Dimethyl Sulfoxide
Apexbio Technology LLC Matrine(Synonyms: Sophocarpidine, Matridin, (-)-Matrine, α-Matrine, (−)-α-Matrine, L-Matrine, Kushenin), 10mM (in 1mL DMSO), CAS: 519-02-8.
Matrine (CAS 519-02-8) is an alkaloid derived from plants in the Sophora genus with demonstrated anticancer and anti-inflammatory activities It functions in part through agonism of kappa-opioid and possibly other receptors Matrine inhibits the MNK45 gastric cancer cell line proliferation (IC50 540 g/ml MTT assay) by modifying protein expression profiles (e g NF- B XIAP CIAP p-ERK) In vitro matrine induces apoptosis in NSCLC cells through ROS generation caspase activation and p38 pathway modulation Animal studies suggest therapeutic roles in cardiac injury and sepsis-related lung inflammation
Apexbio Technology LLC PD 173074 219580-11-7 10mM (in 1mL DMSO)
PD 173074 (CAS 219580-11-7) is a selective inhibitor targeting fibroblast growth factor receptors (FGFR) exerting its effects by suppressing FGFR tyrosine kinase phosphorylation It has demonstrated dose-dependent inhibitory activity against small cell lung cancer (SCLC) cell lines including H-510 and H-69 by reducing their proliferation colony formation and FGF-2 induced chemotherapy resistance in vitro In murine xenograft models of SCLC PD 173074 reduced tumor progression and significantly prolonged animal survival achieving durable complete responses in some cases PD 173074 represents an important tool compound for investigating the oncogenic role of FGFR signaling in cancer research
Apexbio Technology LLC Tiplaxtinin(PAI-039)(Synonyms: Tiplaxtinin, PAI-039, Tiplaxtinin (PAI-039), Tiplaxitin, PAI1 inhibitor, PAI-1 antagonist, RWJ-676070), 10mM (in 1mL DMSO), CAS: 393105-53-8.
Tiplaxtinin (PAI-039 CAS 393105-53-8) is an orally bioavailable small molecule inhibitor targeting plasminogen activator inhibitor-1 (PAI-1) a physiological regulator of the plasminogen activation system Elevated PAI-1 levels stabilize thrombi by inhibiting tissue- and urokinase-type plasminogen activators Tiplaxtinin binds selectively to PAI-1 with a Kd of approximately 480 nM and inhibits its activity with an IC50 value around 2 7 M In animal models oral administration of Tiplaxtinin significantly delayed arterial thrombus-induced occlusion supporting its utility as a research tool for studying fibrinolytic pathways and thrombotic disorders
Apexbio Technology LLC BMH-21(Synonyms: BMH21, BMH 21, CID 46835406, RNA polymerase I inhibitor BMH-21, RNA Pol I inhibitor BMH-21), 10mM (in 1mL DMSO), CAS: 896705-16-1.
BMH-21 (CAS 896705-16-1) is a planar heterocyclic small molecule DNA intercalator that selectively inhibits RNA polymerase I (Pol I)-mediated transcription It preferentially inserts into GC-rich double-stranded DNA regions leading to Pol I blockade and subsequent degradation of its catalytic subunit RPA194 BMH-21 exhibits cytotoxic activity across various human cancer cell lines independently of the p53 status disrupting nucleolar integrity and RNA synthesis Furthermore BMH-21 promotes p53 expression in epithelial compartments of human prostate tissues demonstrating tissue permeability and highlighting its applicability in anticancer research
Apexbio Technology LLC vinblastine 865-21-4 10mM (in 1mL DMSO)
Vinblastine is a naturally-derived alkaloid isolated from Catharanthus roseus It functions as a microtubule inhibitor by binding specifically to tubulin disrupting microtubule polymerization and thereby arresting mitosis at metaphase Due to this mechanism vinblastine is widely investigated for antitumor activities and is commonly employed in biomedical research to study cell division cytoskeletal dynamics and therapeutic interventions in oncology Vinblastine should be stored under sealed dry and cool conditions to maintain molecular integrity and biological activity
Apexbio Technology LLC MLN4924 905579-51-3 10mM (in 1mL DMSO)
MLN4924 (CAS 905579-51-3) is a selective inhibitor targeting NEDD8-activating enzyme (NAE) exhibiting an IC50 of 4 nM It acts competitively against AMP binding within the nucleotide-binding pocket of NAE with strong specificity over related enzymes UAE SAE UBA6 and ATG7 (IC50 1 5 M) In HCT-116 cells MLN4924 reduces Ubc12-NEDD8 and cullin-NEDD8 conjugation disrupting CRL-mediated ubiquitination and thus stabilizing substrates such as CDT1 resulting in cell cycle defects MLN4924 shows antitumor efficacy in HCT-116 H522 and Calu-6 tumor xenograft models highlighting its research utility in cancer biology
Apexbio Technology LLC Org 27569 868273-06-7 10mM (in 1mL DMSO)
Org 27569 (CAS 868273-06-7) is an allosteric modulator targeting the cannabinoid CB1 receptor It enhances the binding of the agonist CP55940 to purified CB1 receptors while simultaneously inhibiting receptor functionality In electrically-stimulated mouse vas deferens assays Org 27569 reduced WIN55212-induced contractions exhibiting a pEC50 of 8 24 0 12 and a maximal response (Emax) of approximately 45 4% Binding studies suggest its interaction at a putative allosteric site on CB1 receptors reflected by parameters such as a pKB of 5 67 0 23 and a Log of 1 14 0 17 Org 27569 serves as a tool compound for studying CB1 receptor allosteric modulation
Medchemexpress LLC Dimethyl sulfoxide | 67-68-5 | MFCD00002089 | 99.9% | 78.13 | C2H6OS | 100mL
Dimethyl sulfoxide cryoprotectant vitrification agent (DMSO cryoprotectant vitrification agent) is a biochemical reagent that can be used as a biological material or organic compound for life science related research[1] This product has been sterilized and has no endotoxin It can be used for long-term cell cryopreservation and will not affect the normal growth of cells
Apexbio Technology LLC Linezolid(Synonyms: Zyvox, Zyvoxid, U-100766, PNU-100766, U-100766E, PNU100766, Linezolide), 10mM (in 1mL DMSO), CAS: 165800-03-3.
