Biotin and derivatives
Medchemexpress LLC Mal-PEG3-C1-NHS ester | 2230016-26-7 | 95.0% | 384.34 g/mol | C16H20N2O9 | 25 MG
Mal-PEG3-C1-NHS ester is a non-cleavable, three-unit polyethylene glycol (PEG) linker bearing maleimide and N-hydroxysuccinimide (NHS) ester functional groups, designed for use in antibody-drug conjugate (ADC) synthesis and related bioconjugation research.
- Non-cleavable three-unit PEG linker
- Contains maleimide and NHS ester functional groups
- Enables conjugation to thiols and amines for ADC assembly
- Purity ≥95.0% and molecular weight 384.34 g/mol
- Available in small milligram packaging for research applications
TARGETMOL CHEMICALS INC Biotin LC hydrazide 50MG
Also available in 1 mL, 5 mg, 10 mg, 25 mg, 100 mg, 200 mg and bulk. Please contact Fisher for quotes. Biotin LC hydrazide (BACH) is a modification reagent of long-chain protein. Biotin LC hydrazide transforms periodate-oxidized glycoproteins and can be used to target glycoproteins and glycans. Purity 99.4%
Medchemexpress LLC Cyclooctyne-O-NHS ester | 1425803-45-7 | 95.0% | 279.29 g/mol | C14H17NO5 | 25 MG
Cyclooctyne-O-NHS ester is an NHS-activated cyclooctyne reagent used for bioconjugation and antibody-drug conjugate synthesis. It couples to primary amines to form stable amide bonds and participates in strain-promoted azide-alkyne cycloaddition (click chemistry) workflows.
- N-hydroxysuccinimide (NHS) activated ester for efficient amide coupling.
- Strained cyclooctyne enables copper-free click reactions with azides.
- Molecular formula C14H17NO5 and molecular weight 279.29 g/mol.
- High purity for research use (95.0%).
- White to off-white solid; store at -20°C under nitrogen.
Medchemexpress LLC Bis-PEG10-NHS ester | 2221949-02-4 | 95.0% | 752.76 | C32H52N2O18 | 25 MG
Bis-PEG10-NHS ester is a PEG/alkyl/ether-based bifunctional NHS ester linker used for amine-reactive bioconjugation in the synthesis of PROTACs and antibody-drug conjugates. Supplied for research use only, it has a molecular weight of 752.76 g/mol and a listed purity of 95.0%.
- NHS ester reactive group for amine coupling.
- PEG10 spacer provides water solubility and flexibility.
- Suitable for PROTAC and ADC synthesis and other bioconjugation applications.
- Available in small milligram pack sizes for research use.
- Storage recommendations: pure form -20°C; in solvent -80°C (6 months), -20°C (1 month).
Abcam Biotin-de x tran, 10MG
MW 73400 g/mol, Purity >98%. Membrane impermeant dextran conjugate containing covalently attached biotin molecules (Vitamin H) making it useful in streptavidin/avidin assay systems. The attached biotins are commonly used haptens that can be detected by using its strong affinity for the proteins avidin (from egg white) or streptavidin. This conjugate contains approximately 12 biotin groups/dextran (based on amine assay; with approx. 1 amine/40 glucose residues). The excess amino groups are not capped, and they can be further labeled with a fluorophore, or can be fixed in place with formaldehyde, lysine or glutaraldehyde, allowing subsequent tissue processing, such as sectioning.
The product is subject to the following: Abcam Restricted Use Statement
Medchemexpress LLC Biotin-PEG8-NHS ester | 2143968-03-8 | 99.89% | C33H56N4O14S | 100 MG
Biotin-PEG8-NHS ester is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs leverage the intracellular ubiquitin-proteasome system for the selective degradation of target proteins by linking a ligand for an E3 ubiquitin ligase and a ligand for the target protein.
- For research use only
- Available in various quantities
- Multiple documentation types available
- White to off-white solid appearance
Medchemexpress LLC Biotin-Ahx-angiotensin II (human) | 115102-72-2 | 100.0% | C66H96N16O15S | 10MG
Biotin-Ahx-Angiotensin II (human) is a biotinylated octapeptide derived from angiotensin II, provided as a lyophilized powder for use as an affinity probe in biochemical and receptor-binding assays. The biotin tag attached via an aminohexanoic acid (Ahx) spacer enables streptavidin-based capture or detection while maintaining the peptide's biological activity. Molecular formula C66H96N16O15S; molecular weight 1385.63.
- Biotin tag for streptavidin-based detection and capture.
- Ahx spacer reduces steric hindrance and preserves peptide activity.
- Sequence corresponds to human angiotensin II for biologically relevant assays.
- High purity for consistent and reproducible results.
- Lyophilized powder format for long-term storage and easy reconstitution.
