Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Z-VRPR-FMK TFA | 1926163-57-6 | MFCD18782585 | 95.9% | 790.81 | 1 MG
Z-VRPR-FMK (TFA) (VRPR) is a tetrapeptide and a selective and irreversible MALT1 (Mucosa-associated lymphoid tissue lymphoma translocation protein 1) inhibitor. It can protect against influenza A virus (IAV) infection.
- Tetrapeptide
- Selective and irreversible MALT1 inhibitor
- Protects against influenza A virus (IAV) infection
Medchemexpress LLC Clovibactin TFA | 97.1% | 903.08 (free base) | 500 UG
Clovibactin TFA is the TFA salt form of Clovibactin. It acts as an antibiotic against drug-resistant bacterial pathogens without detectable resistance, functioning by inhibiting cell wall synthesis, specifically targeting pyrophosphate of peptidoglycan precursors.
- Inhibits cell wall synthesis.
- Targets pyrophosphate of peptidoglycan precursors.
- Effective against Staphylococcus strains with MICs of 0.125-2 μg/mL.
- For research use only.
- Molecular weight: 903.08 (free base).
- Formula: C43H70N10O11.xC2HF3O2.
- Appearance: Solid, white to off-white.
- Solubility: DMSO: 100 mg/mL (Need ultrasonic).
Medchemexpress LLC LL-37, human TFA | 154947-66-7 | 100.0% | 4493.26 | 5 MG
LL-37, human TFA is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide. It demonstrates a broad spectrum of antimicrobial activity.
- Exhibits broad-spectrum antimicrobial activity.
- May help protect the cornea from infection.
- Modulates wound healing.
Medchemexpress LLC GpTx-1 TFA | 99.6% | 4073.82 | 500 UG
GpTx-1 TFA is a peptide-based NaV1.7 sodium channel antagonist isolated from the venom of the Chilean spider Grammostola porter. It demonstrates potent inhibitory activity against the NaV1.7 channel with an IC50 value of 10 nM.
- Shows excellent selectivity for NaV1.4 and NaV1.5.
- Exhibits greater than 20-fold selectivity for NaV1.4.
- Exhibits greater than 950-fold selectivity for NaV1.5.
Medchemexpress LLC Mambalgin 1 TFA | 95.72% | 6554.54 (free acid) | 500 UG
Mambalgin 1 TFA is a potent and selective inhibitor of ASIC1a. It exhibits IC50 values of 192 nM for human ASIC1a and 72 nM for ASIC1a/1b dimer, binding to closed/inactive channels. This compound demonstrates high selectivity for ASIC1a over a range of other channels including ASIC2a, ASIC3, TRPV1, P2X2, 5-HT3, Nav1.8, Cav3.2, and Kv1.2. Research indicates its ability to increase the latency of withdrawal response in mouse tail-flick and paw-flick tests.
- Selective ASIC1a inhibitor
- Binds to closed/inactive channels
- Increases latency of withdrawal response in mouse tail-flick and paw-flick tests
Medchemexpress LLC VU0364572 TFA | 1240514-89-9 | 99.3% | 487.51 | 1 ML
VU0364572 TFA is an orally active, selective, allosteric agonist of the M1 muscarinic receptor with an EC50 of 0.11 μM. It has neuroprotective potential for preventing memory impairments and reducing neuropathology in Alzheimer's Disease and is CNS penetrant.
- Acts as an orally active and selective allosteric agonist of the M1 muscarinic receptor.
- Features an EC50 of 0.11 μM.
- Demonstrates neuroprotective potential.
- Aids in preventing memory impairments and reducing neuropathology in Alzheimer's Disease.
- Is CNS penetrant.
Medchemexpress LLC L-Serine, L-alanyl-L-prolyl-L-prolyl-L-histidyl-L-alanyl-L-leucyl- (TFA) | 99.9% | 805.80 | 1 MG
RS 09 TFA is an LPS peptide mimic and a Toll-like Receptor 4 (TLR4) agonist. It can bind to TLR-4, activate NF-κB, and function as an adjuvant in vivo, enhancing the antigen-specific immune response.
- Stimulates TLR-4 and activates NF-κB in HEK-BLUETM-4 cells
- Induces nuclear translocation of NF-κB and secretion of inflammatory cytokines in RAW264.7 cells
- Used as an adjuvant to co-immunize BALB/c mice with specific antigens
Medchemexpress LLC NN1177 (TFA) | 98.7% | 4570.07 (free base) | 5 MG
NN1177 TFA (NNC9204-1177 TFA) is a long-acting GLP-1/glucagon receptor co-agonist. This compound is known to induce dose-dependent body weight loss in diet-induced obese mice and improves glucose tolerance. It has also been shown to reduce liver fat and relevant inflammatory and fibrosis biomarkers in NASH models.
