Lactams
Apexbio Technology LLC Thalidomide-O-amido-C4-NH2 TFA 1799711-25-3 10mg
Thalidomide-O-amido-C4-NH2 TFA (CAS 1799711-25-3) is a synthetic small molecule composed of a thalidomide-derived cereblon ligand conjugated to a chemical linker This compound selectively binds to cereblon (CRBN) a substrate receptor of the CRL4CRBN E3 ubiquitin ligase complex By facilitating the recruitment of target proteins to the CRBN complex it enables their ubiquitination and subsequent proteasomal degradation Thalidomide-O-amido-C4-NH2 TFA serves as a molecular tool in the development of proteolysis targeting chimeras (PROTACs) and other targeted protein degradation strategies in biomedical research
Medchemexpress LLC Thalidomide-NH-C6-NH2 TFA | 2093386-51-5 | 99.8% | 1 G
Thalidomide-NH-C6-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate, incorporating a Thalidomide-based cereblon ligand and a linker used in PROTAC technology. This compound is characterized by its high purity of 99.8%.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide-based cereblon ligand
- Features a linker used in PROTAC technology
- Designed for use in PROTACs that exploit the intracellular ubiquitin-proteasome system
Medchemexpress LLC Thalidomide-5-O-C6-NH2 hydrochloride | 2761398-05-2 | 409.86 | C19H24ClN3O5 | 10 MG
Thalidomide-5-O-C6-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand used as an E3 ligase recruiting moiety in PROTAC development and chemical biology research. The compound contains a six-carbon linker terminating in a primary amine and is supplied as the hydrochloride salt to aid handling and stability for research applications.
- Used as a cereblon ligand to recruit CRBN in PROTAC and degrader design.
- Contains a C6 linker with a terminal amine for conjugation to linkers or target ligands.
- Provided as a hydrochloride salt for improved handling and solubility.
- Solid form suitable for storage under recommended conditions.
- Intended for research use; consult vendor documentation or COA for purity and analytical data.
Medchemexpress LLC Thalidomide-NH-amido-PEG4-C2-NH2 hydrochloride | 2983037-00-7 | >98.0% | 586.03 | 25 MG
Thalidomide-NH-amido-PEG4-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate. It integrates a thalidomide-based cereblon ligand with a linker, making it suitable for applications in PROTAC technology. This compound is intended for research purposes only and is not for sale to patients.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates thalidomide-based cereblon ligand
- Utilizes a linker for PROTAC technology applications
- Suitable for research use
Medchemexpress LLC 2,6-piperidinedione, 3-(1,3-dihydro-5-iodo-1-oxo-2H-isoindol-2-yl) | 2291364-01-5 | MFCD32853043 | 98.0% | 370.14 g·mol⁻¹ | C13H11IN2O3 | 1 G
Deoxy-thalidomide-5-iodine is a thalidomide analogue used as an E3 ligase ligand in PROTAC research and cereblon-targeting studies. Supplied as a high-purity solid, it is commonly used as a building block for synthesis of degraders and chemical probes.
- High purity suitable for research (98.0%).
- Chemical formula C13H11IN2O3.
- Molecular weight 370.14 g·mol⁻¹.
- Useful as an E3 ligase (cereblon) ligand in PROTAC design.
- Solid form for ease of handling and storage.
- Store protected from light at refrigerated temperatures; in solvent: -80°C (6 months), -20°C (1 month).
Medchemexpress LLC 2,6-piperidinedione, 3-(1,3-dihydro-5-iodo-1-oxo-2h-isoindol-2-yl)- | 2291364-01-5 | MFCD32853043 | 98.0% | 370.14 g/mol | C13H11IN2O3 | 25 MG
Deoxy-thalidomide-5-iodine is a thalidomide analog bearing an iodine substituent at the 5-position used as a cereblon-binding ligand in PROTAC and targeted protein degradation research. Supplied as a colored solid with high reported purity, it is intended for chemical biology and linker-conjugation workflows.
- Thalidomide-derived cereblon ligand suitable for PROTAC design.
- High reported purity (98.0% by NMR) for research applications.
- Blue to blue-green solid physical form for easy handling.
- Molecular formula C13H11IN2O3 and molecular weight 370.14 g/mol.
- Suitable for linker attachment and synthesis of bifunctional degraders.
