Phenylpropanoids and polyketides
Medchemexpress LLC 4'-Methoxychalcone | 959-23-9 | 99.8% | 5 G
4'-Methoxychalcone regulates adipocyte differentiation through PPARγ activation. It also modulates the expression and secretion of various adipokines in adipose tissue that are involved in insulin sensitivity. This product is intended for research use only.
- Regulates adipocyte differentiation via PPARγ activation
- Modulates adipokine expression and secretion involved in insulin sensitivity
- Increases mRNA expression of adipogenic genes during differentiation
- Reduces upregulated mRNA expression of IL-6, PAI-1, and MCP-1
- Causes an increase in PPARγ expression during differentiation
- Exhibits antiproliferative activity and cytotoxicity against various human cell lines
- Targets PPARγ
- Derived from Piperaceae Piper nigrum Linn.
- Classified as flavonoids, chalcones
Medchemexpress LLC PI3K/AKT-IN-1 | 3033069-84-7 | 99.6% | C23H23N5O4S | 25 MG
PI3K/AKT-IN-1 is an effective dual inhibitor of PI3K and AKT, exhibiting anticancer activity by inhibiting the PI3K/AKT axis and inducing caspase 3-dependent apoptosis. This compound has high cytotoxic activity against leukemia K562 and breast cancer MCF-7 cell lines, and is intended for research use only.
- Demonstrates high cytotoxic activity, particularly against leukemia cell line K562 (IC50=2.62 μM) and breast cancer cell line MCF-7 (IC50=3.22 μM)
- Promotes S-phase cell cycle arrest and induces apoptosis in K562 cells
- Significantly reduces the expression of PI3K, p-PI3K, AKT, p-AKT, Cyclin D1, and NF-κB
- Found to be non-toxic and well-tolerated in animal studies, with an LD50 greater than 2000 mg/kg
- Soluble in DMSO at 50 mg/mL
- Solid, off-white to light yellow appearance
Apexbio Technology LLC AKT inhibitor VIII(Synonyms: AKTi-1/2, Akt Inhibitor VIII, AKTi VIII, Akt kinase inhibitor VIII, Isozyme-selective AKT inhibitor VIII), 10mM (in 1mL DMSO), CAS: 612847-09-3.
AKT inhibitor VIII (CAS 612847-09-3) is a cell-permeable reversible inhibitor targeting Akt isoforms Akt1 Akt2 and Akt3 exhibiting IC50 values of 58 nM 210 nM and 2119 nM respectively It acts by suppressing Akt signaling as demonstrated by its ability to inhibit IGF-1-stimulated Akt phosphorylation and to reduce PRAS40 phosphorylation in PC12 cells In MCF-7 breast cancer cells AKT inhibitor VIII enhances the antiproliferative activity of furanodiene augmenting its effects on Akt/p-Akt downregulation and promoting PARP cleavage This compound is valuable for exploring Akt-dependent signaling pathways in oncology research and neuronal cell biology studies
Medchemexpress LLC 4'-Methoxychalcone | 959-23-9 | 99.8% | 10 G
4'-Methoxychalcone regulates adipocyte differentiation through PPARγ activation. It also modulates the expression and secretion of various adipokines in adipose tissue that are involved in insulin sensitivity. This product is for research use only.
- Regulates adipocyte differentiation through PPARγ activation.
- Modulates the expression and secretion of various adipokines.
- Increases mRNA expression of adipogenic genes during differentiation.
- Reduces upregulated mRNA expression of inflammatory cytokines.
- Suitable for research use.
Medchemexpress LLC 4'-Methoxychalcone | 959-23-9 | 99.8% | 50 G
4'-Methoxychalcone is a compound that regulates adipocyte differentiation through PPARγ activation. It modulates the expression and secretion of various adipokines in adipose tissue, which are involved in insulin sensitivity.
- Regulates adipocyte differentiation via PPARγ activation.
- Modulates adipokine expression and secretion.
- Increases mRNA expression of adipogenic genes during differentiation.
- Reduces upregulated mRNA expression of inflammatory markers in preadipocyte cells.
- Exhibits antiproliferative and cytotoxic activity against various human and mouse cell lines.
Medchemexpress LLC AKT-IN-23 | 1226801-23-5 | 517.52 | 25 MG
AKT-IN-23 is an AKT inhibitor primarily used in cancer research. This compound is known for its specific targeting capabilities.
- Acts as an AKT inhibitor
- Suitable for cancer research applications
- Targets Akt
- Involves the PI3K/Akt/mTOR pathway
Medchemexpress LLC Naringenin | 480-41-1 | 99.3% | 272.25 | 1 G
Naringenin is the predominant flavanone found in *Citrus reticulata Blanco*. It exhibits strong anti-inflammatory and antioxidant activities, and also possesses anti-dengue virus (DENV) activity.
