Pyridines and derivatives
6-Methoxy-4-methylquinoline Hydrate 98.0+%, TCI America™
CAS: 41037-26-7 Molecular Formula: C11H11NO Molecular Weight (g/mol): 173.215 MDL Number: MFCD00191547 InChI Key: MBVGYFIYXWVPQY-UHFFFAOYSA-N PubChem CID: 258761 IUPAC Name: 6-methoxy-4-methylquinoline SMILES: CC1=C2C=C(C=CC2=NC=C1)OC
Apexbio Technology LLC Clioquinol 130-26-7 500mg
Clioquinol (130-26-7) is a small-molecule modulator functioning as a metal-ion chelator It is designed to modulate metal homeostasis thereby affecting metal-dependent cellular pathways Clioquinol exerts its biological activity primarily through chelation of metal ions disrupting iron-mediated enzymatic reactions crucial for fungal and cancer cell growth In in vitro studies Clioquinol demonstrates cytotoxic effects in diverse tumor cell lines with IC50 values generally in the low micromolar range (approximately 1 10 M depending on cell type and conditions) Based on these pharmacological properties Clioquinol holds research potential in antifungal antimicrobial and oncological applications
Apexbio Technology LLC Wortmannin 19545-26-7 10mg
Wortmannin is a selective inhibitor targeting phosphatidylinositol-3-kinase (PI3K) with reported IC50 of approximately 1 9 nM It inhibits PI3K through an ATP-noncompetitive binding mechanism interacting directly with the catalytic region Additionally wortmannin functions as a noncompetitive inhibitor of myosin light chain kinase (MLCK) with an IC50 around 1 9 M thus decreasing myosin light chain phosphorylation and associated smooth muscle contraction In biomedical research wortmannin is commonly employed to dissect the PI3K signaling pathway evaluate smooth muscle contractility and explore therapeutic potentials related to vascular dilation and inflammation modulation
Apexbio Technology LLC Nikethamide 59-26-7 500mg
Nikethamide is a small-molecule respiratory stimulant designed to modulate the respiratory center in the medulla oblongata thereby regulating central respiratory sensitivity Nikethamide exerts its biological activity primarily through modulation of neural pathways within the central nervous system potentially involving nicotinic receptors and neurotransmitter signaling cascades Based on these pharmacological properties Nikethamide holds research potential in investigating respiratory dysfunction respiratory failure and the signaling mechanisms governing respiratory neural control
Medchemexpress LLC Nikethamide | 59-26-7 | 500 MG
Nikethamide (N,N-Diethylnicotinamide) is classified as one of the respiratory central stimulants. It is being researched for its potential in addressing respiratory failure.
- Respiratory central stimulant
- Potential for respiratory failure research
Medchemexpress LLC Dihydrolapachenole | 20213-26-7 | 5 MG
Dihydrolapachenole is a laboratory chemical primarily used in the manufacture of various substances. This solid compound has a molecular formula of C16H18O2 and a molecular weight of 242.31.
- Laboratory chemical application
- Used for substance manufacturing
- Solid form
- Molecular formula: C16H18O2
- Molecular weight: 242.31
- Causes skin irritation (Category 2)
- Causes serious eye irritation (Category 2A)
Medchemexpress LLC Sulfaproxiline | 116-42-7 | MFCD00233642 | 99.4% | 334.39 | C16H18N2O4S | 25 MG
Sulfaproxiline is a synthetic sulfonamide-class antimicrobial supplied for research use. It is used in laboratory studies of antibacterial activity and sulfonamide pharmacology and is provided as small milligram packs with high reported purity.
- High reported purity (≈99.4%) suitable for analytical and biological studies.
- Belongs to the sulfonamide class with antibacterial activity.
- Available in small milligram pack sizes for screening and assay workflows.
- Unambiguous chemical identifiers (CAS 116-42-7, MFCD00233642) aid record keeping.
- Defined molecular properties: formula C16H18N2O4S; molecular weight 334.39 g/mol.
Medchemexpress LLC Lartesertib | 2495096-26-7 | C23H21FN6O3 | 1 ML
Lartesertib, also known as M4076, is a potent inhibitor of the serine/threonine protein kinase ATM. It has been shown to inhibit the growth of multiple hematopoietic cell lines. When combined with the ATR inhibitor Tuvusertib, Lartesertib can promote the death of tumor cells, activate the immune signaling pathway, and exhibit significant anti-tumor activity.
- Potent inhibitor of ATM protein kinase.
- Inhibits growth of multiple hematopoietic cell lines.
- Promotes tumor cell death in combination with Tuvusertib.
- Activates the immune signaling pathway.
- Exhibits anti-tumor activity.
