Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Mal-PEG4-C2-NH2 TFA | 2512227-13-1 | 98.6% | 430.37 | 500 MG
Mal-PEG4-C2-NH2 TFA is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Facilitates selective degradation of target proteins
![Medchemexpress LLC L-Prolinamide, N,N-bis(phenylmethyl)glycyl]-4-[4-[[4-[[(phenylmethyl)amino]phosphonomethyl] | 99.9% | 1323.35 | 1 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000386801-logo.png-250.jpg){kind=logo}
Medchemexpress LLC L-Prolinamide, N,N-bis(phenylmethyl)glycyl]-4-[4-[[4-[[(phenylmethyl)amino]phosphonomethyl] | 99.9% | 1323.35 | 1 MG
OncoACP3 TFA from MedChemExpress is a small-molecule ligand of prostatic acid phosphatase (ACP3). This product is applicable to research related to prostate cancer.
- Molecular formula: C62H82F3N12O15P
- Molecular weight: 1323.35
- Appearance: White to off-white solid
- Storage: Powder at -20°C for 3 years; in solvent at -80°C for 6 months, or -20°C for 1 month
- Purity (LCMS): 99.87%
Medchemexpress LLC F992 TFA | 98.19% | 1028.21 | 1 MG
F992 TFA is an antidiuretic peptide and vasopressin (antidiuretic hormone) analogue, intended for research use only. This solid, white to off-white compound has a molecular weight of 1028.21 (free base).
- Antidiuretic peptide and vasopressin analogue
- For research use only
- Solid appearance
- White to off-white color
Medchemexpress LLC Alpha-Melanocyte-Stimulating Hormone TFA | 171869-93-5 | 98.5% | 1 MG
α-MSH TFA (α-Melanocyte-Stimulating Hormone TFA) is an endogenous neuropeptide and a melanocortin receptor 4 (MC4R) agonist. It exhibits anti-inflammatory and antipyretic activities and is a post-translational derivative of pro-opiomelanocortin (POMC).
- Endogenous neuropeptide
- MC4R agonist with anti-inflammatory and antipyretic activities
- Post-translational derivative of pro-opiomelanocortin (POMC)
- Modulates CNS inflammation by acting directly on melanocortin receptors in glial cells
- Modulates NFκB activation
- Inhibits translocation of transcription factor κB to the nucleus
Medchemexpress LLC Vh4127 TFA | 1034.35 (free base) | 1 MG
VH4127 TFA is a cyclic peptide that targets the low-density lipoprotein receptor (LDLR) with a KD of 18 nM for hLDLR. It specifically binds to the epidermal growth factor (EGF) homology domain of both rodent and human LDLR.
- Targets low density lipoprotein receptor (LDLR)
- Has a high binding affinity (KD of 18 nM) for human LDLR
- Binds specifically to the EGF homology domain of rodent and human LDLR
- Available in various quantities
- For research use only
- Information on solubility, in vivo dissolution, and related antibodies is also available
Medchemexpress LLC Colivelin TFA | 2803948-60-7 | 99.8% | 2759.12 | 5 MG
Colivelin TFA is a brain-penetrant neuroprotective peptide and a potent activator of STAT3. It suppresses neuronal death in vitro and offers long-term benefits against neurotoxicity, Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease. It has potential for treating Alzheimer's disease and ischemic brain injury.
- Suppresses neuronal death and activates neuroprotection through Ca2+/calmodulin-dependent protein kinase IV and STAT3 pathways.
- Reverses caspase3, Bax, and Bcl-2 expressions.
- Increases p-STAT3 protein levels.
- Suppresses spatial working memory impairment and antagonizes hippocampal neuronal loss.
- Improves motor/cognitive function and reduces lesion volume/neurological deficits post-MCAO.
- Protects against cholinotoxin-induced amnesia and ischemic brain injury.
Medchemexpress LLC RI(dl)-2 TFA | 98.0% | 1 MG
RI(dl)-2 TFA is a potent and selective RAD51-mediated D-loop formation inhibitor.
- Potent and selective RAD51-mediated D-loop formation inhibitor with an IC50 of 11.1 μM.
