Benzoxadiazoles
![Aobchem B-[2-(3-Methylbutoxy)phenyl]boronic acid | 95% | CAS 934826-18-3 | C11H17BO3 | 10g](https://assets.fishersci.com/TFS-Assets/CCG/product-images/default.jpg-250.jpg)
Aobchem B-[2-(3-Methylbutoxy)phenyl]boronic acid | 95% | CAS 934826-18-3 | C11H17BO3 | 10g
B-[2-(3-Methylbutoxy)phenyl]boronic acid | 95% | CAS 934826-18-3 | C11H17BO3 | 10g
Aobchem 3-Bromo-2-formylthiophene-5-boronic acid | ≥97% | CAS 1451393-26-2 | C5H4BBrO3S | 250mg
3-Bromo-2-formylthiophene-5-boronic acid | ≥97% | CAS 1451393-26-2 | C5H4BBrO3S | 250mg
Aobchem 5-Chloro-2-ethoxypyridine-3-boronic acid | ≥97% | CAS 1217500-52-1 | C7H9BClNO3 | 5g
5-Chloro-2-ethoxypyridine-3-boronic acid | ≥97% | CAS 1217500-52-1 | C7H9BClNO3 | 5g
Medchemexpress LLC Nbd-556 | 333353-44-9 | 99.5% | C17H24ClN3O2 | 100 MG
NBD-556 is a CD4 mimetic and a potent HIV-1 entry inhibitor that blocks the gp120-CD4 interaction. It shows potent cell fusion and virus-cell fusion inhibitory activity at low micromolar levels.
- Inhibits HIV-1 entry by blocking gp120-CD4 interaction.
- Shows potent cell fusion and virus-cell fusion inhibitory activity.
- Inhibits HIV-1 envelope-mediated virus-cell and cell-cell fusion.
- Inhibits infection of MT-2 cells by laboratory-adapted HIV-1 IIIB, MN, and V32 strains.
- Inhibits CD4-dependent virus in a dose-dependent manner.
Medchemexpress LLC NBD-Pen | 1955505-54-0 | 99.94% | 10 MG
NBD-Pen is the first fluorescence probe for lipid radicals, offering high selectivity and sensitivity (λex: 470 nm, λem: 530 nm). It specifically detects lipid-derived radicals over other reactive species found in biological systems, including H2O2, ClO-, O2•-, and •OH. NBD-Pen directly detects lipid radicals in living cells through turn-on fluorescence. It has been observed to decrease inflammation, apoptosis, and oxidative stress markers, and can be utilized in various disease models such as hepatic carcinoma.
- First fluorescence probe for lipid radicals.
- High selectivity and sensitivity (λex: 470 nm, λem: 530 nm).
- Specifically detects lipid-derived radicals over other reactive species (H2O2, ClO-, O2•-, and •OH).
- Directly detects lipid radicals in living cells by turn-on fluorescence.
- Decreases inflammation, apoptosis, and oxidative stress markers.
- Applicable for studying various disease models, including hepatic carcinoma.
![Medchemexpress LLC Hexanamide, N-[(1S,2R,3E)-1-[(β-D-glucopyranosyloxy)methyl]-2-hydroxy-3-heptadecen-1-yl]-6-[(7-nitro | 94885-03-7 | 98.0% | 737.88 g·mol⁻¹ | C36H59N5O11 | 100 UG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000285210.png-250.jpg)
Medchemexpress LLC Hexanamide, N-[(1S,2R,3E)-1-[(β-D-glucopyranosyloxy)methyl]-2-hydroxy-3-heptadecen-1-yl]-6-[(7-nitro | 94885-03-7 | 98.0% | 737.88 g·mol⁻¹ | C36H59N5O11 | 100 UG
C6 NBD Glucosylceramide is a fluorescently labeled glucosylceramide derivative used to investigate sphingolipid metabolism and intracellular trafficking. The NBD fluorophore on a C6 acyl chain provides fluorescence properties suitable for imaging and plate-based assays, and the material is supplied at high purity for biochemical experiments.
- Fluorescent label suitable for microscopy and plate assays.
- Excitation 466 nm and emission 535 nm for standard fluorescence setups.
- High purity suitable for biochemical and enzymatic assays (98.0%).
- Useful for studying glucosylceramide metabolism and internalization.
- Available in small-scale vials ideal for research applications (100 μg, 500 μg).
Medchemexpress LLC 4-nitro-2,1,3-benzoxadiazol-7-amine | 10199-91-4 | 96.7% | 25 MG
NBD-amine is a fluorogenic amine used as a fluorescent probe and labeling reagent. It fluoresces weakly in aqueous solution and strongly in organic solvents, lipid membranes, and other hydrophobic environments, making it suitable for sensing, labeling, and studies of membrane-associated processes.
- Fluorogenic amine that fluoresces weakly in water and strongly in hydrophobic environments.
- Useful as a fluorescent probe and labeling reagent for synthesis and detection.
- Suitable for studying membrane interactions and lipid environments.
- Provided as a solid with purity 96.7% and molecular weight 180.12 g/mol.
- Documentation available: data sheet, safety data sheet (SDS), and certificate of analysis (COA).
Medchemexpress LLC Ikky nbd inhibitory peptide tfa | 98.2% | 3807.32 | 5 MG
IKKγ NBD Inhibitory Peptide TFA is a highly specific NF-κB inhibitor. It functions by disrupting the interaction between IKKγ/NEMO-binding domain (NBD) and IKKα and IKKβ, thereby blocking TNF-α-induced NF-kB activation. This peptide can significantly suppress inflammation and ameliorate cerebral ischemia-induced neurological deficits.
