Lactams
Medchemexpress LLC N-(2-amino-5-(thiophen-2-yl)phenyl)-2-(piperazin-1-yl)quinoline-6-carboxamide | 1609389-52-7 | MFCD30342405 | 99.6% | 429.54 g·mol⁻¹ | C24H23N5OS | 25 MG
ACY-957 is a small-molecule, orally active inhibitor selective for histone deacetylases HDAC1 and HDAC2 used in preclinical research. It potently inhibits HDAC1 (IC50 = 7 nM) and HDAC2 (IC50 = 18 nM), with substantially weaker activity against HDAC3 (IC50 = 1,300 nM), and shows no significant inhibition of HDAC4-HDAC9. The compound is provided as a purified research reagent for biochemical and cellular studies of epigenetic regulation.
- Potent HDAC1 inhibition (IC50 = 7 nM).
- Selective for HDAC1/2 over HDAC3 (IC50 HDAC2 = 18 nM; HDAC3 = 1,300 nM).
- Orally active profile reported in preclinical studies.
- Suitable for biochemical and cellular assays investigating epigenetic regulation.
- High chemical purity for reproducible experimental results.
Medchemexpress LLC 2,6-piperidinedione, 3-(1,3-dihydro-5-iodo-1-oxo-2H-isoindol-2-yl)- | 2291364-01-5 | MFCD32853043 | 98.0% | 370.14 g/mol | C13H11IN2O3 | 500 MG
Deoxy-thalidomide-5-iodine is a thalidomide analog used as a cereblon-binding ligand scaffold in PROTAC and chemical biology research. Provided as a research-grade small molecule with reported purity suitable for biochemical and cell-based studies.
- Purity reported as 98.0%.
- Suitable for PROTAC ligand development and E3 ligase recruitment studies.
- Iodinated scaffold enables further functionalization or conjugation chemistry.
- Available in multiple pack sizes, including 500 mg, for scale flexibility.
- Molecular formula C13H11IN2O3; molecular weight 370.14 g/mol.
Medchemexpress LLC Thalidomide-O-amido-C4-N3 | 2098488-36-7 | MFCD31560486 | 98.4% | 428.40 g/mol | C19H20N6O6 | 10 MG
Thalidomide-O-amido-C4-N3 is a thalidomide-derived cereblon ligand-linker conjugate used as a building block in proteolysis-targeting chimera (PROTAC) and E3 ligase ligand research. It is provided with analytical characterization and storage guidance for research applications.
- Used as a cereblon ligand-linker conjugate for PROTAC and E3 ligase research.
- Molecular formula C19H20N6O6; molecular weight 428.40 g/mol.
- CAS number 2098488-36-7 for unambiguous identification.
- Purity 98.4% by LCMS (as supplied).
- Supplied in small research quantities (for example, 10 mg) and as stock solution preparations.
- Soluble in DMSO and compatible solvent systems for formulation.
- Store at 4°C under nitrogen; in solution, store at -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC Deoxy-thalidomide-5-iodine | 2291364-01-5 | MFCD32853043 | 98.0% | 370.14 g/mol | C13H11IN2O3 | 250 MG
Deoxy-thalidomide-5-iodine is a thalidomide analog used as a cereblon-binding ligand in targeted protein degradation and PROTAC research. It is provided as a characterized small-molecule building block suitable for conjugation in bifunctional degrader synthesis and related chemical biology applications.
- Used as cereblon-binding ligand for PROTAC development.
- High reported purity: 98.0% (NMR).
- Molecular weight 370.14 g/mol and formula C13H11IN2O3.
- Solid; store at 4°C and protect from light.
- Available in multiple package sizes, including 250 mg.
Medchemexpress LLC 5-bromo-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione | 26166-92-7 | MFCD30188073 | 97.0% | 337.13 | C13H9BrN2O4 | 25 MG
Thalidomide-5-Br (5-bromo-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione) is a brominated thalidomide derivative supplied as a research reagent and used in studies of inflammation, tumor biology, and neurology.
