Tetrahydrofuran
Medchemexpress LLC Sar-Arg-Val-Tyr-Val-His-NH2 | 2410957-04-7 | 96.6% | 742.87 | 5 MG
Sar-Arg-Val-Tyr-Val-His-NH2 is a Gq-biased agonist. It exhibits 10-fold larger molecular efficacies at the AT1R-Gq fusion protein compared with the AT1R-βarr2 fusion protein.
- Gq-biased agonist
- High purity of 96.6%
- Molecular weight of 742.87
- Stable under recommended storage conditions
- Useful for research on Angiotensin Receptors and GPCR/G Protein pathways
Medchemexpress LLC CUR61414 | 334998-36-6 | 99.04% | 550.69 | 100 MG
CUR61414 is a novel, potent, and cell-permeable Hedgehog signaling pathway inhibitor. It is a small-molecule aminoproline compound that selectively binds to smoothened (Smo). This compound can induce apoptosis in cancer cells without affecting neighboring non-tumor cells.
- Potent and cell-permeable Hedgehog signaling pathway inhibitor.
- Selectively binds to smoothened (Smo).
- Induces apoptosis in cancer cells.
- Spares neighboring non-tumor cells.
- Exhibits an IC50 of 100-200 nM.
Medchemexpress LLC DS08210767 | 2376334-75-5 | 99.4% | 513.67 g/mol | C31H39N5O2 | 100MG
DS08210767 is a small-molecule antagonist of parathyroid hormone receptor 1 (PTHR1), described as highly potent and orally bioavailable with an IC50 of 90 nM. It is provided as a research-grade, well-characterized compound suitable for receptor pharmacology and oral in vivo studies.
- High potency (IC50 of 90 nM) for PTHR1 inhibition.
- Orally bioavailable, enabling oral dosing in pharmacology studies.
- High purity (99.4%) as verified by certificate of analysis.
- Molecular weight 513.67 g/mol; formula C31H39N5O2.
- Analytical data available: COA, HNMR, and LCMS.
- Supplied in multiple milligram pack sizes for experimental flexibility.
Medchemexpress LLC Erk1/2 inhibitor 2 (ASTX-029) | 2095719-92-7 | >98.0% | 584.04 g/mol | C29H31ClFN5O5 | 25MG
ASTX029 is a dual-mechanism extracellular signal-regulated kinase (ERK) 1/2 inhibitor developed as a clinical candidate. It inhibits ERK catalytic activity and ERK phosphorylation, with reported ERK2 IC50 ≈ 2.7 nM, and has demonstrated antineoplastic activity in preclinical models and early clinical evaluation. Supplied as a crystalline solid for research use, typical vendor-reported purity is ≥98% (CAS 2095719-92-7).
- Potent dual-mechanism ERK inhibitor with low-nanomolar potency.
- Inhibits both catalytic activity and phosphorylation of ERK.
- Demonstrated antineoplastic activity in preclinical and early clinical studies.
- Supplied as a crystalline solid suitable for in vitro and in vivo formulation.
- Typical purity ≥98% by vendor testing.
- CAS number 2095719-92-7 and molecular weight ≈584.04 g/mol.
- For research use only; not for human therapeutic use.
Medchemexpress LLC Cur61414 | 334998-36-6 | 99.0% | 550.69 | 50 MG
CUR61414 is a novel, potent, and cell-permeable Hedgehog signaling pathway inhibitor with an IC50 of 100-200 nM. It is a small-molecule aminoproline class compound that selectively binds to smoothened (Smo) with a Ki value of 44 nM. CUR-61414 can induce apoptosis in cancer cells without affecting neighboring non-tumor cells.
- Novel, potent, and cell-permeable Hedgehog signaling pathway inhibitor.
- Selectively binds to smoothened (Smo).
- Induces apoptosis in cancer cells without affecting neighboring non-tumor cells.
- Able to arrest proliferation of basal cells within BCC-like lesions and induce apoptosis, leading to complete regression of lesions.
- Causes regression of BCC-like lesions in mice exposed to UV light irradiation, with no overt toxicity observed in surrounding skin.
