Pyridines and derivatives
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- (54)
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- (39)
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- (11)
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Filtered Search Results
Medchemexpress LLC GSK3β inhibitor II | 478482-75-6 | 99.5% | 395.22 g·mol⁻¹ | C14H10IN3OS | 5 MG
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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GSK3β inhibitor II is a small-molecule inhibitor of glycogen synthase kinase 3 beta (GSK3β) intended for research use. Supplied as a high-purity solid, it is used in studies of GSK3β-mediated signaling and in models relevant to neurodegenerative disease research.
- High purity suitable for research applications (reported 99.49%).
- Compact 5 mg pack size for small-scale experiments.
- Molecular formula: C14H10IN3OS; molecular weight: 395.22 g·mol⁻¹.
- Provided with supporting documents: data sheet, COA, and SDS.
- Suitable for in vitro signaling and neurobiology studies.
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Ambeed S Propane1 2diol
(S)-Propane-1,2-diol, 4254-15-3, 98%
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC RSK4-IN-1 trifluoroacetate | 00-00-0 | 98.6% | 390.38 g/mol | C19H20F2N4O3 | 5 MG
Small and Specialty Supplier Partner
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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RSK4-IN-1 TFA is the trifluoroacetate salt of a potent small-molecule inhibitor of ribosomal S6 kinase 4 (RSK4). It inhibits RSK4 with an IC50 of 9.5 nM and has reported antitumor activity. Supplied as a research-grade compound with high purity, it is intended for biochemical and cellular studies of RSK4 signaling.
- Potent RSK4 inhibition (IC50 9.5 nM).
- Reported antitumor activity in preclinical studies.
- High purity (98.6%).
- Molecular formula C19H20F2N4O3; molecular weight 390.38 g/mol.
- Supplied as a trifluoroacetate salt suitable for biochemical and cellular assays.
- Available in milligram pack sizes (1 mg-100 mg) for research use.
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Medchemexpress LLC Bardoxolone | 218600-44-3 | MFCD07772296 | 99.5% | 491.66 | 1 ML
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Bardoxolone (CDDO; RTA 401) is a potent Nrf2 activator, exhibiting anti-SARS-CoV-2 3CLpro activity and inhibiting the NF-κB pathway. It is known to induce cell differentiation and apoptosis, and shows antiproliferative activity against various cancer cells. This compound is valuable for research in fields such as cancer, inflammation, and infections like SARS-CoV.
- Activates Nrf2 pathway
- Inhibits NF-κB pathway
- Exhibits anti-SARS-CoV-2 3CLpro activity
- Induces cell differentiation and apoptosis
- Shows antiproliferative activity against cancer cells
- Increases ROS and decreases intracellular GSH levels
- Inhibits necroptosis
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Medchemexpress LLC Nicodicosapent | 1269181-69-2 | 99.8% | 449.63 | 50 MG
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Nicodicosapent is a fatty acid niacin conjugate that inhibits the sterol regulatory element binding protein (SREBP), a key regulator of cholesterol metabolism proteins including PCSK9, HMG-CoA reductase, ATP citrate lyase, and NPC1L1. This product is for research use only.
- Inhibitor of sterol regulatory element binding protein (SREBP)
- Decreases mature SREBP-2 protein production in HepG2 cells
- Synergistically inhibits secreted PCSK9
- Significantly inhibits ApoB secretion in a dose-dependent manner
- Reduces PCSK9 levels, LDL particles, and plasma triglycerides in ApoE*3-Leiden mice
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Medchemexpress LLC 11,15-O-dimethyl-PGE2 | 211230-67-0 | 98.3% | 25 MG
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ONO-AE 248 (CAS 211230-67-0) is a selective prostaglandin EP3 receptor agonist used in research to investigate cardioprotective mechanisms. It has been shown to reduce myocardial infarct size in animal models and is used in pharmacology and mechanistic studies involving protein kinase C and K(ATP) channels.
- Selective EP3 receptor agonist for pharmacology studies.
- Demonstrated cardioprotective activity in myocardial infarction models.
- High purity suitable for research applications.
