Pyrans
FUJIFILM BIOSCIENCES INC Y-27632 MF
Y-27632 is reagent for cell culture applications including human ES/iPS cell culture It is a selective and potent inhibitor of ROCK Rho-associated coiled-coil forming kinase/Rho binding kinase Y-27632 has a variety of activities including vascular smooth muscle contraction through the ROCK signaling Ki 140 nmol/L p160ROCK This product has been reported to suppress death of human ES cells and human iPS cells at the time of cell dispersion and also improve viability of the cells after cryopreservation
FUJIFILM BIOSCIENCES INC Y-27632 MF
Y-27632 is reagent for cell culture applications including human ES/iPS cell culture It is a selective and potent inhibitor of ROCK Rho-associated coiled-coil forming kinase/Rho binding kinase Y-27632 has a variety of activities including vascular smooth muscle contraction through the ROCK signaling Ki 140 nmol/L p160ROCK This product has been reported to suppress death of human ES cells and human iPS cells at the time of cell dispersion and also improve viability of the cells after cryopreservation
Medchemexpress LLC Carboxy pyridostatin trifluoroacetate salt | 2444713-88-4 | 99.5% | 820.73 | 1 ML
Carboxy pyridostatin trifluoroacetate salt is a G-quadruplex ligand with high molecular specificity to RNA on DNA G4s. It reduces ATF-5 protein, inhibits cell proliferation, and hinders stress granule (SG) formation.
- Reduces the size of adult SVZ-derived neurospheres and the number of cells within them (1-25 μM; 3 days).
- Blocks proliferation and neurosphere fusion in adult SVZ-derived neurosphere cultures.
- Hindres stress granule (SG) formation in U2OS cells (10 μM; 24 hours).
- Significantly reduces the number of PCNA-expressing cells in the adult SVZ of mice (10 mg/kg; i.p.; every 12 hours; 3 injections).
- Increases the number of OLIG2-expressing cells in the corpus callosum in mice.
- Affects the differentiation of neural stem and progenitor cells in different brain regions.
Medchemexpress LLC Carboxy pyridostatin trifluoroacetate salt | 2444713-88-4 | 99.5% | 820.73 | 100 MG
Carboxy pyridostatin trifluoroacetate salt is a G-quadruplex ligand with high molecular specificity to RNA on DNA G4s, and it also reduces ATF-5 protein. This compound is known to decrease cell proliferation and inhibit stress granule (SG) formation. It is intended for research use only.
- Reduces the size of adult SVZ-derived neurospheres and the number of cells in neurospheres.
- Blocks proliferation and neurosphere fusion in adult SVZ-derived neurosphere cultures.
- Hinders stress granule (SG) formation in U2OS cells.
- Significantly reduces the number of PCNA-expressing cells in the adult SVZ.
- Increases the number of OLIG2-expressing cells in the corpus callosum in C57BL/6 mice.
- Affects the differentiation of neural stem and progenitor cells in different brain regions.
Medchemexpress LLC Carboxy pyridostatin trifluoroacetate salt | 2444713-88-4 | 99.5% | 820.73 | 25 MG
Carboxy pyridostatin trifluoroacetate salt is a G-quadruplex ligand. It exhibits high molecular specificity to RNA on DNA G4s and reduces ATF-5 protein. Additionally, it reduces cell proliferation and hinders stress granule (SG) formation.
- G-quadruplex ligand
- High molecular specificity to RNA on DNA G4s
- Reduces ATF-5 protein
- Reduces cell proliferation
- Hinders stress granule (SG) formation
- Reduces the size of adult SVZ-derived neurospheres and the number of cells in neurospheres
- Blocks proliferation and neurosphere fusion in adult SVZ-derived neurosphere cultures
- Significantly reduces the number of PCNA-expressing cells in the adult SVZ in mice
- Increases the number of OLIG2-expressing cells in the corpus callosum in mice
Medchemexpress LLC Carboxy pyridostatin trifluoroacetate salt | 2444713-88-4 | 99.5% | 820.73 | 50 MG
Carboxy pyridostatin trifluoroacetate salt is a G-quadruplex ligand with high molecular specificity to RNA on DNA G4s. It reduces ATF-5 protein, inhibits cell proliferation, and hinders stress granule (SG) formation. It is intended for research use only.
- G-quadruplex ligand
- Highly molecular specificity to RNA on DNA G4s
- Reduces ATF-5 protein
- Reduces cell proliferation
- Hinders stress granule (SG) formation
- Reduces the size of adult SVZ-derived neurospheres and the number of cells in neurospheres in vitro
- Blocks proliferation and neurosphere fusion in adult SVZ-derived neurosphere cultures in vitro
- Significantly reduces the number of PCNA-expressing cells in the adult SVZ and increases the number of OLIG2-expressing cells in the corpus callosum in mice in vivo
Medchemexpress LLC (2R)-Octyl-α-hydroxyglutarate | 1391194-67-4 | MFCD30735809 | 99.9% | 260.33 g/mol | C13H24O5 | 1 ML
(2R)-Octyl-α-hydroxyglutarate is a cell-permeable octyl-esterified form of the D-isomer 2-hydroxyglutarate used in biochemical and cell biology research to model 2-HG activity and investigate metabolic and epigenetic effects. It is provided as a ready-to-use solution for cell treatment and as solid material for assay and analytical work.
