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Filtered Search Results
Medchemexpress LLC BI-765423 10mg | 10mg
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BI-765423 is a human monoclonal antibody (mAb) targeting IL-11 BI-765423 can be used in fibrotic diseases research[1]
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Medchemexpress LLC Trequinsin hydrochloride | 78416-81-6 | 99.9% | 441.95 | 25 MG
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Trequinsin hydrochloride (HL 725) is a highly potent inhibitor of platelet CAMP phosphodiesterase (PDE), with an IC50 of 0.25 nM. It is also a very potent inhibitor of the aggregation of human platelets induced in vitro by ADP, collagen, thrombin, and epinephrine. In addition to its cardiovascular and antihypertensive qualities, it exhibits very potent antiplatelet activities. It is also an efficacious agonist of [Ca2+]i.
- Extremely potent inhibitor of platelet CAMP phosphodiesterase (PDE)
- Inhibits aggregation of human platelets induced by ADP, collagen, thrombin, and epinephrine
- Possesses cardiovascular and antihypertensive qualities
- Exhibits potent antiplatelet activities
- Efficacious agonist of [Ca2+]i
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Medchemexpress LLC NEPICASTAT HYDROCHL 10MM 1ML
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NEPICASTAT HYDROCHL 10MM 1ML
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Medchemexpress LLC Tamsulosin hydrochloride | 106463-17-6 | 99.8% | 100 MG
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Tamsulosin hydrochloride is an orally active antagonist of the α1-adrenergic receptor. It induces apoptosis and is used for the research of prostatic hyperplasia. Tamsulosin hydrochloride also attenuates abdominal aortic aneurysm growth and inhibits inflammation in animal models.
- Orally active α1-adrenergic receptor antagonist
- Induces apoptosis
- Used for prostatic hyperplasia research
- Attenuates abdominal aortic aneurysm growth
- Inhibits inflammation in animal models
- Molecular weight: 444.97
- Chemical formula: C20H29ClN2O5S
- Appearance: Solid
- Color: White to off-white
- Recommended storage: 4°C, sealed, away from moisture and light
- Solvent storage: -80°C for 6 months; -20°C for 1 month (sealed, away from moisture and light)
- Solubility in DMSO: 50 mg/mL (112.37 mM)
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Medchemexpress LLC Amantadine hydrochloride | 665-66-7 | 98.0% | 50 G
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Amantadine hydrochloride (1-Adamantanamine) is an orally active and potent antiviral agent effective against influenza A viruses. It inhibits various ion channels, including NMDA, M2, and coronavirus ion channels. It also exhibits anti-orthopoxvirus and anticancer activities. This compound is suitable for research related to Parkinson's disease, postoperative cognitive dysfunction (POCD), and COVID-19.
- Orally active and potent antiviral agent
- Activity against influenza A viruses
- Inhibits NMDA and M2 ion channels
- Inhibits coronavirus ion channels
- Possesses anti-orthopoxvirus activity
- Demonstrates anticancer activity
- Applicable for Parkinson's disease research
- Applicable for postoperative cognitive dysfunction (POCD) research
- Applicable for COVID-19 research
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Medchemexpress LLC Fomepizole hydrochloride | 56010-88-9 | 99.9% | 1 ML
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Fomepizole (4-Methylpyrazole) hydrochloride is a potent and orally active cytochrome P450 (CYP2E1) inhibitor. It is a competitive inhibitor of the enzyme alcohol dehydrogenase, blocking the conversion of methanol and ethylene glycol to toxic metabolites. It has the potential to be an antidote for ethylene glycol or methanol poisoning.
- Potent and orally active cytochrome P450 (CYP2E1) inhibitor.
- Competitive inhibitor of the enzyme alcohol dehydrogenase.
- Blocks further conversion of methanol and ethylene glycol to toxic metabolites.
- Potential for an antidote for ethylene glycol or methanol poisoning.
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Medchemexpress LLC Epinastine hydrochloride | 108929-04-0 | 99.9% | 1 ML
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Epinastine hydrochloride | 108929-04-0 | 99.9% | 1 ML
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Medchemexpress LLC Amantadine hydrochloride | 665-66-7 | 98.0% | 100 MG
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Amantadine hydrochloride is an orally active and potent antiviral agent effective against influenza A viruses. It inhibits several ion channels, including NMDA and M2, as well as Coronavirus ion channels. This compound also exhibits anti-orthopoxvirus and anticancer activities.
- Effective against influenza A viruses.
- Inhibits NMDA, M2, and Coronavirus ion channels.
- Exhibits anti-orthopoxvirus activity.
- Possesses anticancer activities.