Medchemexpress LLC Azido-PEG6-NHS ester | 2055014-64-5 | 98.0% | 1 G
Azido-PEG6-NHS ester is a cleavable 6 unit PEG ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs). It also functions as a PEG- and Alkyl/ether based PROTAC linker for synthesizing PROTACs. This compound is a click chemistry reagent, featuring an Azide group, which allows it to participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules containing Alkyne groups. Additionally, it can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Cleavable linker
- PEG linker type
- Alkyl/ether linker type
- Click chemistry reagent
- Contains an azide group
- Participates in copper-catalyzed azide-alkyne cycloaddition reactions
- Undergoes strain-promoted alkyne-azide cycloaddition reactions
- Used in ADC synthesis
- Used in PROTAC synthesis
Medchemexpress LLC Azido-PEG24-NHS ester | 2375600-46-5 | 95.0% | C55H104N4O28 | 10MG
Azido-PEG24-NHS ester is a polyethylene glycol (PEG) linker bearing an azide and an N-hydroxysuccinimide (NHS) ester functional group. It is designed for bioconjugation and linker synthesis, enabling both click chemistry and amine-directed coupling while improving solubility and flexibility in conjugates.
- Azide functional group enables click chemistry with alkynes.
- NHS ester reacts with primary amines to form stable amide bonds.
- PEG24 spacer provides enhanced water solubility and flexible linker length.
- Suitable for PROTAC synthesis, drug conjugates, and general bioconjugation.
- High purity (~95.0%) suitable for research use.
- Available in small milligram quantities for exploratory synthesis.
Medchemexpress LLC DOTA-NHS-ester (TFA) | 00-00-0 | MFCD23381190 | 95.0% | 615.51 g·mol⁻¹ | C22H32F3N5O12 | 5 MG
DOTA-NHS-ester TFA is an activated N-hydroxysuccinimide (NHS) ester of the DOTA chelator supplied as the trifluoroacetic acid (TFA) salt. It enables efficient conjugation of the DOTA chelator to amine-containing biomolecules for subsequent radiolabeling and imaging applications such as PET and SPECT.
- Activated NHS ester for rapid conjugation to primary amines.
- TFA salt form improves solubility and handling.
- Facilitates stable metal chelation for radiolabeling.
- Suitable for labeling peptides, proteins, and affibodies.
- Available in small-scale research quantities for preclinical work.
Medchemexpress LLC Biotin-PEG8-NHS ester | 2143968-03-8 | MFCD27977502 | 99.9% | C33H56N4O14S | 10MG
Biotin-PEG8-NHS ester is a PEG-based heterobifunctional linker that combines a biotin affinity tag with an N-hydroxysuccinimide (NHS) ester to enable efficient conjugation to primary amines. It is suitable for biotinylation of peptides, proteins, and small molecules, and for use as a linker in targeted protein degradation research and affinity capture workflows.
- Enables efficient conjugation to primary amines via NHS ester chemistry.
- Provides a biotin tag for streptavidin-based capture and detection.
- PEG8 spacer improves solubility and reduces steric hindrance.
- High purity for reproducible conjugation and downstream analysis.
- Suitable for synthesis of linkers and bioconjugates in research applications.
Sigma Aldrich Fine Chemicals Biosciences (+)-Biotin N-hydroxysuccinimide ester >=98% (HPLC), powder | 35013-72-0 | MFCD00078531 | 25MG
(+)-Biotin N-hydroxysuccinimide ester >=98% (HPLC), powder | Purity: >=98% (HPLC) | Mol Wt: 341.38 | 35013-72-0 | MFCD00078531 | 25MG
Medchemexpress LLC N-succinimidyl-3-(2-pyridyldithio)butyrate | 107348-47-0 | MFCD28398150 | 98.3% | 326.4 g/mol | C13H14N2O4S2 | 1 G
PPC-NHS ester (N-succinimidyl-3-(2-pyridyldithio)butyrate, CAS 107348-47-0) is an NHS-activated cleavable linker reagent used for conjugating small molecules to proteins and antibodies. It reacts with primary amines to form stable amide bonds and contains a pyridyldisulfide moiety that enables controlled cleavage under reducing conditions, making it suitable for antibody-drug conjugate synthesis and general bioconjugation.
- Reacts with primary amines to form stable amide bonds.
- Contains a pyridyldisulfide cleavable linkage for controlled release under reducing conditions.
- High purity suitable for conjugation workflows (≈98.3%).
- Compatible with common aqueous and organic conjugation conditions.
Sigma Aldrich Fine Chemicals Biosciences N-(+)-Biotinyl-6-aminohexanoic acid >=97.0% (HPLC) | 72040-64-3 | MFCD00144853 | 100MG
N-(+)-Biotinyl-6-aminohexanoic acid >=97.0% (HPLC) | Purity: >=97.0% (HPLC) | Mol Wt: 357.47 | 72040-64-3 | MFCD00144853 | 100MG