p-Cresyl sulfate (p-Tolyl sulfate) is a uremic toxin that can cause renal damage and dysfunction. It shows antiproliferation activity, increases the protein expression of HIF-1α and VHL, decreases the protein expression of HIF-2α, induces epithelial-mesenchymal transition (EMT), and activates the JNK and p38 MAPK signaling pathways. For research use only.
- Exhibits antiproliferation activity in a dose- and time-dependent manner
- Increases protein expression of HIF-1α and VHL
- Decreases protein expression of HIF-2α
- Induces epithelial-mesenchymal transition (EMT)
- Activates JNK and p38 MAPK signaling pathways
- Inhibits lipogenesis and increases lipolysis in adipocytes
- Induces osteoblast dysfunction
- Induces ROS production in primary osteoblastic cells