Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Ntpa Tfa | 99.8% | 1773.36 | 1 MG
NTPA TFA is a polycarboxylic acid ligand that participates in the coordination reaction with metal ions to form complexes.
- High purity: 99.80%
- Molecular weight: 1773.36 (free base)
- Appearance: solid
- Color: white to off-white
- Sequence: C17H35CONH-Pro-Lys-Lys-Lys-Arg-Lys-Val-Arg-Arg-Arg-Arg-NH2
- Soluble in DMSO (50 mg/mL)
Medchemexpress LLC NLS-StAx-h TFA | 2872559-21-0 | 98.9% | 3559.28 | 100 UG
NLS-StAx-h TFA is a selective, cell-permeable, stapled peptide Wnt signaling inhibitor with an IC50 of 1.4 μM. It efficiently inhibits β-catenin-transcription factor interactions and demonstrates anti-proliferation effects on cancer cells, making it suitable for research into Wnt signaling pathways.
- Efficiently inhibits β-catenin-transcription factor interactions
- Shows anti-proliferation effects on cancer cells
- Reduces the viability of SW-480 and DLD-1 colorectal cancer cells by more than 80%
- Inhibits the migration of colorectal cancer cells in a dose-dependent manner
Medchemexpress LLC Goralatide TFA | 1796568-94-9 | 98.0% | 1 MG
Goralatide TFA is an inhibitor of cell cycle progression that enhances the selectivity of hyperthermic purging of human progenitor cells. It has potential for research related to leukemia.
- Inhibits cell cycle progression.
- Enhances selectivity of hyperthermic purging of human progenitor cells.
- Potential for leukemia research.
Medchemexpress LLC Cn2 toxin TFA | 96.59% | 7588.60 | 5 MG
Cn2 toxin TFA (β-Mammal toxin Cn2 TFA) is a single-chain β-scorpion neurotoxic peptide identified as the main toxin found in scorpion venom. It specifically targets mammalian voltage-gated sodium channels (VGSC) Nav1.6.
- Single-chain β-scorpion neurotoxic peptide
- Main toxin in scorpion venom
- Specifically targets mammalian voltage-gated sodium channels (VGSC) Nav1.6
- Available in various quantities
- For research use only
Medchemexpress LLC FTO-IN-1 TFA | 2797619-81-7 | 98.1% | 505.27 | 1 ML
FTO-IN-1 TFA is a fat mass and obesity-associated enzyme (FTO) inhibitor extracted from patent WO2018157843A1, compound 32. It can be used for the research of cancer and is for research use only.
- FTO inhibitor with an IC50 of <1 μM
- Inhibits FTO enzyme activity by 62% in vitro at 50 μM
- Inhibits the viability of SCLC-21H, RH30 and KP3 cells with IC50s of 2.1 μM, 5.3 μM, and 5.6 μM, respectively
TARGETMOL CHEMICALS INC DEXTROROTATION NIMORAZOL 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Dextrorotation nimorazole phosphate ester TFA is an anti-anaerobic and anti-parasitic agent.
Medchemexpress LLC MC-VC-PAB-NH2 trifluoroacetic acid | 1616727-21-9 | 99.9% | C33H47F3N8O10 | 10MG
MC-VC-PAB-NH2 TFA is a cleavable ADC linker supplied as the trifluoroacetic acid salt for research use. It contains a Val-Cit-PAB cleavable spacer designed for protease-triggered drug release and is provided as a white to off-white solid with high purity.
- Provides a protease-cleavable Val-Cit-PAB spacer for controlled payload release.
- Supplied as a TFA salt to aid handling and stability.
- High purity (≈99.9%) suitable for conjugation workflows.
- Soluble in DMSO at high concentration (100 mg/mL) with ultrasonic assistance.
- Solid, white to off-white appearance for convenient storage and handling.
- Storage recommendations: sealed, away from moisture and light; in solvent: -80°C (6 months), -20°C (1 month).
- Intended for research use only; not for human or clinical use.
Medchemexpress LLC MTvkPABC-P5 TFA | 98.8% | 1190.22 Da | C54H74F3N11O16 | 1 MG
MTvkPABC-P5 TFA is the trifluoroacetic acid (TFA) salt form of a Toll-like receptor 7 (TLR7) agonist used as an immune stimulant and as a synthetic building block for immune-stimulating antibody conjugates (ISACs).
- Acts as a Toll-like receptor 7 (TLR7) agonist and immune stimulant.
- Used as a building block for synthesis of immune-stimulating antibody conjugates (ISACs).
- Provided as a TFA salt for improved handling and stability.
- Reported high purity suitable for research use.
- Offered in small mg pack sizes for laboratory applications.
Medchemexpress LLC UNC0379 trifluoroacetate | 1620401-83-3 | MFCD28167817 | 99.9% | 527.58 g·mol⁻¹ | C25H36F3N5O4 | 5MG
UNC0379 trifluoroacetate is the trifluoroacetate salt of UNC0379, a selective substrate-competitive inhibitor of the lysine methyltransferase SETD8 (KMT5A). It is supplied as a high-purity research reagent for biochemical and cellular studies, with reported activity IC50 = 7.3 μM and KD = 18.3 μM. For laboratory research use only.
Medchemexpress LLC PHF6 TFA | 99.5% | 748.91 | 5 MG
PHF6 (VQIVYK) TFA is a self-assembly sequence capable of initiating the full-length tau protein aggregation. PHF6 TFA is mapped to the third microtubule-binding repeat region of the tau protein.
- Aggregated tau-PHF6 (VQIVYK) TFA potentiates NLRP3 inflammasome expression and autophagy in human microglial cells.
Medchemexpress LLC DX600 TFA | 99.2% | 3074.33 (free acid) | 1 MG
DX600 TFA is a selective ACE2 specific inhibitor (KD: 1.3 nM) that does not cross-react with ACE. It has been observed to exacerbate diabetes-induced cardiovascular dysfunction and increase cardiac and renal NOX activity. It is for research use only.
- Selective ACE2 specific inhibitor
- Does not cross-react with ACE
- Exacerbates diabetes-induced cardiovascular dysfunction
- Increases cardiac and renal NOX activity
Medchemexpress LLC ATX-II TFA | 99.7% | 4934.62 (free acid) | 1 MG
ATX-II TFA is a selective sodium channel modulator toxin. It enhances late sodium current and prevents full sodium channel inactivation, leading to persistent current fractions. This can have pro-arrhythmic effects, such as slowing intrinsic heart rate and prolonging the QT interval. It is suitable for research on atrial fibrillation and long QT syndromes.
- Selective sodium channel modulator toxin
- Enhances late sodium current
- Prevents full sodium channel inactivation
- Generates persistent current fractions
- Has a pro-arrhythmic effect
- Slows intrinsic heart rate
- Prolongs QT interval
- Suitable for research on atrial fibrillation
- Suitable for research on long QT syndrome
- Purity of 99.7%
- Molecular weight of 4934.62 (free acid)
- Appearance as a solid
- White to off-white color