Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Mm-102 trifluoroacetate | 1883545-52-5 | 99.7% | 1 ML
MM-102 TFA is the trifluoroacetate salt of MM-102, a potent inhibitor of the WDR5/MLL protein-protein interaction, supplied as a ready-to-use 10 mM solution in DMSO for research applications.
- Potent WDR5/MLL interaction inhibitor (IC50 = 2.4 nM).
- Supplied as a 10 mM solution in DMSO, 1 mL volume.
- High purity listed at 99.68% (reported as 99.7%).
- Molecular weight 783.83 g·mol⁻1; formula C37H50F5N7O6.
- For research use only; not for human or clinical use.
Medchemexpress LLC Semaglutide (TFA) | 99.9% | 4113.58 | 1 MG
Semaglutide (TFA) | 99.9% | 4113.58 | 1 MG
Medchemexpress LLC Flonoltinib TFA | 2928093-29-0 | 98.04% | 25 MG
Flonoltinib TFA is a potent and orally active dual JAK2/FLT3 inhibitor, demonstrating anti-cancer activity. It effectively inhibits JAK2, FLT3, JAK1, and JAK3, and has shown significant effects in both laboratory and animal studies.
- Potent dual JAK2/FLT3 inhibitor
- Exhibits anti-cancer activity
- Down-regulates p-FLT3 in a dose-dependent manner
- Induces apoptosis and G1/G0 cell cycle arrest in MV4-11 cells
- Shows significant antitumor effects in NOD/SCID mouse models
Medchemexpress LLC NCGC00138783 TFA | 99.4% | C28H27F4N7O3S | 1 ML
NCGC00138783 TFA is a selective inhibitor targeting the CD47/SIRPα axis. It directly blocks the interaction between CD47 and SIRPα axis.
- Selective inhibitor
- Targets CD47/SIRPα axis
- IC50 of 50 μM
- Blocks CD47 and SIRPα axis interaction
Medchemexpress LLC Apstatin TFA | 99.4% | 25 MG
Apstatin TFA is a potent aminopeptidase P (APP) inhibitor. It exhibits Ki values of 2.6 μM for rat APP and 0.64 μM for human APP. This compound has also demonstrated cardioprotective effects.
- Potent aminopeptidase P (APP) inhibitor
- Effective at 2.6 μM for rat APP
- Effective at 0.64 μM for human APP
- Shows cardioprotection
- Reduces myocardial infarct size in acute myocardial ischemia models
- For research use only
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic acid ReagentPlus(R), 99% | 76-05-1 | MFCD00004169 | 2L
Trifluoroacetic acid ReagentPlus(R), 99% | Purity: 99% | Mol Wt: 114.02 | 76-05-1 | MFCD00004169 | 2L
Medchemexpress LLC Cys-PKHB1 TFA | 1487.88 | 10MG
Cys-PKHB1 TFA is a peptide conjugated to PKHB1, functioning as a CD47 agonist peptide and a thrombospondin-1 peptide mimic with antitumor effects. It induces mitochondrial alterations, reactive oxygen species generation, and intracellular calcium accumulation, leading to calcium-dependent cell death in breast cancer cells. This compound also activates the immune system in breast cancer cells via immunogenic cell death.
- Conjugated peptide acting as a CD47 agonist
- Thrombospondin-1 peptide mimic
- Exhibits antitumor effects
- Induces mitochondrial alterations
- Promotes reactive oxygen species (ROS) generation
- Causes intracellular calcium (Ca+) accumulation
- Leads to calcium-dependent cell death in breast cancer cells
- Activates the immune system through immunogenic cell death
Medchemexpress LLC Pepinh-MYD TFA | 3388.03 (free base) | 1 MG
Pepinh-MYD TFA is a MyD88 inhibitor that contains a domain sequence from MyD88 TIR and a protein transduction sequence, enabling it to penetrate the cell membrane. It interferes with MyD88-mediated TLR signaling pathways, thereby inhibiting related immune responses.
- Includes a domain sequence from MyD88 TIR
- Contains a protein transduction sequence
- Penetrates the cell membrane
- Interferes with MyD88-mediated TLR signaling pathways
- Inhibits related immune responses
- Holds potential for studying the role of MyD88 in viral infections
Medchemexpress LLC Ribupatide TFA | 2940971-65-1 | 99.8% | 4907.48 | 1 MG
Ribupatide TFA is a dual gastric inhibitory polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) receptor agonist. It is orally active and can also be administered by injection, making it suitable for antidiabetic research.
- Dual gastric inhibitory polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) receptor agonist
- Can be studied in antidiabetic research
- Orally active
- Can also be administered by injection
Medchemexpress LLC Astax-35r TFA | 99.1% | 2392.86 | 5 MG
aStAx-35R TFA is a stapled peptide that antagonizes the nuclear form of β-catenin and inhibits Wnt signaling. It competitively inhibits the binding of β-catenin to TCF4 and selectively induces growth inhibition of Wnt-dependent cancer cells.
- Antagonizes nuclear form of β-catenin.
- Inhibits Wnt signaling.
- Competitively inhibits the binding of β-catenin to TCF4.
- Selectively induces growth inhibition of Wnt-dependent cancer cells.
Medchemexpress LLC GSNKSKPK-NH2 TFA | 99.91% | 843.97 (free base) | 1 MG
GSNKSKPK-NH2 TFA is a model peptide based on a c-Src N-terminal peptide that can be used as an NMT substrate.
- Model peptide based on a c-Src N-terminal peptide
- Can be used as an NMT substrate
- Classified under peptides
- Related to peptide and derivatives
- Falls under inhibitors and substrates
- Considered an enzyme substrate
Medchemexpress LLC Cn2 toxin TFA (β-mammal toxin Cn2 TFA) | 96.6% | 7588.60 (free base) | 500 UG
Cn2 toxin TFA (β-Mammal toxin Cn2 TFA) is a single-chain β-scorpion neurotoxic peptide. As the main toxin found in scorpion venom, Cn2 toxin (TFA) specifically targets mammalian voltage-gated sodium channels (VGSC) Nav1.6. It is intended for research use only.
- Single-chain β-scorpion neurotoxic peptide
- Main toxin found in scorpion venom
- Specifically targets mammalian voltage-gated sodium channels (VGSC) Nav1.6
- White to off-white solid appearance
![Medchemexpress LLC Hex-[Cys(tMeBn(H-AET))-Pro-Pro-Thr-Gln-Phe-Cys]-OH | 99.3% | 1198.40 | 1 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000398288.png-250.jpg)
Medchemexpress LLC Hex-[Cys(tMeBn(H-AET))-Pro-Pro-Thr-Gln-Phe-Cys]-OH | 99.3% | 1198.40 | 1 MG
3BP-4089 TFA is a highly potent fibroblast activation protein (FAP)-targeting peptide for theranostics. It is often coupled with radionuclides for tumor diagnosis and research.
- Highly potent FAP-targeting peptide
- Used for theranostics
- Can be coupled with radionuclides
- Suitable for tumor diagnosis and research