Dimethyl Sulfoxide
Apexbio Technology LLC BMS-777607 1025720-94-8 10mM (in 1mL DMSO)
BMS-777607 (CAS 1025720-94-8) is an orally bioavailable ATP-competitive inhibitor targeting MET kinase and related receptor tyrosine kinases It selectively inhibits members of the MET family including RON MET Tyro-3 and Axl with IC50 values of 1 8 nmol/L 3 9 nmol/L 4 3 nmol/L and 1 1 nmol/L respectively At higher doses it also inhibits additional tyrosine kinases such as Mer Flt-3 Aurora B Lck and VEGFR2 BMS-777607 has been shown to suppress c-Met autophosphorylation (IC50 20 nmol/L) thereby impairing tumor xenograft growth and metastatic phenotypes supporting its utility in oncological research models exploring MET-driven tumorigenesis and cancer progression
Apexbio Technology LLC PCI-24781 (CRA-024781) 783355-60-2 10mM (in 1mL DMSO)
PCI-24781 (CRA-024781 CAS 783355-60-2) is a histone deacetylase (HDAC) inhibitor targeting HDAC1 HDAC2 HDAC3 HDAC6 HDAC8 and HDAC10 with reported Ki values of 7 19 8 2 17 280 and 24 nM respectively HDAC enzymes catalyze the removal of acetyl groups from lysine residues on histone proteins thereby regulating chromatin structure and gene expression PCI-24781 induces dose-dependent hyperacetylation of histones and tubulin in human cancer cells (HCT116 DLD-1) leading to apoptosis via p21 upregulation PARP cleavage and H2AX accumulation PCI-24781 demonstrates antitumor activity against multiple tumor cell lines and in xenograft models highlighting its utility for oncology research
Apexbio Technology LLC Nisoldipine 63675-72-9 10mM (in 1mL DMSO)
Nisoldipine (CAS 63675-72-9) is a dihydropyridine-based calcium channel blocker selective for the voltage-dependent L-type calcium channel Cav1 2 It inhibits Cav1 2-mediated calcium influx with an IC50 of approximately 10 nM By modulating calcium entry nisoldipine is frequently utilized in cardiovascular research to study vascular smooth muscle contraction calcium signaling pathways and cardiovascular pharmacology Its selective blockade helps elucidate the functional importance of Cav1 2 channels under physiological and pathological conditions
Apexbio Technology LLC Ponatinib (AP24534) 943319-70-8 10mM (in 1mL DMSO)
Ponatinib (AP24534 CAS 943319-70-8) is a second-generation small molecule inhibitor targeting the BCR-ABL fusion kinase The BCR-ABL fusion arising from a t(9 22) chromosomal translocation encodes oncogenic tyrosine kinase variants implicated in chronic myeloid leukemia (CML) acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) Ponatinib inhibits both wild-type BCR-ABL (IC50 0 5 nM) and resistant mutants notably the T315I mutant (IC50 11 nM) Additionally it potently inhibits clinically relevant kinases such as RET FLT3 KIT PDGFR / and FGFR1 Ponatinib is utilized in cancer biology research pertaining to kinase-driven malignancies
Apexbio Technology LLC c-Myc tag Peptide 2918768-02-0 10mM (in 1mL DMSO)
c-Myc tag peptide is a synthetic peptide with the amino acid sequence EQKLISEEDL corresponding to residues 410-419 at the C-terminal region of human c-Myc protein It serves as an epitope tag for recombinant protein expression enabling specific recognition and purification of fusion proteins using anti-c-Myc antibodies In immunoassays the peptide competitively binds to anti-c-Myc antibodies confirming antibody-antigen binding specificity and facilitating analysis of fusion proteins in Western blotting immunoprecipitation and immunofluorescence experiments c-Myc itself encodes a transcription factor regulating cellular processes such as proliferation growth apoptosis differentiation and stem-cell renewal pathways and is frequently overexpressed in cancers
Apexbio Technology LLC QNZ (EVP4593) 545380-34-5 10mM (in 1mL DMSO)
QNZ (EVP4593 CAS number 545380-34-5) is a quinazoline-derived small molecule inhibitor of the NF- B signaling pathway Originally identified using a luciferase reporter assay in human Jurkat T cells QNZ effectively suppresses PMA/PHA-induced NF- B transcriptional activation (IC50 11 nM) and TNF- production (IC50 7 nM) Additionally QNZ demonstrates anti-inflammatory properties reducing edema formation in a carrageenan-induced rat paw swelling model In Huntington s disease research QNZ improved motor performance in transgenic fly models without toxicity suggesting potential neuroprotective applications
Apexbio Technology LLC Quercetin(Synonyms: Sophoretin, Meletin, Quercetine, 3,3',4',5,7-Pentahydroxyflavone, Quercetol, Xanthaurine), 10mM (in 1mL DMSO), CAS: 117-39-5.
