Phenylpropanoids and polyketides
Medchemexpress LLC 4'-Methoxyflavone | 4143-74-2 | 99.63% | 252.26 | 25 MG
4'-Methoxyflavone is a flavonoid with antioxidant properties and anti-proliferative activity against cancer cells. It can inhibit cycle-dependent kinases, leading to cell cycle arrest, and regulate cell signaling pathways to influence cell proliferation and apoptosis. This compound can be used in cancer chemoprevention research.
- Flavonoid with antioxidant properties
- Anti-proliferative activity against cancer cells
- Inhibits cycle-dependent kinases
- Leads to cell cycle arrest
- Regulates cell signaling pathways to influence cell proliferation and apoptosis
- Used in cancer chemoprevention research
AdipoGen Doxorubicin hydrochloride
Chemical. CAS 25316-40-9. Formula C27H29NO11 . HCl. MW 579.98. Doxorubicin, a broad spectrum anthracycline antibiotic, inhibits DNA and RNA synthesis in mammalian cells and has been shown to be a very effective anti-tumor agent. Doxorubicin binds to nucleic acids by intercalating the DNA double helix and stabilizing topoisomerase II cleavage complexes, leading to DNA strand breaks at specific doxorubicin-induced sites and formation of reactive oxygen species ROS in cells. It also been shown to evict histones leading to chromatin damage. Doxorubicin induces apoptosis by inducing the accumulation of the p53 tumor suppressor protein and has been shown to have immunosuppressive properties. DOX can reduce mitochondrial NADH accumulation and impair oxidative phosphorylation in heart tissues, events associated with reduced glucose uptake.
AdipoGen Doxorubicin hydrochloride
Chemical. CAS 25316-40-9. Formula C27H29NO11 . HCl. MW 579.98. Doxorubicin, a broad spectrum anthracycline antibiotic, inhibits DNA and RNA synthesis in mammalian cells and has been shown to be a very effective anti-tumor agent. Doxorubicin binds to nucleic acids by intercalating the DNA double helix and stabilizing topoisomerase II cleavage complexes, leading to DNA strand breaks at specific doxorubicin-induced sites and formation of reactive oxygen species ROS in cells. It also been shown to evict histones leading to chromatin damage. Doxorubicin induces apoptosis by inducing the accumulation of the p53 tumor suppressor protein and has been shown to have immunosuppressive properties. DOX can reduce mitochondrial NADH accumulation and impair oxidative phosphorylation in heart tissues, events associated with reduced glucose uptake.
TARGETMOL CHEMICALS INC Rifabutin 200MG
Also available in 1 mL, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Rifabutin (LM-427) inhibits bacterial DNA-dependent RNA polymerase, thereby suppressing the initiation of RNA formation and leading to inhibition of RNA synthesis and transcription. Rifabutin is a semisynthetic ansamycin antibiotic with potent antimycobacterial properties. Purity 99.27%
Medchemexpress LLC AMG 487 | 473719-41-4 | C32H28F3N5O4 | 100 MG
AMG 487 is an orally active and selective antagonist of CXC chemokine receptor 3 (CXCR3). It inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively.
- Targets CXCR3
- Involved in GPCR/G Protein and immunology/inflammation pathways
- Inhibits CXCR3-mediated cell migration
- Inhibits calcium mobilization
- Leads to fewer lung metastases
- Reduces tumor volume
Medchemexpress LLC Epothilone B | 152044-54-7 | 99.9% | 507.68 | 1 ML
Epothilone B is a microtubule stabilizer (MSA) with a Ki of 0.71μM and possesses blood-brain barrier permeability. It functions by binding to the αβ-tubulin heterodimer subunit, which leads to a decrease in αβ-tubulin dissociation. It is intended for research use only and is not sold to patients.
- Microtubule stabilizer (MSA)
- Blood-brain barrier permeability
- Binds to the αβ-tubulin heterodimer subunit
- Decreases αβ-tubulin dissociation
Medchemexpress LLC (-)-Catechin | 18829-70-4 | 290.27 | 100 MG
(-)-Catechin is a form of catechin that inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM. It promotes the differentiation of human bone marrow mesenchymal stem cells (hBM-MSC) into adipose cells, leading to increased fat cell differentiation and higher levels of PPARγ. This compound is intended for research use only.
- Inhibits cyclooxygenase-1 (COX-1).
- Promotes hBM-MSC adipose cell differentiation.
- Increases fat cell differentiation.
- Elevates PPARγ levels.
Medchemexpress LLC (-)-Catechin | 18829-70-4 | 290.27 | 1 ML
(-)-Catechin is a structural isomer of Catechin. It inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM. Additionally, (-)-Catechin promotes the differentiation of hBM-MSC adipose cells, leading to increased fat cell differentiation and PPARγ levels. It is intended for research use only.
- Inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM.
- Promotes adipocyte differentiation in human bone marrow mesenchymal stem cells (hBM-MSC).
- Increases fat cell differentiation.
- Increases PPARγ level.
Medchemexpress LLC Daunorubicin hydrochloride | 23541-50-6 | 99.7% | 500 MG
Daunorubicin hydrochloride, also known as Daunomycin, is a potent topoisomerase II inhibitor with significant anti-tumor activity. This anthracycline antibiotic functions by inhibiting DNA and RNA synthesis, leading to the suppression of cancer cell viability. It is recognized for its ability to induce apoptosis and necrosis in target cells.
- Potent anti-tumor agent
- Inhibits DNA and RNA synthesis
- Induces apoptosis and necrosis
- Anthracycline antibiotic
- Useful in research for various cancers, including leukemia and lymphomas
Medchemexpress LLC Luteolin-7-rutinoside | 20633-84-5 | 5 MG
Luteolin-7-rutinoside possesses both anti-arthritic and antifungal activities, which can lead to a combination therapy for treating fungal arthritis caused by *C. albicans* infection. It is intended for research use only and not for sale to patients.
- Possesses anti-arthritic activity.
- Possesses antifungal activity.
- Reduces proliferation of T cells in a dose-dependent manner.
- Shifts Th1-Th2 balance away from Th1 towards Th2-type responses.
- Inhibits nitric oxide (NO) production from macrophages.
Apexbio Technology LLC 2-Methoxycinnamaldehyde 1504-74-1 100mg
2-Methoxycinnamaldehyde (CAS 1504-74-1) is a natural compound derived from cinnamon investigated for its biomedical properties Studies indicate that it disrupts mitochondrial membrane potential leading to mitochondrial dysfunction This effect is associated with the activation of caspase-3 and caspase-9 resulting in the induction of apoptosis and reduced cellular proliferation Additionally 2-Methoxycinnamaldehyde has been shown to inhibit the migration of human aortic smooth muscle cells in response to platelet-derived growth factor (PDGF) These attributes support its application in research exploring cancer cell apoptosis and vascular smooth muscle cell biology
Selleck Chemical LLC Doxorubicin (DOX) HCl S1208-1g
Doxorubicin (DOX) HCl is an antibiotic agent that inhibits human DNA topoisomerase I and topoisomerase II with IC50s of 0 8 M and 2 67 M respectively Doxorubicin reduces basal phosphorylation of AMPK Doxorubicin is used in the concomitant treatment of HIV-infected patients but is found to be at high risk of HBV reactivation This product may precipitate when dissolved in PBS solution It is recommended to prepare the stock solution in pure water and dilute with either pure water or saline to obtain the working solution Doxorubicin (Adriamycin) HCl can be used to induce animal models of kidney disease
Medchemexpress LLC Puerarin | 3681-99-0 | 98.9% | 416.38 | 1 ML
Puerarin is an isoflavone extracted from Pueraria root, functioning as a 5-HT2C receptor antagonist. It inhibits the dorsal motor nucleus of the vagus (DMV)-vagus nerve pathway, which leads to decreased fat absorption.
- Acts as a 5-HT2C receptor antagonist
- Inhibits LPS-induced iNOS, COX-2, and CRP protein and mRNA expression
- Functions as a novel open-channel blocker of IK1
- Alleviates hepatic damage from chronic alcohol administration
- Improves early-stage renal damage in diabetic rats
Apexbio Technology LLC Alogliptin Benzoate 850649-62-6 10mg
Alogliptin Benzoate (CAS 850649-62-6) is a potent and highly selective inhibitor of dipeptidyl peptidase-4 (DPP-4) with an IC50 below 10 nM By suppressing DPP-4 activity alogliptin elevates active GLP-1 levels leading to improved glycemic parameters In ob/ob mouse models chronic administration results in dose-dependent reductions in plasma DPP-4 activity non-fasting blood glucose glycated hemoglobin and triglycerides along with increased insulin secretion and pancreatic insulin content Alogliptin Benzoate is widely used in research focused on incretin biology glucose homeostasis and the pharmacological modulation of DPP-4
Apexbio Technology LLC Alogliptin Benzoate 850649-62-6 50mg
Alogliptin Benzoate (CAS 850649-62-6) is a potent and highly selective inhibitor of dipeptidyl peptidase-4 (DPP-4) with an IC50 below 10 nM By suppressing DPP-4 activity alogliptin elevates active GLP-1 levels leading to improved glycemic parameters In ob/ob mouse models chronic administration results in dose-dependent reductions in plasma DPP-4 activity non-fasting blood glucose glycated hemoglobin and triglycerides along with increased insulin secretion and pancreatic insulin content Alogliptin Benzoate is widely used in research focused on incretin biology glucose homeostasis and the pharmacological modulation of DPP-4