Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
![Medchemexpress LLC Coenzyme A S-[2-[[(5S)-5-(acetylamino)-6-amino-6-oxohexyl]amino]-2-oxoethyl] trifluoroacetic acid | 00-00-0 | 98.5% | C33H54F3N10O21P3S | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000261718.png-250.jpg)
Medchemexpress LLC Coenzyme A S-[2-[[(5S)-5-(acetylamino)-6-amino-6-oxohexyl]amino]-2-oxoethyl] trifluoroacetic acid | 00-00-0 | 98.5% | C33H54F3N10O21P3S | 10MG
Lys-CoA TFA (Lys-coenzyme A) is a selective inhibitor of the p300 histone acetyltransferase used as a biochemical tool to study p300-mediated acetylation and transcriptional regulation. It exhibits nanomolar potency against p300 and marked selectivity over related acetyltransferases, and is supplied as a high-purity solid for laboratory research.
- Selective p300 HAT inhibitor with p300 IC50 50-500 nM
- Greater than 100-fold selectivity over PCAF
- High purity (98.5%) for research applications
- Solid, white to off-white physical form
- Recommended sealed storage at -20°C; in solvent store at -80°C for long-term
Medchemexpress LLC N-acetyl-L-valyl-L-alpha-glutamyl-L-isoleucyl-L-aspart-1-al | 00-00-0 | MFCD01318861 | 99.8% | 614.57 g/mol | C24H37F3N4O11 | 5 MG
Ac-VEID-CHO TFA is a peptide-derived aldehyde inhibitor of caspases used in biochemical research to study apoptosis and neurodegenerative disease mechanisms. The trifluoroacetate salt is supplied as a white to off-white solid with high purity and is suitable for assays requiring nanomolar potency against executioner caspases.
- Purity 99.8% by HPLC.
- Potent inhibition of caspase-3, caspase-6, and caspase-7 (IC50: 13.6 nM, 16.2 nM, 162.1 nM).
- Supplied as a solid, white to off-white powder.
- Soluble in water at approximately 1 mg/mL with sonication and warming.
- Storage recommendations include cold, sealed conditions to preserve stability.
- Designed for research applications in apoptosis and neurodegenerative disease models.
- Available in small research-scale quantities for assay development.
Medchemexpress LLC LL-37 amide (TFA) | 99.34% | 4492.28 | 5 MG
LL-37 amide TFA is a selective agonist of formyl peptide receptor-like FPRL1, effectively inhibiting periodontal pathogens. It exerts bactericidal effects by activating immune cell chemotaxis and disrupting bacterial cell membrane integrity. This peptide also regulates inflammatory responses and promotes angiogenesis. Its amidation modification reduces sensitivity to serum inhibition and improves stability, making it suitable for research on infection-related diseases like periodontal disease, deep tissue injuries, and wound healing.
- Selective agonist of formyl peptide receptor-like FPRL1
- Inhibits periodontal pathogens
- Exerts bactericidal effects
- Regulates inflammatory responses
- Promotes angiogenesis
- Improved stability and resistance to enzymatic degradation
- Useful in research for infection-related diseases and wound healing
- Effective against Gram-positive and Gram-negative bacteria
Medchemexpress LLC [D-Lys6]-LH-RH TFA | 1253.41 (free base) | 50 MG
[D-Lys6]-LH-RH TFA is a Luteinizing-hormone-releasing hormone (LHRH) analogue that acts as a GnRH receptor agonist. It is used in research, including studies on the inhibition of growth of experimental prostate cancer.
- Luteinizing-hormone-releasing hormone (LHRH) analogue
- Acts as a GnRH receptor agonist
- Used in research, including studies on the inhibition of growth of experimental prostate cancer
Chem-Impex International, Inc. Trifluoroacetic acid | 76-05-1 | MFCD00004169 | 100G
Trifluoroacetic acid, 76-05-1, MFCD00004169, 100G
Medchemexpress LLC Apstatin trifluoroacetate | 99.4% | 573.56 g/mol | C25H34F3N5O7 | 5 MG
Apstatin TFA is the trifluoroacetate salt of apstatin, a potent aminopeptidase P (APP) inhibitor with reported Ki values of 2.6 μM (rat) and 0.64 μM (human). It has been used in preclinical studies showing cardioprotective effects and is supplied as a solid research compound for biochemical and pharmacological applications.
