Phenylpropanoids and polyketides
Medchemexpress LLC 7-Hydroxyflavone | 6665-86-7 | 100 MG
7-Hydroxyflavone is a flavonoid isolated from *Clerodendrum phlomidis*, demonstrating anti-inflammatory activity. It protects renal cells from nicotine (NIC)-associated cytotoxicity through the ERK/Nrf2/HO-1 pathway, and inhibits PKM2, COX-2, and 5-LOX. This compound is orally active.
- Isolated from *Clerodendrum phlomidis*
- Protects renal cells from nicotine-associated cytotoxicity
- Inhibits PKM2 with an IC50 of 2.12 μM
- Inhibits COX-2 and 5-LOX with IC50s of 27 μg/mL and 33 μg/mL
- Orally active
- Ameliorates neuropathic pain in mice models
- Improves high-fat diet-induced non-alcoholic fatty liver disease
- Reduces malondialdehyde (MDA) and ROS levels in HepG2 cells
Medchemexpress LLC Myricetin 3-O-glucoside (Myricetin 3-β-D-glucopyranoside) | 19833-12-6 | 1 MG
Myricetin 3-O-glucoside is a flavonol found in *Tibouchina paratropica* and Hakmeitau beans. It demonstrates anti-Leishmanial, anti-inflammatory, and antimicrobial activities. This product is for research use only.
- Demonstrates anti-Leishmanial activity
- Demonstrates anti-inflammatory activity
- Demonstrates antimicrobial activity
- Found in *Tibouchina paratropica* and Hakmeitau beans
Medchemexpress LLC 4'-Hydroxyflavone | 4143-63-9 | MFCD00017687 | 97.0% | 238.24 g/mol | C15H10O3 | 10 MG
4'-Hydroxyflavone is a flavone-class small molecule used in research as an aldose reductase inhibitor. It is supplied as a high-purity research reagent for biochemical assays and is commonly used in enzyme inhibition studies, structure-activity relationship (SAR) investigations, and small-molecule screening.
- High purity (97.0%)
- Molecular formula C15H10O3
- Molecular weight 238.24 g/mol
- CAS number 4143-63-9
- Reported aldose reductase IC50 12 μM
- Suitable for enzyme inhibition assays and SAR studies
Medchemexpress LLC 8-Hydroxycoumarin | 2442-31-1 | 99.6% | 162.14 | 1 ML
8-Hydroxycoumarin is an intermediate in the microbial transformation of quinolone. It is for research use only and not sold to patients.
- Intermediate in microbial transformation of quinolone
- Suitable for laboratory research applications
Medchemexpress LLC (-)-Epigallocatechin Gallate-d4 (EGCG-d4) | 989-51-5 | 97.14% | 462.40 | 1 MG
(-)-Epigallocatechin Gallate-d4 (EGCG-d4) | 989-51-5 | 97.14% | 462.40 | 1 MG
Apexbio Technology LLC Tyrphostin AG 1296 146535-11-7 10mM (in 1mL DMSO)
Tyrphostin AG 1296 (CAS 146535-11-7) is a selective inhibitor of platelet-derived growth factor receptor (PDGFR) kinase via ATP-competitive binding Its inhibitory activity (IC50 0 3 0 5 M) results from inducing conformational changes in the ATP-binding domain of PDGFR blocking receptor autophosphorylation induced by ligand binding In vitro studies demonstrate inhibition of PDGF-stimulated mitogenesis (IC50 1 5 M) and cell proliferation (IC50 3 2 M) using Swiss 3T3 cells without significant effects on EGF receptor signaling at concentrations up to 100 M Tyrphostin AG 1296 serves as a research tool for investigating PDGFR-mediated signaling pathways
![Research Products International Corp Trans-Cinnamic Acid [B-Phenylacrylic acid], 25 Grams](https://assets.fishersci.com/TFS-Assets/CCG/product-images/VN00006095-C34400-25.0.JPG-250.jpg)
Research Products International Corp Trans-Cinnamic Acid [B-Phenylacrylic acid], 25 Grams
Auxin like growth regulator.
Medchemexpress LLC 3-Acetylcoumarin | 3949-36-8 | 97.0% | 188.18 | 1 ML
3-Acetylcoumarin (Compound 4) is a chemical compound demonstrating acaricidal activity against Tetranychus cinnabarinus. It also inhibits human recombinant MAO-B with an IC50 of 14.45 μM and exhibits cytotoxicity against human SH-SY5Y cells with an IC50 of 75 μM.