Medchemexpress LLC Lercanidipine | 100427-26-7 | 99.9% | 50 MG
Lercanidipine is a third-generation, lipophilic, brain-penetrant, vascular-selective, and orally active dihydropyridine-calcium channel blocker with a pIC50 of 7.74. It has a long-lasting antihypertensive action and also exhibits reno- and neuro-protective effects. Additionally, Lercanidipine demonstrates anti-oxidant, anti-inflammatory, and anti-apoptotic properties. It is suitable for cardiovascular and neurological research.
- Third-generation dihydropyridine-calcium channel blocker
- Lipophilic and brain-penetrant
- Vascular-selective and orally active
- Long-lasting antihypertensive action
- Reno- and neuro-protective effect
- Anti-oxidant, anti-inflammatory, and anti-apoptotic properties
- Can be used in cardiovascular and neurological research
Medchemexpress LLC Lercanidipine | 100427-26-7 | 99.9% | 1 ML
Lercanidipine is a third-generation, lipophilic, brain-penetrant, vascular-selective, and orally active dihydropyridine-calcium channel blocker. It exhibits long-lasting antihypertensive action and reno- and neuro-protective effects. This product is suitable for use in cardiovascular and neurological research.
- Has a pIC50 of 7.74
- Offers reno- and neuro-protective effects
- Exhibits anti-oxidant, anti-inflammatory, and anti-apoptotic properties
- Used in cardiovascular and neurological research
Medchemexpress LLC Clioquinol | 130-26-7 | C9H5CLINO | 5 G
Clioquinol (Iodochlorhydroxyquin) is a topical antifungal agent with anticancer activity. It acts as an oral antimicrobial for the research of diarrhea and skin infections. Clioquinol is a chelator that binds to Zn²⁺ and Cu²⁺ with a greater affinity than to Ca²⁺ and Mg²⁺, and it can freely cross the blood-brain barrier for the study of Alzheimer's disease.
- Topical antifungal agent
- Exhibits anticancer activity
- Functions as an oral antimicrobial for diarrhea and skin infections research
- Acts as a chelator binding to Zn²⁺ and Cu²⁺
- Freely crosses the blood-brain barrier
- Used for the study of Alzheimer's disease
- Relevant for research in fungal, autophagy, mitophagy, antibiotic, and parasite studies
- Applicable in infection, neurological disease, inflammation/immunology, and cancer research
Medchemexpress LLC Lartesertib | 2495096-26-7 | C23H21FN6O3 | 1 MG
Lartesertib (M4076) is a potent inhibitor of the serine/threonine protein kinase ATM. It has demonstrated the ability to inhibit the growth of various hematopoietic cell lines. When used in combination with the ATR inhibitor Tuvusertib (HY-111451), Lartesertib can induce tumor cell death, activate immune signaling pathways, and exhibit anti-tumor activity. It also alters the tumor microenvironment by upregulating PD-L1.
- Potent inhibitor of ATM protein kinase
- Inhibits growth of multiple hematopoietic cell lines
- Induces tumor cell death when combined with Tuvusertib
- Activates immune signaling pathways
- Demonstrates anti-tumor activity
- Upregulates PD-L1 on immune and tumor cells
- Alters the tumor microenvironment
Medchemexpress LLC 7α-Hydroxycholesterol | 566-26-7 | 1 ML
7α-Hydroxycholesterol is a cholesterol oxide and can serve as a biomarker for oxidative stress and lipid peroxidation. It has cytotoxic and pro-inflammatory activities, and can inhibit sterol synthesis and reduce the activity of HMG-CoA reductase. 7α-Hydroxycholesterol can be used in the research of diseases such as diabetes and atherosclerosis. It is for research use only and not sold to patients.
- Biomarker for oxidative stress and lipid peroxidation
- Cytotoxic and pro-inflammatory activities
- Inhibits sterol synthesis and reduces HMG-CoA reductase activity
- Applicable in diabetes and atherosclerosis research
Medchemexpress LLC Lercanidipine | 100427-26-7 | 99.9% | 25 MG
Lercanidipine is a third-generation, lipophilic, brain-penetrant, vascular-selective, and orally active dihydropyridine-calcium channel blocker. It exhibits long-lasting antihypertensive action and possesses reno- and neuro-protective effects, making it suitable for cardiovascular and neurological research.
- Vascular-selective calcium channel blocker
- Orally active with long-lasting antihypertensive action
- Possesses reno- and neuro-protective effects
- Demonstrates anti-oxidant, anti-inflammatory, and anti-apoptotic properties
Medchemexpress LLC Finasteride | 98319-26-7 | 372.54 | 100 MG
Finasteride, also known as MK-906, is an orally active and competitive 5α-reductase inhibitor. It exhibits an IC50 of 4.2 nM for type II 5α-reductase, demonstrating approximately a 100-fold greater affinity for the type II enzyme compared to the type I enzyme.
- Utilized for research related to benign prostatic hyperplasia (BPH)
- Applied in studies concerning androgenic alopecia