Organooxygen compounds
Medchemexpress LLC Ribociclib hydrochloride | 1211443-80-9 | >99.9% | 471.00 | 10 MG
Ribociclib hydrochloride is an ATP-competitive and orally active CDK4/6 inhibitor designed for research use. It effectively crosses the blood-brain barrier and demonstrates potent inhibitory activity against CDK4 and CDK6.
- ATP-competitive and orally active CDK4/6 inhibitor
- Crosses the blood-brain barrier
- IC50 values of 10 nM for CDK4 and 39 nM for CDK6
- Over 1,000-fold less potent against the cyclin B/CDK1 complex
- Induces cell-cycle arrest in G0/G1 phase
- Significantly delays tumor growth in neuroblastoma xenografts
Medchemexpress LLC Chemerin-9 (149-157) (TFA) | 98.2% | 1177.18 | 1 ML
Chemerin-9 (149-157) TFA is a potent agonist of chemokine-like receptor 1 (CMKLR1) with anti-inflammatory activity. It stimulates the phosphorylation of Akt and ERK, and also induces ROS production. This compound has been shown to ameliorate Aβ1-42-induced memory impairment and regulates immune responses, adipocyte differentiation, and glucose metabolism.
- Potent agonist of chemokine-like receptor 1 (CMKLR1)
- Exhibits anti-inflammatory activity
- Stimulates phosphorylation of Akt and ERK, and induces ROS production
- Ameliorates Aβ1-42-induced memory impairment
- Regulates immune responses, adipocyte differentiation, and glucose metabolism
- Demonstrates in vitro stimulation of migration in cardiac fibroblasts
- Alleviates glucose intolerance and IR in PDM mice in vivo
- Provides anti-inflammatory and anti-angiogenic effects in ApoE-/- mice in vivo
Medchemexpress LLC IRL-1620 | 142569-99-1 | 99.7% | 1820.95 | 5 MG
IRL-1620 is a potent and selective endothelin receptor type B (ETB) agonist (Ki of 16 pM). It is a solid, white to off-white compound (MW 1820.95, C86H117N17O27) intended for research use only. Solutions are unstable, so fresh preparation is recommended.
- Potent and specific ligand for the ETB receptor, with a KiETA/KiETB ratio of 120,000 and 60 times more selective than ET-3.
- In vitro activity: Induces guinea pig trachea contractions and increases cytosolic Ca2+ in vascular endothelium.
- In vivo activity: Improves learning and memory, enhances angiogenic and neurogenic remodeling, and reduces cognitive impairment.
- Storage: Powder stable for 2 years at -80°C or 1 year at -20°C. Ship at room temperature, store sealed away from moisture.
Medchemexpress LLC VU0357017 hydrochloride | 1135242-13-5 | 98.6% | 369.89 | 100 MG
VU0357017 hydrochloride is a potent, selective, and brain-penetrant allosteric agonist of the M1 muscarinic acetylcholine receptor, with an EC50 of 477 nM. It demonstrates high selectivity for M1, exhibiting no activity at M2-M5 even at concentrations up to 30 μM. This compound is suitable for research related to Alzheimer's disease and schizophrenia.
- Potent, selective and brain-penetrant allosteric agonist of M1 muscarinic acetylcholine receptor.
- Exhibits an EC50 of 477 nM for M1.
- Highly selective for M1, with no activity at M2-M5 up to 30 μM.
- Can be used for the research of Alzheimer's disease and schizophrenia.
- Induces calcium release and ERK phosphorylation in a concentration-dependent manner in CHO cells.
- Reverses scopolamine-induced disruption of the contextual fear conditioning response.
Medchemexpress LLC Pumosetrag Hydrochloride | 194093-42-0 | 99.8% | 339.84 | 25 MG
Pumosetrag Hydrochloride is an orally available 5-HT3 partial agonist developed for the treatment of irritable bowel syndrome and gastroesophageal reflux disease. It is intended for research use only.
- Orally available 5-HT3 partial agonist
- Developed for treatment of irritable bowel syndrome and gastroesophageal reflux disease
- Exhibits regional and species specificities
- Delays liquid gastric emptying
- Relaxes the proximal stomach
- Stimulates fasting antroduodenal migrating motor complex activity
- Accelerates small intestinal transit
Medchemexpress LLC Cyclobutanol | 2919-23-5 | 99.99% | 72.11 | 25 G
Cyclobutanol is a biochemical reagent used in life science research. It has synthetic applications in gold-catalyzed ring expansions and the development of novel transition metal-catalyzed cascade reactions. It is for research use only.
- Used as a biochemical reagent
- Suitable for life science related research
- Appears as a colorless to light yellow liquid
- Density of 0.921 g/cm³
Medchemexpress LLC Chetomin | 1403-36-7 | MFCD28137713 | >99.0% | 710.87 g/mol | C31H30N6O6S4 | 1 MG
Chetomin is a natural-product small molecule reported to inhibit the Hsp90/HIF-1α pathway. Supplied as an off-white solid for laboratory research use, it is provided with recommended handling, solubility, and storage guidance for preparation of stock solutions.
- Natural product inhibitor of Hsp90/HIF-1α pathway.
- Off-white solid form, soluble in DMSO with warming and sonication.
- Molecular formula C31H30N6O6S4; molecular weight 710.87 g/mol.
- Recommended stock: DMSO, 5 mg/mL (7.03 mM).
- Storage: powder -20°C; stock -80°C up to 6 months, -20°C up to 1 month.
- For research use only; not intended for human or clinical use.
Medchemexpress LLC R-(+)-SCH-23390 hydrochloride | 125941-87-9 | 99.8% | 324.24 | 25 MG
R-(+)-SCH-23390 hydrochloride | 125941-87-9 | 99.8% | 324.24 | 25 MG
eMolecules 65094-22-6 | Diethyl Bromodifluoromethanephosphonate | AA Blocks LLC | MFCD00069118 | 267.007 | C5H10BrF2O3P | 0.000 | CCOP(=O)(OCC)C(F)(F)Br | 25g | 410166652
Diethyl Bromodifluoromethanephosphonate | AA Blocks LLC | 65094-22-6 | MFCD00069118 | 267.007 | C5H10BrF2O3P | 0.000 | CCOP(=O)(OCC)C(F)(F)Br | 25g | 410166652
Medchemexpress LLC EPZ004777 hydrochloride | 1380316-03-9 | C28H42ClN7O4 | 25 MG
EPZ004777 hydrochloride is an effective and selective DOT1L inhibitor with an IC50 of 0.4 nM. This compound reduces levels of H3K79me2 and H3K79me1, leading to a significant down-regulation of HOXA9 and MEIS1 expression. It selectively inhibits the proliferation of MLL rearrangement cells and promotes the differentiation and subsequent apoptosis of leukemia cells, making it suitable for leukemia research.
- Effective and selective DOT1L inhibitor
- Reduces H3K79me2 and H3K79me1 levels
- Down-regulates HOXA9 and MEIS1 expression
- Selectively inhibits MLL rearrangement cell proliferation
- Promotes differentiation and apoptosis of leukemia cells
- Potent DOT1L enzyme activity inhibition (IC50 of 400±100 pM)
- Demonstrates selectivity over other histone methyltransferases (HMTs)
Medchemexpress LLC VU6036720 hydrochloride | 99.65% | 473.39 | 50 MG
VU6036720 hydrochloride is a potent and specific inhibitor of Kir4.1/5.1 channels. It is suitable for various research applications.
- Inhibits Kir4.1/5.1 channels with an IC50 value of 0.24 μM.
- Can be used for the research of brain and kidney.