Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Cl2e-SN-38 TFA | 99.1% | 1855.95 | C89H117F3N14O26 | 25 MG
CL2E-SN38 TFA is a trifluoroacetate salt of an antibody-linked SN-38 conjugate used for antibody-drug conjugate (ADC) research. It acts as a topoisomerase I inhibitor and is supplied as a high-purity solid characterized for in vitro and in vivo formulation.
- Purity: 99.07% (reported on product page)
- Form: trifluoroacetate salt
- Molecular weight: 1855.95
- Chemical formula: C89H117F3N14O26
- Solubility: soluble in DMSO (example: 100 mg/mL); in vivo formulations reported at ≥2.5 mg/mL
- Storage: protect from light; store under nitrogen; in solvent: -80°C for long term
- Intended use: research reagent for ADC development and topoisomerase I inhibition studies
Medchemexpress LLC UNC0379 trifluoroacetate | 1620401-83-3 | MFCD28167817 | 99.9% | 527.58 g·mol⁻¹ | C25H36F3N5O4 | 5MG
UNC0379 trifluoroacetate is the trifluoroacetate salt of UNC0379, a selective substrate-competitive inhibitor of the lysine methyltransferase SETD8 (KMT5A). It is supplied as a high-purity research reagent for biochemical and cellular studies, with reported activity IC50 = 7.3 μM and KD = 18.3 μM. For laboratory research use only.
Medchemexpress LLC Qtx125 tfa | 2989537-78-0 | 99.9% | 25 MG
QTX125 TFA is the trifluoroacetate salt of QTX125, a potent and highly selective HDAC6 inhibitor with reported antitumor activity. It is supplied as a high-purity off-white to gray solid for biochemical and cell-based research.
- Potent, selective inhibition of HDAC6.
- High purity (99.9%) suitable for research applications.
- Available in 25 MG solid packs for laboratory use.
- Stable when stored sealed away from moisture; recommended storage at 4°C, with longer-term solvent storage at -80°C.
- Applicable to biochemical assays and cell-based antitumor studies.
Medchemexpress LLC Ampreloxetine TFA | 1227056-85-0 | 98.3% | 25 MG
Ampreloxetine TFA (trifluoroacetate) is the TFA salt of ampreloxetine (TD-9855), an orally active inhibitor of norepinephrine and serotonin uptake supplied as a solid research reagent. It is intended for in vitro and preclinical research and is provided in small package sizes with recommended refrigerated storage.
- Potent norepinephrine and serotonin uptake inhibitor.
- Trifluoroacetate (TFA) salt, solid form.
- Purity 98.3%.
- Molecular weight 435.36 g/mol.
- Available in small research sizes, including 25 mg.
- Storage: 4°C sealed; in solvent: -80°C (6 months), -20°C (1 month).
Medchemexpress LLC Ac-VEID-CHO (trifluoroacetate salt) | 00-00-0 | 99.8% | 614.57 Da | C24H37F3N4O11 | 1 MG
Ac-VEID-CHO (TFA) is a peptide-derived reversible caspase inhibitor intended for in vitro research into apoptosis and neurodegenerative pathways. It is supplied as a trifluoroacetate salt and demonstrates potent inhibition of several executioner caspases in biochemical assays. Not for human or clinical use.
- Reversible caspase inhibitor targeting caspase-6, caspase-3, and caspase-7.
- Reported IC50 values in the low nanomolar range for primary targets.
- High purity suitable for biochemical assays (99.8%).
- Available in small mg-scale quantities for research use.
- Limited cellular activity due to poor cellular accumulation.
Medchemexpress LLC W146 trifluoroacetate | 909725-62-8 | 98.2% | 456.39 g/mol | C18H28F3N2O6P | 25 MG
W146 trifluoroacetate is a research-grade selective antagonist of sphingosine-1-phosphate receptor 1 (S1PR1). Supplied as the trifluoroacetate salt in a white to off-white solid form, it has an EC50 of 398 nM, a molecular weight of 456.39 g/mol, and is typically supplied at high purity for in vitro pharmacology and receptor signaling studies. Not for human or clinical use.
- Selective S1PR1 antagonist with EC50 398 nM
- Provided as trifluoroacetate salt for stability
- High purity suitable for biochemical assays
- White to off-white solid for easy handling
- Intended for in vitro pharmacology and receptor signaling studies
Medchemexpress LLC Zifanocycline trifluoroacetate | 00-00-0 | 99.8% | 666.64 g/mol | C31H37F3N4O9 | 5 MG
Zifanocycline TFA is an orally active, semi-synthetic aminomethylcycline antibiotic supplied as the trifluoroacetate salt for research use. It inhibits bacterial ribosome function and demonstrates broad-spectrum in vitro activity against Gram-positive and Gram-negative bacteria, including multidrug-resistant strains. Supplied at high purity for laboratory studies and antimicrobial research applications.
- Orally active aminomethylcycline antibiotic.
- Broad-spectrum activity against gram-positive and gram-negative bacteria.
- Useful for studying skin infections, community-acquired pneumonia, and intra-abdominal infections.
- High purity, suitable for analytical and biological assays.
- Provided as the trifluoroacetate (TFA) salt for improved handling.
