Azobenzenes
Sigma Aldrich Methyl 3-bromo-4-oxo-4-phenylbutanoate
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
Sigma Aldrich Fmoc-3,4-dehydro-L-proline
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
Medchemexpress LLC PR5-LL-CM01, a protein arginine methyltransferase 5 (PRMT5) inhibitor | 1005307-86-7 | 98.4% | 401.51 | 1 ML
PR5-LL-CM01 is a potent protein arginine methyltransferase 5 (PRMT5) inhibitor with an IC50 of 7.5 μM. It exhibits anti-tumor activities. It has a range of IC50 at 2-4 μM in PDAC cells (PANC1, MiaPaCa2 and AsPC1) and 10-11 μM in CRC cells (HT29, HCT116 and DLD1). PR5-LL-CM01 specifically inhibits cancer cells with low toxicity in normal cells and strongly inhibits colony forming ability in PANC1 and HT29 cells. It also inhibits NF-κB activation and its target gene expression, dramatically decreasing TNFα and IL8 expression in both PANC1 and HT29 cells.
- Potent PRMT5 inhibitor.
- Exhibits anti-tumor activities.
- Low toxicity in normal cells.
- Strongly inhibits colony forming ability in PANC1 and HT29 cells.
- Inhibits NF-κB activation and its target gene expression.
- Decreases TNFα and IL8 expression.
Medchemexpress LLC Spdmv | 890409-85-5 | 96.4% | 354.44 g/mol | C15H18N2O4S2 | 100 MG
SPDMV is a glutathione-cleavable antibody-drug conjugate (ADC) linker supplied for research use. It is designed to connect antibodies to cytotoxic payloads and release the payload intracellularly via glutathione-mediated cleavage.
- Glutathione-cleavable disulfide linker.
- Intended for ADC synthesis and conjugation chemistry.
- Purity 96.37%.
- CAS number 890409-85-5.
- Molecular weight 354.44 g/mol.
- Chemical formula C15H18N2O4S2.
- Available in 100 MG vial.
Medchemexpress LLC 2-Pyridinecarboxamide, 5-[[(6-chloro-2-pyridinyl)methyl](1-oxo-2-propen-1-yl)amino]-N-phenyl | 2305052-86-0 | 98.8% | C21H17ClN4O2 | 100 MG
BPK-25 is an active acrylamide that promotes the degradation of nucleosome remodeling and deacetylation (NuRD) complex proteins through a post-translational mechanism involving covalent protein engagement. It also inhibits TMEM173 activation by the cyclic dinucleotide ligand cGAMP.
- Promotes degradation of NuRD complex proteins.
- Inhibits TMEM173 activation.
- Active acrylamide.
- Intended for research and analytical applications.
Medchemexpress LLC BPK-25 | 2305052-86-0 | 99.9% | C21H17ClN4O2 | 50 MG
BPK-25 is an active acrylamide that promotes the degradation of nucleosome remodeling and deacetylation (NuRD) complex proteins through a post-translational mechanism involving covalent protein engagement. It also inhibits TMEM173 activation by the cyclic dinucleotide ligand cGAMP.
- Promotes degradation of NuRD complex proteins.
- Inhibits TMEM173 activation.
- Suppresses activation of NF-κB.
- Blocks nuclear factor of activated T-cells (NFAT) activation.
- Reduces NFATc2 expression in T cells.
- Striking and selective reduction of several proteins in the NuRD complex in a concentration- and time-dependent manner.
Medchemexpress LLC EPQpYEEIPIYL | 147612-86-0 | 99.5% | 1473.52 | 1 MG
EPQpYEEIPIYL is a phosphopeptide that functions as a Src homology 2 (SH2) domain ligand. It activates members of the Src family, such as Lck, Hck, and Fyn, by binding to their SH2 domains. The phosphopeptide pY324, derived from hmT with the sequence EPQpYEEIPIYL, exhibits high-affinity binding to GST fusion proteins of the Lck SH2 domain and the Src SH2 domain. This product is used in cancer and cancer targeted therapy research, and is related to the protein tyrosine kinase/RTK pathway.
- Phosphopeptide and Src homology 2 (SH2) domain ligand
- Activates Src family members such as Lck, Hck, and Fyn
- High-affinity binding to GST fusion proteins of Lck SH2 domain and Src SH2 domain
- Soluble in H2O at 2 mg/mL (1.36 mM) with ultrasonic treatment and pH adjustment to 2 with HCl
- Used in cancer and cancer targeted therapy research
- Related to the protein tyrosine kinase/RTK pathway
amino]-N-phenyl | 2305052-86-0 | MFCD06761688 | 99.9% | C21H17ClN4O2 | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000259801.png-250.jpg)
Medchemexpress LLC 2-pyridinecarboxamide, 5-[[(6-chloro-2-pyridinyl)methyl](1-oxo-2-propen-1-yl)amino]-N-phenyl | 2305052-86-0 | MFCD06761688 | 99.9% | C21H17ClN4O2 | 10MG
BPK-25 is an acrylamide-containing small-molecule research reagent that promotes degradation of nucleosome remodeling and deacetylation (NuRD) complex proteins and inhibits TMEM173 (STING) activation, resulting in modulation of NF-κB signaling. Supplied as a high-purity solid for in vitro and biochemical research; not intended for human use.