- Does not influence RAD51 binding to ssDNA.
- Inhibits homologous recombination (HR) activity in human cells (IC50 of 3.0 μM).
Medchemexpress LLC CCZ01048 TFA | 98.5% | 1622.75 | 5 MG
CCZ01048 TFA is an α-MSH analogue that exhibits high binding affinity to melanocortin 1 receptor (MC1R) with a Ki of 0.31 nM. It shows rapid internalization into B16F10 melanoma cells and demonstrates high in vivo stability, making it a promising candidate for PET imaging of malignant melanoma.
- α-MSH analogue
- High binding affinity to melanocortin 1 receptor (MC1R) with a Ki of 0.31 nM
- Rapid internalization into B16F10 melanoma cells
- High in vivo stability
- Promising candidate for PET imaging of malignant melanoma
Medchemexpress LLC Huwentoxin-IV TFA | 105856-78-4 | 99.04% | 4099.71 | 5 MG
Huwentoxin-IV TFA is a highly potent and selective blocker of neuronal voltage-gated sodium channels. It specifically inhibits NaV1.7 activity in human DRG neurons.
- Potent and selective sodium channel blocker
- Inhibits neuronal NaV1.7, NaV1.2, NaV1.3, and NaV1.4 channels
- IC50 of 2.9 nM for inhibiting NaV1.7-mediated currents
- Reduces NaV1.7 current amplitude by 50% at 0.5 nM
Medchemexpress LLC LARLLT (TFA) | 99.9% | 799.88 | 5 MG
LARLLT (TFA) is an EGFR-binding peptide with potential for research into EGFR overexpressing cancers, including lung, ovarian, and colorectal cancer.
- EGFR-binding peptide
- Potential for research of EGFR overexpressing cancers
- Targets EGFR
- Involves JAK/STAT signaling and protein tyrosine kinase/RTK pathways
- Sequence: Leu-Ala-Arg-Leu-Leu-Thr
- Molecular weight of 799.88
- Purity of 99.9% (HPLC)
- Soluble in DMSO: 50 mg/mL
- Appears as a white to off-white solid
- Powder storage: -80°C for 2 years, -20°C for 1 year
- In solvent storage: -80°C for 6 months, -20°C for 1 month (sealed storage, away from moisture)
Medchemexpress LLC PKA RII peptide TFA | 99.7% | 2226.37 | 10 MG
PKA RII peptide TFA is a PKA substrate that, after being phosphorylated at the serine residue, can be used for the detection of calcineurin activity. It is for research use only.
- Solid appearance, white to off-white color.
- Sequence: Asp-Leu-Asp-Val-Pro-Ile-Pro-Gly-Arg-Phe-Asp-Arg-R-Val-Ser-Val-Ala-Ala-Glu.
- Sequence shortening: DLDVPIPGRFDRRVSVAAE.
- Store as powder at -80°C for 2 years or -20°C for 1 year.
- Store in solvent at -80°C for 6 months or -20°C for 1 month (sealed storage, away from moisture).
- Soluble in H2O at 25 mg/mL (11.23 mM, requires ultrasonic).
Medchemexpress LLC RSM3 TFA | 98.83% | 3049.66 | 5 MG
RSM3 TFA, a stapled peptide, is a METTL3-METTL14 inhibitor with a Kd of 3.10 μM. It inhibits tumor growth and induces cell apoptosis. RSM3 TFA can be used for the study of cancer.
- Inhibits tumor growth
- Induces cell apoptosis
- Used for the study of cancer
- Stapled peptide
- METTL3-METTL14 inhibitor
Medchemexpress LLC 6bK TFA | 1774353-12-6 | 99.7% | 871.94 | 25 MG
6bK TFA is a potent and selective insulin degrading enzyme (IDE) inhibitor with an IC50 value of 50 nM. It increases circulating insulin in high-fat-fed mice and enhances glucose tolerance to oral glucose, especially in high-fat-fed mice.
- Potent and selective insulin degrading enzyme (IDE) inhibitor
- IC50 value of 50 nM
- Increases circulating insulin in high-fat-fed mice
- Enhances glucose tolerance to oral glucose
- Suitable for type 2 diabetes research