- Can be utilized for research related to Parkinson's disease.
- Useful for research on postoperative cognitive dysfunction (POCD).
- Applicable for COVID-19 research.
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Medchemexpress LLC Dipivefrin hydrochloride | 64019-93-8 | 98.4% | 100 MG
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Dipivefrin hydrochloride is an antiglaucoma proagent that is hydrolyzed by esterases in the cornea to its active compound, epinephrine. It is for research use only and not sold to patients.
- Antiglaucoma proagent
- Hydrolyzed to active epinephrine by corneal esterases
- Induces enhancement of memory involving central beta-adrenergic mechanisms in male 60-day-old CFW mice (0.3-10 μg/kg; i.p.), significantly enhancing retention of inhibitory avoidance and Y-maze discrimination tasks in a dose-dependent manner.
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Medchemexpress LLC Naphthol AS-BI | 1237-75-8 | 99.9% | 25 MG
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Naphthol AS-BI is a substrate of β-glucuronidase and produces a bright red effect after staining biological tissues. This fluorescent dye is suitable for various laboratory applications.
- Produces a bright red effect after staining biological tissues.
- Functions as a fluorescent dye.
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Medchemexpress LLC Dipivefrin hydrochloride | 64019-93-8 | MFCD00793796 | 98.4% | 1 ML
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Dipivefrin hydrochloride is an antiglaucoma proagent that is hydrolyzed to epinephrine, the active compound, by esterases in the cornea. This product is for research use only and not intended for patient use.
- Functions as an antiglaucoma proagent
- Hydrolyzed to active compound epinephrine by corneal esterases
- Intended for research use only
- Store solid at -20°C under nitrogen, away from moisture
- Store in solvent at -80°C for 6 months or -20°C for 1 month under nitrogen, away from moisture
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Medchemexpress LLC BI-765063 5mg | 5mg
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BI-765063 (OSE-172) is a humanized antibody expressed in CHO that targets SIRPa/CD172a BI-765063 contains an IgG4-type heavy chain and a hu -type light chain with a predicted molecular weight (MW) of 146 3 kDa The isotype control for BI-765063 can be referenced as Human IgG4 kappa Isotype Control (HY-P99003)
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Medchemexpress LLC Migalastat (hydrochloride) | 75172-81-5 | ≥99.0% | 199.63 | 10MM/1ML
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Migalastat hydrochloride is an orally active α-galactosidase A molecular chaperone, with an IC50 value of 0.04 μM for human α-Gal A. It functions by binding to the active site of certain unstable mutant forms of α-galactosidase A, facilitating their transport to the lysosome. After dissociation in the acidic environment, it enables the mutant α-galactosidase A to exhibit biological activity.
- Binds to the active site of certain unstable mutant forms of α-galactosidase A
- Facilitates transport to the lysosome
- Enables mutant α-galactosidase A to exhibit biological activity
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Medchemexpress LLC Migalastat (hydrochloride) | 75172-81-5 | 99.7% | 199.63 | 25 MG
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Migalastat hydrochloride (GR181413A) is an orally active α-galactosidase A molecular chaperone. It binds to the active site of unstable mutant forms of α-galactosidase A, facilitating their transport to the lysosome. Upon dissociation in the acidic environment, Migalastat enables these mutant enzymes to regain biological activity. It exhibits an IC50 and Ki value of 0.04 μM for human α-Gal A.
- Orally active α-galactosidase A molecular chaperone
- IC50 and Ki of 0.04 μM for human α-Gal A
- Facilitates transport and restores activity of mutant α-galactosidase A enzymes
- Reduces Gb3 accumulation and lysosome volume in vitro
- Increases α-Gal A activity in heart, kidney, spleen, and liver in transgenic mice
- Reduces lyso-Gb3 levels in kidney, heart, and skin in transgenic mice
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Medchemexpress LLC BI-0474 | 2750570-55-7 | 99.8% | 587.74 | 100 MG
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BI-0474 is a potent KRASG12C inhibitor with an IC50 value of 7.0 nM for the GDP-KRAS::SOS1 protein-protein interaction. It demonstrates significant anti-proliferative activity against NCI-H358 cells carrying the G12C mutation and shows favorable anti-tumor activity in non-small cell lung cancer xenograft models.
- Potent KRASG12C inhibitor
- Inhibits GDP-KRAS::SOS1 protein-protein interaction with an IC50 of 7.0 nM
- Exhibits anti-proliferative activity against NCI-H358 cells with G12C mutation
- Shows anti-tumor activity in non-small cell lung cancer xenograft models
- Induces programmed cell death in xenograft models
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