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Filtered Search Results
Medchemexpress LLC Siramesine hydrochloride | 224177-60-0 | 99.7% | C30H32ClFN2O | 2 MG
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Siramesine hydrochloride, also known as Lu 28-179 hydrochloride, is a potent sigma-2 receptor agonist. It demonstrates high selectivity for sigma-2 receptors over sigma-1 receptors. This compound triggers cell death by destabilizing mitochondria and exhibits anti-cancer activity.
- Potent sigma-2 receptor agonist
- High selectivity for sigma-2 receptors
- Triggers cell death via mitochondrial destabilization
- Shows anti-cancer activity
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000401563 4-HYDROXY-2-NAPHTHOI 1G
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Medchemexpress LLC Tetracaine hydrochloride | 136-47-0 | 99.91% | 1 G
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Tetracaine hydrochloride (Amethocaine hydrochloride) is a calcium channel protein inhibitor that blocks voltage-sensitive release of Ca2+ from the sarcoplasmic reticulum. It is primarily used topically in ophthalmology and as an antipruritic. It also alters the function of calcium release channels (ryanodine receptors) that regulate calcium release from intracellular stores.
- Blocks voltage-sensitive release of Ca2+ from the sarcoplasmic reticulum.
- Used topically in ophthalmology.
- Acts as an antipruritic.
- Alters the function of calcium release channels (ryanodine receptors).
- Inhibits spontaneous calcium release events at low concentrations.
- Completely blocks calcium release at high concentrations.
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TARGETMOL CHEMICALS INC BI-4020 5MG
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Also available in 1 mg 10 mg 25 mg 50 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. BI-4020 is a fourth-generation orally active and non-covalent inhibitor of EGFR tyrosine kinase. BI-4020 exhibits activity agains the triple mutant EGFR del19 T790M C797S variant (IC50=0.2 nM in BaF3 cell lines) the double mutant EGFR del19 T790M and primary mutant EGFR del19 (IC50=1 nM) and EGFR wt (IC50=190 nM). BI-4020 exhibits high kinome selectivity and good DMPK properties. purity: 98%
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TARGETMOL CHEMICALS INC BI-2852 5MG
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Also available in 1 mg 10 mg 25 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. BI-2852 is a KRAS inhibitor for the switch I/II pocket (SI/II-pocket) with nanomolar affinity. BI-2852 is leading to inhibition of downstream signaling and an antiproliferative effect in KRAS mutant cells. purity: 98%
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Medchemexpress LLC 6-Methoxy-2-naphthoi 1g | 1G
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6-Methoxy-2-naphthoi 1g | 1G
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Medchemexpress LLC BI-3812 | 2166387-64-8 | 99.3% | 558.03 | 10 MG
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BI-3812 is characterized as a potent and selective BCL6 inhibitor, functioning as a chemical probe. Its primary mechanism involves the suppression of the BCL6 BTB domain, demonstrated by an IC50 value of ≤ 3 nM. This inhibitory action contributes to its observed antitumor activity. The compound also shows an IC50 of 40 nM for cellular BCL6. It is available for research use only and was developed by Boehringer Ingelheim. Researchers can acquire BI-3812 and its negative control from the open innovation portal, opnMe.com.
- Functions as a chemical probe and highly efficient BCL6 inhibitor
- Suppresses the BTB domain of BCL6
- Has an IC50 value of ≤ 3 nM for BCL6 BTB
- Exhibits antitumor activity
- Has an IC50 of 40 nM for cellular BCL6
- Available for research use only
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Medchemexpress LLC Crizotinib (hydrochloride) | 1415560-69-8 | 99.7% | C21H23Cl3FN5O | 1 ML
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Crizotinib hydrochloride is an orally bioavailable, selective, and ATP-competitive dual ALK and c-Met inhibitor. It inhibits tyrosine phosphorylation of NPM-ALK and c-Met in cell-based assays and is also a ROS proto-oncogene 1 (ROS1) inhibitor, demonstrating effective tumor growth inhibition.
