Cycloheptathiophenes
Medchemexpress LLC Ensitrelvir fumarate | 2757470-18-9 | 99.99% | C26H21ClF3N9O6 | 1 ML
Ensitrelvir (S-217622) fumarate is the first orally active, non-covalent, non-peptidic SARS-CoV-2 3CL protease inhibitor. It demonstrates high potency with an IC50 of 13 nM and is intended for research use only. The compound has shown significant antiviral activity in vitro against various SARS-CoV-2 variants.
- First orally active, non-covalent, non-peptidic SARS-CoV-2 3CL protease inhibitor.
- Exhibits an IC50 of 13 nM, indicating high potency.
- Effective against wild-type SARS-CoV-2 and Alpha, Beta, Gamma, and Delta variants with EC50 values of approximately 0.4 μM.
- Also active against SARS-CoV and MERS-CoV, with EC50 values of 0.21 and 1.4 μM, respectively.
- Dose-dependently inhibits intrapulmonary replication of SARS-CoV-2 in mice.
Apexbio Technology LLC Fesoterodine Fumarate 286930-03-8 50mg
Fesoterodine Fumarate (CAS 286930-03-8) is a synthetic antimuscarinic agent that acts as a competitive antagonist at muscarinic acetylcholine receptors particularly the M3 subtype in the bladder detrusor muscle By inhibiting these receptors the compound modulates involuntary bladder contractions reducing symptoms associated with overactive bladder syndrome such as urgency and frequency Fesoterodine Fumarate is utilized in biomedical research to study cholinergic signaling mechanisms involved in urinary function and to explore pharmacological interventions targeting muscarinic pathways in urological disorders
Medchemexpress LLC Fumarate hydratase-IN-2 sodium salt | 2070009-45-7 | 98.7% | 440.47 g/mol | C25H25N2NaO4 | 1 ML
Fumarate hydratase-IN-2 sodium salt is a cell-permeable, competitive inhibitor of fumarate hydratase (Ki = 4.5 μM) used for biochemical and cell-based research into enzyme function and metabolic responses. It is supplied in high-purity form with solution and solid formats to support varied experimental workflows.
- Cell-permeable competitive inhibitor of fumarate hydratase (Ki = 4.5 μM).
- Reported nutrient-dependent cytotoxicity in cell studies.
- High purity suitable for research applications (98.7% reported).
- Available as 10 mM solution in DMSO (1 mL) and as solid quantities for flexibility.
- Molecular formula C25H25N2NaO4 and molecular weight 440.47 g/mol.
- Includes product data sheet and certificate of analysis for batch-specific quality assurance.
Medchemexpress LLC Fumarate hydratase-I 50mg
Fumarate hydratase-IN-1 (compound 2) is a cell-permeable fumarate hydratase inhibitor Fumarate hydratase-IN-1 has antiproliferative activity against several cancer cell lines with a mean IC50 of 2 2 M1]
Medchemexpress LLC Crozbaciclib fumarate | 2567494-39-5 | 99.4% | 604.65 g/mol | C32H34F2N6O4 | 5 MG
Crozbaciclib fumarate is the fumarate salt of crozbaciclib, a small-molecule cyclin-dependent kinase inhibitor selective for CDK4 and CDK6, provided for laboratory research. It exhibits low-nanomolar biochemical potency (CDK4 IC50 ≈ 3 nM; CDK6 IC50 ≈ 1 nM) and demonstrates antiproliferative activity in cellular assays.
- Fumarate salt form for improved chemical stability.
- Potent inhibition of CDK4 and CDK6 (low-nanomolar IC50s).
- High chemical purity (reported 99.4%).
- Supplied in small milligram quantities for research use.
Cayman Chemical Tenofovir Disoproxil fumarat
A prodrug of the HIV reverse transcriptase and hepatitis B virus polymerase inhibitor, tenofovir; >100-fold greater anti-HIV activity than that of poorly bioavailable tenofovir in a T cell line and primary blood lymphocytes
TARGETMOL CHEMICALS INC VUF11207 fumarate 10MG
Also available in 1 mL, 1 mg, 2 mg, 5 mg, 25 mg, 50 mg, 100 mg, 200 mg and bulk. Please contact Fisher for quotes. VUF11207 fumarate is an agonist of CXCR7 and a high-potency ligand of CXCR7 (pKi 8.1). Purity 99.5%
Medchemexpress LLC Ocifisertib fumarate | 1616420-30-4 | 99.3% | 650.72 Da | C37H38N4O7 | 5MG
Ocifisertib fumarate is the fumarate salt of Ocifisertib (CFI-400945), a potent, selective, orally bioavailable inhibitor of polo-like kinase 4 (PLK4) used as a research tool in oncology and cell biology to study centriole duplication and mitotic defects. Reported potency values support activity in biochemical and cellular assays.
