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Organic compounds that are derived from or have a benzene group in their molecular structure. Benzene is an aromatic organic molecule composed of 6 carbon atoms and 6 hydrogen atoms that form a ring. Includes derivatives and substituted molecules.
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Also available in 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. PTP Inhibitor IV is an effective protein tyrosine phosphatase (PTP) inhibitor which can selectively inhibit DUSP14 phosphatase activity (IC50.5.21uM). PTP Inhibitor IV inhibited SHP-2 PTP1B PTp-(epsilon) PTP Meg-2 PTP-(sigma) PTP-(beta) and PTP-u IC50 were 1.8 uM 2.5 uM 8.4 uM 13 uM 20 uM 6.4 uM and 6.7 uM respectively. PTP Inhibitor IV affects cellular signaling by inhibiting PTP activity and may regulate specific pathways associated with PTP-mediated signaling events. purity: 99%
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Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. CCT241161 is an orally active pan-RAF inhibitor with IC50 values of 3 6 10 15 and 30 nM for LCK CRAF SRC V600E-BRAF and BRAF respectively. It displays significant activity against BRAF and NRAS mutant melanomas as well as demonstrating anticancer cell proliferative effects [1]. purity: 98%
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Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. Inaxaplin is an apolipoprotein L1 ( APOL1 ) function inhibitor (WO2020131807 compound 2). Inaxaplin can be used for the research of kidney disease. purity: 98%
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Also available in 1 mg 2 mg 5 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Zt-12-037-01 is a ATP competitive STK19 inhibitor(IC50 values of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N)respectively). purity: 98%
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Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. all-trans-4-Oxoretinoic acid (all-trans 4-Keto Retinoic Acid) is an active metabolite of vitamin A. purity: 96%
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m-PEG7-alcohol is a PEG-based PROTAC linker for use in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker, one for an E3 ubiquitin ligase and the other for the target protein. They exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
PEG-based PROTAC linker
Used in the synthesis of PROTACs
Exploits the intracellular ubiquitin-proteasome system
Selectively degrades target proteins
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Acid-PEG3-mono-methyl ester is an alkyl/ether-based PROTAC linker. It can be used in the synthesis of PROTACs, which are designed with two different ligands connected by a linker. One ligand targets an E3 ubiquitin ligase, and the other targets a specific protein. PROTACs work by leveraging the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Alkyl/ether-based PROTAC linker
Used in the synthesis of PROTACs
PROTACs contain two different ligands connected by a linker
Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins
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Nh-bis(peg2-c2-boc) is an alkyl/ether-based PROTAC linker used in the synthesis of PROTACs. PROTACs are compounds designed to exploit the intracellular ubiquitin-proteasome system for selective degradation of target proteins, functioning by connecting an E3 ubiquitin ligase ligand to a target protein ligand via a linker.
Alkyl/ether-based PROTAC linker
Used in the synthesis of PROTACs
Exploits ubiquitin-proteasome system
Selectively degrades target proteins
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More