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Filtered Search Results
Aobchem AOBCHEM
5000866093 2-CHLORO-6-METHOXYNAPHTHALENE
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Ambeed AMBEED
5000870739 6-BROMO-1234-TETRAHYDRONAP 1GR
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Medchemexpress LLC Adapalene | 106685-40-9 | 99.9% | C28H28O3 | 100 MG
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Adapalene is a third-generation synthetic retinoid widely used for acne research. It acts as a potent RAR agonist, with AC50s of 2.3 nM for RARβ, 9.3 nM for RARγ, and 22 nM for RARα. This compound also non-competitively inhibits the enzymatic activity of GOT1 and exhibits anti-tumor activity.
- Third-generation synthetic retinoid
- Potent RAR agonist for RARβ, RARγ, and RARα
- Non-competitive inhibitor of GOT1 enzymatic activity
- Exhibits anti-tumor activity
- Induces apoptosis and inhibits proliferation in ES-2 cells
- Inhibits growth of DLD1 cell-derived xenograft tumors
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Accela Chembio Inc 4-bromo-1-naphthoic Acid | 1g | 16650-55-8 | MFCD00094221 | 97+% | Shelf Life: 1260 Days | Light Sensitive/+4
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4-bromo-1-naphthoic Acid | 1g | 16650-55-8 | MFCD00094221 | 97+% | Shelf Life: 1260 Days | Light Sensitive/+4
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000703741 BI-69A11 1MG
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Medchemexpress LLC 6-(5-(methoxymethyl)pyridin-3-yl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide | 1633009-87-6 | MFCD28502113 | 99.2% | 298.34 g/mol | C16H18N4O2 | 10 MG
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BI 689648 is a novel, highly selective aldosterone synthase (CYP11B2) inhibitor characterized for research use. It potently inhibits CYP11B2 (reported IC50 2.1 nM) while showing substantially reduced activity against CYP11B1 (IC50 310 nM), and has been profiled in nonhuman primate pharmacology studies. The compound is supplied as a purified research chemical for biochemical and in vivo investigations.
- Potent and selective inhibition of aldosterone synthase (CYP11B2).
- Reduced activity against cortisol synthase (CYP11B1) compared with CYP11B2.
- Suitable for in vitro and in vivo pharmacology studies.
- Supplied as a high-purity research compound.
- Documented chemical identifiers (CAS 1633009-87-6, formula C16H18N4O2).
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Medchemexpress LLC 4-[4-[(dimethylamino)methyl]-2,5-dimethoxyphenyl]-2-methyl-1,2-dihydro-2,7-naphthyridin-1-one | 1883429-22-8 | MFCD30182324 | 98.7% | 353.41 Da | C20H23N3O3 | 50 MG
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BI-9564 is a small-molecule chemical probe that selectively inhibits BRD9 and, to a lesser extent, BRD7 bromodomains. It is cell-permeable, exhibits high affinity for BRD9, and has been used in both in vitro and in vivo studies to probe BAF complex biology and bromodomain function.
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Medchemexpress LLC 4-[4-[(dimethylamino)methyl]-3,5-dimethoxyphenyl]-2-methyl-2,7-naphthyridin-1-one | 1883429-21-7 | MFCD30489736 | >98.0% | 353.4 Da | C20H23N3O3 | 10 MM x 1 ML
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BI-7273 is a selective, cell-permeable bromodomain inhibitor primarily targeting BRD9 with secondary activity against BRD7. It has been characterized in biochemical, structural, and cellular assays and is supplied for research use in both concentrated DMSO solution and solid formats.
- High affinity for BRD9 (KD ≈ 15 nM) and low-nanomolar biochemical potency.
- Reduced activity against BRD7 (IC50 ≈ 117 nM), enabling differential target studies.
- High selectivity versus BET bromodomains (no measurable activity up to 100 μM).
- Supplied as a 10 mM solution in DMSO or as solid quantities for reconstitution.
- Typical purity ≥98% and molecular weight 353.4 Da.
