Pyrazines
TARGETMOL CHEMICALS INC CU-115 5MG
Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. CU-115 is a selective and potent TLR8 antagonist with IC50 of 1.04 µM and =>50 µM for TLR8 and TLR7 respectively. CU-115 decreases production of TNF-(alpha) and IL-1(beta) activated by R-848 in THP-1 cells. purity: 100%
TARGETMOL CHEMICALS INC DALBAVANCIN 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Dalbavancin (BI-397) a novel second-generation lipoglycopeptide antibiotic possesses in vitro activity against a variety of Gram-positive pathogens including methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant Staphylococcus epidermidis (MRSE)Dalbavancin inhibits Staphylococcus aureus and Bacillus anthracis with MIC90s of 0.06 ug/mL and 0.25 ug/mL respectivelypurity: 98%
TARGETMOL CHEMICALS INC OAC2 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. OAC2 is an Oct4 activator which activates expression through the Oct4 gene promoter; enhances reprogramming efficiency by increasing the rate of production of induced pluripotent stem cells (iPSCs) from embryonic fibroblasts; an analog of OAC1. purity: 99%
TARGETMOL CHEMICALS INC CHRYSOSPLENETIN 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Chrysosplenetin is a metabolic inhibitor of artemisinin. purity: 98%
TARGETMOL CHEMICALS INC RSV604 25MG
Also available in 2 mg 5 mg 10 mg 50 mg 100 mg 200 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. RSV604 ((S)-1-(2-Fluorophenyl)-3-(2-oxo-5-phenyl-23-dihydro-1H-benzo[e][14]diazepin-3-yl)urea) is an inhibitor of respiratory syncytial virus (RSV) that binds to RSV nucleoprotein (Kd = 1.31 uM)purity: 98%
TARGETMOL CHEMICALS INC NAVTEMADLIN 5MG
Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Navtemadlin (AMG232) is a potent selective and orally available inhibitor of p53-MDM2 interaction (IC50 0.6 nM). It binds to MDM2 with a Kd of 0.045 nM. purity: 98%
TARGETMOL CHEMICALS INC ICFSP1 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. icFSP1 is a mitochondria-associated apoptosis-inducing factor regulator with antitumor activity for the study and treatment of tumor diseases. purity: 99%
TARGETMOL CHEMICALS INC EHOP-016 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 200 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. EHop-016 is a specific Rac GTPase inhibitor with IC50 of 1.1 uM for Rac1 in MDA-MB-231 and MDA-MB-435 cells equally effective inhibition for Rac3. purity: 99%
TARGETMOL CHEMICALS INC N8-ACETYLSPERMIDINE DIHY 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. N8-Acetylspermidine dihydrochloride is a polyamine that regulates ischemic cardiac apoptosis and resultant cardiac dysfunction. purity: 99%
TARGETMOL CHEMICALS INC 6H05 5MG
Also available in 10mg 25mg 50mg and bulk. Please contact Fisher for quotes. 6H05 (K-Ras inhibitor) is a selective allosteric inhibitor of oncogenic mutant K-Ras(G12C). purity: 98%
TARGETMOL CHEMICALS INC ICG001 10MG
Also available in 1 mg 2 mg 5 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. ICG001 (PRI-724 isomer) antagonizes Wnt/(beta)-catenin/TCF-mediated transcription and specifically binds to element-binding protein (CREB)-binding protein (CBP) with IC50 of 3 uM but is not the related transcriptional coactivator p300. purity: 99%
TARGETMOL CHEMICALS INC ICA-121431 25MG
Also available in 2 mg 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. ICA-121431 (22-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl) is a nanomolar potent small molecule Nav1.7 channel inhibitor with IC50 of 19 nM for rat Nav1.7 with little or no activity against human Nav1.5 or Nav1.7 channels. purity: 98%
TARGETMOL CHEMICALS INC CPCDPK1/TGCDPK1-IN-2 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. CpCDPK1/TgCDPK1-IN-2 is a dual inhibitor of CpCDPK1 and TgCDPK1 with IC50 values of 12 and 5 nM for CpCDPK1 and TgCDPK1 respectively.CpCDPK1/TgCDPK1-IN-2 can be used in the study of diseases associated with infection of toxoplasmas such as Toxoplasma gondii Cryptosporidium parvum and C. hominus. CpCDPK1/TgCDPK1-IN-2 can be used to study diseases associated with infections of toxoplasma gondii (T. gondii) Cryptosporidium parvum (C. parvum) and Cryptosporidium hominus (C. hominus). purity: 99%
TARGETMOL CHEMICALS INC LIPOFERMATA 5MG
Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Lipofermata is a fatty acid transport protein (FATP) inhibitor that prevents lipid transport to melanoma cells and reduces melanoma growth and invasion. purity: 99%
TARGETMOL CHEMICALS INC ORM-10103 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. ORM-10103 is a novel potent and selective inhibitor of the Na+/Ca2+ exchanger (NCX).ORM-10103 inhibited NCX currents with estimated IC50 values of 55 and 67 nM at -80 and 20 mV respectively and reduced early and delayed postdepolarization in canine hearts. purity: 98%