Dimethyl Sulfoxide
Apexbio Technology LLC Tie2 kinase inhibitor 948557-43-5 10mM (in 1mL DMSO)
Tie2 kinase inhibitor (CAS 948557-43-5) is a selective and reversible small-molecule inhibitor targeting the Tie2 receptor tyrosine kinase a critical modulator of endothelial cell survival angiogenesis and vascular integrity By inhibiting Tie2 autophosphorylation this compound disrupts subsequent signaling pathways involved in endothelial maturation and tumor-associated angiogenesis In vitro studies demonstrate potent inhibition of Tie2 kinase activity (IC50 0 25 M) with substantial selectivity over other kinases including p38 In vivo treatment reduces angiogenesis and tumor progression in murine xenograft tumor models This inhibitor is thus relevant for research examining angiogenic mechanisms and cancer progression
Apexbio Technology LLC INCB28060 1029712-80-8 10mM (in 1mL DMSO)
INCB28060 (CAS 1029712-80-8) also known as Capmatinib or INC280 is an ATP-competitive inhibitor of the receptor tyrosine kinase c-Met (HGFR) This receptor plays essential roles in cellular processes including embryogenesis healing proliferation invasion and angiogenesis and is frequently overexpressed or mutated in cancers INCB28060 blocks c-Met phosphorylation and downstream signaling exhibiting an IC50 of 0 13 nM In preclinical studies it suppresses proliferation in cancer cell lines (e g SNU-5 S114) and inhibits migration in U-87MG and H441 cells In mouse tumor models oral administration reduces c-Met activation and tumor progression INCB28060 serves as a tool compound for investigating c-Met function in cancer research
Apexbio Technology LLC AdipoRon 924416-43-3 10mM (in 1mL DMSO)
AdipoRon (CAS 924416-43-3) is an agonist of adiponectin receptors AdipoR1 and AdipoR2 displaying binding affinities (Kd) of 1 8 M and 3 1 M respectively Upon receptor activation it promotes phosphorylation of AMPK via AdipoR1 and upregulates expression of PGC-1 improving mitochondrial biogenesis in muscle cell models In vivo studies show that AdipoRon administration stimulates AMPK and PPAR- signaling in liver and muscle tissues subsequently reducing circulating glucose insulin triglycerides and inflammatory cytokines This compound is employed in metabolic and cardiovascular disease research especially regarding insulin resistance dyslipidemia obesity-related inflammation and ischemia-induced myocardial damage
Apexbio Technology LLC Cefoperazone 62893-19-0 10mM (in 1mL DMSO)
Cefoperazone is a third-generation cephalosporin antibiotic with broad-spectrum antibacterial activity widely applied in biomedical research focused on transport-related mechanisms It exhibits inhibitory effects on rMrp2-mediated transport of [ 3H]estradiol-17 -glucuronide ([ 3H]E217 G) with a reported IC50 value of approximately 199 M Importantly the inhibitory profile of cefoperazone displays biphasic characteristics suggesting distinct binding sites the obtained IC50 values are 6 66 3 23 M (high-affinity component) and 3 88 1 32 mM (low-affinity component) These properties facilitate its use as a probe compound to assess transport pathways in pharmacokinetic and drug disposition studies
Apexbio Technology LLC 17-AAG (KOS953) 75747-14-7 10mM (in 1mL DMSO)
17-AAG (KOS953) is a synthetic derivative of geldanamycin that inhibits heat shock protein 90 (HSP90) It acts by binding to HSP90 causing destabilization of client proteins including HER2 Raf-1 p53 and components of MAPK signaling pathways Reported IC50 for 17-AAG in BT474 cells is approximately 6 nM Its biological activity has been investigated broadly including in multiple myeloma breast cancer thyroid cancer Hodgkin lymphoma and melanoma cellular models Ongoing studies explore 17-AAG both as monotherapy and in combination with agents like bortezomib or trastuzumab for addressing treatment-resistant cancer cell lines Currently 17-AAG is evaluated in Phase II clinical trials
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide Hybri-Max, 99.7, 67-68-5, MFCD00002089, 100mL
Linear Formula (CH3)2SO, ≥99.7%, Molecular Weight 78.13, Hybri-Max™, sterile-filtered, BioReagent, Synonym: DMSO
Apexbio Technology LLC JIB-04 199596-05-9 10mM (in 1mL DMSO)
