Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC MS9427 TFA | 98.4% | 1107.50 | 25 MG
MS9427 TFA is a potent PROTAC EGFR degrader that selectively degrades mutant EGFR through both the ubiquitin/proteasome system (UPS) and autophagy/lysosome pathways. It inhibits the proliferation of NSCLC cells and can be used for anticancer research. MS9427 TFA has antiproliferative activity against HCC-827 cells, potently inducing EGFRDel19 degradation and inhibiting EGFR phosphorylation.
- Potent PROTAC EGFR degrader
- Selectively degrades mutant EGFR
- Functions through ubiquitin/proteasome system (UPS) and autophagy/lysosome pathways
- Inhibits proliferation of NSCLC cells
- Supports anticancer research
- Displays antiproliferative activity against HCC-827 cells
- Induces EGFRDel19 degradation
- Inhibits EGFR phosphorylation
Medchemexpress LLC Dendrotoxin K TFA | 99.5% | 6559.66 (free base) | 1 MG
Dendrotoxin K TFA is a Kv1.1 channel blocker. It determines glutamate release in CA3 neurons in a time-dependent manner through the control of the presynaptic spike waveform.
- Kv1.1 channel blocker
- Determines glutamate release in CA3 neurons
- Controls presynaptic spike waveform
Medchemexpress LLC DPC-AJ1951 TFA | 99.4% | 1666.99 (free base) | 5 MG
This 14 amino acid peptide acts as a potent agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR). Its activity has been characterized in ex vivo and in vivo assays of bone resorption.
- Potent agonist of parathyroid hormone (PTH)/PTH-related peptide receptor (PPR)
- Activity characterized in ex vivo and in vivo bone resorption assays
- Induces intracellular Ca2+ mobilization in HEK 293 cells transfected with human PPR
Medchemexpress LLC CREBtide TFA | 98.7% | 1716.99 (free acid) | 5 MG
CREBtide TFA is a synthetic 13 amino acid peptide, a CREB (cAMP response element binding protein)-like peptide. It functions as a substrate for both Protein Kinase A (PKA) and Protein Kinase C (PKC).
- Solid appearance
- White to off-white color
- Amino acid sequence: Lys-Arg-Arg-Glu-Ile-Leu-Ser-Arg-Arg-Pro-Ser-Tyr-Arg
- Reported as a PKA and PKC substrate
- Apparent Km of 3.9 μM for phosphorylation by cAK
- Apparent Km of 2.9 μM for phosphorylation by cGK
Medchemexpress LLC NH2-UAMC1110 TFA | 2990021-73-1 | C23H24F5N5O5 | 5 MG
NH2-UAMC1110 TFA | 2990021-73-1 | C23H24F5N5O5 | 5 MG
Medchemexpress LLC Jbsnf-000028 TFA | C13H14F3N3O2 | 5 MG
JBSNF-000028 TFA is an orally active small molecule inhibitor of the tricyclic nicotinamide N-methyltransferase (NNMT). It has demonstrated significant anti-obesity and anti-diabetic activities in diet-induced obesity models and is used for studying metabolic diseases such as obesity, type 2 diabetes, and non-alcoholic fatty liver disease.
- Orally active small molecule inhibitor of tricyclic nicotinamide N-methyltransferase (NNMT).
- Inhibits NNMT activity with an EC50 of 2.5 μM in U2OS cells.
- Shows no cytotoxicity against HepG2 cells at 10-100 μM.
- Improves glucose and lipid handling in mice with diet-induced obesity.
- Improves glucose tolerance in NNMT knockout mice with diet-induced obesity.
Medchemexpress LLC WDR5-IN-4 TFA | 2749300-35-2 | 98.0% | 612.40 | 1 ML
WDR5-IN-4 TFA (Compound C6) is an inhibitor of the WIN site of chromatin-associated WD repeat-containing protein 5 (WDR5), with a Kd of 0.1 nM. It displaces WDR5 from chromatin and decreases the expression of associated genes, leading to translational inhibition and nucleolar stress. This compound also exhibits anti-cancer activity.
- Inhibits the proliferation of MLL1-rearranged cancer cells MV4:11 and K562 cells with GI50s of 3.20 μM and 25.4 μM respectively, when treated with 0-50 μM for 3 days.
- Arrests the cell cycle of MV4:11 at the sub-G1 phase and induces apoptosis in MV4:11 when treated with 2 μM for 6 days.
- Promotes Hox genes in hindbrains of Rnf220+/- mice at late embryonic stages with an intrauterine injection of 100 μg (single dose).
Medchemexpress LLC Colivelin TFA | 2803948-60-7 | 99.5% | 2759.12 | 25 MG
Colivelin TFA is a brain-penetrant neuroprotective peptide that acts as a potent activator of STAT3, suppressing neuronal death in vitro. It demonstrates long-term beneficial effects against neurotoxicity, amyloid-beta (Aβ) deposition, neuronal apoptosis, and deficits in synaptic plasticity associated with neurodegenerative diseases. This compound holds potential for the treatment of Alzheimer's disease and ischemic brain injury.