- contains a brominated thalidomide core
- used in inflammation research
- applicable to tumor biology studies
- suitable for neurology research
- available in small research quantities
Medchemexpress LLC Thalidomide-piperazine-PEG1-NH2 diTFA | 00-00-0 | 99.4% | C25H29F6N5O9 | 10MG
Thalidomide-Piperazine-PEG1-NH2 diTFA is a synthesized E3 ligase ligand-linker conjugate that combines a thalidomide-based cereblon ligand with a short PEG1/piperazine linker for PROTAC design. Intended for research use only, the compound is supplied as a solid (white to yellow) with characterized solubility and storage recommendations to support experimental workflows.
- High purity for research use (99.4%).
- Thalidomide-based cereblon ligand facilitates E3 ligase recruitment.
- Short PEG1/piperazine linker suitable for PROTAC assembly.
- DMSO solubility: 100 mg/mL; sonication recommended.
- In vivo formulation options reach ~2.5 mg/mL as suspended or clear solutions.
- Storage: sealed at 4°C; in solvent -80°C (6 months) or -20°C (1 month).
![Medchemexpress LLC 7-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}heptanoic acid | 2169266-69-5 | MFCD32063464 | 99.3% | C20H22N2O7 | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000261970.png-250.jpg)
Medchemexpress LLC 7-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}heptanoic acid | 2169266-69-5 | MFCD32063464 | 99.3% | C20H22N2O7 | 10MG
Thalidomide-O-C6-COOH is a thalidomide-based cereblon (CRBN) E3 ligase ligand-linker conjugate terminating in a six-carbon carboxylic acid. It is used as a building block in PROTAC synthesis and chemical biology research, providing a convenient carboxylic acid handle for linker attachment and efficient recruitment of CRBN.
- Used in PROTAC design to recruit cereblon (CRBN) E3 ligase.
- Thalidomide-based ligand with a six-carbon carboxylic acid linker.
- High purity, 99.3% (reported).
- Soluble ≥100 mg/mL in DMSO.
- Off-white to light yellow solid suitable for synthesis.
- Molecular formula C20H22N2O7; molecular weight 402.40 g·mol⁻1.
- Storage recommendations provided for powder and solutions to maintain stability.
Medchemexpress LLC Thalidomide-4-O-C7-NH2 hydrochloride | 00-00-0 | 99.8% | C20H26ClN3O5 | 10MG
Thalidomide-4-O-C7-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand-linker conjugate provided as the hydrochloride salt for research use in PROTAC development and E3 ligase recruitment studies. It is supplied as a high-purity, well-characterized reagent suitable for biochemical assays, linker conjugation, and medicinal chemistry workflows.
- High purity (99.8%) suitable for research applications.
- Hydrochloride salt form for consistent handling and storage.
- Characterized molecular formula C20H26ClN3O5 and molecular weight 387.43 g/mol.
- Functions as a cereblon (CRBN) E3 ligase ligand for PROTAC design.
- Available in small, lab-scale quantities for screening and synthesis.
- Datasheet and certificate of analysis available from the supplier.
Medchemexpress LLC Thalidomide-4-O-C10-COOH | 2379870-45-6 | MFCD03424822 | 99.1% | 458.50 g·mol⁻¹ | C24H30N2O7 | 5 MG
Thalidomide-4-O-C10-COOH is an E3 ligase ligand-linker conjugate intended as a building block for PROTAC synthesis. It features a thalidomide-derived cereblon-recruiting motif linked via a C10 spacer to a terminal carboxylic acid, allowing standard coupling chemistry for attachment to target-binding ligands. Supplied as a high-purity solid for laboratory research use.
- High purity suitable for synthesis work.
- Carboxylic acid terminus for standard coupling reactions.
- Contains a C10 spacer to provide linker flexibility.
- Molecular formula: C24H30N2O7; molecular weight: 458.50 g·mol⁻¹.
- Supplied in small mg-scale quantities appropriate for research.