Tetrahydrofuran
Polysorbate 20, MP Biomedicals™
CAS: 9005-64-5 Molecular Formula: (C2H4O)y(C2H4O)w(C2H4O)x(C2H4O)zC18H34O6 Molecular Weight (g/mol): 522.68 MDL Number: MFCD00165986 InChI Key: HMFKFHLTUCJZJO-UHFFFAOYNA-N Synonym: tween 20,polysorbate 20,polyoxyethylene sorbitan monolaurate,polyoxyethylene 20 sorbitan monolaurate,polysorbate inn,2-2-3,4-bis 2-hydroxyethoxy oxolan-2-yl-2-2-hydroxyethoxy ethoxy ethyl dodecanoate,alkest tw 20,polysorbate 20 nf,polysorbate 40 nf PubChem CID: 443314 IUPAC Name: 2-[2-[3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy]ethyl dodecanoate SMILES: CCCCCCCCCCCC(=O)OCCOCC(OCCO)C1OCC(OCCO)C1OCCO
Tetrahydrofuran, 99.9%, for HPLC, unstabilized, Thermo Scientific Chemicals
CAS: 109-99-9 Molecular Formula: C4H8O Molecular Weight (g/mol): 72.11 MDL Number: MFCD00005356 InChI Key: WYURNTSHIVDZCO-UHFFFAOYSA-N Synonym: tetrahydrofuran,furan, tetrahydro,butylene oxide,furanidine,hydrofuran,tetramethylene oxide,oxacyclopentane,1,4-epoxybutane,tetrahydrofuranne,tetraidrofurano PubChem CID: 8028 ChEBI: CHEBI:26911 IUPAC Name: oxolane SMILES: C1CCOC1
Tetrahydrofuran, 99.5+%, for spectroscopy
CAS: 109-99-9 Molecular Formula: C4H8O Molecular Weight (g/mol): 72.11 MDL Number: MFCD00005356 InChI Key: WYURNTSHIVDZCO-UHFFFAOYSA-N Synonym: tetrahydrofuran,furan, tetrahydro,butylene oxide,furanidine,hydrofuran,tetramethylene oxide,oxacyclopentane,1,4-epoxybutane,tetrahydrofuranne,tetraidrofurano PubChem CID: 8028 ChEBI: CHEBI:26911 IUPAC Name: oxolane SMILES: C1CCOC1
Tetrahydrofuran, 99.8%, for HPLC, unstabilized
CAS: 109-99-9 Molecular Formula: C4H8O Molecular Weight (g/mol): 72.11 MDL Number: MFCD00005356 InChI Key: WYURNTSHIVDZCO-UHFFFAOYSA-N Synonym: tetrahydrofuran,furan, tetrahydro,butylene oxide,furanidine,hydrofuran,tetramethylene oxide,oxacyclopentane,1,4-epoxybutane,tetrahydrofuranne,tetraidrofurano PubChem CID: 8028 ChEBI: CHEBI:26911 IUPAC Name: oxolane SMILES: C1CCOC1
Medchemexpress LLC CUR61414 | 334998-36-6 | 99.04% | 550.69 | 100 MG
CUR61414 is a novel, potent, and cell-permeable Hedgehog signaling pathway inhibitor. It is a small-molecule aminoproline compound that selectively binds to smoothened (Smo). This compound can induce apoptosis in cancer cells without affecting neighboring non-tumor cells.
- Potent and cell-permeable Hedgehog signaling pathway inhibitor.
- Selectively binds to smoothened (Smo).
- Induces apoptosis in cancer cells.
- Spares neighboring non-tumor cells.
- Exhibits an IC50 of 100-200 nM.
Medchemexpress LLC Cur61414 | 334998-36-6 | 99.0% | 550.69 | 50 MG
CUR61414 is a novel, potent, and cell-permeable Hedgehog signaling pathway inhibitor with an IC50 of 100-200 nM. It is a small-molecule aminoproline class compound that selectively binds to smoothened (Smo) with a Ki value of 44 nM. CUR-61414 can induce apoptosis in cancer cells without affecting neighboring non-tumor cells.
- Novel, potent, and cell-permeable Hedgehog signaling pathway inhibitor.
- Selectively binds to smoothened (Smo).
- Induces apoptosis in cancer cells without affecting neighboring non-tumor cells.
- Able to arrest proliferation of basal cells within BCC-like lesions and induce apoptosis, leading to complete regression of lesions.
- Causes regression of BCC-like lesions in mice exposed to UV light irradiation, with no overt toxicity observed in surrounding skin.
Medchemexpress LLC CIL62 | 117593-36-9 | 97.0% | 382.45 | 50 MG
CIL62 is a caspase-3/7-independent cell death inducer that operates via Necrostatin-1 dependent mechanisms. It exhibits antiproliferative activity against human COLO205, IMR32, and K562 cells.
- Caspase-3/7-independent cell death inducer
- Necrostatin-1 dependent mechanism of action
- Antiproliferative activity against COLO205, IMR32, and K562 cells
Medchemexpress LLC TMX-4100 | 2367619-63-2 | 98.2% | C11H10N4O2S | 100 MG
TMX-4100 is a selective phosphodiesterase 6D (PDE6D) degrader. It demonstrates a high degradation preference for PDE6D with DC50 values less than 200 nM in MOLT4, Jurkat, and MM.1S cells. This compound can be utilized for research into multiple myeloma.
