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Fluorizoline is a small-molecule antitumor agent that selectively binds prohibitin 1 (PHB1) and prohibitin 2 (PHB2) to induce apoptosis. It reduces chronic lymphocytic leukemia (CLL) cell viability through upregulation of NOXA and BIM and demonstrates activity independent of p53. The compound is supplied as a solid powder for preclinical research.
High purity (99.77%) suitable for research assays.
Molecular weight 362.20 g/mol and formula C15H8Cl2F3NS.
Soluble in DMSO (50 mg/mL); may require ultrasonic treatment.
Powder stable at -20°C for long-term storage.
Direct binder of prohibitin proteins; useful for apoptosis and mechanism-of-action studies.
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An alkylphospholipid that induces apoptotic cell death in a time- and dose-dependent manner in a variety of tumor cell lines but not in normal vascular endothelial cells; causes inhibition of PC-3 prostate carcinoma cell growth (GI50 = 5 µM at 24h) associated with rapidly decreased Akt activation; induces p21WAF1 expression in squamous carcinoma cells, leading to loss in cyclin-dependent kinase activity and cell cycle arrest
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