Furans
Medchemexpress LLC DMA-135 hydrochloride | 2237925-62-9 | 98.0% | C16H18ClN7O | 50 MG
DMA-135 hydrochloride is an inhibitor targeting enterovirus 71 (EV71) IRES-dependent translation and replication. It binds to the EV71 SLII domain with moderately high affinity (KD= 520 nM) and shows no significant toxicity in cell-based studies. It induces conformational changes in the RNA structure and stabilizes the ternary complex DMA135-RNA-AUF1, inhibiting the translation and replication of EV71 with an IC50 of 7.54 μM.
- Targets enterovirus 71 (EV71) IRES-dependent translation and replication.
- Binds to the EV71 SLII domain with moderately high affinity.
- Induces conformational changes in RNA structure.
- Stabilizes the ternary complex DMA135-RNA-AUF1.
- Inhibits translation and replication of EV71 with an IC50 of 7.54 μM.
- Demonstrates no significant toxicity in cell-based studies.
Medchemexpress LLC Nitrofurazone | 1217220-85-3 | 99.6% | 201.12 g/mol | (13C)C5H6(15N)2N2O4 | 10 MG
Nitrofurazone-13C,15N2 is a stable isotope-labeled form of the antibacterial nitrofurazone, supplied as a high-purity analytical standard for use in mass spectrometry, tracer studies, and quantitative assays. The labeled product contains one 13C and two 15N atoms and has a molecular weight of 201.12 g/mol and a reported chemical purity of 99.56%.
- Stable isotope labeled for use as an internal standard and tracer.
- High chemical purity suitable for analytical workflows.
- Available in small, weighed quantities for laboratory use.
- Provided as a solid with defined molecular weight and CAS number for traceability.
![Medchemexpress LLC 4-[1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,2,3-triazol-4-yl]-N-isopropyl-N-methyl-3,6-dihydropyridine-... | 873551-53-2 | 99.3% | 358.41 g/mol | C18H23FN6O | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000214055.png-250.jpg)
Medchemexpress LLC 4-[1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,2,3-triazol-4-yl]-N-isopropyl-N-methyl-3,6-dihydropyridine-... | 873551-53-2 | 99.3% | 358.41 g/mol | C18H23FN6O | 10 MG
FTIDC is a selective, noncompetitive allosteric antagonist of metabotropic glutamate receptor 1 (mGluR1) intended for research use. It is orally active and demonstrates potent antagonism against recombinant mGluR1, supporting pharmacology and neuroscience studies.
- Potent mGluR1 antagonism (IC50 5.8 nM for human mGluR1a).
- Selective noncompetitive allosteric mechanism.
- High chemical purity suitable for research applications.
- Defined physicochemical properties: C18H23FN6O; MW 358.41 g/mol; CAS 873551-53-2.
- Supplied in small-scale quantities appropriate for laboratory experiments.
Medchemexpress LLC Pyribencarb | 799247-52-2 | MFCD22200855 | ≥95.0% | 361.83 | C18H20ClN3O3 | 50 MG
Pyribencarb is a benzylcarbamate-class fungicide supplied as a research-grade standard. It acts as a Qo inhibitor of cytochrome b (complex III) in the mitochondrial electron transport chain and shows activity against a broad range of plant pathogenic fungi. The compound is intended for analytical, in vitro antifungal, and mode-of-action studies.
- Inhibits cytochrome b (complex III) via the Qo site, enabling mechanism-of-action research.
- Active against common plant pathogens such as Botrytis cinerea and Sclerotinia sclerotiorum.
- Provided as a solid reference material suitable for analytical assays and standards.
- Storage stability as powder at low temperatures supports long-term archiving.
- Applicable to in vitro antifungal testing and comparative potency studies.
![Medchemexpress LLC 6-(5-chloropyridin-2-yl)-6,7-dihydro-5h-pyrrolo[3,4-b]pyrazin-5-one | 148891-53-6 | MFCD27967008 | 99.8% | 246.65 | C11H7ClN4O | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000223427.png-250.jpg)
Medchemexpress LLC 6-(5-chloropyridin-2-yl)-6,7-dihydro-5h-pyrrolo[3,4-b]pyrazin-5-one | 148891-53-6 | MFCD27967008 | 99.8% | 246.65 | C11H7ClN4O | 5 MG
RP 48497 is a photodegradation impurity of eszopiclone provided as a high-purity analytical reference for research, method development, and impurity profiling. It is characterized by a defined molecular formula, validated purity, and recommended storage conditions for stability.