Apexbio Technology LLC Quetiapine Fumarate 111974-72-2 50mg
Quetiapine Fumarate (CAS 111974-72-2) is a small-molecule atypical antipsychotic with antagonistic activity at dopamine (D1 D2) serotonin (5-HT1A 5-HT2) and adrenergic ( 1 2) receptors In vitro it exhibits affinity for multiple neurotransmitter receptors with dopamine-2 binding characteristics similar to clozapine Preclinical in vivo studies demonstrate antipsychotic effects minimal extrapyramidal side effects and a lower propensity for sustained prolactin elevation Quetiapine has been shown to modulate neurotrophin expression and restore hippocampal neurogenesis following chronic stress in animal models supporting its value in neuropsychiatric and neuropharmacological research
Medchemexpress LLC VUF11207 fumarate | 1785665-61-3 | 99.9% | 586.65 | 50 MG
VUF11207 fumarate is a CXCR7 agonist that binds specifically to CXCR7. It reduces CXCL12-mediated osteoclastogenesis and bone resorption by inhibiting ERK phosphorylation.
- Reduces CXCL12-mediated osteoclastogenesis and bone resorption by inhibiting ERK phosphorylation.
- Binds specifically to CXCR7.
![Medchemexpress LLC 3aH-indole-3a-carboxylic acid, 1-([1,1'-biphenyl]-4-ylmethyl)-hexahydro-3-substituted, sodium salt | 2070009-45-7 | 98.7% | 440.47 g/mol | C25H25N2NaO4 | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000215663.png-250.jpg)
Medchemexpress LLC 3aH-indole-3a-carboxylic acid, 1-([1,1'-biphenyl]-4-ylmethyl)-hexahydro-3-substituted, sodium salt | 2070009-45-7 | 98.7% | 440.47 g/mol | C25H25N2NaO4 | 10 MG
Fumarate hydratase-IN-2 sodium salt is a cell-permeable, competitive inhibitor of fumarate hydratase (Ki = 4.5 μM). Supplied as the sodium salt as a white to off-white solid, it is intended for biochemical and cell-based research, including studies of metabolic regulation and nutrient-dependent cytotoxicity.
- Cell-permeable competitive inhibitor of fumarate hydratase (Ki = 4.5 μM).
- Sodium salt form for improved solubility in aqueous and polar solvents.
- High purity (98.7%) appropriate for research use.
- Soluble in DMSO (10.66 mg/mL) and water (6.25 mg/mL) with warming and sonication.
- Stable when stored sealed away from moisture; follow solvent storage recommendations.
Apexbio Technology LLC 3-Aminopropionitrile fumarate (2:1) 2079-89-2 500mg
3-Aminopropionitrile fumarate (2 1) (CAS 2079-89-2) is a small molecule derivative originally identified from Apocynaceae species It acts by inhibiting collagen cross-linking through interference with enzymatic pathways responsible for covalent bonding among collagen molecules Modulation of enzyme activity and signaling cascades by this compound leads to altered collagen stability within biological tissues Owing to its capacity to disrupt collagen maturation 3-Aminopropionitrile fumarate (2 1) serves as a valuable tool in studies of fibrotic disorders and related metabolic processes where aberrant extracellular matrix remodeling is implicated
Medchemexpress LLC 2-butenedioic-2,3-d2 acid, 1-methyl ester, (2E)- | 253122-44-0 | 98.2% | 132.11 | C5H4D2O4 | 5 MG
Monomethyl fumarate-d2 is the deuterium-labeled analogue of monomethyl fumarate, supplied as a solid research reagent for use in analytical, pharmacological, and metabolic studies. It serves as an internal standard and tracer in mass spectrometry and mechanistic experiments, and represents the active metabolite of dimethyl fumarate (DMF).
- Deuterium labeled for isotope-tracing and mass spectrometry applications.
- High purity suitable for analytical reference and research use.
- Solid form for stable storage and handling.
- Useful as a tracer in metabolic and pharmacokinetic studies.
- CAS 253122-44-0 corresponds to the d2 isotopologue.
Medchemexpress LLC HY-B0157A 100mg Medchemexpress, Ketotifen (fumarate) CAS:34580-14-8 Purity:>98%
Medchemexpress, HY-B0157A 100mg Ketotifen (fumarate) CAS:34580-14-8 Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
TARGETMOL CHEMICALS INC Org-13011 fumarate 1MG
Also available in 5 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Org-13011 fumarate1 is an agonist of the 5-HT1A receptor and can be used to study neurological disorders. Purity 98.61%