- Neuroprotective properties
- Potent activator of STAT3
- Suppresses neuronal death
- Exhibits long-term beneficial effects against neurotoxicity
- Reduces amyloid-beta (Aβ) deposition
- Prevents neuronal apoptosis
- Addresses synaptic plasticity deficits
- Potential treatment for Alzheimer's disease
- Potential treatment for ischemic brain injury
Medchemexpress LLC Tamapin TFA | 98.8% | 3458.11 | 5 MG
Tamapin TFA is a venom peptide, targeting to small conductance Ca(2+)-activated K(+) (SK) channels. It is a selective blocker of SK2 (Potassium Channel) and inhibits SK channel-mediated currents in pyramidal neurons of the hippocampus. Tamapin TFA can be isolated from the Indian red scorpion (Mesobuthus tamulus).
- Targets small conductance Ca(2+)-activated K(+) (SK) channels
- Selective blocker of SK2 (Potassium Channel)
- Inhibits SK channel-mediated currents in pyramidal neurons of the hippocampus
Medchemexpress LLC Balixafortide TFA (POL6326 TFA) | 1051366-32-5 | 99.9% | 1978.16 | 25 MG
Balixafortide TFA (POL6326 TFA) is a potent, selective, and well-tolerated peptidic CXCR4 antagonist with an IC50 less than 10 nM. It demonstrates significant selectivity for CXCR4, approximately 1000-fold, over various other receptors including CXCR7. This compound effectively blocks β-arrestin recruitment and calcium flux with IC50s less than 10 nM, functioning as a potent hematopoietic stem and progenitor cell (HSPC) mobilizing agent with observed anti-cancer effects.
- Potent and selective CXCR4 antagonist
- Demonstrates high selectivity over other receptors like CXCR7
- Blocks β-arrestin recruitment and calcium flux
- Functions as a potent hematopoietic stem and progenitor cell (HSPC) mobilizing agent
- Exhibits anti-cancer effects
- Optimized for favorable mouse ADME properties
Medchemexpress LLC Peptide R (TFA) | 98.3% | 900.08 (free base) | 1 MG
Peptide R (TFA) is a synthetic and specific CXCR4 antagonist. It shows outstanding capacities to remodel the tumor stroma and can be used for solid tumor (glioblastoma, etc.) research.
- Synthetic and specific CXCR4 antagonist
- Remodels tumor stroma
- Used for solid tumor research (glioblastoma, etc.)
- Supports cancer immunotherapy
- Supports cancer metabolism and metastasis research
- Relevant to immunology and inflammation
- Relevant to GPCR/G protein studies
- Exhibits anti-cancer properties
- Modulates microglia reactivity
- Influences self-renewal mechanisms
- Supports angiogenesis research
- Acts as an inhibitor
Medchemexpress LLC L-lysine, L-lysyl-L-glutaminyl-L-phenylalanyl- | 99.6% | 891.73 | 25 MG
KQFK TFA is a peptide, the trifluoroacetate salt form of KQFK, and serves as an inactive control for KRFK, a peptide derived from TSP-1. This product is for research use only and has not been fully validated for medical applications.
- Molecular formula: C32H46F9N7O12
- Molecular weight: 891.73
- Purity (LCMS): 99.55%
- Appearance: White to off-white solid
- Storage: Powder at -80°C for 2 years or -20°C for 1 year; in solvent at -80°C for 6 months or -20°C for 1 month (sealed, away from moisture)
Medchemexpress LLC QL47B TFA | 96.0% | 992.07 | 1 MG
QL47B TFA is a biotinylated analogue of QL47, functioning as a potent inhibitor of BTK with an IC50 value of 1.3 μM. It has demonstrated anti-tumor activity.
- Potent inhibitor of BTK (IC50 value of 1.3 μM)
- Biotinylated analogue
- Exhibits anti-tumor activity
- Available in various pack sizes
- Purity of 96.03%
Medchemexpress LLC Lys-CoA TFA | 98.5% | 50 MG
Lys-CoA TFA is a selective p300 histone acetyltransferase (HAT) inhibitor with an IC50 of 50-500 nM. It demonstrates over 100-fold selectivity for p300 compared to PCAF (IC50=200 μM). Lys-CoA TFA effectively inhibits p300 HAT activity-dependent transcriptional activation.
- Selective p300 histone acetyltransferase (HAT) inhibitor
- Displays >100-fold selectivity for p300 over PCAF
- Inhibits p300 HAT activity-dependent transcriptional activation
- Induces a senescent phenotype in human normal melanocytes at concentrations of 0.1 and 1 mM over 60 hours
- Almost completely abolished proliferation, induced high levels of SA-β-Gal, and inhibited cyclin E expression in a dose-dependent manner in normal human melanocytes
- For research use only
Medchemexpress LLC OS-2966 5mg | 5mg
OS-2966 is a humanized antibody expressed in CHO cells targeting Integrin b1/ITGB1/CD29 OS-2966 carries a huIgG1 type heavy chain and a hu type light chain with a predicted molecular weight (MW) of 145 5 kDa The isotype control for OS-2966 can be referenced as Human IgG1 kappa Isotype Control (HY-P99001)