- Long-acting GLP-1/glucagon receptor co-agonist
- Induces body weight loss
- Improves glucose tolerance
- Reduces liver fat
- Reduces inflammatory and fibrosis relevant biomarkers
- For research use only
Medchemexpress LLC Ribupatide (TFA) | 2940971-65-1 | 98.74% | 4907.48 | 5 MG
Ribupatide (TFA) is a dual gastric inhibitory polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) receptor agonist. This compound is used in antidiabetic research and is for research use only. It is orally active and can also be administered by injection.
- Dual GIP and GLP-1 receptor agonist
- Orally active
- Can be administered by injection
- Suitable for antidiabetic research
Medchemexpress LLC LAGIPRA peptide (TFA) | 98.2% | 5756.50 (free base) | 5 MG
LAGIPRA peptide TFA is a long-acting GIP1R agonist that enhances insulin sensitivity by augmenting glucose disposal. It also reduces branched-chain amino acids (BCAAs) and ketoacids, making it a potential subject for research into type 2 diabetes.
- Long-acting GIP1R agonist
- Enhances insulin sensitivity by augmenting glucose disposal
- Reduces branched-chain amino acids (BCAAs) and ketoacids
- Potential for research into type 2 diabetes
Medchemexpress LLC Dota-octreotide tfa | 99.3% | 1519.66 | 1 MG
DOTA-Octreotide TFA is composed of the chelator DOTA and Octreotide (HY-P0036). It is utilized for cancer research through its combination with radioactive elements and can be employed for the synthesis and research of Radionuclide-Drug Conjugates (RDCs). Its molecular formula is C67H93F3N14O19S2 with a molecular weight of 1519.66. It appears as a white to off-white solid.
- Used for cancer research
- Combines with radioactive elements
- Can be used for synthesis and research of radionuclide-drug conjugates (RDCs)
- Soluble in H2O at ≥ 50 mg/mL (32.90 mM)
- Powder stable for 2 years at -80°C and 1 year at -20°C
- Solution stable for 6 months at -80°C and 1 month at -20°C
Medchemexpress LLC Galantide TFA | 98.1% | 2313.55 | 5 MG
Galantide TFA from MedChemExpress is a synthetic peptide, identified by its chemical structure L-Methioninamide, glycyl-L-tryptophyl-L-threonyl-L-leucyl-L-asparaginyl-L-seryl-L-alanylglycyl-L-tyrosyl-L-leucyl-L-leucylglycyl-L-prolyl-L-glutaminyl-L-glutaminyl-L-phenylalanyl-L-phenylalanyl-glycyl-L-leucyl- (TFA). This compound, with a molecular weight of 2313.55, is provided as a white to off-white solid with a purity of 98.09% as determined by LCMS.
- High purity of 98.09%
- White to off-white solid appearance
- Recommended storage at -80°C for up to 2 years in powder form
Medchemexpress LLC L2P4 TFA | 98.3% | 1961.83 (free base) | 1 MG
L2P4 TFA is a peptide-based, EBNA1 targeting fluorescent probe. It works by inhibiting EBNA1 homodimer formation, which selectively inhibits EBV+ tumor growth. It shows cytotoxicity in EBV-positive C666-1 cells with an LC50 of 46.4 μM.
- Peptide-based, EBNA1 targeting fluorescent probe
- Inhibits EBNA1 homodimer formation
- Selectively inhibits EBV+ tumor growth
- Shows cytotoxicity in EBV-positive C666-1 cells with an LC50 of 46.4 μM
- Molecular weight: 1961.83 (free base)
- Appearance: Solid
- Color: Purple to purplish red
- Soluble in DMSO at 50 mg/mL
Medchemexpress LLC Tpp-CAQK TFA | 99.1% | 906.95 | 1 MG
Tpp-CAQK TFA is an engineered mitochondrial compound that can bind to mitochondria, enabling the construction of Mito-Tpp-CAQK TFA with excellent bioactivity. Mito-Tpp-CAQK TFA can be internalized by macrophages, thereby enhancing the phagocytosis of myelin debris, alleviating mitochondrial dysfunction, and reducing proinflammatory profiles, ultimately facilitating tissue repair and functional recovery in mice after spinal cord injury.
- Can bind to mitochondria
- Enables construction of Mito-Tpp-CAQK TFA
- Enhances macrophage phagocytosis of myelin debris
- Alleviates mitochondrial dysfunction
- Reduces proinflammatory profiles
- Facilitates tissue repair and functional recovery in mice after spinal cord injury
- For research use only
Medchemexpress LLC Cpp12 (Tfa) | 98.69% | 1700.55 | 1 MG
CPP12 TFA is a small, amphiphilic, cyclic cell-penetrating peptide (CPP) in salt form. It binds directly to plasma membrane phospholipids, enters mammalian cells via endocytosis, and is then efficiently released from endosomes. It can be used for intracellular delivery of drugs and chemical probes.
- Small, amphiphilic, cyclic cell-penetrating peptide (CPP)
- Binds directly to plasma membrane phospholipids
- Enters mammalian cells via endocytosis
- Efficiently released from endosomes
- Can be used for intracellular delivery of drugs and chemical probes