Piperidines
Medchemexpress LLC HY-10684 5mg Medchemexpress, Pridopidine CAS:346688-38-8 Purity:>98%
Medchemexpress, HY-10684 5mg Pridopidine CAS:346688-38-8 Pridopidine, a dopamine (DA) stabilizer, acts as a low affinity dopamine D2 receptor (D2R) antagonist. Pridopidine exerts high affinity towards sigma 1 receptor (S1R) with Ki between 70 and 80 nM, which is ~100× higher than its affinity toward D2R. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC PI-103 hydrochloride | 371935-79-4 | MFCD10687102 | 98.0% | 384.82 | C19H16N4O3.HCl | 10 MG
PI-103 (hydrochloride) is a research-grade small-molecule inhibitor that targets class I PI3K isoforms, mTOR, and DNA-PK. It is used as a biochemical and cellular tool to study PI3K/mTOR signaling, apoptosis, and autophagy in cancer and related research.
- Dual PI3K and mTOR inhibitory activity with low-nanomolar potency.
- Reported IC50 values: p110α 8 nM; p110β 88 nM; p110δ 48 nM; p110γ 150 nM; mTORC1 20 nM; mTORC2 83 nM; DNA-PK 2 nM.
- Available in small-mass packs suitable for analytical and research use.
- Soluble in DMSO and compatible with cell-based and biochemical assays.
- Used to probe PI3K/mTOR pathway, autophagy, and apoptosis mechanisms in oncology research.
Medchemexpress LLC HY-10006 100mg , Flavopiridol (Hydrochloride) HL 275;NSC 649890;MDL 107826A;FLAVOPIRIDOL HCL;Alvocidib Hydrochloride CAS:131740-09-5 Purity:98%
Medchemexpress, HY-10006 100mg Flavopiridol (Hydrochloride) HL 275;NSC 649890;MDL 107826A;FLAVOPIRIDOL HCL;Alvocidib Hydrochloride CAS:131740-09-5 Formula:C21H21Cl2NO5 IC50: 30 nM (CDK1), 170 nM (CDK2), 100 nM (CDK4) Purity:98% Flavopiridol Hydrochloride is a broad inhibitor of CDK , competing with ATP to inhibit CDKs including CDK1, CDK2, CDK4 with IC 50 s of 30, 170, 100 nM, respectively. Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
eMolecules 1127498-03-6 | Medchem Express | JNJ-40411813 | 5mg | 446266527 | HY-15748 | MFCD22572363 | 344.88 | C20H25ClN2O
ChemScene | 3-Bromo-6-methoxypicolinic acid | 100mg | 642098137 | CS-0186789 | 1196147-56-4 | MFCD13185812 | 232.033 | C7H6BrNO3
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Medchemexpress LLC HY-10019 50mg Medchemexpress, Varenicline CAS:249296-44-4 Purity:>98%
Medchemexpress, HY-10019 50mg Varenicline CAS:249296-44-4 Varenicline (CP 526555) is a selective α4β2 nicotinic receptor (nAChR) partial agonist. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC 2-(4-(2-(trifluoromethyl)phenyl)piperidine-1-carboxamido)benzoic acid | 1152782-19-8 | MFCD12912393 | 99.7% | 392.37 g/mol | C20H19F3N2O3 | 25 MG
A 1120 is a nonretinoid, high-affinity antagonist of retinol-binding protein 4 (RBP4). It binds RBP4 with a reported Ki of 8.3 nM and disrupts the interaction between RBP4 and transthyretin. The compound is provided as a solid research reagent with documented purity, solubility, and storage recommendations.
- High-affinity RBP4 antagonist with Ki 8.3 nM.
- Purity reported as 99.73%.
- Molecular formula C20H19F3N2O3; molecular weight 392.37 g/mol.
- Supplied as a solid suitable for research use.
- Soluble in DMSO (100 mg/mL); in vivo vehicle example 10% DMSO, 90% corn oil.
- Storage guidance provided for powder and solutions to maintain stability.