Medchemexpress LLC CCT365623 hydrochloride | 2126136-98-7 | 98.1% | 443.99 g/mol | C18H18ClNO4S3 | 5MG
CCT365623 hydrochloride is the hydrochloride salt of a small-molecule lysyl oxidase (LOX) inhibitor used in preclinical research. It suppresses EGFR (pY1068) and AKT phosphorylation driven by EGF, and has reported oral activity and favorable pharmacokinetic properties. The material is supplied as a solid and as a prepared DMSO solution for laboratory use and is intended for research use only.
Medchemexpress LLC Cobomarsen | 1848257-52-2 | C148H177N52O77P13S13 | 10MG
Cobomarsen is a locked nucleic acid (LNA)-based antisense oligonucleotide that selectively inhibits microRNA-155 (miR-155). Supplied as a solid (white to off-white) research reagent, it is used in preclinical studies to modulate miR-155-driven signaling and investigate oncology models by affecting pathways such as JAK/STAT, MAPK/ERK, and PI3K/AKT. The sodium salt form offers improved stability; the compound is highly water soluble and requires sealed, moisture-free storage.
- Selective inhibition of miR-155 and related survival pathways
- Suitable for preclinical oncology and lymphoma research
- High aqueous solubility; may require ultrasonication
- Improved stability as the sodium salt compared with the free acid
- Store sealed and protected from moisture; long-term storage in solution at -80 °C
Medchemexpress LLC Opiranserin hydrochloride | 1440796-75-7 | MFCD34676620 | 99.6% | 430.97 g/mol | C21H35ClN2O5 | 5 MG
Opiranserin hydrochloride is a research-stage, non-opioid analgesic candidate that acts as a dual antagonist of glycine transporter 2 (GlyT2) and the serotonin 2A receptor (5-HT2A). Supplied as the hydrochloride salt, it is used in preclinical pharmacology and mechanism-of-action studies.
- Dual antagonist activity at GlyT2 and 5-HT2A demonstrated in vitro.
- Non-opioid, non-NSAID analgesic candidate suitable for postoperative pain research.
- Available in solid and DMSO solution formats for flexible dosing and formulation.
- High reported purity (99.6%) appropriate for preclinical experiments.
- Supplied in small pack sizes compatible with early-stage studies.
Apexbio Technology LLC Azimilide 10mg. 709002-46-0. MFCD04173051
Azimilide 10mg. 709002-46-0. MFCD04173051
eMolecules Medchem Express / C646 / 10mg / 446263588 / HY-13823 / / 328968-36-1 / MFCD06125650 / 445.431 / C24H19N3O6
Medchem Express / C646 / 10mg / 446263588 / HY-13823 / / 328968-36-1 / MFCD06125650 / 445.431 / C24H19N3O6
Medchemexpress LLC Mometasone furoate | 83919-23-7 | 99.86% | 521.43 | 500 MG
Mometasone furoate (Sch32088) is a glucocorticoid receptor agonist that demonstrates anti-inflammatory and anti-allergic properties. It functions as a corticosteroid agent, employed in topical applications for the management of chronic skin eczema and airway inflammation associated with asthma in living organisms.
- Functions as a glucocorticoid receptor agonist.
- Possesses anti-inflammatory activity.
- Exhibits anti-allergic activity.
- Acts as a corticosteroid.
- Suitable for topical applications.
- Aids in the management of chronic skin eczema.
- Contributes to the management of airway inflammation in asthma.
Apexbio Technology LLC Mometasone furoate 83919-23-7 10mM (in 1mL DMSO)
Mometasone furoate (83919-23-7) is a glucocorticoid receptor agonist targeting intracellular glucocorticoid receptors It is designed to modulate glucocorticoid signaling pathways thereby regulating gene expression linked to inflammatory and allergic responses Mometasone furoate exerts its biological activity primarily through binding to cytoplasmic glucocorticoid receptors forming an activated complex that translocates into the nucleus and modulates target gene transcription This mechanism suppresses inflammatory cytokine production and inhibits inflammatory mediator release Based on these pharmacological properties Mometasone furoate holds research potential in experimental models of skin inflammatory disorders such as eczema and psoriasis as well as respiratory inflammatory processes including asthma