Benzoxadiazoles
Medchemexpress LLC A 410099.1, amine-Boc | 1613552-03-6 | 583.76 | 25 MG
A 410099.1, amine-Boc is a functionalized IAP ligand that can be utilized for synthesizing PROTACs, specifically PROTACs targeting BTK (PROTACs 4 and 5).
- Functionalized IAP ligand.
- Can be used for the synthesis of PROTACs.
- Applicable for PROTACs targeting BTK.
- For research use only.
Medchemexpress LLC 3-NBD-C12 cholesterol | 186833-02-3 | MFCD00075336 | 10 MG
3-NBD-C12 cholesterol is an NBD-tagged fluorescent cholesterol analog used to study cholesterol uptake, membrane incorporation, intracellular trafficking, and metabolism in biological systems. The NBD fluorophore enables visible-range fluorescence detection for microscopy and spectroscopy; supplied as a solid for research use.
- NBD fluorophore with typical excitation ≈465 nm and emission ≈535 nm
- Suitable for studies of membrane dynamics and cholesterol trafficking
- Soluble in DMF and DMSO for stock solutions with recommended handling
- Solid, yellow to orange appearance for easy visual identification
- Store protected from light; use cold storage for solutions to maintain stability
Medchemexpress LLC Int-767 | 1000403-03-1 | 99.8% | 494.66 g/mol | C25H43NaO6S | 10MG
INT-767 is a semisynthetic dual farnesoid X receptor (FXR) and TGR5 (GPBAR1) agonist used in preclinical research to modulate bile acid signaling, liver, and metabolic pathways. The compound shows mean EC50s of 30 nM for FXR and 630 nM for TGR5, and is supplied as the sodium salt with high reported purity.
Medchemexpress LLC 1H-Pyrrole-2-carboxamide, N-[(1S)-2-amino-1-[4-(hydroxymethyl)-2-thiazolyl]ethyl]-5-[3-fluoro-4-(trifluoromethyl)phenyl]- | 2234273-72-2 | 99.8% | 428.40 | 1 ML
NBD-14189 is a potent HIV-1 entry antagonist with an IC50 of 89 nM against the HIV-1HXB2 pseudovirus. It binds to HIV-1 gp120 and demonstrates potent antiviral activity (EC50 < 200 nM). It is intended for research use only.
- Potent HIV-1 entry antagonist
- Binds to HIV-1 gp120
- Shows potent antiviral activity (EC50<200 nM)
- Anti-HIV-1 activity (IC50=0.089 μM) in single-cycle (TZM-bl cells) assays
- Prevents HIV-1 mediated cell-cell fusion
Medchemexpress LLC NBD-14189 | 2234273-72-2 | 99.8% | 428.40 | 25 MG
NBD-14189 is a potent HIV-1 entry antagonist that binds to HIV-1 gp120, exhibiting potent antiviral activity. It demonstrates anti-HIV-1 activity and cytotoxicity in both single-cycle (TZM-bl cells) and multi-cycle (MT-2 cells) assays, and prevents HIV-1 mediated cell-cell fusion.
- Potent HIV-1 entry antagonist (IC50 of 89 nM against HIV-1HXB2 pseudovirus)
- Binds to HIV-1 gp120
- Potent antiviral activity (EC50<200 nM)
- Anti-HIV-1 activity (IC50=0.089 μM) and cytotoxicity (CC50=21.9 μM) in single-cycle assays
- Anti-HIV-1 activity (IC50=0.18 μM) and cytotoxicity (CC50=22.1 μM) in multi-cycle assays
- Prevents HIV-1 mediated cell-cell fusion (IC50=9.4 μM)
- Weak or no inhibition of hERG current (IC50=3.0 μM)
Medchemexpress LLC Nbd-14270 | 2411819-82-2 | 99.5% | 425.43 | C18H18F3N5O2S | 5 MG
NBD-14270 is a pyridine analogue that functions as a potent HIV-1 entry antagonist by binding to the gp120 envelope protein. It exhibits sub-micromolar antiviral activity with low cytotoxicity and is provided for research applications with characterized purity, formula, and storage recommendations.
- High purity: 99.53%.
- Chemical formula: C18H18F3N5O2S; molecular weight: 425.43.
- CAS number: 2411819-82-2.
- Recommended solvent: DMSO; use ultrasonic aid for dissolution.
- Storage: solid at 4°C; in solvent store at -80°C for long-term stability.
- Typical applications: in vitro antiviral and HIV-1 entry assays.