Medchemexpress LLC HY-100748 100mg , HDAC-IN-4 CAS:934828-12-3 Purity:98%
Medchemexpress, HY-100748 100mg HDAC-IN-4 CAS:934828-12-3 Formula:C24H29N5O Purity:98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Selleck Chemical LLC Ceritinib dihydrochloride-5mg
Ceritinib (Zykadia, LDK378) dihydrochloride is a selective, orally bioavailable and ATP-competitive inhibitor of ALK with IC50 of 0.2 nM. Ceritinib dihydrochloride also inhibits InsR, IGF-1R and STK22D with IC50 of 7 nM, 8 nM and 23 nM, respectively. Ceritinib exhibits antitomor activity.
Medchemexpress LLC RIDR-PI-103 | 2581114-71-6 | 98.0% | C27H25N7O4 | 10MG
RIDR-PI-103 is a reactive oxygen species (ROS)-activated prodrug that releases a pan-PI3K inhibitor upon activation. It is supplied for research use to study PI3K/mTOR signaling, ROS-dependent prodrug activation, and related cellular models. Available as a solid powder and as DMSO solutions for in vitro applications.
- Reactive oxygen species-activated prodrug enabling controlled release under oxidative conditions.
- Designed to study PI3K/mTOR signaling and ROS-dependent therapeutic strategies.
- Available as solid powder and as ready-to-use DMSO solution for assay flexibility.
- High purity suitable for biochemical and cellular assays.
- Molecular formula C27H25N7O4; molecular weight 511.53 g/mol.
Medchemexpress LLC HY-10619A 5mg Medchemexpress, Niraparib hydrochloride CAS:1038915-64-8 Purity:>98%
Medchemexpress, HY-10619A 5mg Niraparib HCl CAS:1038915-64-8 Niraparib hydrochloride (MK-4827 hydrochloride) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with IC50s of 3.8 and 2.1 nM, respectively. Niraparib hydrochloride (MK-4827 hydrochloride) leads to inhibition of repair of DNA damage and shows anti-tumor activity[3]. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC HY-10006 5mg Medchemexpress, Flavopiridol (Hydrochloride) CAS:131740-09-5 Purity:>98%
Medchemexpress, HY-10006 5mg Flavopiridol (Hydrochloride) CAS:131740-09-5 Flavopiridol Hydrochloride is a broad inhibitor of CDK , competing with ATP to inhibit CDKs including CDK1, CDK2, CDK4 with IC 50 s of 30, 170, 100 nM, respectively. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Almonertinib mesylate | 2134096-06-1 | 99.67% | 621.75 | 100 MG
Almonertinib mesylate (HS-10296) is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor. It exhibits high selectivity for EGFR-sensitizing and T790M resistance mutations, showing significant inhibitory activity against T790M, T790M/L858R, and T790M/Del19 mutations while being less effective against wild-type EGFR. It is primarily used in research for non-small cell lung cancer and can also inhibit other EGFR sensitive mutations.
- Orally available, irreversible EGFR tyrosine kinase inhibitor
- High selectivity for EGFR-sensitizing and T790M resistance mutations
- Significant inhibitory activity against various T790M mutations
- Less effective against wild-type EGFR
- Used in research for non-small cell lung cancer
- Inhibits other EGFR sensitive mutations including G719X, del19, L858R, and L861Q
Apexbio Technology LLC Hoechst 33342/PI Double Staining Kit 500T
Hoechst 33342 PI Double Staining Kit is a fluorescence-based assay kit designed to distinguish apoptosis and necrosis in cell populations The kit utilizes two fluorescent probes Hoechst 33342 and propidium iodide (PI) to assess plasma membrane integrity and nuclear morphology Hoechst 33342 penetrates live cells and binds to DNA producing blue fluorescence with intensity increasing upon apoptotic chromatin condensation PI is impermeable to intact cell membranes and selectively labels necrotic cells with red fluorescence Compared to single-stain apoptosis assays this dual-stain approach enables simultaneous detection of viable apoptotic and necrotic cells Based on these properties Hoechst 33342 PI Double Staining Kit is applicable in pharmacological evaluation and cytotoxicity studies