- Orally bioavailable
- Selective ALK and c-Met inhibitor
- Inhibits tyrosine phosphorylation of NPM-ALK and c-Met
- Functions as a ROS proto-oncogene 1 (ROS1) inhibitor
- Demonstrates effective tumor growth inhibition
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Medchemexpress LLC (+)-camphor-10-sulfonic acid | 3144-16-9 | MFCD00064157 | ≥98.0% | 232.3 g·mol⁻¹ | C10H16O4S | 250g
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( )-Camphor-10-sulfonic acid (( )-10-Camphorsulfonic acid) is an effective pancreatic lipase (PL) inhibitor ( )-Camphor-10-sulfonic acid is promising for research of obesity[1]
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000695746 CYSTEAMINE HYDROCHL 50G
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Medchemexpress LLC Cefozopran hydrochloride | 113981-44-5 | 95.0% | 100 MG
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Cefozopran hydrochloride is a semi-synthetic, parenteral, fourth-generation cephalosporin. This antibiotic exhibits a broad spectrum of antibacterial activity, effectively inhibiting most gram-negative and gram-positive organisms.
- Exhibits broad-spectrum antibacterial activity.
- Effectively inhibits most gram-negative and gram-positive organisms.
- Shows good activity against methicillin-susceptible staphylococci, enterococci, and viridans group streptococci.
- Active against gram-negative organisms, including Haemophilus influenza.
- Demonstrates comparatively good activity against enterococci and P. aeruginosa.
- Effective against acute respiratory tract infections in mice models.
- Effective against chronic respiratory tract infection in mice models.
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Medchemexpress LLC Moroxydine (hydrochloride) | 3160-91-6 | 99.4% | 10 G
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Moroxydine hydrochloride (ABOB hydrochloride) is a broad-spectrum agent with multi-antiviral activities against both DNA and RNA viruses. These include influenza virus, herpes simplex, varicella zoster, measles, mumps disease, and hepatitis C virus. It demonstrates excellent antiviral activity with low cytotoxicity to cells infected by dsRNA viruses like grass carp reovirus (GCRV) and large DNA viruses such as giant salamander iridovirus (GSIV).
- Blocks GCRV-induced cytopathic effects
- Removes nucleocapsids in ctenopharyngodon idella kidney (CIK) cells
- Maintains normal morphological structure of CIK cells
- Significantly inhibits apoptosis
- Inhibits caspase 3 activity and Bax expression
- Down-regulates Bcl-2 levels
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Cayman Chemical 6-methoxy-2-NaphthoIc AcId 25g
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An active metabolite of nabumetone; inhibits COX-1 and LPS-induced COX-2 activities in isolated human whole blood (IC50s = 31.01 and 19.84 µM, respectively); a potential impurity in commercial preparations of naproxen
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Medchemexpress LLC Selegiline hydrochloride | 14611-52-0 | 99.96% | C13H18ClN | 100 MG
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Selegiline hydrochloride (Deprenyl) is a potent, selective, and irreversible inhibitor of MAO-B, with an IC50 of 51 nM. It exhibits 450-fold selectivity for MAO-B over MAO-A (IC50=23 μM). This compound is used in research for Parkinson's disease, Alzheimer's disease, and major depressive disorder.
- Potent, selective, irreversible MAO-B inhibitor.
- IC50 of 51 nM for MAO-B.
- 450-fold selectivity for MAO-B over MAO-A.
- Research applications: Parkinson's, Alzheimer's, major depressive disorder.
- Inhibits recombinant human MAO-B.
- Increases efflux of NE, DA, and 5-HT from rat hypothalamus in vitro.
- Reduces cocaine self-administration in mice.
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Medchemexpress LLC BMS-582949 hydrochloride | 912806-16-7 | 98.90% | C22H27ClN6O2 | 25 MG
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BMS-582949 hydrochloride is an orally active and highly selective p38α MAPK inhibitor with an IC50 of 13 nM. It displays a significantly improved pharmacokinetic profile and is effective in inflammatory disease. BMS-582949 is a weak inhibitor of CYP3A4 and displays >2000-fold selectivity for p38α over a diverse panel of 57 kinases. In vivo, it is effective in both the acute murine model of inflammation and rat adjuvant arthritis model. Storage conditions: 4°C, sealed storage, away from moisture. In solvent: -80°C for 6 months; -20°C for 1 month (sealed storage, away from moisture).
- Orally active and highly selective p38α MAPK inhibitor
- Improved pharmacokinetic profile
- Effective in inflammatory disease
- Weak inhibitor of CYP3A4
- Displays >2000-fold selectivity for p38α over 57 kinases
- Effective in acute murine models of inflammation and rat adjuvant arthritis models
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