- Molecular weight 666.64 g/mol.
Medchemexpress LLC Thymotrinan | 00-00-0 | MFCD00237286 | 98.7% | 531.48 g·mol⁻¹ | C18H32F3N7O8 | 5 MG
Thymotrinan TFA is the trifluoroacetate (TFA) salt of a biologically active fragment of the thymus hormone thymopoietin. It exhibits immunomodulatory activity similar to TP5, affecting both humoral and cellular immune responses, and is supplied as a white to off-white solid for research use. Manufacturer storage and handling guidelines should be followed.
Medchemexpress LLC Glutaurine TFA 5mg | 5MG
Glutaurine (Litoralon) TFA containing glutamine and taurine residues is an orally active hormone of the parathyroid Glutaurine (Litoralon) TFA as a hormone is isolated from parathyroid gland oxyphil cells Glutaurine (Litoralon) TFA can be used for the research of antiepileptic and anti-amnesia[1 [2 [3 [4
Medchemexpress LLC Huwentoxin-IV TFA | 526224-73-7 | 4106.78 | 500 UG
Huwentoxin-IV is a potent and selective sodium channel blocker. It inhibits neuronal Nav1.7, Nav1.2, Nav1.3, and Nav1.4, with preferential blocking of peripheral nerve subtype Nav1.7. This compound has also demonstrated analgesic effects in animal models of inflammatory and neuropathic pain.
- Potent and selective sodium channel blocker
- Inhibits neuronal Nav1.7, Nav1.2, Nav1.3, and Nav1.4
- Preferentially blocks peripheral nerve subtype Nav1.7
- Binds to neurotoxin receptor site 4
- Analgesic effects in animal models of inflammatory and neuropathic pain
Medchemexpress LLC Diprotin A TFA | 209248-71-5 | 99.6% | 455.47 | 50 MG
Diprotin A TFA (Ile-Pro-Ile TFA) is an inhibitor of dipeptidyl peptidase IV (DPP-IV) for research use only. It increases the phosphorylation of Src and vascular endothelial-cadherin (VE-cadherin) in human endothelial cells and disrupts endothelial cell-to-cell junctions. In in vivo models, it has been shown to increase retinal vascularity and leakage, and aggravate vascular leakage in diabetic retinopathy by augmenting the SDF-1α/CXCR4/Src/VE-cadherin signaling pathway.
- Inhibits dipeptidyl peptidase IV (DPP-IV).
- Increases phosphorylation of Src and vascular endothelial-cadherin (VE-cadherin) in human endothelial cells.
- Disrupts endothelial cell-to-cell junctions.
- Induces vascular leakage by augmenting the SDF-1α/CXCR4/Src/VE-cadherin signaling pathway.
Medchemexpress LLC Atwlppr peptide tfa | 98.6% | 954.00 | 5 MG
ATWLPPR Peptide TFA is a heptapeptide that acts as a selective neuropilin-1 inhibitor. It prevents VEGF165 binding to NRP-1 and is utilized in angiogenesis research, showing promise in reducing early retinal damage associated with diabetes.
- Inhibits VEGF165 binding to neuropilin-1 by 82% at 100 μM
- Preserves vascular integrity and reduces oxidative stress in vivo
- May decrease early retinal damage associated with diabetes
- Prevents increase of inflammation-associated proteins in the retina
Medchemexpress LLC 6bK TFA | 1774353-12-6 | 99.7% | 871.94 | 10 MG
6bK TFA is a potent and selective inhibitor of insulin degrading enzyme (IDE) with an IC50 value of 50 nM. It increases circulating insulin in high-fat-fed mice and enhances glucose tolerance to oral glucose, notably to a greater extent in high-fat-fed mice. This product is suitable for type 2 diabetes research.
- Potent and selective inhibitor of insulin degrading enzyme (IDE)
- Increases circulating insulin in high-fat-fed mice
- Enhances glucose tolerance to oral glucose
- Suitable for type 2 diabetes research
- For research use only
Medchemexpress LLC Glycyl-Exatecan (TFA) | 1883333-57-0 | 96.9% | 10 MG
Glycyl-Exatecan TFA is a derivative of Exatecan and acts as an anticancer agent. It demonstrates significant antitumor activity.
- Acts as an anticancer agent
- Demonstrates significant antitumor activity
- Suitable for research on cancers such as solid tumors
- Derivative of Exatecan
Medchemexpress LLC 6bK TFA | 1774353-12-6 | 99.68% | 871.94 | 1 ML
6bK TFA is a potent and selective insulin degrading enzyme (IDE) inhibitor with an IC50 value of 50 nM. It has been shown to increase circulating insulin in high-fat-fed mice. Acute administration of 6bK TFA enhances glucose tolerance to oral glucose, particularly in high-fat-fed mice. This compound is suitable for use in type 2 diabetes research. It is intended for research use only and is not sold to patients.
- Potent and selective insulin degrading enzyme (IDE) inhibitor with an IC50 value of 50 nM.
- Increases circulating insulin in high-fat-fed mice.
- Enhances glucose tolerance to oral glucose.
- Suitable for use in type 2 diabetes research.
- Intended for research use only.