JIB-04 (CAS 199596-05-9) is a selective small-molecule inhibitor targeting Jumonji histone demethylases specifically suppressing enzymes including JARID1A JMJD2 family members (JMJD2A-E) and JMJD3 Structurally categorized as a pyridine hydrazone derivative JIB-04 inhibits demethylase activity independently of competitive binding with -ketoglutarate In vitro assays revealed IC50 values ranging from 230 nM to 1100 nM across various Jumonji enzymes Additionally JIB-04 demonstrates preferential inhibition of cancer cell proliferation versus normal cells notably in lung and prostate cancer cell lines and effectively reduces tumor growth in mouse xenograft models highlighting its relevance for cancer research
Apexbio Technology LLC Griseofulvin 126-07-8 10mM (in 1mL DMSO)
Griseofulvin is an antifungal antibiotic known to inhibit fungal growth by interfering with microtubule polymerization thereby disrupting mitotic spindle formation and cellular division Through binding to tubulin it stabilizes microtubule structures preventing their normal assembly and leading to impaired fungal cell replication Experimentally Griseofulvin has been frequently utilized to study microtubule dynamics mitotic processes and antifungal mechanisms in research settings involving medically relevant fungi including dermatophytes Reported IC50 values for Griseofulvin range approximately from 5 to 20 M depending on fungal strains and conditions tested serving as a guideline for establishing antifungal assays and investigating fungal response mechanisms in vitro
TARGETMOL CHEMICALS INC TRAMETINIB DMSO SOLVATE 200MG
Also available in 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Trametinib (DMSO solvate) (GSK-1120212 (DMSO solvate)) is a Highly Potent and Selective MEK Inhibitor that specifically inhibits MEK1/2(IC50 2 nM)purity: 99%
Apexbio Technology LLC BX795 702675-74-9 10mM (in 1mL DMSO)
BX795 (CAS 702675-74-9) is a small-molecule inhibitor targeting 3-phosphoinositide-dependent kinase-1 (PDK1) through ATP-competitive binding inhibiting its enzymatic activity with an IC50 of approximately 11 nM Additionally BX795 selectively inhibits TBK1 and IKK with reported IC50 values of 6 nM and 41 nM respectively In macrophages activated by poly(I C) and LPS BX795 suppresses TBK1/IKK -mediated interferon regulatory factor-3 (IRF3) phosphorylation nuclear translocation transcriptional activity and consequent interferon- production This compound is utilized in biomedical research examining kinase signaling pathways and innate immune responses
Apexbio Technology LLC RG7388 1229705-06-9 10mM (in 1mL DMSO)
RG7388 (CAS 1229705-06-9) is a second-generation selective inhibitor of the MDM2-p53 interaction It functions by blocking the binding between MDM2 and wild-type p53 thereby stabilizing and activating the p53 tumor-suppressor pathway In human cancer cell lines RG7388 shows high potency with reported IC50 values of 6 nM (MDM2 binding assay) and 0 03 M (MTT assay) Preclinical studies demonstrate cell-cycle arrest and apoptosis selectively in wild-type p53-expressing cells and tumor regression in xenograft mouse models including sarcoma and neuroblastoma RG7388 is currently under clinical evaluation for multiple solid and hematologic malignancies
Apexbio Technology LLC Tinidazole 19387-91-8 10mM (in 1mL DMSO)
Tinidazole is a synthetic nitroimidazole derivative with antiparasitic and antibacterial activity used to study protozoal infections and anaerobic bacterial conditions After cellular uptake it is activated by nitroreductase enzymes forming cytotoxic metabolites that induce DNA strand breaks and inhibit nucleic acid synthesis leading to cell death Tinidazole is commonly used in vitro to evaluate its efficacy against pathogens like Giardia lamblia Trichomonas vaginalis and Entamoeba histolytica IC50 values against Giardia lamblia trophozoites typically range from 0 5 to 5 M making it a useful tool for antiparasitic drug screening and antimicrobial studies
Apexbio Technology LLC Ambrisentan 177036-94-1 10mM (in 1mL DMSO)
Ambrisentan (CAS 177036-94-1) is an orally active selective endothelin receptor antagonist specifically targeting ETA receptors It exhibits strong selectivity towards ETA over ETB receptor subtypes shown by Ki values of approximately 1 nM for recombinant ETA receptors expressed in vitro versus 195 nM for ETB In recombinant human receptor assays using intact cells this selectivity is enhanced with reported Ki values of 0 63 nM (ETA) and 48 7 nM (ETB) Pharmacologically ambrisentan s selective ETA blockade preserves the ETB receptor s intrinsic vasodilatory and endothelin clearance functions making it useful in research involving pulmonary arterial hypertension cerebrovascular conditions and ischemia-reperfusion injury