Lactams
Medchemexpress LLC Thalidomide-5-COOH | 1216805-11-6 | 99.9% | 302.24 | 100 MG
Thalidomide-5-COOH is a Thalidomide-based cereblon ligand that recruits the CRBN protein. It can be linked to a target protein ligand via a linker to form PROTACs. PROTACs utilize the intracellular ubiquitin-proteasome system to specifically degrade target proteins. It is for research use only.
- Thalidomide-based cereblon ligand
- Recruits CRBN protein
- Can be linked via a linker to form PROTACs
- Utilizes the intracellular ubiquitin-proteasome system
- Specifically degrades target proteins
- For research use only
Chemscene ChemScene | Thalidomide-O-PEG2-propargyl | 100MG | CS-0104609 | 0.98 | 2098487-52-4| MFCD32063462 | 400.38
ChemScene | Thalidomide-O-PEG2-propargyl | 100MG | CS-0104609 | 0.98 | 2098487-52-4| MFCD32063462 | 400.38
Medchemexpress LLC Thalidomide-pyrrolidine hydrochloride | 2616553-35-4 | 98.0% | 335.74 g·mol⁻¹ | C15H14ClN3O4 | 100 MG
Thalidomide-pyrrolidine hydrochloride is an E3 ligase ligand (compound 18) used as a building block in the synthesis of PROTACs. Provided as the hydrochloride salt at research-grade purity, it is supplied in milligram-scale packages and includes storage recommendations for long-term stability.
- E3 ligase ligand suitable for PROTAC assembly.
- Hydrochloride salt form for improved handling.
- High purity: 98.0%.
- Molecular weight: 335.74 g·mol⁻¹.
- CAS number: 2616553-35-4.
- Available in multiple package sizes including 100 mg.
- Storage recommendations: in solvent -80°C for 2 years, -20°C for 1 year.
Medchemexpress LLC Thalidomide-O-C6-COOH | 2169266-69-5 | 99.3% | 1 ML
Thalidomide-O-C6-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates a thalidomide-based cereblon ligand and a linker used in PROTAC technology. This product targets cereblon.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates thalidomide-based cereblon ligand
- Designed for PROTAC technology
- Targets cereblon
- Appearance: off-white to light yellow solid
- Solubility: ≥ 100 mg/mL in DMSO
Medchemexpress LLC Biotin-thalidomide | 2230857-87-9 | MFCD32851674 | 99.7% | 945.09 g/mol | C44H64N8O13S | 5 MG
Biotin-Thalidomide is a biotin-conjugated thalidomide derivative that binds the cereblon (CRBN) E3 ligase and is supplied for research use in target engagement studies and PROTAC synthesis. It is provided as a high-purity chemical probe for biochemical assays, affinity capture, and conjugation workflows; not for human therapeutic use.
- High purity (≈99.7%) suitable for research applications
- Cereblon-binding probe useful for PROTAC development
- Biotin tag enables affinity capture and pull-down assays
- Compatible with conjugation and synthetic workflows
- Intended for research use only
Medchemexpress LLC Thalidomide-5-O-CH2-COOH | 2467425-53-0 | MFCD34186095 | 95.0% | 332.26 | C15H12N2O7 | 5 MG
Thalidomide-5-O-CH2-COOH is an E3 ligase ligand-linker conjugate used as a cereblon (CRBN) ligand and an intermediate in PROTAC and conjugate synthesis. The compound is fully characterized (CAS 2467425-53-0, C15H12N2O7, MW 332.26) and is provided in small milligram quantities for research use with supporting analytical documentation.
- Functions as a cereblon (CRBN) ligand for E3 ligase recruitment.
- Serves as an intermediate for PROTAC and ligand-linker conjugation.
- Characterized by CAS 2467425-53-0 and formula C15H12N2O7.
- Supplied with datasheet, certificate of analysis, SDS, and spectral data.
- Typical purity approximately 95.0% by HPLC.
- Available in milligram pack sizes suitable for medicinal chemistry research.
Medchemexpress LLC Thalidomide-NH-C6-NH2 TFA | 2093386-51-5 | 99.8% | 250 MG
Thalidomide-NH-C6-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. This product is for research use only.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates thalidomide-based cereblon ligand
- Used in PROTAC technology
- Purity of 99.8%
- CAS number: 2093386-51-5
- Molecular weight: 486.44
- Chemical formula: C21H25F3N4O6
- Appearance as a solid
- Color ranges from light yellow to yellow
- Targets cereblon
Medchemexpress LLC Thalidomide-piperazine-PEG2-NH2 diTFA | 00-00-0 | 99.7% | C27H33F6N5O10 | 10MG
Thalidomide-Piperazine-PEG2-NH2 diTFA is a synthesized E3 ligase ligand-linker conjugate that incorporates a thalidomide-derived cereblon (CRBN) ligand and a PEG2-piperazine amino linker. Supplied as the bis(trifluoroacetate) salt, it is designed as a building block for assembling heterobifunctional degraders (PROTACs) to recruit CRBN and enable targeted protein degradation.
- Incorporates thalidomide-based cereblon ligand for CRBN recruitment.
- Contains a PEG2-piperazine linker with a terminal primary amine for conjugation chemistry.
- Supplied as the bis(trifluoroacetate) salt to aid handling and solubility.
- High purity suitable for synthesis (99.7%).
- Water solubility up to 50 mg/mL with ultrasonic assistance.
- Store sealed at 4°C, away from moisture.
Medchemexpress LLC Thalidomide-propargyne-PEG3-COOH | 2797649-54-6 | 96.3% | C23H24N2O9 | 10MG
Thalidomide-Propargyne-PEG3-COOH is a thalidomide-derived E3 ligase ligand-linker conjugate featuring a terminal propargyl alkyne and a PEG3 spacer terminating in a carboxylic acid. It is intended as a research reagent for chemical biology and PROTAC synthesis to enable cereblon recruitment and bioorthogonal conjugation in degradation studies.
- Provides a cereblon-binding ligand for CRBN-mediated degradation
- Contains an alkyne handle for copper-catalyzed azide-alkyne cycloaddition
- PEG3 spacer improves solubility and linker flexibility
- Terminal carboxylic acid enables amide coupling and conjugation
- Supplied at research-grade purity suitable for synthesis
Medchemexpress LLC Thalidomide-5-O-CH2-COOH | 2467425-53-0 | 95.0% | 332.26 g/mol | C15H12N2O7 | 25 MG
Thalidomide-5-O-CH2-COOH is a thalidomide-derived E3 ligase ligand-linker conjugate used as a cereblon ligand in chemical biology and targeted protein degradation research. It is supplied as a solid reagent intended for in vitro studies and synthetic applications.
- Acts as a cereblon (CRBN) ligand for targeted protein degradation studies.
- Designed as a ligand-linker conjugate to enable attachment to target-binding warheads.
- High solubility in DMSO (125 mg/mL) facilitates preparation of concentrated stocks.
- Supplied with typical purity of 95.0% suitable for research use.
- Molecular weight 332.26 g/mol and formula C15H12N2O7 for accurate dosing.
- Stable as a powder when stored frozen for long-term retention.
- Accompanied by datasheet, certificate of analysis, and safety data for handling guidance.
Medchemexpress LLC Thalidomide-O-PEG4-Boc | 2411681-87-1 | C28H38N2O11 | 25MG
Thalidomide-O-PEG4-Boc is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
- Incorporates thalidomide-based cereblon ligand.
- Utilizes a linker in PROTAC technology.
- Contains two different ligands connected by a linker.
- One ligand is for an E3 ubiquitin ligase, and the other is for the target protein.
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Used in PROTAC technology.