Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Claramine TFA | 3030428-57-7 | 95.0% | 703.02 | 5 MG
Claramine TFA is a steroidal polyamine that regulates the properties of lipid membranes and offers protection to cells against various biological toxins. These toxins include misfolded protein oligomers and those derived from biological proteins.
- Does not affect cell viability in human neuroblastoma cells (sh-sy5y) at concentrations below 10 μM.
- Does not impact cell activity in hek293 cells.
- Protects human neuroblastoma (sh-sy5y) cells from the harmful effects of pore-forming agents, melittin and α-hemolysin, by inhibiting their binding to cell membranes.
Medchemexpress LLC Ss47 Tfa | 00-00-0 | 99.9% | 1067.09 | C51H57F3N6O14S | 5 MG
SS47 TFA is a PROTAC-based HPK1 degrader supplied as the trifluoroacetic acid salt for research use. It promotes proteasome-mediated degradation of HPK1 and is used in immuno-oncology and CAR-T cell studies.
- Research reagent for HPK1 degradation and immuno-oncology studies.
- Contains an alkyne moiety compatible with copper-catalyzed azide-alkyne cycloaddition.
- Purity 99.88%.
- Chemical formula C51H57F3N6O14S; molecular weight 1067.09.
- Soluble in DMSO at 100 mg/mL; ultrasonic assistance recommended.
- Store protected from light under nitrogen; in solvent: -80°C (6 months), -20°C (1 month).
- Available in small research pack sizes such as 1 mg, 5 mg, and 10 mg.
Medchemexpress LLC BIBP3226 TFA | 1068148-47-9 | 99.3% | 587.59 | 5 MG
BIBP3226 TFA is a potent and selective neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor antagonist, with Ki values of 1.1, 79, and 108 nM for rNPY Y1, hNPFF2, and rNPFF, respectively. It has been observed to display an anxiogenic-like effect.
- Potent and selective neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor antagonist.
- Ki values of 1.1 nM for rNPY Y1, 79 nM for hNPFF2, and 108 nM for rNPFF.
- Induces an anxiogenic-like effect at higher doses in vivo.
- Available in 5 mg quantity.
Medchemexpress LLC Charybdotoxin (TFA) | 96.8% | 4295.89 | 1 MG
Charybdotoxin (TFA) | 96.8% | 4295.89 | 1 MG
Medchemexpress LLC GsMTx4 TFA | 99.9% | 4095.84 | 1 MG
GsMTx4 TFA is a spider venom peptide that selectively inhibits cationic-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families. It also blocks cation-selective stretch-activated channels (SACs) and attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity and microglial reactivity, making it a pharmacological tool for identifying the role of these excitatory MSCs in normal physiology and pathology.
- Selectively inhibits cationic-permeable mechanosensitive channels (MSCs)
- Blocks cation-selective stretch-activated channels (SACs)
- Attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity
- Attenuates microglial reactivity
- Useful as a pharmacological tool for identifying the role of excitatory mechanosensitive channels