Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Α-MSH (TFA) | 171869-93-5 | 98.5% | 25 MG
α-MSH TFA (α-Melanocyte-Stimulating Hormone TFA) is an endogenous neuropeptide that acts as a melanocortin receptor 4 (MC4R) agonist. It exhibits anti-inflammatory and antipyretic activities, being a post-translational derivative of pro-opiomelanocortin (POMC).
- Modulates CNS inflammation by acting directly on melanocortin receptors in glial cells.
- Modulates NFκB activation.
- Inhibits translocation of transcription factor κB to the nucleus.
- Effectively modulates inflammatory reactions when given systemically.
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic acid 99 fo100G
TRIFLUOROACETIC Trifluoroacetic acid 99 fo100G
Medchemexpress LLC L2P4 TFA | 98.3% | 1961.83 (free base) | 1 MG
L2P4 TFA is a peptide-based, EBNA1 targeting fluorescent probe. It works by inhibiting EBNA1 homodimer formation, which selectively inhibits EBV+ tumor growth. It shows cytotoxicity in EBV-positive C666-1 cells with an LC50 of 46.4 μM.
- Peptide-based, EBNA1 targeting fluorescent probe
- Inhibits EBNA1 homodimer formation
- Selectively inhibits EBV+ tumor growth
- Shows cytotoxicity in EBV-positive C666-1 cells with an LC50 of 46.4 μM
- Molecular weight: 1961.83 (free base)
- Appearance: Solid
- Color: Purple to purplish red
- Soluble in DMSO at 50 mg/mL
Medchemexpress LLC Cyclorasin 9A5 (TFA) | 1 MG
Cyclorasin 9A5 (TFA) from MedChemExpress is a laboratory chemical intended for research use only. It is presented as a solid and is stable under recommended storage conditions, emphasizing careful handling and storage to maintain its integrity.
- Stable under recommended storage
- Keep sealed in cool, well-ventilated area, away from direct sunlight and ignition
- Powder storage: -80°C for 2 years, -20°C for 1 year
- Solution storage: -80°C for 6 months, -20°C for 1 month
- Ships at room temperature (less than 2 weeks)
- Not classified as hazardous
- Requires personal protective equipment (safety goggles, gloves, impervious clothing, respirator)
- Ensure adequate ventilation, safety shower, and eye wash station
Medchemexpress LLC LY117018 TFA 25mg | 2390041-98-0 | 25 MG
LY117018 TFA is a raloxifene analog and a selective estrogen receptor modulator (SERM) reported to exert antiproliferative effects on breast cancer cell lines. Supplied as a trifluoroacetate salt, the compound is provided as a small-scale research reagent for in vitro studies.
- Selective estrogen receptor modulator activity.
- Reported antiproliferative effects on breast cancer cell lines.
- Supplied as a trifluoroacetate salt for improved handling.
- Available in milligram-scale quantities for research use.
- Chemical formula C29H26F3NO6S; molecular weight 573.58 g/mol.
Medchemexpress LLC DV1 TFA | 98.5% | 2424.85 | 5 MG
DV1 TFA is a selective antagonist for CXC chemokine receptor 4 (CXCR4) and exhibits antiviral activity. This product is for research use only and has not been fully validated for medical applications.
- Selective antagonist for CXC chemokine receptor 4 (CXCR4)
- Exhibits antiviral activity
- For research use only
Medchemexpress LLC Ecallantide (DX-88) trifluoroacetate | 00-00-0 | 7053.81 g/mol (free base) | C305H442N88O91S8 · xC2HF3O2 | 5 MG
Ecallantide TFA is a recombinant plasma kallikrein inhibitor supplied as the trifluoroacetate salt for research use. It inhibits kallikrein-mediated formation of bradykinin and is used in laboratory studies of angioedema and bradykinin-related pathways. Provided in defined small-scale packages for analytical and preclinical research; not for human use.
- Specific recombinant plasma kallikrein inhibitor.
- Trifluoroacetate salt formulation for stability and handling.
- Available in small, defined package sizes suitable for research.
- Characterized molecular weight and molecular formula provided.
- Intended for research use only; not for clinical or human use.