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Medchemexpress LLC 1,4-Naphthoquinone | 130-15-4 | MFCD00001676 | 99.5% | 158.16 g/mol | C10H6O2 | 500 G
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1,4-Naphthoquinone (CAS 130-15-4) is a research-grade small-molecule quinone used in biochemical and pharmacological studies. It acts as an MAO-A/B inhibitor and is used in antibacterial, antitumor, and anti-inflammatory research. Supplied as a solid powder with documented purity and storage recommendations, it is appropriate for in vitro assays and synthesis applications.
- High purity suitable for research applications.
- Molecular formula C10H6O2; molecular weight 158.16 g/mol.
- Available in solid form, including 500 g package sizes.
- Documentation available: datasheet, certificate of analysis, and safety data sheet.
- Storage recommendations provided for powder and solutions.
- Suitable for biochemical assays targeting monoamine oxidases and related studies.
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Medchemexpress LLC Bi-78d3 | 883065-90-5 | MFCD12912396 | 99.9% | 379.37 g/mol | C13H9N5O5S2 | 10 MG
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BI-78D3 is a substrate-competitive inhibitor of c-Jun N-terminal kinase (JNK) used as a research tool to probe JNK-mediated signaling. It inhibits JNK kinase activity with an IC50 of approximately 280 nM and is supplied in solid and solution formats for in vitro and cell-based studies. For research use only.
- Substrate-competitive inhibitor of JNK.
- Reported IC50 of 280 nM against JNK.
- High purity (99.85%).
- Available as solid (10 mg) and as 10 mM solution in DMSO.
- Powder storage: -20°C for long-term stability.
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Medchemexpress LLC Carmoxirole hydrochloride | 115092-85-8
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Carmoxirole hydrochloride | 115092-85-8
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Medchemexpress LLC (±)-BI-D | 1416258-16-6 | 98.06% | 405.49 | 50 MG
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(±)-BI-D is a potent allosteric integrase inhibitor (ALLINI). It operates by binding to integrase at the LEDGF/p75 binding site, effectively inhibiting HIV-Luc infection in cellular assays.
- Potent allosteric integrase inhibitor.
- Binds integrase at the LEDGF/p75 binding site.
- Inhibits HIV-Luc infection in cells.
- For research use only.
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Selleck Chemical LLC BI-D1870 S2843-1g
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BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM in cell-free assays respectively 10- to 100-fold selectivity for RSK than MST2 GSK-3 MARK3 CK1 and Aurora B BI-D1870 exhibits anticancer attributes including the generation of reactive oxygen species (ROS) and increases in endoplasmic reticulum (ER) stress and autophagy
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Medchemexpress LLC BI 224436 | 1155419-89-8 | 99.7% | 442.51 | 50 MG
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BI 224436 is a novel HIV-1 noncatalytic site integrase inhibitor. It exhibits EC50 values of less than 15 nM against different HIV-1 laboratory strains. Originally designed by Boehringer Ingelheim, this compound is suitable for various laboratory research applications.
- Novel HIV-1 noncatalytic site integrase inhibitor
- Effective against different HIV-1 laboratory strains with EC50 values less than 15 nM
- Displays an additive effect in combination with most approved antiretrovirals
- Retains full antiviral activity against recombinant viruses encoding INSTI resistance substitutions
- Exhibits excellent pharmacokinetic profiles in rat, monkey, and dog
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Medchemexpress LLC Jnj28871063 hydrochloride | 944342-90-9 | 98.4% | 519.42 | C24H28Cl2N6O3 | 100 MG
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JNJ28871063 hydrochloride is an ATP-competitive pan-ErbB (EGFR/ErbB) kinase inhibitor used for research. It is orally active, shows potent inhibition of ErbB family kinases, crosses the blood-brain barrier, and has demonstrated antitumor activity in xenograft models.
- Orally active, ATP-competitive pan-ErbB kinase inhibitor.
- Potent inhibition of EGFR (ErbB1), ErbB2, and ErbB4 (IC50 ≈ 21-38 nM).
- Crosses the blood-brain barrier.
- Demonstrated antitumor activity in EGFR/ErbB2-overexpressing xenograft models.
- Supplied as the hydrochloride salt.
- Intended for in vitro and in vivo research use only.
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