Dimethyl Sulfoxide
Apexbio Technology LLC Cefoperazone 62893-19-0 10mM (in 1mL DMSO)
Cefoperazone is a third-generation cephalosporin antibiotic with broad-spectrum antibacterial activity widely applied in biomedical research focused on transport-related mechanisms It exhibits inhibitory effects on rMrp2-mediated transport of [ 3H]estradiol-17 -glucuronide ([ 3H]E217 G) with a reported IC50 value of approximately 199 M Importantly the inhibitory profile of cefoperazone displays biphasic characteristics suggesting distinct binding sites the obtained IC50 values are 6 66 3 23 M (high-affinity component) and 3 88 1 32 mM (low-affinity component) These properties facilitate its use as a probe compound to assess transport pathways in pharmacokinetic and drug disposition studies
Apexbio Technology LLC 17-AAG (KOS953) 75747-14-7 10mM (in 1mL DMSO)
17-AAG (KOS953) is a synthetic derivative of geldanamycin that inhibits heat shock protein 90 (HSP90) It acts by binding to HSP90 causing destabilization of client proteins including HER2 Raf-1 p53 and components of MAPK signaling pathways Reported IC50 for 17-AAG in BT474 cells is approximately 6 nM Its biological activity has been investigated broadly including in multiple myeloma breast cancer thyroid cancer Hodgkin lymphoma and melanoma cellular models Ongoing studies explore 17-AAG both as monotherapy and in combination with agents like bortezomib or trastuzumab for addressing treatment-resistant cancer cell lines Currently 17-AAG is evaluated in Phase II clinical trials
Apexbio Technology LLC Bepotastine Besilate 190786-44-8 10mM (in 1mL DMSO)
Bepotastine Besilate (CAS number 190786-44-8) is a small molecule antagonist targeting the histamine H1 receptor By binding selectively to this receptor subtype Bepotastine attenuates histamine-induced cellular responses decreasing symptoms associated with allergic reactions In experimental settings it serves as a pharmacological tool to investigate histamine-related inflammatory pathways and receptor signaling mechanisms Its utility extends to studies of allergic responses inflammation modulation and histamine receptor pharmacodynamics in biomedical research
Apexbio Technology LLC PKI-402 1173204-81-3 10mM (in 1mL DMSO)
PKI-402 (CAS 1173204-81-3) is an ATP-competitive inhibitor targeting class I PI3Ks (PI3K ) with IC50 values of 1 nM 7 nM 16 nM and 14 nM respectively PI3Ks are enzymes central to the PI3K/Akt/mTOR signaling pathway impacting cellular proliferation survival differentiation and migration processes critically involved in cancer progression PKI-402 reduces cell growth and phosphorylation of PI3K/mTOR downstream signaling proteins in human tumor cell lines including breast glioma pancreatic and non-small cell lung cancers In xenograft mouse models (MDA-MB-361) PKI-402 administration suppresses Akt phosphorylation triggers apoptosis (PARP cleavage) and inhibits tumor growth highlighting its significance for cancer biology research
Medchemexpress LLC Toltrazuril sulfoxide | 69004-15-5 | MFCD10567359 | 99.6% | C18H14F3N3O5S | 10MG
Toltrazuril sulfoxide is an analytical standard corresponding to the short-lived sulfoxide metabolite of toltrazuril. It is intended for research and analytical applications, including metabolic studies, method development, and quantitative analysis of toltrazuril metabolites.
- Analytical standard suitable for metabolic and pharmacokinetic studies.
- High purity (99.6%) for reliable analytical results.
- Provided in small pack sizes for trace-level assays and method validation.
- Compatible with LC-MS and other chromatographic detection methods.
- Stable solid form for routine storage and handling.
Medchemexpress LLC Terbufoxon sulfoxide | 56165-57-2 | 1 MG
Terbufoxon sulfoxide (Terbufos oxon sulfoxide) is a metabolite of the insecticide Terbufos found in the pepper leaf matrix. This product is intended for research use only.