Medchemexpress LLC Sonlicromanol | 1541170-75-5 | 99.8% | 25MG
Sonlicromanol | 1541170-75-5 | 99.8% | 25MG
eMolecules 121138-01-0 | 3-Iodotetrahydrofuran | Synthonix | MFCD09878873 | 198.003 | C4H7IO | 95.000 | IC1CCOC1 | 10g | 204725743
3-Iodotetrahydrofuran | Synthonix | 121138-01-0 | MFCD09878873 | 198.003 | C4H7IO | 95.000 | IC1CCOC1 | 10g | 204725743
Medchemexpress LLC Pd-1/pd-l1-in-23 | 2597056-04-5 | 100.0% | 703.41 g/mol | C32H30BrCl2N3O6 | 5 MG
PD-1/PD-L1-IN-23 is a small-molecule inhibitor of the PD-1/PD-L1 immune checkpoint provided as a research reagent. Described as an orally active ester prodrug of L7, it is supplied as a solid suitable for biochemical assays and preclinical studies. CAS 2597056-04-5; molecular formula C32H30BrCl2N3O6; molecular weight 703.41 g/mol.
- Potent small-molecule inhibitor of PD-1/PD-L1 interaction
- Orally active prodrug with demonstrated preclinical activity
- Designed to convert to an active metabolite in vivo
- Solid, white to off-white form with high purity (99.98%)
- Soluble in DMSO; available as solution and powder formats
- Available in multiple research-scale package sizes including 5 mg
Medchemexpress LLC Mpt0b392 | 1346169-92-3 | 99.6% | 404.44 g/mol | C19H20N2O6S | 10 MG
MPT0B392 is a research-grade microtubule-depolymerizing agent for preclinical studies of tubulin dynamics and cancer drug resistance. It is an orally active quinoline derivative that inhibits tubulin polymerization, activates c-Jun N-terminal kinase (JNK), induces mitotic arrest, and promotes apoptosis. Supplied as a solid or as a 10 mM solution in DMSO for in vitro and in vivo research use.
- Novel microtubule-depolymerizing mechanism supporting tubulin studies.
- Induces JNK activation and mitotic arrest for apoptosis research.
- Available as solid or 10 mM solution in DMSO for flexible dosing.
- High listed purity (99.63%) suitable for biochemical assays.
- Documented molecular weight and formula to aid experimental planning.
![Medchemexpress LLC 2-((4-(Benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate | 99.5% | 612.63 | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000439242-Logo.png-250.jpg){kind=logo}
Medchemexpress LLC 2-((4-(Benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate | 99.5% | 612.63 | 50 MG
GSK2983559 is an orally active and potent receptor interacting protein 2 (RIP2) kinase inhibitor. It blocks many proinflammatory cytokine responses in vivo and in human inflammatory bowel disease explant samples.
- Blocks MDP-induced IL-8 in THP-1 cells.
- Inhibits MDP-induced IL-6 in mouse.
![Medchemexpress LLC 1-[[4-[4-[[4-(4-chloro-N-methylanilino)quinolin-1-ium-1-yl]methyl]phenyl]phenyl]methyl]-N-(4-chlor... | 850807-63-5 | 98.4% | 877.53 g/mol | C46H38Br2Cl2N4 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000211949.png-250.jpg)
Medchemexpress LLC 1-[[4-[4-[[4-(4-chloro-N-methylanilino)quinolin-1-ium-1-yl]methyl]phenyl]phenyl]methyl]-N-(4-chlor... | 850807-63-5 | 98.4% | 877.53 g/mol | C46H38Br2Cl2N4 | 5 MG
RSM-932A is a small-molecule choline kinase α (ChoKα) inhibitor used as a research tool in preclinical oncology studies. It shows potent antiproliferative activity in vitro and antitumor efficacy in vivo, and is commonly used to study ChoKα biology and evaluate therapeutic hypotheses in cellular and animal models.
- Selective ChoKα inhibitor with reported IC50 ≈ 1 μM and ~33 μM for ChoKβ.
- Potent antiproliferative activity across tumor-derived cell lines.
- Demonstrated antitumor efficacy in xenograft models.
- High-purity synthetic compound suitable for research applications.
- Solid form; molecular weight 877.53 g/mol.
- Store sealed at 4°C; long-term storage in solution recommended at -80°C.
Medchemexpress LLC Benzobicyclon | 156963-66-5 | MFCD09751259 | 98.0% | 446.97 g/mol | C22H19ClO4S2 | 100 MG
Benzobicyclon is a research-grade herbicide compound used as a 4-HPPD inhibitor and supplied as an analytical standard for laboratory and analytical applications. It is documented with CAS and molecular identity and is typically provided in a quantified solid form for testing and reference purposes.
- Acts as a 4-HPPD (4-hydroxyphenylpyruvate dioxygenase) inhibitor.
- Intended for research and analytical applications.
- CAS number 156963-66-5 for unambiguous identification.
- Molecular formula C22H19ClO4S2 and molecular weight 446.97 g/mol.
- Supplied as a solid standard with typical purity of 98%.