Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Nangibotide TFA | 2014384-91-7 | 99.4% | 1457.46 | 25 MG
Nangibotide TFA | 2014384-91-7 | 99.4% | 1457.46 | 25 MG
Medchemexpress LLC SJ1008030 TFA | 2863634-97-1 | 99.8% | 987.96 | 1 MG
SJ1008030 TFA is a JAK2 PROTAC designed for selective degradation of JAK2. This compound inhibits MHH-CALL-4 cell growth and is suitable for leukemia research. It degrades JAKs, GSPT1, and IKZF1 in a dose-dependent manner, indicating inhibition of the JAK-STAT signaling pathway.
- Selectively degrades JAK2
- Inhibits MHH-CALL-4 cell growth with an IC50 of 5.4 nM
- Can be used for leukemia research
- Degrades JAKs, GSPT1, and IKZF1 in a dose-dependent manner
- Indicates inhibition of the JAK-STAT signaling pathway
Medchemexpress LLC Pam3CSK4 (TFA) | 112208-01-2 | 99.9% | 1852.30 | 25 MG
Pam3CSK4 TFA is a toll-like receptor 1/2 (TLR1/2) agonist, demonstrating an EC50 of 0.47 ng/mL for human TLR1/2. This compound is a TLR1/2 heterodimer that specifically recognizes triacylated lipopeptides. It has been shown to enhance the antibacterial functions of granulocyte macrophage-colony stimulating factor (GM-CSF) induced neutrophils against Methicillin-resistant Staphylococcus aureus (MRSA).
- Acts as a TLR1/2 agonist
- Effective at an EC50 of 0.47 ng/mL for human TLR1/2
- Recognizes triacylated lipopeptides
- Enhances antibacterial functions of GM-CSF induced neutrophils
- For research use only
- Appears as a white to off-white solid
Medchemexpress LLC Guangxitoxin 1E TFA | ≥95.0% | 3948.61 | 100 UG
Guangxitoxin 1E TFA is the trifluoroacetate salt form of Guangxitoxin 1E, a peptide toxin. It functions as a potent and selective blocker of voltage-gated potassium channels KV2.1 and KV2.2, with an IC50 of 1-3 nM. This compound is intended for research purposes only and is not for human therapeutic use.
- Potent and selective blocker of KV2.1 and KV2.2 channels (IC50 of 1-3 nM)
- Inhibits KV4.3 channels (IC50 of 24-54 nM)
- Inhibits 90% of IDR in mouse β-cells
- Shifts voltage dependence of channel activation to more depolarized potentials
- Broadens β-cell action potential
- Enhances glucose-stimulated intracellular calcium oscillations
- Increases insulin secretion from mouse pancreatic islets in a glucose-dependent manner
Medchemexpress LLC Ss47 Tfa | 00-00-0 | 99.9% | 1067.09 | C51H57F3N6O14S | 5 MG
SS47 TFA is a PROTAC-based HPK1 degrader supplied as the trifluoroacetic acid salt for research use. It promotes proteasome-mediated degradation of HPK1 and is used in immuno-oncology and CAR-T cell studies.
- Research reagent for HPK1 degradation and immuno-oncology studies.
- Contains an alkyne moiety compatible with copper-catalyzed azide-alkyne cycloaddition.
- Purity 99.88%.
- Chemical formula C51H57F3N6O14S; molecular weight 1067.09.
- Soluble in DMSO at 100 mg/mL; ultrasonic assistance recommended.
- Store protected from light under nitrogen; in solvent: -80°C (6 months), -20°C (1 month).
- Available in small research pack sizes such as 1 mg, 5 mg, and 10 mg.
Medchemexpress LLC Adrixetinib TFA | C27H25F6N5O7 | 25 MG
Adrixetinib TFA is an Axl/Mer/CSF1R inhibitor. This product is supplied as an off-white to light yellow solid, with a purity of 99.82% as determined by HPLC.
- Axl/Mer/CSF1R inhibitor
- High purity (99.82% by HPLC)
- Off-white to light yellow solid appearance
Medchemexpress LLC Huwentoxin-IV TFA | 526224-73-7 | 4106.78 | 500 UG
Huwentoxin-IV is a potent and selective sodium channel blocker. It inhibits neuronal Nav1.7, Nav1.2, Nav1.3, and Nav1.4, with preferential blocking of peripheral nerve subtype Nav1.7. This compound has also demonstrated analgesic effects in animal models of inflammatory and neuropathic pain.