- Applicable to studies of bradykinin-mediated signaling and angioedema models.
Medchemexpress LLC Ecallantide TFA | 9007-83-4 | 99.54% | 7053.81 | 50 MG
Ecallantide TFA is a specific recombinant plasma kallikrein inhibitor that works by inhibiting the production of bradykinin, thereby offering a potential treatment for acute attacks of angioedema.
- Specific recombinant plasma kallikrein inhibitor
- Inhibits the production of bradykinin
- May be used to prevent acute attacks of angioedema
Medchemexpress LLC GRL-1720 TFA | 2835511-03-8 | C16H12ClF3N2O4 | 5 MG
GRL-1720 TFA is a potent inhibitor of SARS-CoV-2 Mpro, exhibiting anti-SARS-CoV2 activity with an EC50 value of 15 μM. This compound has a molecular weight of 388.73 and appears as a solid, ranging from light brown to brown in color.
- High purity of 98.94%.
- Shipped at room temperature.
- Store at -20°C, sealed, away from moisture.
- In solution, stable for 6 months at -80°C or 1 month at -20°C with sealed storage, away from moisture.
Medchemexpress LLC KRFK TFA | 99.8% | 577.73 (free base) | 5 MG
KRFK TFA is a peptide derived from TSP-1 that activates TGF-β. It promotes TGF-β-mediated signaling and its downstream role, independently of thrombospondin (TSP) receptors like CD47 and CD36. KRFK TFA is used in research for chronic ocular surface inflammatory disorders.
- Activates TGF-β.
- Promotes TGF-β-mediated signaling.
- Acts independently of thrombospondin (TSP) receptors (CD47 and CD36).
- Can be used for chronic ocular surface inflammatory disorders research.
Medchemexpress LLC PZ703b trifluoroacetate | 98.6% | 1714.46 g/mol | C82H103ClF6N10O13S4 | 5 MG
PZ703b TFA is a Bcl-xL-targeting PROTAC degrader provided for laboratory research use. It induces rapid BCL-XL degradation, triggers caspase-3-mediated apoptosis, and inhibits cancer cell proliferation in vitro, including activity in bladder cancer models and hematologic cell lines. Supplied as a trifluoroacetate salt, it is intended for biochemical and cell-based studies only.
- Bcl-xL PROTAC degrader that promotes targeted protein degradation.
- Induces caspase-3-mediated apoptosis in susceptible cell lines.
- Inhibits cell proliferation and can act synergistically with other small-molecule inhibitors in vitro.
- Demonstrated low-nanomolar cellular potency in selected hematologic cell lines.
- High purity (>98%) suitable for biochemical and cell-based assays.
- Available in small milligram pack sizes for research use only.
Medchemexpress LLC RVG TFA | 99.3% | 3266.62 | 5 MG
RVG TFA is a peptide derived from Rabies Virus Glycoprotein. It binds to the α-7 subunit of nicotinic acetylcholine receptors (AchR) of neuronal cells and enhances the delivery of *Mycobacterium tuberculosis* antigens to antigen-presenting cells.
- Binds to α-7 subunit of nicotinic acetylcholine receptors
- Enhances delivery of *Mycobacterium tuberculosis* antigens
- Appears as a solid
- Color: white to off-white
- Soluble in water at ≥ 100 mg/mL
- For research use only
Medchemexpress LLC KS-133 (TFA) | 98.95% | 1672.93 | 1 MG
KS-133 TFA is a highly selective and potent antagonist of the vascular active enteropeptide receptor 2 (VIPR2). It reverses the tumor-promoting M2 phenotype of tumor-associated macrophages to the anti-tumor M1 phenotype, alters the tumor immune microenvironment, and inhibits tumor growth. It is suitable for research on schizophrenia and cancer immune regulation.
- Highly selective and potent VIPR2 antagonist
- IC50 values for Ca influx measurement: 24.8 nM; cAMP measurement: 500 nM
- Reverses M2 to M1 macrophage phenotype
- Alters tumor immune microenvironment and inhibits tumor growth
- Inhibits excessive VIPR2 activation, preventing cognitive impairments and neuronal damage
- Demonstrates anti-tumor activity and synergistic effects with anti-PD-1 antibodies