- Promotes NuRD complex protein degradation by covalent protein engagement.
- Inhibits STING (TMEM173) activation by the cyclic dinucleotide cGAMP.
- High purity suitable for biochemical assays and in vitro studies.
- Supplied as an off-white to light yellow solid for convenient handling.
- Recommended storage: 4°C under nitrogen; in solvent: -80°C (6 months) or -20°C (1 month).
- For research use only; not for clinical or human use.
Medchemexpress LLC Cdc7-IN-5 | 1402057-86-6 | 96.0% | 100 MG
Cdc7-IN-5 is a potent Cdc7 kinase inhibitor. This compound is extracted from patent WO2019165473A1 and targets Cdc7, a serine-threonine protein kinase enzyme essential for initiating DNA replication in the cell cycle.
- Potent Cdc7 kinase inhibitor
- Extracted from patent WO2019165473A1
- Targets serine-threonine protein kinase enzyme Cdc7
- Essential for DNA replication initiation
- Appearance: solid, white to light yellow
- Molecular weight: 445.47
- Molecular formula: C25H23N3O5
Medchemexpress LLC Nimbin | 5945-86-8 | 1 MG
Nimbin is an orally active intermediate limonoid found in Azadirachta. It prevents tau aggregation, increases cell viability, and effectively inhibits the envelope protein of the dengue virus. It shows promise for research in neurodegenerative diseases and viral infections.
- Prevents tau aggregation
- Increases cell viability
- Effectively inhibits the envelope protein of the dengue virus
- Possesses anti-inflammatory, antipyretic, antifungal, antihistamine, antiseptic, antioxidant, anti-cancer, and anti-viral properties
- Promising for research in neurodegenerative diseases and viral infections
Medchemexpress LLC EPQpYEEIPIYL | 147612-86-0 | 99.5% | 1473.52 | 5 MG
EPQpYEEIPIYL, a phosphopeptide, is a Src homology 2 (SH2) domain ligand. It activates Src family members (e.g. Lck, Hck, Fyn) by binding to SH2 domains.
- Phosphopeptide and Src homology 2 (SH2) domain ligand
- Activates Src family members (e.g., Lck, Hck, Fyn)
- Binds to SH2 domains
- Exhibits highest affinity binding to GST fusion proteins of Lck SH2 domain and Src SH2 domain
- Target: Src
- Pathway: Protein Tyrosine Kinase/RTK
Medchemexpress LLC P32 inhibitor M36 | 802555-85-7 | MFCD31666371 | 98.6% | 448.52 g·mol-1 | C23H28N8O2 | 25MG
p32 inhibitor M36 is a small-molecule research reagent that binds directly to the mitochondrial p32 (C1QBP) protein and blocks its association with LyP-1, enabling biochemical and cell-based studies investigating p32-related pathways such as proliferation and viability.
- Binds directly to mitochondrial p32 protein.
- Inhibits p32 association with LyP-1.
- Suitable for cell-based and biochemical assays.
- High purity for research applications.
- Supplied as a solid, convenient for storage and handling.
- Molecular formula C23H28N8O2; molecular weight 448.52 g·mol-1.
Medchemexpress LLC Nimbin | 5945-86-8 | 5 MG
Nimbin is an orally active intermediate limonoid found in Azadirachta. It prevents tau aggregation, increases cell viability, and effectively inhibits the envelope protein of the dengue virus. It possesses anti-inflammatory, antipyretic, antifungal, antihistamine, antiseptic, antioxidant, anti-cancer, and anti-viral properties, showing promise for research into neurodegenerative diseases and viral infections.
- Orally active intermediate limonoid
- Prevents tau aggregation and increases cell viability
- Effective inhibitor of the dengue virus envelope protein
- Anti-inflammatory, antipyretic, antifungal, antihistamine, antiseptic, antioxidant, anti-cancer, and anti-viral properties
- Promising for research of neurodegenerative diseases and viral infections
Medchemexpress LLC Cdc7-IN-5 | 1402057-86-6 | 96.7% | 50 MG
Cdc7-IN-5 is a potent Cdc7 kinase inhibitor extracted from patent WO2019165473A1. Cdc7 is a serine-threonine protein kinase enzyme which is essential for the initiation of DNA replication in the cell cycle.
- Potent Cdc7 kinase inhibitor.
- Essential for the initiation of DNA replication in the cell cycle.
- For research use only.
Medchemexpress LLC FzM1.8 | 322.3 g/mol | C18H14N2O4 | 10MG
FzM1 8 derives from FzM1 is an allosteric agonist of FZD4 with pEC50 of 6 4 FzM1 8 binds to FZD4 and activates the WNT/ -catenin pathway by promoting TCF/LEF transcriptional activity in the absence of any WNT ligand FzM1 8 stabilizes FZD4 with an increased affinity for heterotrimeric G protein and stimulates the release of the G subunit that in turn activates PI3K[1]