- Metabolite of the insecticide Terbufos
- For research use only
- Molecular weight: 288.36
- Formula: C9H21O4PS2
- Shipping: Room temperature (continental US)
- Storage: As per Certificate of Analysis
Apexbio Technology LLC Reversine 656820-32-5 10mM (in 1mL DMSO)
Reversine (CAS 656820-32-5) is a small molecule inhibitor targeting Aurora kinases a family of serine/threonine kinases involved in mitotic progression Reversine inhibits Aurora kinase A B and C with IC50 values of 150 nM 500 nM and 400 nM respectively In vitro studies show reversine can induce dedifferentiation of murine myoblast cells and possesses regenerative potential Additionally reversine displays anti-tumor effects by suppressing the expression of Aurora kinases thus disrupting cell-cycle progression In cervical carcinoma mouse models (U14 cells) reversine combined with aspirin synergistically decreases tumor growth highlighting reversine s value for cancer biology research
Apexbio Technology LLC Cyclosporin A 59865-13-3 10mM (in 1mL DMSO)
Cyclosporin A is an immunosuppressive agent acting primarily through inhibition of cyclophilins intracellular peptidyl-prolyl isomerases with a reported IC50 of 7 nM Cyclophilins regulate mitochondrial permeability transition pore (MPTP) opening intracellular calcium signaling and NFAT transcriptional activation pathways Cyclosporin A s ability to inhibit calcineurin-NFAT signaling in T-cell activation leads to suppression of inflammatory immune responses indicating potential use in autoimmune disorder research Additionally it modulates cell apoptosis and survival mechanisms in diverse models including retinal ischemic injury viral entry (HBV HCV) and tumor biology in colon cancer cell lines
Apexbio Technology LLC KN-93 139298-40-1 10mM (in 1mL DMSO)
KN-93 (CAS 139298-40-1) is a selective inhibitor of calcium/calmodulin-dependent protein kinase II (CaMKII) a serine/threonine kinase activated by calcium-bound calmodulin KN-93 inhibits CaMKII enzymatic activity with reported IC50 values of approximately 0 37 0 5 M in vitro and a Ki value of 2 58 M against cardiac CaMKII In NIH 3T3 cells KN-93 (12 M) induces G1 cell-cycle arrest and at higher concentrations (24 M) promotes apoptosis Due to CaMKII s role in neuronal function cardiac signaling immune activation and disease states including Alzheimer s and arrhythmias KN-93 serves as a tool compound for studying CaMKII-mediated processes in biomedical research
Apexbio Technology LLC AEBSF.HCl 30827-99-7 10mM (in 1mL DMSO)
AEBSF HCl is an irreversible serine protease inhibitor that covalently binds and inhibits several proteases including trypsin chymotrypsin plasmin and thrombin It has been applied in cellular research to study amyloid-beta (A ) production mechanisms In APP695 (K695sw)-transfected K293 cells AEBSF dose-dependently reduces A formation with an IC50 around 1 mM while in wild-type APP695-transfected HS695 and SKN695 cells it shows inhibitory effects with an IC50 of approximately 300 M Besides suppressing -cleavage AEBSF promotes -cleavage of APP In macrophage-mediated leukemic cell lysis assays incubation with AEBSF at 150 M for 6 hours achieves near-maximal protease inhibition thus impeding cell lysis
Apexbio Technology LLC YO-01027 (Dibenzazepine, DBZ) 209984-56-5 10mM (in 1mL DMSO)
YO-01027 (Dibenzazepine DBZ CAS 209984-56-5) is a potent inhibitor targeting -secretase a multimeric aspartyl protease involved in the proteolytic cleavage of type I integral membrane proteins notably amyloid precursor protein-like (APPL) proteins and Notch receptors YO-01027 interacts with the N-terminal regions of presenilin dose-dependently inhibiting cleavage of APPL and Notch proteins Research indicates that YO-01027 modulates cell differentiation by suppressing Notch signaling pathways influencing cellular transitions and mucin (MUC16) synthesis illustrating its utility in cell biology and therapeutic studies of Notch-related signaling processes
Apexbio Technology LLC WP1066 857064-38-1 10mM (in 1mL DMSO)
WP1066 (CAS 857064-38-1) is a small molecule analog of AG490 and functions primarily as an inhibitor of Janus kinase 2 (JAK2) It disrupts JAK2 signaling by reducing phosphorylation and promoting degradation of the JAK2 protein thereby inhibiting downstream STAT3/STAT5 transcription factors and the phosphoinositide-3 kinase pathway WP1066 has demonstrated antiproliferative and pro-apoptotic activity in models of acute myeloid leukemia (AML) including patient-derived AML cells and AML cell lines (OCIM2 K562) Additionally WP1066 shows inhibitory effects against tumor growth and angiogenesis in renal cell carcinoma (RCC) model systems highlighting its potential for hematologic cancers and RCC therapeutic research
Apexbio Technology LLC Vidarabine 5536-17-4 10mM (in 1mL DMSO)
Vidarabine is an antiviral nucleoside analog widely studied for inhibiting replication of herpes simplex virus (HSV) and varicella-zoster virus (VZV) Structurally vidarabine is an adenine arabinoside analog that interferes with viral DNA synthesis via competitive inhibition of viral DNA polymerase resulting in chain termination In vitro studies demonstrate antiviral activity against HSV type 1 and type 2 with IC50 values typically ranging approximately from 0 1 to 1 0 M depending on experimental conditions and viral strains Vidarabine is commonly used in biomedical laboratories for investigating viral replication mechanisms screening for antiviral candidates and elucidating nucleoside analog resistance patterns
Apexbio Technology LLC Chidamide(Synonyms: Epidaza, HBI-8000, CS055, Tucidinostat, Entinostat analog, Chidamide (CS055)), 10mM (in 1mL DMSO), CAS: 743420-02-2.
Chidamide (CAS 743420-02-2) is a benzamide-based histone deacetylase (HDAC) inhibitor that targets enzymes responsible for the reversible acetylation of lysine residues on histone tails By modulating HDAC activity Chidamide promotes chromatin remodeling influencing transcription factor access and subsequent gene transcription In vitro studies on human leukemia cell lines and primary myeloid leukemia cells indicate that Chidamide induces cell cycle arrest at the G1 phase differentiation and apoptosis via ROS-dependent mechanisms Therefore Chidamide shows considerable potential in research focused on hematologic malignancies and cancer therapy
Apexbio Technology LLC Trametinib DMSO solvate 1187431-43-1 10mM (in 1mL DMSO)
Trametinib DMSO solvate (CAS 1187431-43-1) is a potent allosteric inhibitor of MEK1 and MEK2 that acts through an ATP-noncompetitive mechanism In preclinical models it has demonstrated broad antitumor activity notably in colorectal cancer cell lines such as HT-29 and COLO205 Trametinib induces the expression of p15 and p27 suppresses cyclin D1 promotes RB dephosphorylation and G1 cell cycle arrest and reduces thymidylate synthase expression Furthermore it inhibits ERK1/2 phosphorylation leading to growth suppression in B-RAF mutant tumor cells Trametinib serves as a valuable tool for studying MAPK pathway signaling and targeted cancer therapeutics