- Exhibits strong anti-inflammatory activity.
- Exhibits strong antioxidant activity.
- Possesses anti-dengue virus (DENV) activity.
- Inhibits HepG2 cell proliferation.
- Reduces plasma and liver triglycerides and cholesterol.
- Enhances hepatic fatty acid oxidation.
Medchemexpress LLC Chalcone 4 hydrate 1mg | 1202866-96-3 | ≈288.73 g/mol (anhydrous basis); varies with hydration (xH2O) | C16H13ClO3·xH2O | 1 MG
Chalcone 4 hydrate (CAS 1202866-96-3) is an anti-parasite small-molecule research reagent reported to inhibit the growth of Babesia and Theileria. The compound is supplied as a hydrated solid and is intended for in vitro parasitology and chemical biology studies; handle and store under recommended conditions.
- Hydrated solid form (xH2O)
- Purity 98.0%
- Molecular formula C16H13ClO3·xH2O
- Typical molecular weight ~288.73 g/mol (anhydrous basis)
- Offered in low-quantity research sizes (e.g., 1 mg)
- Store at 4°C; in solution, store -80°C up to 6 months or -20°C up to 1 month under nitrogen
Medchemexpress LLC 2-propen-1-one, 1,3-diphenyl- | 94-41-7 | 100.0% | 100 MG
Chalcone is a small-molecule research chemical used as a synthetic intermediate and a reference compound in medicinal chemistry and biological assays. Offered in solid and solution formats, it is supplied with a certificate of analysis for batch verification.
- High purity suitable for analytical and synthetic work.
- Off-white to light yellow solid for easy handling.
- Soluble in DMSO at up to 100 mg/mL with sonication.
- Recommended storage for powder at -20°C for long-term stability.
- Certificate of analysis available for batch verification.
TARGETMOL CHEMICALS INC AKT-I-1 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. AKT-I-1 is a selective and reversible inhibitor of Akt1. purity: 98%
Apexbio Technology LLC Naringenin 480-41-1 10mM (in 1mL DMSO)
Naringenin (CAS 480-41-1) is a small-molecule inhibitor designed to modulate inflammatory and antiviral pathways thereby regulating cellular inflammatory responses and viral replication Naringenin exerts its biological activity primarily through inhibition of the NF- B pathway resulting in reduced inflammatory cytokine production Additionally it demonstrates antioxidative properties by scavenging reactive oxygen species (ROS) In in vitro studies naringenin exhibits inhibition of dengue virus replication with reported IC50 values ranging from approximately 52 64 M to 143 M depending on experimental conditions and viral strains Based on these pharmacological properties naringenin holds research potential in inflammation oxidative stress-related cellular models and dengue virus infection studies
Sigma Aldrich Fine Chemicals Biosciences Phospho Akt pSer473 pan
The Phospho-Akt (pSer473) ELISA (Enzyme-Linked Immunosorbent Assay) kit is a very rapid convenient and sensitive assay kit that can monitor the activation or function of important biological pathways in cell lysates.
Medchemexpress LLC 1,7-Bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one | 149732-52-5 | 292.33 | 1 MG
This product is 1,7-Bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one, a potent nucleocapsid (N) protein inhibitor derived from *Curcuma kwangsiensis*. It demonstrates significant antiviral activity, particularly against HCoV-OC43 and SARS-CoV-2.
- Potent nucleocapsid protein inhibitor
- Isolated from *Curcuma kwangsiensis*
- Exhibits excellent antiviral activity against HCoV-OC43
- Shows strong antiviral activity against SARS-CoV-2
- Ideal for antiviral research and related applications
Medchemexpress LLC (S)-(+)-1,2-propanediol | 4254-15-3 | 99.97% | C3H8O2 | 10 MM 1 ML
(S)-(+)-1,2-Propanediol is an endogenous metabolite. It can be used as an organic solvent and diluent in drug preparations. It can also be used as a chiral synthetic intermediate and a substrate for enzyme research. It is for research use only.
- Endogenous metabolite
- Organic solvent and diluent in drug preparations
- Chiral synthetic intermediate
- Substrate for enzyme research
- For research use only
Medchemexpress LLC (S)-(+)-1,2-Propanediol | 4254-15-3 | 99.8% | C₃H₈O₂ | 100 G
(S)-(+)-1,2-Propanediol is an endogenous metabolite that can be used as an organic solvent and diluent in drug preparations. It also serves as a chiral synthetic intermediate and a substrate for enzyme research.
- Used as an organic solvent and diluent
- Serves as a chiral synthetic intermediate
- Acts as a substrate for enzyme research
- Endogenous metabolite