- Exhibits acaricidal activity against Tetranychus cinnabarinus
- Inhibits human recombinant MAO-B (IC50 of 14.45 μM)
- Demonstrates cytotoxicity against human SH-SY5Y cells (IC50 of 75 μM)
Medchemexpress LLC Tyrphostin AG1296 | 146535-11-7 | 99.7% | 266.29 | 25 MG
Tyrphostin AG1296 is a potent and selective inhibitor of platelet-derived growth factor receptor (PDGFR), with an IC50 of 0.8 μM. It inhibits signaling of human PDGF α- and β-receptors, as well as the related stem cell factor receptor (c-Kit). This compound is also a potent inhibitor of FLT3, with an IC50 in the micromolar range.
- Potent and selective inhibitor of platelet-derived growth factor receptor (PDGFR)
- Inhibits signaling of human PDGF α- and β-receptors
- Inhibits signaling of the related stem cell factor receptor (c-Kit)
- Potent inhibitor of FLT3
- Suppresses viability of PLX4032-resistant melanoma cells
- Induces apoptosis of A375R cells
- Inhibits PDGFR phosphorylation
- Suppresses A375R tumor growth in vivo
- Inhibits atherosclerotic plaque progression
Medchemexpress LLC 3′-hydroxyflavanone | 92496-65-6 | MFCD00017738 | >=98.0% | 240.25 g/mol | C15H12O3 | 250 MG
3′-Hydroxyflavanone is a cyclized flavanone research compound reported to induce apoptosis in HeLa cells and to possess antitumor activity. It is supplied as a solid for research use and is characterized by its molecular formula and reported physicochemical properties.
Medchemexpress LLC Daunorubicin hydrochloride | 23541-50-6 | 99.7% | 500 MG
Daunorubicin hydrochloride, also known as Daunomycin, is a potent topoisomerase II inhibitor with significant anti-tumor activity. This anthracycline antibiotic functions by inhibiting DNA and RNA synthesis, leading to the suppression of cancer cell viability. It is recognized for its ability to induce apoptosis and necrosis in target cells.
- Potent anti-tumor agent
- Inhibits DNA and RNA synthesis
- Induces apoptosis and necrosis
- Anthracycline antibiotic
- Useful in research for various cancers, including leukemia and lymphomas
Medchemexpress LLC 4-Methoxycinnamic acid | 830-09-1 | 178.19 | 1 ML
4-Methoxycinnamic acid | 830-09-1 | 178.19 | 1 ML
Medchemexpress LLC Oxytetracycline dihydrate | 6153-64-6 | 99.4% | 500 MG
Oxytetracycline dihydrate is an antibiotic of the tetracycline class, acting as a potent inhibitor of both Gram-negative and Gram-positive bacteria. It functions by preventing the binding of aminoacyl-tRNA to the m-ribosomal RNA complex and also exhibits anti-HSV-1 activity. This compound is synthesized by a type II polyketide synthase from microorganisms, specifically *Streptomyces rimosus*.
- Inhibits Gram-negative and Gram-positive bacteria
- Acts as a protein synthesis inhibitor
- Exhibits anti-HSV-1 activity
- Light yellow to yellow solid appearance
Medchemexpress LLC Cinnamyl-3,4-dihydroxy-α-cyanocinnamate (CDC) | 132465-11-3 | 99.41% | 321.33 | 50 MG
Cinnamyl-3,4-dihydroxy-α-cyanocinnamate (CDC) is a potent inhibitor of 12/15-Lipoxygenases (LO) with potential for type 1 diabetes mellitus research. In vitro studies demonstrated that CDC partially suppressed dextran transport, while in vivo, it antagonized the effect of high glucose on protein phosphorylation, mitigating endothelial cell barrier destruction in a mouse diabetes mellitus model.
- Potent 12/15-Lipoxygenases (LO) inhibitor
- Potential for research of type 1 diabetes mellitus
- Partially suppressed dextran transport increased by high glucose or 12(S)-HETE in vitro
- Antagonized the effect of high glucose on protein phosphorylation in vivo
- Mitigated endothelial cell barrier destruction in a mouse diabetes mellitus model