Furans
Medchemexpress LLC MBCQ | 10MG
MBCQ is a potent and selective cGMP-specific phosphodiesterase (PDE V PDE5) inhibitor with an IC50 of 19 nM MBCQ lacks inhibitory activity toward other PDE isozymes (all IC50s 100 M) MBCQ dilates coronary arteries via specific inhibition of cGMP-PDE[1][2][3]
Medchemexpress LLC Sincalide (ammonium) | 70706-98-8 | 99.2% | 1160.30 | 10 MG
Sincalide ammonium is a rapid-acting amino acid polypeptide hormone analogue of cholecystokinin (CCK) for intravenous use in postevacuation cholecystography. It is a major bioactive segment of CCK that retains most of its biological activities. CCK-8 can promote gallbladder contraction by injection and helps diagnose gallbladder and pancreas disorders, increasing bile secretion, causing gallbladder contraction, and relaxing the sphincter of Oddi for bile drainage into the duodenum.
- Significant inhibitory effect on myocardial fibrosis in noninfarcted areas
- Positive role in fighting inflammation, apoptosis, and collagen deposition
- Protects H9c2 cardiomyoblasts from Ang II‐induced apoptosis
- Alleviates fibrosis in noninfarcted regions
- Delays left ventricular remodeling and the progress of heart failure in a MI rat model
Medchemexpress LLC SRI-37330 hydrochloride | 2322245-49-6 | 99.7% | 424.87 g/mol | C16H20ClF3N4O2S | 5 MG
SRI-37330 hydrochloride is an orally bioavailable thioredoxin-interacting protein (TXNIP) inhibitor supplied as the hydrochloride salt for preclinical and biochemical research into metabolic disease and diabetes-related pathways. The compound is provided as a purified solid with solution formats available for assay use.
- Orally bioavailable TXNIP inhibitor suitable for metabolic research.
- Modulates glucagon secretion and reduces hepatic glucose production in models.
- Supplied as a hydrochloride salt to aid solubility and handling.
- High chemical purity (99.7%).
- Available in small milligram quantities and solution formats for assays.
- Documentation provided: datasheet and certificate of analysis.
Medchemexpress LLC PF-06456384 trihydrochloride | 1834610-75-1 | MFCD31697702 | 99.4% | 829.18 | C35H35Cl3F3N7O3S2 | 10 MG
PF-06456384 trihydrochloride is a research-grade small-molecule inhibitor selective for the voltage-gated sodium channel NaV1.7. It is reported to have extremely high potency (IC50 = 0.01 nM) and is supplied at high purity for use in in vitro and in vivo pain-model research.
- Highly potent NaV1.7 inhibitor (IC50 = 0.01 nM).
- High purity suitable for research applications (>99%).
- Molecular weight 829.18 and formula C35H35Cl3F3N7O3S2.
- Provided as the trihydrochloride salt for enhanced stability and handling.
- Intended for laboratory research use only.
eMolecules 5-Bromo-3-furoic acid | 58832-36-3 | MFCD08669547 | 1g
Apollo Scientific | 5-Bromo-3-furoic acid | 1g | 562432220 | OR3279 | | 58832-36-3 | MFCD08669547 | 190.980 | C5H3BrO3
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eMolecules Medchem Express / ML167 / 5mg / 446267012 / HY-15951 / / 1285702-20-6 / MFCD27978379 / 335.363 / C19H17N3O3
Medchem Express / ML167 / 5mg / 446267012 / HY-15951 / / 1285702-20-6 / MFCD27978379 / 335.363 / C19H17N3O3
Medchemexpress LLC Dantrolene (sodium salt) | 14663-23-1 | 99.5% | 336.2 | 100 MG
Dantrolene sodium is an orally active, non-competitive glutathione reductase inhibitor and a calcium channel protein inhibitor. It inhibits the release of Ca²± from RyR1 and RyR3, which is beneficial in pathologies caused by disruptions in calcium homeostasis, such as stroke and neurodegenerative diseases. It also offers relief of muscle spasms, malignant hyperthermia, and has antitoxic, antipyretic, and anti-inflammatory properties.
