Phenylpropanoids and polyketides
Selleck Chemical LLC AMG-458 S2747-50mg
AMG 458 is a potent c-Met inhibitor with Ki of 1 2 nM 350-fold selectivity for c-Met than VEGFR2 in cells
TARGETMOL CHEMICALS INC Seviteronel R enantiomer 1MG
Also available in 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Seviteronel R enantiomer (VT-464 R enantiomer) is a Seviteronel isomer produced during the manufacturing process. Purity 99.98%
Aobchem (1E 2E)-1 2-Bis(2 6-Diisopropylphenylimino)ethane | ≥95% | CAS 74663-75-5 | C26H36N2 | 500mg
(1E 2E)-1 2-Bis(2 6-Diisopropylphenylimino)ethane | ≥95% | CAS 74663-75-5 | C26H36N2 | 500mg
![eMolecules N-(1-[4-(dimethylamino)phenyl]-3-{2-[(4-hydroxy-3-iodo-5-methoxyphenyl)methylidene]hydrazinyl}-3-oxoprop-1-en-2-yl)benzamide | ChemDiv SC |584.414 | C26H25IN4O4COc1cc(\C=N\NC(=O)C(\NC(=O)c2ccccc2)=C/c2ccc(cc2)N(C)C)cc(I)c1O | 2mg | 828451810](https://assets.fishersci.com/TFS-Assets/CCG/product-images/NC3733135.jpg-250.jpg)
eMolecules N-(1-[4-(dimethylamino)phenyl]-3-{2-[(4-hydroxy-3-iodo-5-methoxyphenyl)methylidene]hydrazinyl}-3-oxoprop-1-en-2-yl)benzamide | ChemDiv SC |584.414 | C26H25IN4O4COc1cc(\C=N\NC(=O)C(\NC(=O)c2ccccc2)=C/c2ccc(cc2)N(C)C)cc(I)c1O | 2mg | 828451810
N-(1-[4-(dimethylamino)phenyl]-3-{2-[(4-hydroxy-3-iodo-5-methoxyphenyl)methylidene]hydrazinyl}-3-oxoprop-1-en-2-yl)benzamide | ChemDiv SC |584.414 | C26H25IN4O4COc1cc(\C=N\NC(=O)C(\NC(=O)c2ccccc2)=C/c2ccc(cc2)N(C)C)cc(I)c1O | 2mg | 828451810
Apexbio Technology LLC (E,E)-Bisdemethoxycurcumin 33171-05-0 10mg
(E E)-Bisdemethoxycurcumin (CAS 33171-05-0) is a naturally derived curcuminoid and a structural analog within the demethoxycurcumin class Research demonstrates that this compound modulates multiple inflammatory signaling pathways and alters the expression of various inflammatory mediators It has been shown to induce cell cycle arrest promote apoptosis in cancer cells and inhibit proliferation-related pathways (E E)-Bisdemethoxycurcumin is widely utilized in studies investigating the molecular mechanisms of inflammation tumor cell biology and the pharmacological properties of curcuminoid derivatives
Medchemexpress LLC Curcumin 5-8 | 890984-26-6 | 98.6% | 339.39 | 1 ML
Curcumin 5-8 (CUR5-8) is a potent and orally active naturally active curcumin (CUR) analog. It inhibits lipid droplet formation, increases autophagy, inhibits Apoptosis, and improves insulin resistance and insulin sensitivity.
- Potent and orally active curcumin analog
- Inhibits lipid droplet formation
- Increases autophagy
- Inhibits apoptosis
- Improves insulin resistance and insulin sensitivity
- Decreases palmitic acid (PA)-induced SREBP1 expression levels in AML12 cells
- Ameliorates insulin resistance and hepatic steatosis in mice with high-fat diet-induced obesity
Medchemexpress LLC Curcumin 5-8 | 890984-26-6 | 98.6% | 339.39 | 25 MG
Curcumin 5-8 (CUR5-8) is a potent and orally active naturally active curcumin (CUR) analog. It inhibits lipid droplet formation, increases autophagy, and inhibits apoptosis. Curcumin 5-8 also improves insulin resistance and insulin sensitivity. This product is for research use only and not sold to patients.