Medchemexpress LLC Apelin-16, human, bovine acetate | 99.8% | 2010.37 | 10 MG
Apelin-16, human, bovine acetate is a biologically active peptide that acts as the endogenous ligand for the G-protein-coupled APJ receptor. It is produced as a pre-proprotein of 77 amino acids, with Apelin-16 being one of its active fragments. This product is for research use only.
- White to off-white solid appearance
- Molecular weight of 2010.37 (free base)
- Purity of 99.77%
- Sequence: Phe-Arg-Arg-Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe
- Soluble in DMSO at 100 mg/mL
Sigma Aldrich Fine Chemicals Biosciences 7-Fluorobenzofurazan-4-sulfonic acid ammonium salt >=98% | 84806-27-9 | MFCD02682109 | 25MG
7-Fluorobenzofurazan-4-sulfonic acid ammonium salt >=98% | Purity: >=98% | Mol Wt: 235.19 | 84806-27-9 | MFCD02682109 | 25MG
Sigma Aldrich Fine Chemicals Biosciences 7-Fluorobenzofurazan-4-sulfonic acid ammonium salt >=98% | 84806-27-9 | MFCD02682109 | 10MG
7-Fluorobenzofurazan-4-sulfonic acid ammonium salt >=98% | Purity: >=98% | Mol Wt: 235.19 | 84806-27-9 | MFCD02682109 | 10MG
Medchemexpress LLC NBD-Pen | 1955505-54-0 | 99.9% | 390.46 | C19H28N5O4 | 5 MG
NBD-Pen is a turn-on fluorescent probe for selective detection of lipid-derived radicals in biological systems. It enables live-cell imaging and biochemical studies of lipid peroxidation and oxidative stress with sensitive fluorescence readout.
- High selectivity and sensitivity for lipid radicals.
- Turn-on fluorescence enables low-background detection in cells.
- Excitation at 470 nm and emission at 530 nm for standard imaging.
- High purity (99.94%) suitable for research use.
- Soluble in DMSO (100 mg/mL); ultrasonic assistance recommended.
- Store protected from light; follow solvent storage guidelines.
Medchemexpress LLC NBD-F (4-fluoro-7-nitrobenzofurazan) | 29270-56-2 | MFCD00010196 | 98.0% | 183.10 | C6H2FN3O3 | 10 MG
NBD-F (4-fluoro-7-nitrobenzofurazan) is a pro-fluorescent derivatization reagent that reacts with primary and secondary amines to produce stable fluorescent adducts. It is used for amino acid analysis, HPLC fluorescence detection, and other sensitive analytical applications.
- Pro-fluorescent reagent for derivatizing primary and secondary amines.
- Excitation 445 nm, emission 515 nm for fluorescence detection.
- Molecular weight 183.10 g/mol; formula C6H2FN3O3.
- Typical purity approximately 98.0%.
- Light yellow solid; store protected from light at 4°C; freeze solutions for long-term storage.
2,1,3-Benzoxadiazole-4-carboxaldehyde 98.0+%, TCI America™
CAS: 32863-32-4 Molecular Formula: C7H4N2O2 Molecular Weight (g/mol): 148.12 MDL Number: MFCD07772900 InChI Key: YBBRQAXNTWMMFZ-UHFFFAOYSA-N Synonym: 4-Benzofurazancarboxaldehyde, 4-Formylbenzofurazan PubChem CID: 10290873 IUPAC Name: 2,1,3-benzoxadiazole-4-carbaldehyde SMILES: O=CC1=CC=CC2=NON=C12
![6-[[7-(N,N-Dimethylaminosulfonyl)-2,1,3-benzoxadiazol-4-yl]amino]hexanoic Acid 98.0+%, TCI America™](https://assets.fishersci.com/TFS-Assets/CCG/Chemical-Structures/chemical-structure-cas-1820741-40-9.jpg-250.jpg)
6-[[7-(N,N-Dimethylaminosulfonyl)-2,1,3-benzoxadiazol-4-yl]amino]hexanoic Acid 98.0+%, TCI America™
CAS: 1820741-40-9 Molecular Formula: C14H20N4O5S Molecular Weight (g/mol): 356.397 InChI Key: ODEWENLZBOAUCF-UHFFFAOYSA-N Synonym: 4-(5-Carboxypentylamino)-7-(N,N-dimethylaminosulfonyl)-2,1,3-benzoxadiazole PubChem CID: 44629791 IUPAC Name: 6-[[4-(dimethylsulfamoyl)-2,1,3-benzoxadiazol-7-yl]amino]hexanoic acid SMILES: CN(C)S(=O)(=O)C1=CC=C(C2=NON=C12)NCCCCCC(=O)O