- Molecular formula C22H36O5; molecular weight ~380.5 g/mol.
- Supplied in a 25 MG quantity for laboratory use.
- Store as recommended to preserve stability and activity.
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Medchemexpress LLC K-756 | 130017-40-2 | 433.50 | 100 MG
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K-756 is a direct and selective tankyrase (TNKS) inhibitor that inhibits the ADP-ribosylation activity of TNKS1 and TNKS2. This novel and selective Wnt/β-catenin pathway inhibitor binds to the induced pocket of TNKS, inhibiting its enzyme activity and showing isoform selectivity.
- Direct and selective tankyrase (TNKS) inhibitor
- Inhibits ADP-ribosylation activity of TNKS1 and TNKS2
- Novel and selective Wnt/β-catenin pathway inhibitor
- Binds to the induced pocket of TNKS
- Inhibits cell growth in APC-mutant colorectal cancer cells
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Medchemexpress LLC K-8012 | 1346513-17-4 | 98.2% | 5 MG
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K-8012 is a small-molecule RXRα antagonist used for research. It has molecular formula C23H23FN4, molecular weight 374.45 g/mol, and reported purity of 98.24%.
- Antagonist of retinoid X receptor alpha (RXRα).
- Reported activity in PI3K/AKT and apoptosis pathways.
- High purity suitable for research applications.
- Available as a 5 mg research-grade sample.
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TARGETMOL CHEMICALS INC Alosetron hydrochloride 50MG
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Also available in 10 mg, 25 mg, 100 mg, 200 mg and bulk. Please contact Fisher for quotes. Alosetron hydrochloride (GR 68755) is the hydrochloride salt form of alosetron, a potent and selective 5-HT3 receptor antagonist. Alosetron blocks the actions of serotonin at 5-HT3 sites in the peripheral nervous system, particularly on enteric and nociceptive sensory neurons, thereby affecting the regulation of visceral pain, decreasing gastrointestinal contraction and motility, and decreasing gastrointestinal secretions. Purity 100%
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Medchemexpress LLC Nsc 66811 | 6964-62-1 | 98.12% | 340.42 | 1 ML
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NSC 66811 is an MDM2-p53 inhibitor, with a Ki of 120 nM for binding to MDM2, suitable for research use. It has a molecular weight of 340.42 and a purity of 98.12%. This compound demonstrates the following biological activities:
- Dose-dependently induces the accumulation of p53, MDM2, and p21cip1/waf proteins due to the functional activation of p53.
- Effective in HCT-116 human colon cancer cell line with wild-type p53.
- Has no effect on the levels of p53, MDM2, and p21cip1/waf protein in the isogenic HCT-116 p53-/- cell line.
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Medchemexpress LLC Lom612 | 2173232-79-4 | 98.9% | 258.30 | C13H10N2O2S | 25 MG
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LOM612 is a small-molecule FOXO relocator that promotes nuclear translocation of FOXO transcription factors (FOXO1, FOXO3a) and increases expression of FOXO target genes such as p27 and FasL. It is active in cellular assays (U2fox RELOC) with an EC50 of 1.5 μM and shows cytotoxicity to HepG2 cells (IC50 0.64 μM). Supplied as a solid with high reported purity for research use.
- Potent FOXO relocator with EC50 1.5 μM in U2fox RELOC cells.
- Induces nuclear translocation of FOXO1 and FOXO3a and upregulates p27 and FasL.
- Shows cytotoxicity to HepG2 cells (IC50 0.64 μM) with lower activity in THLE2 cells.
- High reported purity (98.85%) and solid, pink to red appearance.
- Soluble in DMSO at 1 mg/mL with recommended warming and sonication; follow storage instructions.
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000659539 DT-061 1MG
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Selleck Chemical LLC LGR5-A2657-1MG-25
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LGR5 is a human specific monoclonal antibody targeting the GPCR-LGR5 It can be used in the treatment of metastatic colorectal cancer (CRC) MW 150 KD
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eMolecules EMOLECULES INC
5000841264 VISMODEGIB 1G
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eMolecules EMOLECULES INC
5000841400 3-ISOPROPYLPYRAZOLE 1G
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