Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Lys-coenzyme A trifluoroacetate | 98.5% | 1108.82 g·mol⁻1 | C33H54F3N10O21P3S | 5 MG
Lys-CoA TFA is a bisubstrate-mimic inhibitor of the p300 histone acetyltransferase (HAT). It inhibits p300-dependent acetylation (reported IC50 = 50-500 nM) with >100-fold selectivity over PCAF and is intended for use in biochemical and cell-based studies probing p300-mediated acetylation.
- Selective p300 histone acetyltransferase (HAT) inhibitor (IC50 = 50-500 nM)
- Greater than 100-fold selectivity versus PCAF
- High purity (98.5%) suitable for research applications
- Molecular formula C33H54F3N10O21P3S
- Molecular weight 1108.82 g·mol⁻1
- Supplied as a small-quantity solid for biochemical assays and cell studies
Medchemexpress LLC Tcmcb07 (TFA) | 99.7% | 1230.46 (free base) | 5 MG
TCMCB07 (TFA) is a chemical product from MedChemExpress USA, identified for use as laboratory chemicals and for the manufacture of substances. It is supplied as a solid and is stable under recommended storage conditions.
- Designed for laboratory use and substance manufacturing
- Stable under recommended storage conditions
- Supplied as a solid
- Storage recommended at -80°C for 2 years or -20°C for 1 year (powder)
- Sealed storage, away from moisture and light
Medchemexpress LLC Dendrotoxin-I TFA | 99.9% | 7149.24 | 1 MG
Dendrotoxin-I TFA (DTX-I TFA) is a potent K+ channel blocker with IC50s of 0.13-50 nM for voltage-gated potassium channel subunits Kv1.1, Kv1.2, and Kv1.6. This neurotoxin shows potential for cancer research.
- Potent K+ channel blocker
- Targets voltage-gated potassium channel subunits Kv1.1, Kv1.2, and Kv1.6
- Displays tumor growth inhibition effect with hyperthermia in vivo studies
- White to off-white solid appearance
Medchemexpress LLC CPP9 TFA | 99.9% | 1553.37 | 1 MG
CPP9 TFA is a small, amphipathic, cyclic cell penetrating peptide (CPP). CPPs bind directly to the plasma membrane phospholipids and enter mammalian cells via endocytosis, followed by efficient release from the endosome. It can be used for intracellular delivery of therapeutic agents and chemical probes.
- Small, amphipathic, cyclic cell penetrating peptide
- Binds directly to plasma membrane phospholipids
- Enters mammalian cells via endocytosis
- Efficient release from the endosome
- Used for intracellular delivery of therapeutic agents
- Used for intracellular delivery of chemical probes
Apexbio Technology LLC FSLLRY-NH2 TFA 245329-02-6 (free base) 10mg
FSLLRY-NH2 TFA is a synthetic peptide antagonist targeting protease-activated receptor 2 (PAR-2) It is designed to block PAR-2 activation thereby inhibiting intracellular signaling cascades such as calcium mobilization and MAP kinase activation that underlie inflammatory responses nociceptive transmission and immune modulation FSLLRY-NH2 TFA exerts its biological activity primarily through competitive binding to PAR-2 preventing receptor activation and downstream signaling events Based on these pharmacological properties FSLLRY-NH2 TFA holds research potential in the study of inflammation-associated disorders and pain pathways
Medchemexpress LLC SJ1008030 TFA | 2863634-97-1 | 99.8% | 987.96 | 5 MG
SJ1008030 TFA is a JAK2 PROTAC that selectively degrades JAK2. It inhibits MHH-CALL-4 cell growth with an IC50 of 5.4 nM and can be utilized for leukemia research. The compound is composed of a JAK2 ligand, a Cereblon ligand, and a linker.
- Selective JAK2 PROTAC degrader.
- Inhibits MHH-CALL-4 cell growth with an IC50 of 5.4 nM.
- Can be used for leukemia research.
- Degrades JAKs, GSPT1, and IKZF1 in a dose-dependent manner in MHH-CALL-4 cells.
- Dose-dependently degrades JAK2 and GSPT1 protein in xenograft bone marrow SJBALL021415 cells, indicating inhibition of the JAK-STAT signaling pathway.
Medchemexpress LLC 2H-Cho-Arg (TFA) | 1609010-59-4 | 99% | 886.06 | 1 MG
2H-Cho-Arg (TFA) is a steroid-based cationic lipid that contains a 2H-cholesterol skeleton coupled to an L-arginine head group and can be used to facilitate gene transfection.
