Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC CREBtide TFA | 98.7% | 1716.99 (free acid) | 5 MG
CREBtide TFA is a synthetic 13 amino acid peptide, a CREB (cAMP response element binding protein)-like peptide. It functions as a substrate for both Protein Kinase A (PKA) and Protein Kinase C (PKC).
- Solid appearance
- White to off-white color
- Amino acid sequence: Lys-Arg-Arg-Glu-Ile-Leu-Ser-Arg-Arg-Pro-Ser-Tyr-Arg
- Reported as a PKA and PKC substrate
- Apparent Km of 3.9 μM for phosphorylation by cAK
- Apparent Km of 2.9 μM for phosphorylation by cGK
Medchemexpress LLC SJ1008030 TFA | 2863634-97-1 | 99.81% | 987.96 | 25 MG
SJ1008030 TFA is a JAK2 PROTAC designed to selectively degrade JAK2. This compound has demonstrated potent inhibitory effects on MHH-CALL-4 cell growth with an IC50 of 5.4 nM, making it a valuable tool for leukemia research.
- Selectively degrades JAK2.
- Inhibits MHH-CALL-4 cell growth with an IC50 of 5.4 nM.
- Useful for leukemia research.
- Degrades JAKs, GSPT1, and IKZF1 in a dose-dependent manner in MHH-CALL-4 cells.
- Dose-dependently degrades JAK2 and GSPT1 protein in xenograft bone marrow SJBALL021415 cells, indicating the inhibition of the JAK-STAT signaling pathway.
Medchemexpress LLC SJ1008030 TFA | 2863634-97-1 | 99.8% | 987.96 | 1 MG
SJ1008030 TFA is a JAK2 PROTAC designed for selective degradation of JAK2. This compound inhibits MHH-CALL-4 cell growth and is suitable for leukemia research. It degrades JAKs, GSPT1, and IKZF1 in a dose-dependent manner, indicating inhibition of the JAK-STAT signaling pathway.
- Selectively degrades JAK2
- Inhibits MHH-CALL-4 cell growth with an IC50 of 5.4 nM
- Can be used for leukemia research
- Degrades JAKs, GSPT1, and IKZF1 in a dose-dependent manner
- Indicates inhibition of the JAK-STAT signaling pathway
Medchemexpress LLC Bio-AMS TFA | 1393881-52-1 | 98.0% | 685.65 | 1 MG
Bio-AMS (TFA) is a potent bacterial biotin protein ligase inhibitor. It exhibits selective activity against *Mycobacterium tuberculosis* (Mtb) and hinders fatty acid and lipid biosynthesis. It is for research use only and not sold to patients.
- Potent bacterial biotin protein ligase inhibitor.
- Selective activity against *Mycobacterium tuberculosis* (Mtb).
- Arrests fatty acid and lipid biosynthesis.
- Excellent antitubercular activity against Mtb H37Rv and MDR/XDR-TB strains with MICs ranging from 0.16 to 0.625 μM.
- Its activity is not affected by changes to the primary carbon source.
- Inhibits growth of Mtb in Mtb-infected mouse macrophages in a concentration-dependent manner (2.5, 5 and 10 μM; 24 h).
- Shows no signs of mitochondrial toxicity.
Medchemexpress LLC Cef20 (Tfa) | 99.3% | 1057.19 | 25 MG
CEF20 TFA is an HLA-A*0201-restricted epitope from cytomegalovirus pp65 (495-503).
- High purity of 99.31%
- Molecular weight of 1057.19
- Solid appearance
- White to off-white color
- Sequence: Asn-Leu-Val-Pro-Met-Val-Ala-Thr-Val (NLVPMVATV)
- Soluble in DMSO
- Store in sealed container, away from moisture
- Powder storage: -80°C for 2 years, -20°C for 1 year
- Storage in solvent: -80°C for 6 months, -20°C for 1 month
Medchemexpress LLC Charybdotoxin (TFA) | 96.8% | 4295.89 (free acid) | 500 UG
Charybdotoxin (TFA) is a research-grade peptide supplied as a white to off-white solid. It has a molecular weight of 4295.89 (free acid) and a purity of 96.8% as determined by LCMS. This substance is intended for laboratory use and substance manufacturing, offering stability under recommended storage conditions.
- Supplied as a white to off-white solid
- Purity of 96.8% (LCMS)
- Molecular weight of 4295.89 (free acid)
- Suitable for use as laboratory chemical and for substance manufacturing
- Stable under recommended storage conditions
- Store powder at -80°C for 2 years or -20°C for 1 year
- Store in solvent at -80°C for 6 months or -20°C for 1 month
Medchemexpress LLC C-telopeptide TFA | 868.89 (free base) | 25 MG
C-telopeptide TFA is a cross-linked peptide of type I collagen. It is released during bone resorption and has been correlated with bone mineral density (BMD). This product is intended for research use only.