- Potent aminopeptidase P inhibitor with reported Ki values of 2.6 μM (rat) and 0.64 μM (human).
- Demonstrated cardioprotective effects in preclinical studies.
- Supplied as a solid with reported purity of 99.43%.
- Molecular formula C25H34F3N5O7 and molecular weight 573.56 g/mol.
- Recommended storage: powder -80°C (2 years) or -20°C (1 year); protect from moisture.
- Available in small research pack sizes suitable for preclinical experiments.
Medchemexpress LLC Forigerimod trifluoroacetate | 00-00-0 | 99.9% | C117H181N34O32PS·xC2HF3O2 | 5 MG
Forigerimod TFA is a 21-amino-acid peptide fragment supplied as the trifluoroacetate salt. It acts as a CD4 T-cell modulator and has been used in research on autophagy and autoimmune disorders, including systemic lupus erythematosus. Supplied as a powder with high listed purity, it is intended for research use in cellular and immunology studies.
- 21-amino-acid peptide, TFA salt
- High purity suitable for research (listed 99.88%)
- Soluble in DMSO and water at 100 mg/mL with sonication
- Powder storage: -80°C (2 years) or -20°C (1 year)
- In solvent storage: -80°C (6 months) or -20°C (1 month)
Medchemexpress LLC L-lysyl-L-cysteine trifluoroacetate | 97.8% | 477.38 g/mol | C13H21F6N3O7S | 5 MG
L-lysyl-L-cysteine trifluoroacetate is a dipeptide formed from lysine and cysteine, provided as a solid TFA salt for research use. The material is characterized by a reported purity, defined molecular formula and molecular weight, and specified storage recommendations for powder and solutions.
- Dipeptide composed of lysine and cysteine.
- Supplied as trifluoroacetate (TFA) salt in solid powder form.
- Reported purity 97.8%.
- Molecular formula C13H21F6N3O7S and molecular weight 477.38 g/mol.
- Available in small research quantities: 5 mg, 10 mg, 25 mg.
- Store sealed, away from moisture; powder: -80°C for 2 years, -20°C for 1 year; in solvent: -80°C for 6 months, -20°C for 1 month.
Medchemexpress LLC MIP-1095 trifluoroacetate | 00-00-0 | MFCD09802015 | 99.8% | 678.35 g/mol | C21H26F3IN4O10 | 5 MG
MIP-1095 trifluoroacetate is a small-molecule inhibitor of prostate-specific membrane antigen used for research and imaging probe development. The compound is supplied as a high-purity trifluoroacetate salt, suitable for radiolabeling and preclinical assays.
- Potent inhibitor of prostate-specific membrane antigen (PSMA).
- Provided as trifluoroacetate (TFA) salt for stability.
- High purity suitable for research applications.
- Compatible with radiolabeling for imaging probe development.
- Soluble in DMSO for assay preparation.
- Available in small-mass quantities for preclinical studies.
Hampton Research 50% W/V POLYETHYLENE GL 200ML
HR2-607/50% w/v Polyethylene glycol 10,000 - 200 ml. Please note items from this supplier are non-returnable.
Medchemexpress LLC Achn-975 tfa | 1410809-37-8 | 99.0% | 483.44 | 1 ML
ACHN-975 TFA is a selective LpxC inhibitor that demonstrates subnanomolar LpxC inhibitory activity. It is effective against a broad spectrum of gram-negative bacteria, exhibiting low MIC values (≤1 μg/mL).
- Selective LpxC inhibitor.
- Exhibits subnanomolar LpxC inhibitory activity.
- Active against a wide range of gram-negative bacteria.
- Demonstrates low MIC values (≤1 μg/mL).
eMolecules Oakwood Chemical Trifluoroacetic acid biochemical grade 1kg 662699512 008708 0 000 76-05-1 MFCD00004169 114 023 C2HF3O2
Oakwood Chemical Trifluoroacetic acid biochemical grade 1kg 662699512 008708 0 000 76-05-1 MFCD00004169 114 023 C2HF3O2