- Demonstrates a high degradation preference for PDE6D in MOLT4 cells.
- Exhibits better proteome-wide degradation selectivity in MOLT4 cells.
- Does not hinder the growth of KRAS-dependent cell lines.
Medchemexpress LLC AVJ16 | 2775241-92-2 | 99.6% | C28H27N3O4 | 100 MG
AVJ16 is a cancer cell migration inhibitor targeting the insulin-like growth factor 2 mRNA binding protein IGF2BP1 with an affinity (Kd) of 1.4 μM. It interferes with IGF2BP1 binding target mRNA to regulate gene expression and translation, inhibiting proliferation, invasion, and migration of IGF2BP1-expressing lung adenocarcinoma cells. It also suppresses colony formation and spheroid growth, induces apoptosis in certain cell lines, and demonstrates antitumor activity in xenograft mouse models.
- Targets IGF2BP1, a key protein in cancer cell migration.
- Interferes with mRNA binding to regulate gene expression.
- Inhibits proliferation, invasion, and migration of lung adenocarcinoma cells.
- Suppresses colony formation and spheroid growth.
- Induces apoptosis in relevant cell lines.
- Shows antitumor activity in xenograft mouse models.
Medchemexpress LLC Isoformononetin | 486-63-5 | 5 MG
Isoformononetin is an analog of Daidzein with immunoprotective effects.
- Inhibits the differentiation of Th17 cells
- Inhibits B-cell lymphopoiesis
- Promotes osteogenesis in estrogen-deficient bone loss conditions
![Medchemexpress LLC 2-[[5-[(4-fluorophenyl)carbamoyl]pyrimidin-2-yl]sulfanylmethyl]-4-(trifluoromethoxy)phenyl boronic acid | 1648843-04-2 | 99.7% | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000234135.png-250.jpg)
Medchemexpress LLC 2-[[5-[(4-fluorophenyl)carbamoyl]pyrimidin-2-yl]sulfanylmethyl]-4-(trifluoromethoxy)phenyl boronic acid | 1648843-04-2 | 99.7% | 10 MG
SX-682 is an orally bioavailable small-molecule allosteric inhibitor of chemokine receptors CXCR1 and CXCR2 under clinical investigation for oncology indications; it blocks recruitment of myeloid-derived suppressor cells and can enhance T-cell activity.
- Orally bioavailable small-molecule CXCR1/2 inhibitor
- Blocks recruitment of myeloid-derived suppressor cells (MDSCs)
- Enhances T-cell activation and antitumor immune responses
- Demonstrated activity in preclinical tumor models and clinical trials
- Supplied with high purity (typical >99%) and available in small-mass packaging for research
Medchemexpress LLC Ganodermanontriol | 106518-63-2 | 472.70 | 5 MG
Ganodermanontriol is a sterol isolated from Ganoderma lucidum that induces anti-inflammatory activity in tert-butyl hydroperoxide (t-BHP)-damaged hepatic cells by expressing HO-1. It also exhibits hepatoprotective activity. It has been shown to inhibit breast cancer cell lines MCF-7 and MDA-MB-231 with IC50 values of 5.8 and 9.7 μM, respectively.
- Induces anti-inflammatory activity in damaged hepatic cells.
- Exhibits hepatoprotective activity.
- Inhibits breast cancer cell lines MCF-7 and MDA-MB-231.
Medchemexpress LLC Ganodermanontriol | 106518-63-2 | 472.70 | 1 MG
Ganodermanontriol is a sterol isolated from *Ganoderma lucidum* that induces anti-inflammatory activity in tert-butyl hydroperoxide (t-BHP)-damaged hepatic cells through the expression of HO-1. It also exhibits hepatoprotective activity and antiproliferative activity against human MCF7 and MDA-MB-231 breast cancer cells.
- Induces anti-inflammatory activity.
- Exhibits hepatoprotective activity.
- Suppresses growth of colon cancer cells through β-catenin signaling.
- Exhibits anti-melanogenic effects through regulation of CREB and MAPK signaling pathways.
- Inhibits breast cancer cell lines MCF-7 and MDA-MB-231.
Medchemexpress LLC Tmx-4116 | 2766385-56-0 | 99.8% | C17H19N5O4S | 100 MG
TMX-4116 is a casein kinase 1α (CK1α) degrader. It exhibits a degradation preference for CK1α with DC50s less than 200 nM in MOLT4, Jurkat, and MM.1S cells.
- Can be utilized for research related to multiple myeloma.
- Demonstrates a high degradation preference for CK1α in MOLT4 cells at 1 μM for 4 hours.
- Induces primary target degradation of CK1α without downregulating PDE6D, IKZF1, and IKZF3 in MOLT4 cells.
Medchemexpress LLC ABD957 | 3007772-60-0 | 98.14% | C27H36F3N7O5S | 100 MG
ABD957 is a potent and selective covalent inhibitor of the ABHD17 family of depalmitoylases, with an IC50 of 0.21 μM for ABHD17B. It can block N-Ras signaling and the growth of NRAS-mutant AML cells.
- Blocks N-Ras signaling
- Blocks the growth of NRAS-mutant AML cells