- Cross-linked peptide of type I collagen
- Released during bone resorption
- Correlated with bone mineral density (BMD)
- Sequence: Glu-Lys-Ala-His-Asp-Gly-Gly-Arg
- Target: MMP
- Pathway: Metabolic Enzyme/Protease
Medchemexpress LLC Sar441255 TFA | 99.9% | 4866.56 (free base) | 1 MG
SAR441255 TFA is a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist. It demonstrates high potency with balanced activation of all three target receptors. This compound shows positive acute glucoregulatory effects in diabetic obese monkeys, indicating its potential for metabolic and endocrine disease research, particularly in areas like obesity and type 2 diabetes.
- Potent unimolecular peptide receptor triagonist.
- Displays high potency with balanced activation of three target receptors.
- Shows positive acute glucoregulatory effects in diabetic obese monkeys.
- Relevant for research in metabolic diseases, including obesity and type 2 diabetes.
Medchemexpress LLC TcY-NH2 TFA ((trans-cinnamoyl)-YPGKF-NH2 TFA) | 1262750-73-1 | 99.7% | 853.88 | 10 MG
tcY-NH2 TFA is a potent and selective PAR4 antagonist peptide. It is capable of inhibiting thrombin- and AY-NH2-induced platelet aggregation and endostatin release. This peptide is suitable for research applications in inflammation and immunology.
- Potent and selective PAR4 antagonist peptide.
- Inhibits thrombin- and AY-NH2-induced platelet aggregation.
- Prevents endostatin release.
- Suitable for inflammation and immunology research.
- Purity of 99.7%.
- Soluble in DMSO at 100 mg/mL.
- Demonstrated activity in various in vitro and in vivo models.
Medchemexpress LLC TFLLR-NH2(TFA) | 1313730-19-6 | 99.6% | 761.83 | 25 MG
TFLLR-NH2 (TFA) is a selective PAR1 agonist with an EC50 of 1.9 μM. It stimulates concentration-dependent increases in [Ca2+]i, upregulates E-cadherin, and downregulates vimentin expression in SW620 cells. It also induces a dose-dependent increase of secreted TGF-β1 in activated platelets. In vivo, it causes marked and sustained oedema and Evans blue extravasation, and produces contraction and relaxation in rat duodenal smooth muscle.
- Selective PAR1 agonist with an EC50 of 1.9 μM
- Appears as a white to off-white solid
- Soluble in DMSO and H2O at 100 mg/mL
- Upregulates E-cadherin and downregulates vimentin expression
- Induces dose-dependent increase of secreted TGF-β1
- Stimulates oedema and Evans blue extravasation in vivo
- Produces contraction and relaxation in rat duodenal smooth muscle
Medchemexpress LLC Colivelin TFA | 2803948-60-7 | 99.5% | 2759.12 | 25 MG
Colivelin TFA is a brain-penetrant neuroprotective peptide that acts as a potent activator of STAT3, suppressing neuronal death in vitro. It demonstrates long-term beneficial effects against neurotoxicity, amyloid-beta (Aβ) deposition, neuronal apoptosis, and deficits in synaptic plasticity associated with neurodegenerative diseases. This compound holds potential for the treatment of Alzheimer's disease and ischemic brain injury.
- Neuroprotective properties
- Potent activator of STAT3
- Suppresses neuronal death
- Exhibits long-term beneficial effects against neurotoxicity
- Reduces amyloid-beta (Aβ) deposition
- Prevents neuronal apoptosis
- Addresses synaptic plasticity deficits
- Potential treatment for Alzheimer's disease
- Potential treatment for ischemic brain injury
Apexbio Technology LLC FSLLRY-NH2 TFA 245329-02-6 (free base) 25mg
FSLLRY-NH2 TFA is a synthetic peptide antagonist targeting protease-activated receptor 2 (PAR-2) It is designed to block PAR-2 activation thereby inhibiting intracellular signaling cascades such as calcium mobilization and MAP kinase activation that underlie inflammatory responses nociceptive transmission and immune modulation FSLLRY-NH2 TFA exerts its biological activity primarily through competitive binding to PAR-2 preventing receptor activation and downstream signaling events Based on these pharmacological properties FSLLRY-NH2 TFA holds research potential in the study of inflammation-associated disorders and pain pathways