- Orally active glutathione reductase and calcium channel inhibitor
- Inhibits Ca²± release from RyR1 and RyR3
- Beneficial in calcium homeostasis disruptions
- Relieves muscle spasms and malignant hyperthermia
- Antitoxic, antipyretic, and anti-inflammatory effects
- Targets calcium channel, ROS, and apoptosis
- Used in cardiovascular, neurological, and metabolic disease research
eMolecules 4-BROMOBENZOFURAN-3(2H)-ONE | 1020966-78-2 | MFCD09744091 | 1g
AstaTech | 4-BROMOBENZOFURAN-3(2H)-ONE | 1g | 392628609 | F13692 | 95.000 | 1020966-78-2 | MFCD09744091 | 213.030 | C8H5BrO2
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Medchemexpress LLC Ry796 | 1393441-53-6 | 98.6% | 5 MG
RY796 is a potent, selective inhibitor of voltage-gated potassium (KV2) channels used in preclinical research; it shows analgesic activity and inhibits KV2.1 and KV2.2 with IC50 values in the submicromolar range.
- Selective KV2 channel inhibitor (IC50: 0.25 μM for KV2.1, 0.09 μM for KV2.2).
- Demonstrates analgesic activity in preclinical models.
- High research-grade purity (98.6%).
- Soluble in DMSO at 100 mg/mL; in vivo formulations documented.
- Stable as a powder at standard low-temperature storage conditions.
Medchemexpress LLC Cct365623 hydrochloride | 2126136-98-7 | 98.1% | 443.99 | C18H18ClNO4S3 | 10MG
CCT365623 hydrochloride is the hydrochloride salt of a small-molecule lysyl oxidase (LOX) inhibitor used for preclinical research. It suppresses EGFR (pY1068) and AKT phosphorylation, is orally active in models, and has demonstrated favorable tolerability and pharmacokinetic properties.
- Orally active LOX inhibitor (IC50 = 0.89 μM).
- High purity (98.1%) suitable for biological studies.
- Available in small research pack sizes for in vitro and in vivo use.
- Soluble in DMSO (250 mg/mL); in vivo formulation protocols provided.
- Storage guidance included for solid and solution stability.
- Intended for research use only; not for human administration.
Medchemexpress LLC HY-15701A 5mg Medchemexpress, (Z)-Leukadherin-1 CAS:2055362-72-4 Purity:>98%
Medchemexpress, HY-15701A 5mg (Z)-Leukadherin-1 CAS:2055362-72-4 (Z)-Leukadherin-1 (ADH-503 free base) is an orally active and allosteric CD11b agonist. (Z)-Leukadherin-1 leads to the repolarization of tumor-associated macrophages, reduction in the number of tumor-infiltrating immunosuppressive myeloid cells, and enhances dendritic cell responses. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC SEW2871 | 256414-75-2 | 99.9% | 440.36 | 10 MG
SEW2871 is an orally active, potent, highly selective S1P1 (sphingosine-1-phosphate type 1 receptor) agonist, with an EC50 of 13.8 nM. It activates ERK, Akt, and Rac signaling pathways and induces S1P1 internalization and recycling. SEW2871 reduces lymphocyte numbers in blood and can be used for the research of diabetes, Alzheimer's disease, liver fibrosis, and inflammatory responses.
- Orally active, potent, highly selective S1P1 agonist.
- Activates ERK, Akt, and Rac signaling pathways.
- Induces S1P1 internalization and recycling.
- Reduces lymphocyte numbers in blood.
- Can be used for research of diabetes, Alzheimer's disease, liver fibrosis, and inflammatory responses.
Medchemexpress LLC 2-isopropylphenyl N-(2-naphthalen-2-yl)ethyl carbamate | 1354359-53-7 | MFCD20926355 | 99.5% | 333.42 g/mol | C22H23NO2 | 10 MG
JW480 is a potent, selective carbamate inhibitor of the serine hydrolase KIAA1363 (AADACL1). It is used as a research reagent to probe KIAA1363 function in lipid metabolism and cancer-relevant cellular pathways, and is supplied with characterization data appropriate for biochemical and cellular studies.
- Selective inhibitor of the serine hydrolase KIAA1363.
- Suitable for biochemical and cell-based assays.
- Carbamate-based small-molecule structure for target engagement studies.
- High purity and defined molecular properties for reproducible results.
- Provided with catalog and registry identifiers for traceability.
Selleck Chemical LLC Mometasone furoate S1987-200mg
Mometasone Furoate (SCH-32088 mometasone 17-furoate) is a glucocorticoid receptor agonist used topically to reduce inflammation of the skin or in the airways