Alpha-halocarboxylic acids and derivatives

Cayman Chemical W146 trifluoroacetate salt

An S1P1 receptor antagonist (Ki = 77 nM); selective for S1P1 over S1P2, S1P3, and S1P5 (Kis = >10 µM); prevents ligand-induced receptor internalization in CHO cells and inhibits ERK and Akt phosphorylation at 10 µM; increases AMD3100-induced KSL-HSPC entrance into mouse blood circulation from the bone marrow at 5 mg/kg in combination with AMD3100; disrupts the endothelial barrier and induces PMN neutrophil infiltration into the lungs and skin in an ovalbumin-induced mouse model of immune cell-mediated vascular injury at 10 UG intranasally or intradermally

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Cayman Chemical W146 trifluoroacetate salt

An S1P1 receptor antagonist (Ki = 77 nM); selective for S1P1 over S1P2, S1P3, and S1P5 (Kis = >10 µM); prevents ligand-induced receptor internalization in CHO cells and inhibits ERK and Akt phosphorylation at 10 µM; increases AMD3100-induced KSL-HSPC entrance into mouse blood circulation from the bone marrow at 5 mg/kg in combination with AMD3100; disrupts the endothelial barrier and induces PMN neutrophil infiltration into the lungs and skin in an ovalbumin-induced mouse model of immune cell-mediated vascular injury at 10 UG intranasally or intradermally

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Cayman Chemical W146 trifluoroacetate salt

An S1P1 receptor antagonist (Ki = 77 nM); selective for S1P1 over S1P2, S1P3, and S1P5 (Kis = >10 µM); prevents ligand-induced receptor internalization in CHO cells and inhibits ERK and Akt phosphorylation at 10 µM; increases AMD3100-induced KSL-HSPC entrance into mouse blood circulation from the bone marrow at 5 mg/kg in combination with AMD3100; disrupts the endothelial barrier and induces PMN neutrophil infiltration into the lungs and skin in an ovalbumin-induced mouse model of immune cell-mediated vascular injury at 10 UG intranasally or intradermally

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Cayman Chemical W140 trifluoroacetate salt

An inactive enantiomer of W146; binds weakly to S1P1 (Ki = 4.6 µM for the human receptor); has been used as a negative control in the study of S1P1 receptor signaling

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Sigma Aldrich Fine Chemicals Biosciences Sodium iodoacetate, 305-53-3, MFCD00002686, 25 g

Linear Formula: ICH2COONa, Molecular Weight: 207.93, ≥98%, Synonym: Iodoacetic acid sodium salt. Reagent for the modification of cysteine residues in proteins. Used in protein sequencing (including by Sanger in sequencing bovine insulin) to prevent oxidation of -SH sidechains. Reagent for the modification of cysteine residues in proteins. Used to induce animal osteoarthritis model system, which mimics both symptoms and histopathology of the human disease.

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Sigma Aldrich Fine Chemicals Biosciences Ethyl 2-bromopropionate 99% | 535-11-5 | MFCD00000144 | 25G

Ethyl 2-bromopropionate 99% | Purity: 99% | Mol Wt: 181.03 | 535-11-5 | MFCD00000144 | 25G

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Chem-Impex International, Inc. ETHYL TRIFLUOROACETATE 100GR

NC3861488 ETHYL TRIFLUOROACETATE 100GR

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Cayman Chemical Indolicidin trifluoroacetate

An antimicrobial peptide; active against MDR-EAEC (MICs = 32 µM for all); active against S. cerevisiae, T. beigelii, and C. albicans (MICs = 5-10, 2.5-5, and 5-10 µM, respectively); reduces viral replication of HIV-1 in MT-2 cells from 67-100 UG/ml; increases survival of MDR-EAEC-infected G. mellonella larvae

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Chloroacetic Acid (Certified), Fisher Chemical

CAS: 79-11-8 Molecular Formula: C2H3ClO2 Molecular Weight (g/mol): 94.494 MDL Number: MFCD00002683 InChI Key: FOCAUTSVDIKZOP-UHFFFAOYSA-N Synonym: chloroacetic acid,monochloroacetic acid,chloracetic acid,acetic acid, chloro,acide chloracetique,chloroethanoic acid,monochloroethanoic acid,monochloracetic acid,monochloorazijnzuur,monochloressigsaeure PubChem CID: 300 ChEBI: CHEBI:27869 IUPAC Name: 2-chloroacetic acid SMILES: C(C(=O)O)Cl

MP Biomedicals, Inc Sodium Trifluoroacetate, MP Biomedicals

CAS: 2923-18-4 Molecular Formula: C2F3NaO2 Molecular Weight (g/mol): 136.01 MDL Number: MFCD00013217 InChI Key: UYCAUPASBSROMS-UHFFFAOYSA-M Synonym: sodium trifluoroacetate,trifluoroacetic acid sodium salt,acetic acid, trifluoro-, sodium salt,sodium perfluoroacetate,trifluoroacetate sodium,sodium 2,2,2-trifluoroacetate,trifluoroacetic acid sodium,trifluoroacetic acid,sodium salt,acetic acid, 2,2,2-trifluoro-, sodium salt 1:1,trifluoroacetic acid, sodium salt PubChem CID: 517019 IUPAC Name: sodium trifluoroacetate SMILES: [Na+].[O-]C(=O)C(F)(F)F

Thermo Scientific Chemicals Ethyl 2-bromooctanoate, 98+%, Thermo Scientific™

Thermo Scientific Chemicals Ethyl 2-bromobutyrate, 97%, Thermo Scientific™

Ethyl 2-chloropropionate, 97%, Thermo Scientific™

CAS: 535-13-7 Molecular Formula: C5H9ClO2 Molecular Weight (g/mol): 136.58 MDL Number: MFCD00000864 InChI Key: JEAVBVKAYUCPAQ-UHFFFAOYNA-N Synonym: ethyl 2-chloropropionate,2-chloropropionic acid ethyl ester,propanoic acid, 2-chloro-, ethyl ester,ethyl-2-chloropropionate,2-chloropropionic acid, ethyl ester,ethyl alpha-chloropropionate,ethyl .alpha.-chloropropionate,propionic acid, 2-chloro-, ethyl ester,+-ethyl 2-chloropropionate,ethyl ?-chloropropionate PubChem CID: 10807 IUPAC Name: ethyl 2-chloropropanoate SMILES: CCOC(=O)C(C)Cl

MP Biomedicals, Inc Bromoacetic acid, 99%, MP Biomedicals™

Thermo Scientific Chemicals 2,3-Dibromopropionic acid, 99%, Thermo Scientific™