Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Chem-Impex International, Inc. Trifluoroacetic acid | 76-05-1 | MFCD00004169 | 500G
Trifluoroacetic acid, 76-05-1, MFCD00004169, 500G
Pfaltz & Bauer Trifluoroacetic acid anhydride 100G | 407-25-0
Trifluoroacetic acid anhydride 100G | 407-25-0
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic acid eluen
Trifluoroacetic acid is commonly used as a mobile phase additive in liquid chromatography-mass spectrometry (LC-MS). FeaturesExtensive QC testing ensures the highest specifications.AAAAAAAAOptimized to improve ionization and reSOLUTIONon.AAAAAAAA Extremely low levels of inorganic and organic impurities.AAAAAAAManufactured specifically for accurate and fast LC-MS.
Apexbio Technology LLC CYCLORLSKDK TFA 5MG
Cyclo(RLsKDK) TFA is a cyclic pentapeptide inhibitor targeting the metalloproteinase ADAM8 a transmembrane protein frequently dysregulated in pathological conditions such as inflammation cancer and neurodegenerative diseases By specifically inhibiting ADAM8 enzymatic activity cyclo(RLsKDK) TFA may modulate disease-associated cellular processes This molecule holds promise as a research tool for studying ADAM8 function and as a potential therapeutic candidate in inflammatory disorders and oncology
Apexbio Technology LLC GR 94800 TFA 5mg
GR 94800 TFA is a selective antagonist targeting neuropeptide Y (NPY) Y2 receptors Neuropeptide Y signaling via Y2 receptor subtypes participates in energy balance appetite modulation mood regulation anxiety-related behaviors and neuronal response to stress GR 94800 TFA specifically inhibits NPY Y2 receptor-mediated signaling thereby facilitating studies on the physiological and behavioral outcomes regulated by this receptor pathway It is commonly utilized by biomedical researchers investigating functions of NPY systems in feeding control emotional responses anxiety and depressive behaviors as well as cognition-related processes such as learning and memory Additionally this compound serves as an investigative tool to elucidate downstream signaling pathways and potential pharmacological targets linked to the Y2 receptor
Apexbio Technology LLC 2X HyperFusion High-Fidelity Master Mix 10X1ml
2X HyperFusion High-Fidelity Master Mix provides high fidelity strong amplification capability and faster amplification speed for most PCR applications HyperFusion DNA polymerase is composed of a Pyrococcus-like proofreading polymerase fused with a DNA-binding domain Its unique structure which combines a novel Pyrococcus-like enzyme and a domain enhancing synthesis capability increases fidelity and speed Due to its high fidelity HyperFusion DNA polymerase is an ideal choice for molecular cloning or other downstream applications HyperFusion DNA polymerase is among the DNA polymerases with the highest fidelity having a 50-fold lower error rate compared to Taq DNA polymerase and a 6-fold lower error rate than Pyrococcus Furious DNA polymerase HyperFusion DNA polymerase exhibits 5 to 3 polymerase activity and 3 to 5 exonuclease activity It generates blunt-ended PCR products without A-overhangs The extension rate is approximately 15-30 sec per kb (up to 10 kb in length)
TARGETMOL CHEMICALS INC Elarofiban TFA 1MG
Also available in 5 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Elarofiban TFA (RWJ-53308 TFA) is a novel and orally active and selective GPIIb/IIIa antagonist for the study of cardiovascular disease. Purity 100%
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic acid Reage
TRIFLUOROACETIC Trifluoroacetic acid Reage
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic acid 99 fo100G
TRIFLUOROACETIC Trifluoroacetic acid 99 fo100G
Selleck Chemical LLC Iberiotoxin TFA-E0015-25MG
Iberiotoxin TFA(IbTX) is a toxin purified from the scorpion Buthus tamulus Iberiotoxin is a potent blocker of the large conductance Ca(2 )-activated K channel with a Kd of 1 nM
Selleck Chemical LLC Iberiotoxin TFA-E0015-5MG
Iberiotoxin TFA(IbTX) is a toxin purified from the scorpion Buthus tamulus Iberiotoxin is a potent blocker of the large conductance Ca(2 )-activated K channel with a Kd of 1 nM