- Potent and orally active naturally active curcumin (CUR) analog.
- Inhibits lipid droplet formation.
- Increases autophagy.
- Inhibits apoptosis.
- Improves insulin resistance and insulin sensitivity.
- For research use only and not sold to patients.
Selleck Chemical LLC AG 494
AG-494 a member of the tyrphostin family of tyrosine kinase inhibitors is a potent inhibitor of EGF receptor autophosphorylation (IC50 1 2 M) and EGF-dependent cell growth (IC50 6 M)
Medchemexpress LLC Tyrphostin AG 112 | 144978-82-5 | 98.3% | 236.23 | 25 MG
Tyrphostin AG 112 is an EGFR phosphorylation inhibitor intended for research use only. It inhibits EGFR in human A431 cells with an IC50 of 0.1 μM.
- EGFR phosphorylation inhibitor
- Inhibits EGFR in human A431 cells with an IC50 of 0.1 μM
- For research use only
- Appears as a light yellow to yellow solid
eMolecules 2699937-04-5 | Medchem Express | MRL-494 (hydrochloride) | 5mg | 552386588 | HY-128773A | 659.13 | C26H36ClFN16O2
Medchem Express | Apramycin (sulfate) | 100mg | 446273816 | HY-B1329 | 65710-07-8 | 637.660 | C21H43N5O15S
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Selleck Chemical LLC Tyrphostin AG-528
Tyrphostin AG-528 (Tyrphostin B66) is a potent inhibitor of epidermal growth factor receptors (EGFR) and ErbB2/HER2 with IC50 of 4 9 M and 2 1 M respectively Tyrphostin AG-528 exhibits anticancer activity
Medchemexpress LLC Tyrphostin A1 | 2826-26-8 | 99.0% | 184.19 | 10 MG
Tyrphostin A1 (AG9) inhibits CD40L-stimulated IL-12 production in macrophage cultures and antigen-induced generation of Th1 cells. It is for research use only.
- Inhibits CD40L-stimulated IL-12 production in macrophage cultures
- Decreases IL-12 p40 production in a dose-dependent manner
- Blocks CD40L-induced translocation of NF-κB to the nucleus
- Reduces activation of IL-12 p40 gene
- Leads to a decrease in the generation of myelin basic protein (MBP) specific encephalitogenic T cells in vivo therapy
- Attenuates experimental allergic encephalomyelitis (EAE) in SJL/J mice
- Weaker inhibitor of TK compared to other tyrphostins, useful for differentiating TK-mediated effects
Medchemexpress LLC Tyrphostin A1 | 2826-26-8 | 99.0% | 184.19 | 100 MG
Tyrphostin A1 inhibits CD40L-stimulated IL-12 production in macrophage cultures and antigen-induced generation of Th1 cells. It causes a dose-dependent decrease of IL-12 p40 and blocks CD40L-induced translocation of NF-κB to the nucleus, reducing activation of the IL-12 p40 gene. This compound is a weaker inhibitor of TK, often used to differentiate TK-mediated effects from other non-specific effects.
- Inhibits CD40L-stimulated IL-12 production
- Reduces antigen-induced generation of Th1 cells
- Blocks CD40L-induced translocation of NF-κB to the nucleus
- Attenuates experimental allergic encephalomyelitis (EAE) in SJL/J mice
- Useful for differentiating TK-mediated effects from non-specific effects
- For research use only
Medchemexpress LLC Curcumin 5-8 | 890984-26-6 | 98.6% | 339.39 | 5 MG
Curcumin 5-8 is a potent and orally active natural curcumin analog. It inhibits lipid droplet formation, increases autophagy, and inhibits apoptosis. It also improves insulin resistance and insulin sensitivity.
- Inhibits lipid droplet formation.
- Increases autophagy.
- Inhibits apoptosis.
- Improves insulin resistance.
- Improves insulin sensitivity.