Medchemexpress LLC Thalidomide-NH-PEG2-COOH | 2412056-45-0 | MFCD34368531 | ≥95.0% | 433.41 g/mol | C20H23N3O8 | 5 MG
Thalidomide-NH-PEG2-COOH is a synthesized E3 ligase ligand-linker conjugate that combines a thalidomide-derived cereblon (CRBN) ligand with a short PEG2 carboxylic acid linker. It is designed as a building block for PROTAC (proteolysis targeting chimera) synthesis and related chemical biology research. For research use only.
- Provides CRBN engagement via a thalidomide-derived ligand.
- Contains a PEG2 spacer terminating in a carboxylic acid for linker conjugation.
- Suitable as a building block for PROTAC synthesis and E3 ligase recruitment studies.
- Characterized by analytical data, including HPLC, LC-MS, and NMR files.
- Available in small research-scale quantities for medicinal chemistry applications.
Medchemexpress LLC Thalidomide-Piperazine-PEG2-NH2 (diTFA) | 99.7% | 701.57 | 25 MG
Thalidomide-Piperazine-PEG2-NH2 diTFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide-based cereblon ligand and a linker used in PROTAC technology. It is for research use only.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide-based cereblon ligand
- Includes a linker used in PROTAC technology
- Targets Cereblon
- Utilizes the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Apexbio Technology LLC Thalidomide-O-amido-C4-NH2 TFA 1799711-25-3 50mg
Thalidomide-O-amido-C4-NH2 TFA (CAS 1799711-25-3) is a synthetic small molecule composed of a thalidomide-derived cereblon ligand conjugated to a chemical linker This compound selectively binds to cereblon (CRBN) a substrate receptor of the CRL4CRBN E3 ubiquitin ligase complex By facilitating the recruitment of target proteins to the CRBN complex it enables their ubiquitination and subsequent proteasomal degradation Thalidomide-O-amido-C4-NH2 TFA serves as a molecular tool in the development of proteolysis targeting chimeras (PROTACs) and other targeted protein degradation strategies in biomedical research
Medchemexpress LLC Thalidomide-NH-PEG3-COOH | 2375283-62-6 | 98.9% | 477.46 | 100 MG
Thalidomide-NH-PEG3-COOH is a synthesized E3 ligase ligand-linker conjugate. It incorporates a thalidomide-based cereblon ligand and a linker utilized in PROTAC technology. This product is intended for research purposes only.
- Incorporates a thalidomide-based cereblon ligand
- Designed for use in PROTAC technology
- Targets cereblon
- Appears as a white to yellow solid
- Useful in cancer research applications
- Functions as an E3 ligase ligand-linker conjugate
- Involved in autophagy and apoptosis studies
- Acts as an inhibitor
Cayman Chemical -ThalIdomIde 1g
An immunomodulatory compound with diverse biological activities; prevents PMN chemotaxis at 1, 10, and 100 UG/ml; increases IL-2-induced proliferation and IFN-γ production in primary human T cells in vitro; enhances NK cell-mediated cytotoxicity in MM.1S multiple myeloma cells; reduces lung IL-6, TGF-β, VEGF, angiopoietin-1, angiopoietin-2, and collagen type Iα1 expression, inhibits pulmonary angiogenesis, and attenuates fibrosis in a mouse model of bleomycin-induced pulmonary fibrosis at 4 mg/animal; induces apoptosis in primary human embryonic fibroblasts (EC50 = 8.9 µM) and induces limb and eye defects in chicken embryos (EC50 = 50 UG/kg egg weight)
Medchemexpress LLC Vh 101 phenol-alkylC6-amine dihydrochloride | 2564467-16-7 | ≥95% | 704.72 | 250 MG
VH 101 phenol-alkylC6-amine dihydrochloride is a functionalized von-Hippel-Lindau (VHL) protein-ligand designed for optimal PROTAC (Proteolysis Targeting Chimeras) functionality. It binds the VHL protein, enabling ubiquitination of target proteins, and the terminal amine on its C6 linker allows conjugation to target ligands for PROTAC synthesis.
- Functionalized VHL protein-ligand.
- Designed for optimal PROTAC functionality.
- Binds VHL protein to recruit E3 ligase.
- Enables ubiquitination of target proteins.
- Terminal amine on C6 linker allows conjugation to target ligands.
- Used in PROTAC synthesis against various targets.