Quercetin (CAS 117-39-5) is a dietary flavonoid widely found in fruits vegetables nuts tea and red wine exhibiting notable antineoplastic and anti-inflammatory effects It functions primarily as a potent inhibitor of intracellular signaling kinases including PI3K and NF- B and moderately inhibits Akt1/2 with weaker effects on PKC p38 and ERK1/2 pathways Moreover quercetin can elevate cytosolic Ca levels disrupt mitochondrial membrane potential induce cytochrome c release and activate caspases (3 8 and 9) thereby promoting apoptosis through mitochondrial pathways It also affects cell cycle progression and apoptosis via stabilizing and phosphorylating p53 Thus quercetin serves as a valuable tool in cancer research providing insights into chemoprevention mechanisms and therapeutic potentials
Apexbio Technology LLC E-64 66701-25-5 10mM (in 1mL DMSO)
E-64 is a selective inhibitor targeting cysteine proteases isolated originally from Aspergillus cultures Structurally classified as an L-trans-epoxysuccinyl peptide it irreversibly inhibits proteases such as papain ficin and bromelain by covalent binding to the active-site cysteine residue Its inhibitory activity additionally extends to mammalian cysteine proteases including cathepsins B H and L as well as calcium-dependent protease calpain with reported IC50 values ranging approximately between 10-100 nM depending on specific enzyme assays and conditions In research laboratories E-64 is primarily utilized for mechanistic studies active-site titration assays and quantitative evaluation of cysteine protease concentrations and enzyme kinetics
Apexbio Technology LLC Baicalein 491-67-8 10mM (in 1mL DMSO)
Baicalein is a natural flavonoid compound extracted from the medicinal herb Scutellaria baicalensis known to function as an inhibitor of lipoxygenase enzymes It selectively inhibits the 12-lipoxygenase (12-LOX) mediated metabolic pathway involved in arachidonic acid metabolism subsequently modulating inflammatory responses and cell proliferation signaling Baicalein demonstrates bioactivity as reflected by reported IC50 values typically ranging from 0 6 M to 2 5 M against purified human platelet 12-LOX enzyme It is utilized in biomedical research primarily to study inflammation pathways tumor cell proliferation processes and mechanisms underlying apoptosis induction
Medchemexpress LLC Nvp-Dky709 Soltn 10Mm 1Ml Dmso | HY-144998-10MM 1ML DMSO
Nvp-Dky709 Soltn 10Mm 1Ml Dmso
Apexbio Technology LLC Pyrazinamide 98-96-4 10mM (in 1mL DMSO)
Pyrazinamide is an antimycobacterial agent primarily used in the laboratory research of tuberculosis infection As a synthetic pyrazine derivative it acts by targeting mycobacterial fatty acid synthesis pathways and disrupting bacterial membrane energetics thereby exerting bactericidal activity particularly under acidic conditions Pyrazinamide is routinely employed in in vitro cell and bacterial culture studies to investigate mechanisms of tuberculosis pathogenesis drug resistance and potential combination therapies Its inhibitory effect is usually quantified in terms of IC50 values typically ranging from approximately 10 to 60 g/mL depending on experimental conditions and mycobacterial strain types
Apexbio Technology LLC Aurora A Inhibitor I 1158838-45-9 10mM (in 1mL DMSO)
Aurora A Inhibitor I (CAS 1158838-45-9) is a selective and potent small-molecule inhibitor of Aurora A kinase exhibiting an IC50 of 3 4 nM Aurora kinases are serine/threonine kinases crucially involved in mitotic progression with Aurora A specifically implicated in centrosome maturation and spindle assembly Aurora A Inhibitor I exerts high specificity significantly favoring Aurora A over Aurora B or cyclin-dependent kinases (CDKs) in vitro Subtle amino acid changes within kinase active sites significantly impact inhibitor potency highlighting residue-dependent selectivity This compound represents a valuable research tool for investigating Aurora A-related signaling pathways and their roles in cell division and oncogenesis