Linezolid (CAS 165800-03-3) is a synthetic oxazolidinone antimicrobial compound with broad-spectrum activity primarily against Gram-positive bacteria including multi-drug resistant pathogens such as methicillin-resistant Staphylococcus aureus (MRSA) vancomycin-resistant Enterococcus (VRE) and penicillin-resistant Streptococcus pneumoniae Linezolid inhibits bacterial protein synthesis by binding to the 23S ribosomal RNA of the 50S subunit thereby preventing formation of the functional 70S initiation complex In cell-free transcription-translation assays using E coli linezolid demonstrates an IC50 of approximately 1 8 mM Due to its pharmacokinetics and high oral bioavailability linezolid is widely utilized in clinical research related to complicated skin infections and bacterial pneumonia
Apexbio Technology LLC Belinostat (PXD101) 414864-00-9 10mM (in 1mL DMSO)
Belinostat (PXD101) is a hydroxamic acid-based inhibitor targeting histone deacetylase (HDAC) enzymes Its mechanism involves the suppression of HDAC enzymatic activity leading to increased acetylation of histone proteins H3 and H4 within cells In biochemical assays using Hela cell extracts belinostat exhibits inhibitory activity against HDAC with an IC50 value of approximately 27 nM In tumor cell culture models belinostat induces cytotoxicity and represses cellular proliferation with reported IC50 values ranging roughly from 0 5 M to 10 M varying by cell type and origin making it suitable for research on epigenetic modulation in oncology specifically in studies of bladder prostate and related cancer cell lines
Apexbio Technology LLC Ambrisentan 177036-94-1 10mM (in 1mL DMSO)
Ambrisentan (CAS 177036-94-1) is an orally active selective endothelin receptor antagonist specifically targeting ETA receptors It exhibits strong selectivity towards ETA over ETB receptor subtypes shown by Ki values of approximately 1 nM for recombinant ETA receptors expressed in vitro versus 195 nM for ETB In recombinant human receptor assays using intact cells this selectivity is enhanced with reported Ki values of 0 63 nM (ETA) and 48 7 nM (ETB) Pharmacologically ambrisentan s selective ETA blockade preserves the ETB receptor s intrinsic vasodilatory and endothelin clearance functions making it useful in research involving pulmonary arterial hypertension cerebrovascular conditions and ischemia-reperfusion injury
Apexbio Technology LLC Ornidazole 16773-42-5 10mM (in 1mL DMSO)
Ornidazole a 5-nitroimidazole derivative exhibits antibacterial and antiprotozoal activities by interfering with DNA synthesis in anaerobic microorganisms through the reduction of its nitro group forming cytotoxic intermediates In experimental assays Ornidazole demonstrates inhibitory activity against diverse anaerobic bacterial strains including Bacteroides and Clostridium species and protozoan pathogens such as Giardia lamblia and Trichomonas vaginalis typically showing IC50 values ranging from micromolar to low millimolar concentrations This compound is widely utilized in microbiology and infectious disease research to elucidate anaerobic microbial drug sensitivity pathogen resistance mechanisms and protozoan infection biology
Apexbio Technology LLC NVP-AEW541 475489-16-8 10mM (in 1mL DMSO)
NVP-AEW541 (CAS 475489-16-8) is a selective small-molecule inhibitor targeting the insulin-like growth factor-I receptor (IGF-IR) kinase activity Structurally classified as a pyrrolo[2 3-d]pyrimidine derivative NVP-AEW541 effectively inhibits IGF-IR autophosphorylation disrupting downstream IGF-IR mediated signaling cascades It exhibits an IC50 of approximately 0 086 M against IGF-IR kinase In vitro research has demonstrated that treatment of ECC-1 and USPC-1 endometrial cancer cell lines with NVP-AEW541 leads to altered cell cycle progression induction of apoptosis and suppression of proliferation Furthermore NVP-AEW541 has been shown to enhance radiosensitivity specifically in PTEN wild-type cancer cell lines indicating its potential utility as an adjunctive therapeutic agent in oncology research