- Prevents p65 phosphorylation in BT-474 cells.
- Slightly inhibits BT-474 cell viability while markedly enhancing Doxorubicin's effects.
- Exhibits neuroprotective effect with reduction in DNA fragmentation in a rat model.
- Reduces striatal IL-1b level and microglial OX-42 staining.
- Protects the blood-brain barrier from ischemic insult.
Medchemexpress LLC NBD-14189 | 2234273-72-2 | 99.8% | 428.40 | C18H16F4N4O2S | 5 MG
NBD-14189 is a small-molecule HIV-1 entry antagonist that binds the viral gp120 protein and exhibits potent antiviral activity in cell-based assays. It is provided as a high-purity research reagent available as solids and as a DMSO solution, with characterized activity in single- and multi-cycle assays.
- Binds HIV-1 gp120 to inhibit viral entry.
- Potent antiviral activity (IC50 ≈ 89 nM; EC50 <200 nM).
- Characterized in single-cycle (0.089 μM) and multi-cycle (0.18 μM) assays.
- Available as solid quantities and as a 10 mM solution in DMSO.
- High purity (99.84%) suitable for research use.
- Storage recommendations provided for solids and solutions.
Medchemexpress LLC NBD-557 | 333352-59-3 | 99.4% | C17H24BrN3O2 | 25 MG
NBD-557 is a small molecule organic compound identified as a potential HIV-1 inhibitor. It targets viral entry by inhibiting the binding of HIV-1 envelope glycoprotein gp120 to the CD4 receptor without affecting later stages of the HIV-1 life cycle.
- Exhibits potent cell fusion and virus-cell fusion inhibitory activity at low micromolar levels.
- Active against X4 and R5 viruses, and laboratory-adapted HIV-1 strains, including an AZT-resistant strain.
- Binds to unliganded HIV-1 gp120, but not to the cellular receptor CD4.
Medchemexpress LLC NBD-PE | 178119-00-1 | 99.9% | 956.24 | 5 MG
NBD-PE is an effective lipid fluorescent probe with Excitation/Emission at 465/535 nm and a green color. It has wide applications in membrane and cell biology.
- Effective lipid fluorescent probe
- Excitation/emission: 465/535 nm
- Color: green
- Wide array of applications in membrane and cell biology
Medchemexpress LLC 3-C12-NBD-cholesterol | 1246303-05-8 | 99.9% | 747.06 | 1 MG
3-C12-NBD-cholesterol is a fluorescent cholesterol analog used for measuring membrane and intracellular trafficking dynamics. This product is a colorless to light yellow liquid with a purity of 99.9%.
- Fluorescent cholesterol analog
- Measures membrane and intracellular trafficking dynamics
- High purity of 99.9%
- Suitable for cell staining analysis
- Used as an organelle dye
- Used as a lipid droplet dye
- Solution storage at -20°C for up to 2 years
Medchemexpress LLC TNF-alpha/TNFSF2 Bo 10ug
Tumour Necrosis Factor alpha (TNF alpha) is a potent pro-inflammatory cytokine[1] TNF alpha binds to its receptors mainly TNFR1 and TNFR2 and then transmits molecular signals for biological functions such as inflammation and cell death[2] TNF alpha stimulates NF- B pathway via TNFR2 promotes cancer growth invasion and metastasis Anti-TNF- MAb significantly suppresses the tumor development in colitis-associated cancer (CAC) mouse[3] TNF alpha as a proneurogenic factor activates the SAPK/JNK Pathway and can facilitate neuronal replacement and brain repair in response to brain injury[4] TNF-alpha/TNFSF2 Protein Bovine is produced in E coli
Medchemexpress LLC NBD-14189 | 2234273-72-2 | 99.8% | C18H16F4N4O2S | 10MG
NBD-14189 is a small-molecule HIV-1 entry antagonist that binds the viral gp120 envelope protein and blocks virus entry. It shows potent activity in cell-based assays (IC50 ≈ 89 nM against HIV-1 HXB2 pseudovirus; antiviral EC50 <200 nM) and is supplied as a high-purity research compound for in vitro studies.
- Potent gp120-directed entry antagonist with IC50 ≈ 89 nM.
- Demonstrated antiviral activity in cell assays (EC50 <200 nM).
- High purity suitable for research use (≈99.8%).
- Supplied as solid and as 10 mM solution in DMSO for screening.
- Molecular formula C18H16F4N4O2S and molecular weight 428.40 g·mol⁻1.
- Recommended storage: 4°C sealed; in solvent store at -80°C for long term.
Medchemexpress LLC NBD-Pen | 1955505-54-0 | 99.9% | 50 MG
NBD-Pen is a fluorescent probe designed for the selective and sensitive detection of lipid radicals in biological systems. It functions by turn-on fluorescence to directly detect lipid radicals in living cells.
- First fluorescence probe for lipid radicals
- Offers high selectivity and sensitivity (λex: 470 nm, λem: 530 nm)
- Specifically detects lipid-derived radicals over other reactive species (e.g., H2O2, ClO-, O2-?, and ?OH)
- Directly detects lipid radicals in living cells through turn-on fluorescence
- Decreases inflammation, apoptosis, and oxidative stress markers
- Applicable in various disease models such as hepatic carcinoma