- Molecular formula: C13H24O5; molecular weight: 260.33 g/mol.
- High purity: 99.91% (as reported).
- Cell-permeable octyl ester for efficient intracellular delivery of 2-HG activity.
- Common applications: metabolic studies, epigenetic research, and cell-based assays.
- Available as a 10 mM solution in DMSO (1 mL) and in multiple solid sizes for analytical use.
- Storage: sealed at 4°C; in solution, store at -80°C for long-term stability.
FUJIFILM BIOSCIENCES INC CHIR99021 MF
CHIR99021 is a potent and selective GSK-3a/b inhibitor used to promote stem cell maintenance and signal pathway modulation
FUJIFILM BIOSCIENCES INC CHIR99021 MF
CHIR99021 is a potent and selective GSK-3a/b inhibitor used to promote stem cell maintenance and signal pathway modulation
Medchemexpress LLC (2R)-octyl-α-hydroxyglutarate | 1391194-67-4 | MFCD30735809 | 99.9% | 260.33 | C13H24O5 | 50 MG
(2R)-Octyl-α-hydroxyglutarate (CAS 1391194-67-4) is a membrane-permeable ester derivative of the oncometabolite D-2-hydroxyglutarate, provided for laboratory research use. It is used as a cell-permeable precursor to study metabolic and epigenetic effects mediated by 2-hydroxyglutarate in cultured cells.
- Cell-permeable ester derivative of D-2-hydroxyglutarate.
- Useful for investigating IDH mutation-related metabolic pathways.
- Supplied at high purity suitable for biochemical and cellular assays.
- Available in small milligram pack sizes for laboratory experiments.
- For research use only; not for human or clinical use.
Medchemexpress LLC (2R)-octyl-α-hydroxyglutarate | 1391194-67-4 | MFCD30735809 | 99.9% | 260.33 g·mol⁻¹ | C13H24O5 | 100 MG
(2R)-Octyl-α-hydroxyglutarate is a cell-permeable, esterified derivative of D-2-hydroxyglutarate used as a research reagent to investigate the biological effects of 2-HG in cellular systems, including effects on histone methylation, DNA damage, and mitochondrial oxidative processes.
- Cell-permeable analogue of D-2-hydroxyglutarate.
- Used to study histone methylation and epigenetic regulation.
- Reported purity approximately 99.9%.
- Molecular weight 260.33 g·mol⁻¹; chemical formula C13H24O5.
- Provided as an analytical/research standard in small pack sizes suitable for cell-based assays.
![Medchemexpress LLC Methanone, [1-(4-methoxyphenyl)-1H-benzimidazol-5-yl]-1-piperidinyl- | 452077-89-3 | 98.8% | 335.40 | C20H21N3O2 | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000226532.png-250.jpg)
Medchemexpress LLC Methanone, [1-(4-methoxyphenyl)-1H-benzimidazol-5-yl]-1-piperidinyl- | 452077-89-3 | 98.8% | 335.40 | C20H21N3O2 | 10 MG
A research-use small molecule inhibitor of human NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase intended for biochemical and cell-based studies. Supplied as solid and as a DMSO solution, the compound is characterized by its molecular properties and accompanied by a certificate of analysis.
- Selective inhibitor of human NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase.
- Suitable for enzyme inhibition assays and cell-based studies.
- Available as solid (5, 10, 25, 50, 100 MG) and as 10 mM solution in DMSO.
- Purity 98.8% as supplied.
- Molecular weight 335.40; formula C20H21N3O2.
Medchemexpress LLC (2R)-octyl-α-hydroxyglutarate | 1391194-67-4 | MFCD30735809 | 99.9% | 260.33 | C13H24O5 | 10 MG
(2R)-Octyl-α-hydroxyglutarate is an octyl-esterified analogue of the D-isomer of 2-hydroxyglutarate. It is membrane permeable and supplied for laboratory research to probe oncometabolite biology and epigenetic regulation.
- Membrane-permeable octyl ester of D-2-hydroxyglutarate for cellular studies.
- Used to study oncometabolite effects on histone methylation and cell viability.
- Reported to increase histone methylation and enhance viability of LMP1-negative NPC cells.
- High purity (≈99.9%) suitable for biochemical experiments.
- Available as solids (5-500 mg) and as 10 mM solution in DMSO.
- CAS 1391194-67-4; molecular formula C13H24O5; molecular weight 260.33.
- Store and handle per the product COA and SDS; for research use only.
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