- Steroid-based cationic lipid
- Contains a 2H-cholesterol skeleton
- Coupled to an L-arginine head group
- Facilitates gene transfection
- Stable under recommended storage conditions
- For research use only
Medchemexpress LLC Nampt-IN-10 (TFA) | 2567724-20-1 | >98.6% | 701.59 | 25 MG
Nampt-IN-10 TFA (compound 4) is a Nicotinamide Phosphoribosyltransferase (NAMPT) inhibitor. It shows cellular potency to A2780 and CORL23 cell lines with IC50s of 5 and 19 nM, respectively. Nampt-IN-10 TFA can be used as a novel non-antimitotic payload for ADCs.
- Shows cellular potency to A2780, CORL23, and c-Kit and HER2 expressing cell lines.
- IC50 values are 5 nM (A2780), 19 nM (CORL23), 2 nM (NCI-H526 with c-Kit expressing), 0.4 nM (MDA-MB453 with HER2 expressing), and 1 nM (NCI-N87 with HER2 expressing).
- Can be used as a novel non-antimitotic payload for ADCs.
Medchemexpress LLC Valylleucine TFA | 27530-02-5 | 99.3% | 344.33 | 25 MG
Valylleucine TFA is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. It can be used for protein interaction, functional analysis, and epitope screening, especially in agent research and development.
- Polypeptide
- Used in peptide screening
- Pools active peptides by immunoassay
- Supports protein interaction studies
- Enables functional analysis
- Facilitates epitope screening
- Applicable in agent research and development
Medchemexpress LLC Retatrutide TFA 10mg
Retatrutide, (LY3437943) is a triple agonist peptide of the glucagon receptor (GCGR), glucosedependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R). Retatrutide binds human GCGR, GIPR, and GLP-1R with EC50 values of 5.79, 0.0643 and 0.775 nM, respectively. Retatrutide can be used for the research of obesity. 10mg
Medchemexpress LLC TFLLR-NH2(TFA) | 1313730-19-6 | 99.6% | 761.83 | 10 MG
TFLLR-NH2(TFA) is a selective PAR1 agonist with an EC50 of 1.9 μM, intended for research use. It stimulates concentration-dependent increases in intracellular calcium and promotes upregulation of E-cadherin expression in SW620 cells. In vivo, it can induce oedema and extravasation in various organs.
- Selective PAR1 agonist (EC50 of 1.9 μM)
- Induces concentration-dependent increases in intracellular calcium
- Upregulates E-cadherin expression in SW620 cells
- Stimulates secreted TGF-β1 in platelet cultures
- Can induce oedema and extravasation in animal models
- Stable for 2 years as powder at -80°C
- Stable for 6 months in solvent at -80°C
Medchemexpress LLC MI-1061 TFA | 1410737-35-7 | 97.5% | 696.47 | C32H27Cl2F4N3O6 | 10MM 1ML
MI-1061 TFA is the trifluoroacetate salt of MI-1061, a potent, orally bioavailable inhibitor of the MDM2-p53 interaction (reported IC50 = 4.4 nM; Ki = 0.16 nM). The compound is offered as a solid and as a ready-to-use 10 mM solution in DMSO (1 mL) for in vitro assays, and the manufacturer provides solubility and in vivo formulation guidance. Typical uses include biochemical and cell-based studies of p53 pathway modulation.
- Potent MDM2-p53 interaction inhibitor (IC50 4.4 nM).
- Available as solid and as a 10 mM solution in DMSO for immediate use.
- High purity (approximately 97.5%), suitable for research assays.
- Soluble in DMSO (reported solubility 120 mg/mL), enabling concentrated stocks.
- Manufacturer provides recommended stock concentrations and in vivo vehicle guidance.
Medchemexpress LLC MtvkPabc-p5 TFA | 1190.22 | C54H74F3N11O16 | 5 MG
MTvkPABC-P5 TFA is a Toll-like receptor 7 (TLR7) agonist and immune stimulant used as a reagent for synthesizing immune-stimulating antibody conjugates (ISACs). It is supplied as the trifluoroacetic acid (TFA) salt in solid form. Molecular formula: C54H74F3N11O16; molecular weight: 1190.22.
- Acts as a TLR7 agonist and immune stimulant.
- Used to synthesize immune-stimulating antibody conjugates (ISACs).
- Supplied as the trifluoroacetic acid (TFA) salt in solid form.
- Storage: solid -20°C; protect from light; store under nitrogen.
- Available pack sizes: 1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg.
TARGETMOL CHEMICALS INC GSMTX4 TFA 1209500-46-8 5MG
Also available in 1 mg 2 mg 10 mg and bulk. Please contact Fisher for quotes. GsMTx4 TFA (1209500-46-8 free base) (GsMTx4 TFA) is a spider venom peptide that selectively inhibits cationic permeable mechanically-sensitive channels (MSCs) belonging to the Piezo and TRP channel families.