-like kinase 1) a serine/threonine kinase pivotal in regulating autophagy initiation ULK1 functions downstream of mTORC1 and is modulated by AMPK influencing cellular responses to nutrient deprivation In cellular assays using A549 cells SBI-0206965 at 5 mM effectively suppresses AZD8055-induced autophagy and increases apoptotic response upon nutrient starvation in MEFs U87MG glioblastoma and mouse lung cancer cell lines SBI-0206965 serves as a useful research tool for investigating autophagy pathways tumor cell survival and apoptosis mechanisms
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide ReagentPlus(R), >=99.5% | 67-68-5 | MFCD00002089 | 10L
Dimethyl sulfoxide ReagentPlus(R), >=99.5% | Purity: >=99.5% | Mol Wt: 78.13 | 67-68-5 | MFCD00002089 | 10L