- Potent and selective sodium channel blocker
- Inhibits neuronal Nav1.7, Nav1.2, Nav1.3, and Nav1.4
- Preferentially blocks peripheral nerve subtype Nav1.7
- Binds to neurotoxin receptor site 4
- Analgesic effects in animal models of inflammatory and neuropathic pain
Medchemexpress LLC SJ1008030 TFA | 2863634-97-1 | 99.81% | 987.96 | 25 MG
SJ1008030 TFA is a JAK2 PROTAC designed to selectively degrade JAK2. This compound has demonstrated potent inhibitory effects on MHH-CALL-4 cell growth with an IC50 of 5.4 nM, making it a valuable tool for leukemia research.
- Selectively degrades JAK2.
- Inhibits MHH-CALL-4 cell growth with an IC50 of 5.4 nM.
- Useful for leukemia research.
- Degrades JAKs, GSPT1, and IKZF1 in a dose-dependent manner in MHH-CALL-4 cells.
- Dose-dependently degrades JAK2 and GSPT1 protein in xenograft bone marrow SJBALL021415 cells, indicating the inhibition of the JAK-STAT signaling pathway.
Medchemexpress LLC CRA-2059 TFA | 99.9% | 864.83 | 1 ML
CRA-2059 is a highly specific and selective tryptase inhibitor, with a Ki of 620 pM for recombinant human tryptase-β (rHTβ). Tryptase is a trypsin-like serine protease found as a major protein component in human mast cell secretory granules. CRA-2059 has the potential for inflammatory bowel disease research.
- Highly specific and selective tryptase inhibitor
- Potential for inflammatory bowel disease research
- Inhibits recombinant human tryptase-β (rHTβ) with a Ki of 620 pM
- Targets tryptase, a trypsin-like serine protease
Medchemexpress LLC K1 peptide TFA | 98.2% | 1489.59 (free acid) | 1 MG
K1 peptide TFA is a high-affinity peptide ligand for GABAA receptor-associated protein (GABARAP).
- High-affinity peptide ligand for GABAA receptor-associated protein (GABARAP)
- Solid appearance
- White to off-white color
- Target: GABA Receptor
- Pathway: Membrane Transporter/Ion Channel, Neuronal Signaling
- Powder storage: -80°C for 2 years, -20°C for 1 year
- In solvent storage: -80°C for 6 months, -20°C for 1 month
Medchemexpress LLC KRFK TFA | 99.8% | 577.73 | 25 MG
KRFK TFA is a peptide derived from TSP-1 that can activate TGF-β. It promotes TGF-β-mediated signaling and its downstream role, independent of thrombospondin (TSP) receptors such as CD47 and CD36. This product can be used for research on chronic ocular surface inflammatory disorders.
- Activates TGF-β
- Promotes TGF-β-mediated signaling
- Independent of thrombospondin (TSP) receptors
- Suitable for research on chronic ocular surface inflammatory disorders
Medchemexpress LLC Sairga (TFA) | 99.6% | 573.64 (free base) | 1 MG
Sairga (TFA) is a laboratory chemical primarily used for the manufacture of substances. This solid compound is stable under recommended storage conditions and is intended for research use by experienced personnel in appropriately equipped facilities.
- Solid appearance
- Stable under recommended storage conditions
- Suitable for shipping at room temperature if less than 2 weeks
- Recommended storage for powder: -80 °C for 2 years or -20 °C for 1 year
- Recommended storage in solvent: -80 °C for 6 months or -20 °C for 1 month
- Should be stored in a tightly sealed container in a cool, well-ventilated area
- Keep away from direct sunlight and sources of ignition
Medchemexpress LLC TcY-NH2 TFA ((trans-cinnamoyl)-YPGKF-NH2 TFA) | 1262750-73-1 | 99.7% | 853.88 | 10 MG
tcY-NH2 TFA is a potent and selective PAR4 antagonist peptide. It is capable of inhibiting thrombin- and AY-NH2-induced platelet aggregation and endostatin release. This peptide is suitable for research applications in inflammation and immunology.
- Potent and selective PAR4 antagonist peptide.
- Inhibits thrombin- and AY-NH2-induced platelet aggregation.
- Prevents endostatin release.
- Suitable for inflammation and immunology research.
- Purity of 99.7%.
- Soluble in DMSO at 100 mg/mL.
- Demonstrated activity in various in vitro and in vivo models.
Medchemexpress LLC Iberiotoxin (TFA) | 4230.85 | 500 UG
Iberiotoxin (TFA) is a selective high conductance Ca2+-activated K+ channel inhibitor with a Kd of approximately 1 nM. It does not block other types of voltage-dependent ion channels.
- Selective high conductance Ca2+-activated K+ channel inhibitor
- Kd of approximately 1 nM
- Does not block other types of voltage-dependent ion channels